• Oncology Letters
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• v.41 no.6
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• pp.3305-3312
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• 2019

Histone H2B monoubiquitination has been shown to play critical roles in diverse cellular processes including DNA damage response. Although recent data indicate that H2B monoubiquitination is strongly connected with tumor progression and regulation, the implications of this modification in lung adenocarcinoma are relatively unknown. In the present study, we demonstrated the clinical implication of H2B monoubiquitination and the potential role of tumor necrosis factor receptor-associated factor-interacting protein (TRAIP) in regulating its modification in lung adenocarcinoma. Immunohistochemical analysis showed that H2B monoubiquitination was significantly downregulated in 68 human lung adenocarcinoma patient samples compared to their normal adjacent tissues. Depletion of TRAIP by specific siRNA treatment markedly decreased ionizing radiation (IR)-induced H2B monoubiquitination. In addition, deletion mutants without RING domain or C-terminus of TRAIP diminished the ability to induce H2B monoubiquitination at lysine 120. Notably, the nuclear expression of TRAIP was positively related with H2B monoubiquitination levels in patients with lung adenocarcinoma. Furthermore, statistical analysis indicated that low levels of both TRAIP and H2B monoubiquitination, not each alone, in patients with lung adenocarcinoma were strongly correlated with poor survival. Taken together, these results suggest that TRAIP is a novel regulator of H2B monoubiquitination in DNA damage response and cancer development in lung adenocarcinoma.

• Computational Structural Engineering
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• v.9 no.4
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• pp.229-237
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• 1996

In some current procedures, ground motions from different sources have been scaled by their peak ground accelerations and combined to obtain smoothed response spectra for specific regions. As consideration of the inelastic deformation capacity of structure, inelastic deformations are permitted under seismic ground excitation in all codes. In the ATC(Applied Technology Council) and UBC(Uniform Building Code), the inelastic design spectrum is obtained by reducing the elastic design spectrum by a factor that is independent of structural period. In this study, the average of nonlinear response spectra calculated from a sample of 20 records for each event are constructed to obtain the smoothed response spectra. These response spectra are used to examine the effects of structural strength factors such as the yield strength ratio and damping value. Through the regression analysis of nonlinear response of system for a given damping value and yield strength ratio, the required yield strength for seismic design can be estimated for a certain earthquake event. And a response modification coefficient depending on the natural period for current seismic design specifications are proposed.

• Journal of Korean Society of Steel Construction
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• v.19 no.6
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• pp.715-723
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• 2007

A displacement-based seismic design procedure was proposed for mid-to-low-rise steel moment frames. The proposed method was totally different from the current R-factor approach in that it directly uses available connection rotation capacity as a primary design variable. To this end, the relationship between available connection rotation capacity and seismic response modification (R factor) was established first; this relationship has been a missing link in current ductility-based design practice. A step-by-step displacement-based iterative design procedure was then proposed and verified using inelastic dynamic analysis.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2002.04a
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• pp.208-213
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• 2002

Near field ground motions contain distinct, large amplitude pulses in both velocity and displacement. This paper presents an investigation on the characteristics of near filed earthquakes and their effects on seismic demands. For this purpose 20 sets of near field ground motion and 20 sets of far filed ground motion are compared with respect to Linear Elastic Response Spectrum(LERS), Response Modification Factor(R), Inelastic Response Spectrum(IRS), and performance point of Capacity Spectum Method(CSM).

• Structural Engineering and Mechanics
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• v.10 no.4
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• pp.405-426
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• 2000

Two approximate methods based on mechanism analysis suitable for seismic assessment/design of structural concrete are reviewed. The methods involve use of equal energy concept or equal displacement concept along with appropriate patterns of inelastic deformations to relate structure's maximum lateral displacement to member and plastic deformations. One of these methods (Clough's method), defined here as a ductility-based approach, is examined in detail and a modification for its improvement is suggested. The modification is based on estimation of maximum inelastic displacement using inelastic design response spectra (IDRS) as an alternative to using equal energy concept. The IDRS for demand displacement ductilities are developed for a single degree of freedom model subjected to several accelerograms as functions of response modification factor (R), damping ratios, and strain hardening. The suggested revised methodology involves estimation of R as the ratio of elastic strength demand to code level demand, and determination of design base shear using $R_{design}{\leq}R$ and maximum displacement, determination of plastic displacement using IDRS and subsequent local plastic deformations. The methodology is demonstrated for the case of a 10-story precast wall panel building.

• Earthquakes and Structures
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• v.16 no.2
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• pp.185-196
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• 2019

