• Journal of Institute of Control, Robotics and Systems
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• v.15 no.8
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• pp.804-811
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• 2009

This paper deals with the relationship between zeros and step response of the second and third order LTI(Linear Time Invariant) SISO(Single-Input and Single-Output) systems. As well known, if a system has a single unstable zero, it shows the step response with undershoot and, on the other hand, a stable zero slower than the dominant pole causes the system to have the step response with overshoot. Generally, in the case of a system with two unstable real zeros, it is known to have B type undershoot[7]. But there are many complex cases of the step response extrema corresponding to zeros location in third order systems. This paper investigates the whole cases depending on DC gains of the additive equivalence systems and they are to be classified by the region of zeros which are related to the shape of the step response. Moreover, monotone nondecreasing conditions are proposed in the case of complex conjugate zeros as well as the case of two stable zeros.

• The Journal of Korean Medicine
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• v.39 no.4
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• pp.136-157
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• 2018

Objectives: This systematic review aimed to put the case reports of lung cancer on Korean medicine (KM) together and adopt the results in clinical practice. Methods: Researches were searched using the PubMed, EMBASE, OASIS, KoreanTK, KISTI, RISS, KISS, and NDSL. The search term were 'lung cancer' and KM. There was no restriction in year. Results: 1. Among the 48 studies, 68 patients were reported in total. The types of lung cancer were non-small-cell lung cancer (n=41) and small-cell lung cancer (n=6). 2. The number of patients who received KM therapy alone was 40. On the other hand, 25 patients were treated with KM and chemotherapy simultaneously. All case reports used herbal medicine except 2 studies. Other types of treatment were acupuncture, moxibustion, pharmacopuncture, cupping, meditation, etc. 3. Several efficacy evaluation variables were used such as tumor size, changes of symptoms, duration of survival, the quality of life, and so on. The safety was evaluated by checking adverse effects using blood test. 4. Regarding the tumor response, partial response was reported in 12 cases, stable disease was in 22 cases, 50% of the total cases, which is a high level of tumor response. Furthermore, all 11 cases with the evaluation on the length of survival showed prolonged survival than the expectancy of corresponding stage, with the stable quality of life. Conclusion: We have found that the applicability of KM for treatment of lung cancer through this review. Evidence based medicine can be realized by checking cases and applying them in clinical practice.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1341-1347
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• 2012

Introduction: Diffuse large B-cell lymphomas (DLBCL) can be divided into germinal centre (GC-DLBCL) and post germinal centre (post GC-DLBCL) groups by applying immunohistochemical antibodies. As these subgroups respond differently to chemotherapy, it is possible at diagnosis to select a poor prognostic subgroup for aggressive treatment. Objective: To determine the frequencies of GC-DLBCL and post GC-DLBCL in patients by immunohistochemistry (IHC) and the clinical response after six cycles of chemotherapy. Subjects and Methods: In this descriptive study conducted in AFIP and CMH, Rawalpindi and NORI, Islamabad, from September 2010 to September 2011, a total of 75 pretreatment cases of DLBCL diagnosed during the study period were included. Cases were segregated in to GC-DLBCL and post GC-DLBCL groups according to results of immunohistochemistry markers CD10, BCL6 and MUM1. Immediate clinical response was assessed after 6 cycles of chemotherapy. Response was divided into complete response, partial response, stable disease or relapse or progression. Results: The mean age was $54.2{\pm}15$. Males were 53 (70.7%). Forty (53.3%) cases comprised the GC-DLBCL group; 25(62.5%) of them showed a complete response. Most patients of the post GC-DLBCL 19(54%) showed relapse/progression. Results of immediate clinical response in both prognostic subgroups were significant (p<0.05). Results regarding positivity with immunohistochemical antibodies CD10 (p 0.011), BCL6 (p 0.013) and MUM1 (p 0.000) regarding immediate clinical response were also significant. Conclusion: GC-DLBCL group shows better response to CHOP chemotherapy regimen. Immunohistochemistry should be used to further classify DLBCL as this can enable us to select aggressive group for aggressive treatment. This manuscript is important because the study is the first to becarried out exclusively in Pakistan or our part of the world.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.7
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• pp.383-391
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• 2021

