• Journal of Advanced Marine Engineering and Technology
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• 제26권1호
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• pp.116-124
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• 2002

The bubble model by Keller and Prosperetti is adapted to solve the nonlinear oscillation of a gas bubble. This formulation leads to accurate results since it introduces the energy equation instead of the polytropic assumption for the bubble interior. The numerical method used in this study is stable enough to handle large amplitude of bubble oscillation. The numerical results show some interesting nonlinear phenomena fur the bubble oscillator. The excitation changes the natural frequency of the bubble and makes some harmonic resonances at $f/f_0=1/2, 1/3$ and so on. The natural frequency of a bubble oscillator decreases compared with the linear case result, which means that the nonlinear bubble oscillation system is a "softening"system. In addition, the frequency response curve jumps up or down at a certain frequency. It is also found that there exist multi-valued regions in the frequency response curve depending on the initial conditions of bubble. The dependency of the bubble motion on the initial condition can generate extremely large pressure and temperature which might be the cause of the acoustic cavitation and the sonoluminescence.inescence.

• 한국전기전자재료학회논문지
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• 제32권2호
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• pp.122-128
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• 2019

Porcelain insulators have been used mainly for power line fixing and electrical insulation in transmission towers. Porcelain insulators have generally a 30 years desired life, but over 50% exceed their life expectancy. Since the damage to porcelain insulators is usually accompanied by enormous loss of human resource material, their efficient maintenance has emerged as an important issue. In this regard, this study applied a frequency response function (FRF) for integrity assessment of the insulator. The characteristics of the FRF according to damage types were identified and analyzed by the change in natural frequencies, curve shape, attenuation, and Nyquist diagram stability. The results showed significant differences in the FRF according to damage types, which can be used as basic data for the effective integrity assessment of porcelain insulators.

• Earthquakes and Structures
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• 제16권6호
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• pp.705-714
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• 2019

Seismic assessment of underground structures is one of the challenging problems in engineering design. This is because there are usually many sources of uncertainties in rocks and probable earthquake characteristics. Therefore, for decreasing of the uncertainties, seismic response of underground structures should be evaluated by sufficient number of earthquake records which is scarcely possible in common seismic assessment of underground structures. In the present study, a practical risk-based approach was performed for seismic risk assessment of an unsupported tunnel. For this purpose, Incremental Dynamic Analysis (IDA) was used to evaluate the seismic response of a tunnel in south-west railway of Iran and different analyses were conducted using 15 real records of earthquakes which were chosen from the PEER ground motion database. All of the selected records were scaled to different intensity levels (PGA=0.1-1.7 g) and applied to the numerical models. Based on the numerical modeling results, seismic fragility curves of the tunnel under study were derived from the IDA curves. In the next, seismic risk curve of the tunnel were determined by convolving the hazard and fragility curves. On the basis of the tunnel fragility curves, an earthquake with PGA equal to 0.35 g may lead to severe damage or collapse of the tunnel with only 3% probability and the probability of moderate damage to the tunnel is 12%.

• 한국항만경제학회지
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• 제27권3호
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• pp.1-12
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• 2011

본 논문은 금융위기 이후 대중 수출증가가 경기회복에 주도적 역할을 하고, 우리경제의 중국경제 의존도가 크게 상승하는 상황에서 J-curve 효과가 우리나라 대중국 항만 수출입 흐름에 적용되는가를 월별자료를 이용하여 2000년부터 2010년까지의 기간에 대해 실증분석 하였다. 오차수정모형을 추정한 결과 단기적인 조정역할은 실질실효환율이 수행하는 것으로 나타났으며, 분산분해 결과 대중국 항만 무역수지에 대한 영향력이 국내경기보다 실질실효 환율과 세계경기가 더 크게 나타남을 알 수 있었다. 이와 더불어 수준변수로 구성된 VAR과 오차수정항을 포함한 VECM을 이용한 충격반응 분석을 실시한 결과 대중국 항만 무역수지는 환율 충격에 대하여 시차를 두고 반응을 보이는 것으로 나타나 J-curve 효과가 존재함을 알 수 있었다.

• 전기학회논문지
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• 제66권1호
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• pp.16-22
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• 2017

In order to reduce costs of electricity energy at periods of peak demand, there has been an exponential interest in Demand Response (DR). This paper discusses the effect on the participants' behavior in response to DR. Under the assumption of perfect competition, the equilibrium point of the electricity market with DR is derived by modeling a DR curve, which is suitable for microeconomic analysis. Cournot model is used to analyze the electricity market of imperfect competition that includes strategic behavior of the generation companies. Strategic behavior with DR makes it harder to compute equilibrium point due to the non-differential function of payoff distribution. This paper presents a solution method for achieving the equilibrium point using the best response function of the strategic players. The effect of DR on the electricity market is illustrated using a test system.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.301-301
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• 1994

〔$^3$H〕Ouabain binding parameters(K$\_$D/ and B$\_$max/,) in homogenates prepared fpom control rat ventricular strip and Langendorff preparations which were not previously exposed to ouabain were compared to those in homogenates from ventricular strip and Langendorff preparations that had been first exposed to a complete ouabain dose-response curve(10$\^$-7/M to 10$\^$-4/ M). In rat ventricular strips and Langendorff perfused rat heart preparations, cumulative dose-response cruves of ouabain revealed biphasic positive inotropic effects, a "low-dose" and a "high-dose" effect with ED$\_$50/ values of 0.5${\mu}$M and 35${\mu}$M ouabain, respectively- The "low-dose" effect in rat ventricular strips disappeared or was diminished significantly when the ouabain dose-response curve wag repeated after the washout of the effects of the first curve, whereas the maximal "high-dose" effect was identical in both exposures to oubain. However, there was no change in the "low-dose" effects in both sets of the Langendorff perfused hearts. The contractile activity of the pre-exposed strips did not indicate the presence of residual ouabain since their basal contractile force was decreased 10% compared to initial control. 〔$^3$H〕Ouabain binding parameters, K$\_$D/ and B$\_$max/, were not changed comparing homogenate of control ventricular strips with that of strips pre-exposed to ouabain. These results suggest that digitalis receptor desensitization in the rat ventricular strip may due to the change of post-receptor events induced by ouabain binding to a high affinity site(${\alpha}$$_2$ isoform).

