• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 추계학술대회 논문집
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• pp.402-403
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• 2014

Damping of multi-span tube with loose supports according to the finite support clearances is investigated through the experimental modal analysis. Loose intermediate support leads to strong nonlinearity in tube dynamics, provides statistical nature, and increases tube damping through impacting and friction at the supports. Fraction of critical damping was estimated by the modal curve fitting to parameter estimation from the measured frequency response functions. Magnitude of random excitation force, which can reproduce the in-situ excitation in operating environment, was maintained as constant value with a fine tolerance during vibration testing. Range of input force was carefully selected to cover from the low magnitude excitation for linearly behaved tube motion to high magnitude of force for nonlinearly-behaved tube motion. Estimated critical damping ratio shows scatters in data and tends to increase as the magnitude of rising force and decrease with upward frequency variation. Larger size of support gap increases multi-span tube damping for high magnitude of excitation.

• 한국농공학회논문집
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• 제51권3호
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• pp.37-43
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• 2009

The objective of this study was to investigate the basic relationships between spectral reflectance and varying concentrations of sediment in surface waters. An experimental method for determining suspended sediment concentration (SSC) in the water by use of a spectroradiometer above the water surface, in visible and near-infrared (NIR) wavelengths, is applied. The main advantage of the method is the direct comparison of spectral reflectance and the SSC, but it requires an accurate knowledge of the water body and sediment. Therefore numerous spectroradiometric measurements are carried out in situ measurements, for SSC, ranging from zero to 100 percentage and two types of sediment applied in the water tank. The results indicate that the suspended sediment causes increasing spectral reflectance response in waters. We observed that spectral reflectance increases with SSC, first at the lower wavelengths (430-480 nm), then in the middle wavelengths (570-700 nm), and finally, in the NIR domain (800-820 nm); a characteristic maximum reflectance appears at 400-670 nm. Relationships between the wavelength, integral value, and the SSC were evaluated on the basis of the regression analysis. The regression curve for the relation between the wavelength, integral value, and the SSC were determined ($R^2$>0.98). Finally, the specular wavelength can be estimated to recognize the sediment and to improve SC estimation accuracy in the water.

• The Korean Journal of Physiology and Pharmacology
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• 제2권4호
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• pp.471-477
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• 1998

Cyclosporin A (CsA), a widely used immunosuppressant, is well known to cause nephrotoxicity and hypertension as major side effects. The present study was aimed at investigating the effects of CsA-pretreatment on the activities of cytosolic guanylate cyclase (cGC) in relation to the alteration of relaxant responses in the rat thoracic aorta. CsA $(10\;{\mu}M)-preincubation$ for 90 min significantly attenuated the vasodilatation induced by sodium nitroprusside (SNP), a cytosolic guanylate cyclase activator, shifting the dose-response curve to the right. The increase in cGMP contents induced by SNP was markedly attenuated by CsA. SNP ($1\;{\mu}M{\sim}\;mM$) increased the cGC activity dose-dependently, and the increase was completely abolished by CsA. CsA attenuated the SNP-induced cGC activation dose-dependently. The abolishing effect of CsA-pretreatment on the SNP-induced cGC activation was not affected by washing the preparation, suggesting that the inhibition is irreversible. When CsA was added simultaneously with SNP, cGC activation was not attenuated. 1-(5-isoquinolinylsulfonyl)-2-methyl piperazine (H-7), a protein kinase C (PKC) inhibitor, decreased SNP-induced cGC activation and blocked the CsA-attenuation of cGC activation. These results suggest that CsA directly inhibits cGC participating in the CsA-induced impairment of vasodilatation, and that PKC is involved in the inhibitory action of CsA on cGC.