This study examines the connectedness between the number of COVID-19 cases in Thailand and trading value among investors in the Stock Exchange of Thailand. Daily data of COVID-19 cases and trading value were sourced from the Thailand ministry of public health and the Stock Exchange of Thailand, from January 12, 2020 to May 11, 2021. This study applies a multiple linear regression analysis to explain the relationship between variables. Empirical evidence clearly shows that the volatility of trading value was affected by COVID-19's new, confirmed, and deaths cases within the first pandemic period more than during the second pandemic period. Nevertheless, during the third pandemic period there is no evidence that the new, confirmed, and deaths cases significantly influenced trading value. Furthermore, the results show that COVID-19's new and deaths cases have a negative coefficient that indicated the trading value-buy/sell decreased in response to COVID-19's new and deaths cases, whereas the confirmed COVID-19 cases have a positive coefficient that indicated the trading value-buy/sell increased in response to COVID's confirmed cases. In summary, this study suggests that the number of COVID-19 cases have a significant impact on the trading value in the short term more than in the intermediate and long term.

• Asia pacific journal of information systems
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• v.29 no.1
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• pp.144-164
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• 2019

In their role as stewards of organizational information technology (IT), IT managers participate in crisis management activities. While much has been said about the power of technology in improving preparation for emergencies, the behavior of IT managers in crisis situations is not well understood. This paper addresses IT manager actions during the crisis response effort, when appropriate actions need to be taken at short notice. Recognizing that few guidelines exist for IT managers in these situations, we use recommendations from the crisis management literature in analyzing five earthquake cases from Japan and Taiwan. We identify several recommendations from this set for IT managers, which are related mainly to communications and leadership behaviors, suggesting that the IT manager role is a vital one in crisis response. The research additionally shows that recommendations from the crisis management literature have value also when applied to IT managers. Finally, we conclude on several ways that our understanding of IT manager crisis response could be developed by future research.

• International Journal of Ocean Engineering and Technology Speciallssue:Selected Papers
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• v.6 no.1
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• pp.44-50
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• 2003

If the accelerometers are used in measuring the response, the absolute values of the velocity and displacement are not usually obtainable because their initial values are not accounted for in the integration of the acceleration response. A new dynamic response conversion algorithm of both the time domain and the frequency domain is proposed for the problem in estimating the displacement data by defining the transformed responses. In this algorithm, the displacement response can be obtained from the measured acceleration records by integration without requiring the knowledge of the initial velocity and displacement information. The applicability of the technique is tested by an example problem using the real bridge's superstructure under several cases of moving load. In the response conversion procedure of the frequency domain, the identified response according to the frequency can be estimated by changing over the limits of integration. If the reliability of the identified responses is ensured, it is expected that the proposed method for estimating the impact factor can be useful in the bridge's dynamic test. This method can be useful in those practical cases when the direct measurement of the displacement is difficult as in the dynamic studies of huge structure.

• Fire Science and Engineering
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• v.28 no.6
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• pp.90-98
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• 2014

Lately accidents of harmful chemical substance in korea were repeatedly replaying. We studied problems and preparation plan in 2008 years~2014 years through analysis cases of harmful chemical substance. Leakage of chemical substance's accident situation shows that leakage in the workplace is the most 10 cases, accounting for 58.6% is the largest proportion in 2009. Leakage according to explosion accounting for 50% (5 cases) in 2004, 25% (4 cases) in 2007 and 33.3% (4 cases) in 2011 has very irregular change. Therefore, A major cause of accidents is lack of safety management. Harmful chemical substance showed various aspects, high residual substance and non-visible characteristic so response and recovery was easy. And the second damage to move a distance causes environment pollution. So a mutual-assistance system and integrated system of related organization have to build and expert of chemical incident response and therapist of chemical substance response have to establish to do efficient and rapid response.