• Journal of the Korean Data and Information Science Society
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• 제25권5호
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• pp.987-998
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• 2014

본 연구에서는 우리나라 환경부에서 최근에 구축한 아동 동집단 경시적 자료인 아동 건강과 환경 연구 (CHEER) 자료에 기초하여 주의력 결핍 과잉행동 장애 (ADHD)와 혈중 납 농도의 상관을 선형혼합모형을 사용하여 규명하고, CHEER 자료의 경시적 특성으로 나타나는 ADHD 점수의 "평균으로의 회귀" 현상을 보고하고자 한다. 또한 ADHD를 종점으로 한 혈중 납 농도의 용량-반응 곡선을 도출하며, 이렇게 도출된 용량-반응 곡선에 기초하여 몇 가지 상황 하에서 독성기준치인 벤치마크 용량 하한 (BMDL)을 유도한다.

• 대한환경공학회지
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• 제28권11호
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• pp.1148-1153
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• 2006

이온 선택성 미소전극과 전위계를 이용하여 생물막내 이온 농도 측정을 위한 신호 계측 시스템을 구성하였다. 제작된 신호 계측 시스템의 성능과 적용성을 평가하기 위하여 보정곡선의 기울기, 검출한계, 시간경과에 따른 응답신호의 변화, 전위차 선택계수를 조사하였다. 보정곡선의 기울기는 목적이온 농도에 밀접한 비례관계를 나타내었다. 신호 계측 시스템은 $10{\mu}M$ 이하의 낮은 검출한계를 가졌으며, 실험에 사용된 방해이온에 민감하지 않았다. 본 연구에서 제작된 전위계는 상용되는 전위계와의 성능을 비교하였을 때 보정곡선 기울기, 검출한계, 응답시간에서 비슷한 경향을 나타내었다. 본 연구에서 제작된 신호 계측 시스템은 생물막내 이온농토 측정 연구를 위한 경제적이며 신뢰성 있는 시스템으로 사용될 수 있을 것이다.

• Communications for Statistical Applications and Methods
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• 제15권3호
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• pp.465-481
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• 2008

문항반응이론(Item response theory: IRT)에서는 문항이 가지고 있는 특성을 기초로 피험자의 능력을 추정하고 동시에 각 문항별 문항특성곡선(Item characteristics curve: ICC)을 이용하여 문항모수를 추정하게 된다. 그러나 모수추정에 있어서 최대 우도추정의 경우는 초기값과 다른 여러 문제들이 발생할 수 있다. 본 연구에서는 추정 문제 해결방법의 대안으로 점근적 근사화 방법(Asymptotic approximation method: AAM)을 제안한다. 이는 자료의 수가 적거나 국소 변동이 있는 경우에 효과적인 추정방법이라고 할 수 있다. 이에 개발된 'Any Assess' 시스템을 모의실험을 통하여 신뢰성을 검정하였다.

• Toxicological Research
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• 제6권2호
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• pp.205-213
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• 1990

The regulation of neurotoxicants has usually been based upon setting reference doses by dividing a no observed adverse effect level (NOAEL) by uncertainty factors that theoretically account for interspecies and intraspecies extraploation of experimental results in animals to humans. Recently, we have proposed a four-step alternative procedure which provides quantitative estimates of risk as a function of dose. The first step is to establish a mathematical relationship between a biological effect or biomarker and the dose of chemical administered. The second step is to determine the distribution (variability) of individual measurements of biological effects or their biomarkers about the dose response curve. The third step is to define an adverse or abnormal level of a biological effect or biomarker in an untreated population. The fourth and final step is to combine the information from the first three steps to estimate the risk (proportion of individuals exceeding on adverse or abnormal level of a biological effect or biomarker) as a function of dose. The primary purpose of this report is to enhance the certainty of the first step of this procedure by improving our understanding of the relationship between a biomarker and dose of administered chemical. Several factors which need to be considered include: 1) the pharmacokinetics of the parent chemical, 2) the target tissue concentrations of the parent chemical or its bioactivated proximate toxicant, 3) the uptake kinetics of the parent chemical or metabolite into the target cell(s) and/or membrane interactions, and 4) the interaction of the chemical or metabolite with presumed receptor site(s). Because these theoretical factors each contain a saturable step due to definitive amounts of required enzyme, reuptake or receptor site(s), a nonlinear, saturable dose-response curve would be predicted. In order to exemplify this process, effects of the neurotoxicant, methlenedioxymethamphetamine (MDMA), were reviewed and analyzed. Our results and those of others indicate that: 1) peak concentrations of MDMA and metabolites are ochieved in rat brain by 30 min and are negligible by 24 hr, 2) a metabolite of MDMA is probably responsible for its neurotoxic effects, and 3) pretreatment with monoamine uptake blockers prevents MDMA neurotoxicity. When data generated from rats administerde MDMA were plotted as bilolgical effect (decreases in hippocampal serotonin concentrations) versus dose, a saturation curve best described the observed relationship. These results support the hypothesis that at least one saturable step is involved in MDMA neurotoxicity. We conclude that the mathematical relationship between biological effect and dose of MDMA, the first step of our quantitative neurotoxicity risk assessment procedure, should reflect this biological model information generated from the whole of the dose-response curve.