• Journal of electromagnetic engineering and science
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• 제9권1호
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• pp.7-11
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• 2009

An Ultra-WideBand(UWB) Low-Noise Amplifier(LNA) is proposed and is implemented in a $0.18-{\mu}m$ CMOS technology. The proposed UWB LNA provides excellent wideband characteristics by combining a High-Pass Filter (HPF) with a conventional resistive-loaded LNA topology. In the proposed UWB LNA, the bell-shaped gain curve of the overall amplifier is much less dependent on the frequency response of the HPF embedded in the input stage. In addition, the adoption of fewer on-chip inductors in the input matching network permits a lower noise figure and a smaller chip area. Measurement results show a power gain of + 10 dB and an input return loss of more than - 9 dB over 2.7 to 6.2 GHz, a noise figure of 3.1 dB at 3.6 GHz and 7.8 dB at 6.2 GHz, an input PldB of - 12 dBm, and an IIP3 of - 0.2 dBm, while dissipating only 4.6 mA from a 1.8-V supply.

• 약학회지
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• 제45권6호
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• pp.656-663
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• 2001

The quality of an intravenous immunoglobulin preparation (IVIG) is reflected by the degree of nonspecific activation of complements, the so-called anticomplementary activity (ACA). ACA of aggregates in IVIG was investigated using method by the European Pharmacopoeia and Clq-coated microtiter enzyme-linked immunosorbent assay (ELISA). Both the EP method and the ELISA method showed a dose response curve with the amount of complements bound increasing with the percentage content of aggregates in immunoglobulin standard. The correlation between the two tests was good (r=0.96, r=0.99). However, the correlation was not found when the ACA (EP method) of IVIG product was compared with its aggregate percentage. These results emphasize that the method of aggregate formation affects ACA and that estimation of the percentage distribution of aggregates by HPLC may not reflect ACA. In analysing WIG product for Clq binding activity test with the ELISA, the result by using Protein A-HRP correlated with aggregate percentage (r=0.84). But the correlation decreased (r=0.48) when the result used Protein A-AP(having poorer sensitivity than HRP) was compared with aggregate percentage. As a result, some variation between the two methods, due to differences in assay principles, is to be expected. However, ELISA technique has the advantage in that it is easier to perform, more precise and less subject to reagent variability, and is the more suitable screening method than HPLC analysis.

• 한국전산구조공학회논문집
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• 제13권2호
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• pp.221-230
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• 2000

스위프 기하학적 모델은 곡선, 면 또는 입방체를 주어진 경로를 따라 이동시킴으로써 기하학적 모델을 생성하는 기법이다. 따라서 스위핑을 사용하면 프리즘 쉘의 곡면을 쉽게 정의할 수 있다. 본 논문은 스위프 기하학적 모델을 프리즘 쉘의 최적화에 적용하는 절차에 대하여 기술하였다. 제시한 스위프 기하학적 모델을 유한요소법과 융합하였고 프리즘 쉘의 반응을 계산하기 위해 9절점 퇴화쉘요소를 채용하였다. 본 연구에서 제시한 최적화과정을 증명하기 위하여 수치예제를 풀어 보았다. 수치예제를 통하여 제시한 스위프 기하학적 모델이 많은 종류의 프리즘 쉘을 최적화하는데 효율적이고 신뢰적인 방법인 것으로 나타났다.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2010년도 정기 학술발표대회
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• pp.51.2-51.2
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• 2010

A novel approach of Poisson cluster stochastic rainfall generator was validated in its ability to reproduce important rainfall and watershed response characteristics at 104 locations of the United States. The suggested novel approach - The Hybrid Model(THM), as compared to the traditional ones, has an additional function to account for the year-to-year variability of rainfall statistics. The two-sample Kolmogorov-Smirnov test was used to see how well THM and traditional approach of Poisson cluster rainfall model reproduce the distribution of the following hydrologic variables: monthly maximum rainfall depths with 1, 3, 6, 12, and 24 hour duration, monthly maximum flow peaks at the virtual watersheds with Curve Number of 50, 60, 70, 80 and 90; and monthly runoff depths at the same virtual watersheds. In all of the testing variables, THM significantly outperformed the traditional approach. This result indicates that the year-to-year variability of rainfall statistics contains important information about the characteristics of rainfall processes that were not considered by the conventional approach of Poisson cluster rainfall modeling and that further considering it in rainfall simulation will enhance the performance of the rainfall models.