• Structural Engineering and Mechanics
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• v.33 no.2
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• pp.113-136
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• 2009

The seismic induced interaction between multistory structures with unequal story heights (inter-story pounding) is studied taking into account the local response of the exterior beam-column joints. Although several parameters that influence the structural pounding have been studied sofar, the role of the joints local inelastic behaviour has not been yet investigated in the literature as key parameter for the pounding problem. Moreover, the influence of the infill panels as an additional parameter for the local damage effect of the joints on the inter-story pounding phenomenon is examined. Thirty six interaction cases between a multistory frame structure and an adjacent shorter and stiffer structure are studied for two different seismic excitations. The results are focused: (a) on the local response of the critical external column of the multistory structure that suffers the hit from the slab of the adjacent shorter structure, and (b) on the local response of the exterior beam-column joints of the multistory structure. Results of this investigation demonstrate that the possible local inelastic response of the exterior joints may be in some cases beneficial for the seismic behaviour of the critical column that suffers the impact. However, in all the examined cases the developing demands for deformation of the exterior joints are substantially increased and severe damages can be observed due to the pounding effect. The presence of the masonry infill panels has also been proved as an important parameter for the response of the exterior beam-column joints and thus for the safety of the building. Nevertheless, in all the examined inter-story pounding cases the presence of the infills was not enough for the total amelioration of the excessive demands for shear and ductility of the column that suffers the impact.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2057-2060
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• 2014

Purpose: To assess the effect and safety of lobaplatin combinated floxuridine /pirarubicin in transcatheter hepatic arterial chemoembolization(TACE) of unresectable primary liver cancer. Patients and Methods: TACE combined with the chemotherapy regimen was used to treat 34 unresectable primary liver cancer patients. DSA/MRI/CT/blood routine examinations were used to evaluate short term activity and toxicity after 4-5 weeks, the process being repeated if necessary. Results: Among the 34 cases, 1 (2.9%) showed a complete response, 21 (61.7%) a partial response, 8 (23.5%) stable disease, and 4 progressive disease, with a total effective rate of 67.6%. The content of alpha fetoprotein dropped by over 50% in 20 cases (58.8%). The rate of recovery was hepatalgia (88.2%), ascites (47.1%), appetite (55.9%), Performance Status(30.4%). The median follow-up time (MFT) was 281 days (63-558 days), and median progression-free survival was 118.5 days (95%, CI:88.8-148.2days). Adverse reactions (III-IV grade) were not common, with only 4 cases of vomiting and 2 cases of thrombocytopenia (III grade). Conclusions: Lobaplatin-based TACE is an effective and safe treatment for primary liver cancer.

• The Korean Journal of Physiology
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• v.10 no.1
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• pp.67-71
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• 1976

Effect of Electro Convulsion Therapy (ECT) on the Human Growth Hormone (HGH) response was observed in 32 cases of various mental illness. The patients were fasting overnight and ECT was induced in the morning by application of $90{\sim}120V$ for a period of $0.1{\sim}0.5\;sec$. In all patients, venous blood samples were taken prior to simultaneously with 1 and 4 hours after the ECT. Plasma was immediately seperated and stored in $-20^{\circ}C$ refrigerator. HGH concentrantion was determined by means of radioimmunoassay Results were as follows: 1. Application of electric current was not followed by a significant change in mean plasma HGH of 52 cases. 2 Increases of plasma HGH following ECT were observed in about half cases showing low initial level but in 20 other cases with high initial level of plasma HGH, reasonable decreases after therapy were not found. 3. Plasma concentration of HGH one hour after application of current were always higher than just after the current. 4. There were no differences between HGH responses to a 1st, 2nd or 5th ECT. 5. Discussions were made on the possible modification of HGH response following ECT by the autoregulatory control mechanism.