One of the shortcomings of seismic bridge design codes is the lack of clarity in defining the role of different seismic isolation systems with linear or nonlinear behavior in terms of R-factor. For example, based on AASHTO guide specifications for seismic isolation design, R-factor for all substructure elements of isolated bridges should be half of those expressed in the AASHTO standard specifications for highway bridges (i.e., R=3 for single columns and R=5 for multiple column bent) but not less than 1.50. However, no distinction is made between two commonly used types of seismic isolation devices, i.e., elastomeric rubber bearing (ERB) with linear behavior, and lead rubber bearing (LRB) with nonlinear behavior. In this paper, five existing bridges located in Iran with two types of deck-pier connection including ERB and LRB isolators, and two bridge models with monolithic deck-pier connection are developed and their R-factor values are assessed based on the Uang's method. The average R-factors for the bridges with ERB isolators are calculated as 3.89 and 4.91 in the longitudinal and transverse directions, respectively, which are not in consonance with the AASHTO guide specifications for seismic isolation design (i.e., R=3/2=1.5 for the longitudinal direction and R=5/2=2.5 for the transverse direction). This is a clear indicator that the code-prescribed R-factors are conservative for typical bridges with ERB isolators. Also for the bridges with LRB isolators, the average computed R-factors equal 1.652 and 2.232 in the longitudinal and transverse directions, respectively, which are in a good agreement with the code-specified R-factor values. Moreover, in the bridges with monolithic deck-pier connection, the average R-factor in the longitudinal direction is obtained as 2.92 which is close to the specified R-factor in the bridge design codes (i.e., 3), and in the transverse direction is obtained as 2.41 which is about half of the corresponding R-factor value in the specifications (i.e., 5).

• Earthquakes and Structures
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• v.20 no.2
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• pp.149-160
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• 2021

Buildings made using the locally available clay materials are amongst the least expensive forms of construction in many developing countries, and therefore, widely popular in remote areas. It is despite the fact that these low-strength masonry structures are vulnerable to seismic forces. Since transporting imported materials like cement and steel in areas inaccessible by motorable roads is challenging and financially unviable. This paper presents, and experimentally investigates, adobe masonry structures that utilize the abundantly available local clay materials with moderate use of imported materials like cement, aggregates, and steel. Shake-table tests were performed on two 1:3 reduce-scaled adobe masonry models for experimental seismic testing and verification. The model AM1 was confined with vertical lightly reinforced concrete columns provided at all corners and reinforced concrete horizontal bands (i.e., tie beams) provided at sill, lintel, and eave levels. The model AM2 was confined only with the horizontal bands provided at sill, lintel, and eave levels. The models were subjected to sinusoidal base motions for studying the damage evolution and response of the model under dynamic lateral loading. The lateral forcedeformation capacity curves for both models were developed and bi-linearized to compute the seismic response parameters: stiffness, strength, ductility, and response modification factor R. Seismic performance levels, story-drift, base shear coefficient, and the expected structural damages, were defined for both the models. Seismic performance assessment of the selected models was carried out using the lateral seismic force procedure to evaluate their safety in different seismic zones. The use of vertical columns in AM1 has shown a considerable increase in the lateral strength of the model in comparison to AM2. Although an R factor equal to 2.0 is recommended for both the models, AM1 has exhibited better seismic performance in all seismic zones due to its relatively high lateral strength in comparison to AM2.

• Tribology and Lubricants
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• v.35 no.3
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• pp.158-168
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• 2019

This paper presents the investigation of two types of rotordynamic modeling issues for 2.2 kW-class, rated speed of 1,800 rpm, squirrel-cage type induction motors. These issues include the lamination structure of rotor cores, and the radial clearance of ball bearings that support the shaft of the motor. Firstly, we focus on identifying the effects of rotor core lamination on the rotordynamic analysis via a 2D prediction model. The influence of lamination is considered as the change in the elastic modulus of the rotor core, which is determined by a modification factor ranging from 0 to 1.0. The analysis results show that the unbalanced response of the rotor-bearing system significantly varies depending on the value of the modification factor. Through modal testing of the system, the modification factor of 0.079 is proven to be appropriate to consider the effects of lamination. Next, we investigate the influence of ball bearing clearance on the rotordynamic analysis by establishing a bearing analysis model based on Hertz's contact theory. The analysis results indicate that negative clearance greatly changes the bearing static behavior. Rotordynamic analysis using predicted bearing stiffness with various clearances from -0.005 mm to 0.010 mm reveals that variations in clearance result in a slight difference in the displacement of the system up to 18.18. Thus, considering lamination in rotordynamic analysis is necessary as it can cause serious analysis errors in unbalanced response. However, considering the effect of the bearing clearance is optional because of its relatively weak impact.

• Journal of Electrical Engineering and Technology
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• v.7 no.3
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• pp.330-335
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• 2012

The shape optimization of a Thomson coil actuator used in an arc eliminator is done for fast response by adopting topology modification method. The displacement of the plate in a fixed calculation time is taken as the objective function. The objective function and contribution factor are calculated by using an adaptive equivalent circuit method which has been proved accurate and efficient. Both shape optimization and performance analysis are accomplished based on the segmentation of plate. Through the refinement of the sensitive segments a precise optimal plate shape can be obtained. The effectiveness of the proposed method is proved by the comparison of results before and after the shape optimization.

• Journal of Electrical Engineering and Technology
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• v.7 no.1
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• pp.58-63
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• 2012

The shape optimization of a Thomson coil actuator used in an arc eliminator is done for fast response by adopting topology modification method. The displacement of the plate in a fixed calculation time is taken as the objective function. The objective function and contribution factor are calculated by using an adaptive equivalent circuit method which has been proved accurate and efficient. Both shape optimization and performance analysis are accomplished based on the segmentation of plate. Through the refinement of the sensitive segments a precise optimal plate shape can be obtained. The effectiveness of the proposed method is proved by the comparison of results before and after the shape optimization.