• Bulletin of the Korean Chemical Society
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• 제24권1호
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• pp.70-74
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• 2003

The heterogeneous bioluminescence immunoassay for digoxin was developed using photoprotein, native aequorin as a label and the site-directed immobilization technique based on avidin/biotin interaction. Aequorin is a bioluminescence protein, originally isolated from the jellyfish Aequoria Victoria and an attractive label in analytical applications because of sensitive detection due to virtually no background bioluminescent signal. Digoxin is a cardioactive drug, and its therapeutic level in serum is at low concentration with very narrow therapeutic index. The aequorin-digoxigenin conjugates were synthesized by the N-hydroxysuccinimide ester method and characterized in terms of bioluminescent residual activity. The resulting dose-response curve shows that the detection limit is $1.0\;{\times}\;10^{-10}\;M$ and a dynamic range is three orders of magnitude, which was obtained by $1.0\;{times}\;10^{-10}\;M$ conjugate and 0.9 μg/mL anti-digoxin antibody. Three structurally similar molecules to digoxin were examined for their cross-reactivity. None of these three compounds showed any crossreactivity with digoxin antibody employed in this study. Standard amounts of digoxin corresponding to the therapeutic range were spiked into the each serum solution. Study of the serum matrix effect indicated that correlation coefficient shows good agreement between luminescence light intensity between in buffer and in serum.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2015년도 추계학술대회
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• pp.202-204
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• 2015

2010년부터 최근 5년간 해양안전심판원의 충돌사고 통계분석 결과에 따르면 98%가 인적과실이 원인이 될 정도로 경계소홀 등 해기사에 의한 운항과실이 해양사고의 대부분을 차지하고 있으나 그동안 외국뿐만 아니라 국내에서도 이에 대한 연구는 극히 미흡한 실정이다. 본 연구는 항해중인 선박이 타 선박과 6가지 유형(Head-on, $045^{\circ}$, $090^{\circ}$, $135^{\circ}$, Overtaking, Overtaken)의 다른 방위각으로 조우 상황시 양 선박의 거리가 가까워지면서 거리별 항해당직사관인 해기사가 느끼는 스트레스(주관적 위험도)를 실제 항해중인 선박에 승선하여 실험하였고 획득한 데이터를 통계적으로 분석 및 처리하였다. 데이터를 곡선적합(Curve fitting) 적용 결과 6가지 조우각도별 거리에 따른 연속 데이터 획득이 가능 하였고 인적과실의 주요 원인 중의 하나인 타 선박 조우 상황시 해기사가 느끼는 스트레스 일반화 모델을 위한 기초 식을 제안하였다. 이러한 결과는 향후 해기사의 인적과실을 줄여 해양사고 예방을 위한 기초 자료로 활용 할 수 있을 것이다.

• Bulletin of the Korean Chemical Society
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• 제31권4호
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• pp.845-849
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• 2010

A gold nanoparticles modified carbon paste electrode (GN-CPE) has been used for the determination of atenolol (ATN) in drug formulations by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronocoulometric methods. The results revealed that the modified electrode shows an electrocatalytic activity toward the anodic oxidation of atenolol by a marked enhancement in the current response in buffered solution at pH 10.0. The anodic peak potential shifts by -80.0 mV when compared with the potential using bare carbon paste electrde. A linear analytical curve was observed in the range of $1.96\;{\times}\;10^{-6}$ to $9.09\;{\times}\;10^{-4}\;mol\;L^{-1}$. The detection limit for this method is $7.3\;{\times}\;10^{-8}\;mol\;L^{-1}$. The method was then successfully applied to the determination of atenolol in tablets and human urine. The percent recoveries in urine ranged from 92.0 to 110.0%.