• 생물정신의학
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• 제18권1호
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• pp.36-45
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• 2011

Objectives : Though a proportion of Alzheimer's disease(AD) patients treated with donepezil have shown positive response on cognition, but the responders' characteristics are still uncertain. This study attempts to identify whether a single oral dose of donepezil(5mg) can change cognition and the relationship between single dose responder items and long-term responder are examined. Methods : Twenty-three AD patients for single donepezil challenge study group and eleven AD patients for controls were participated in the study. Seven days after baseline study for neuropsychological test and EEG, same studies were rechecked after donepezil medication in study group. In donepezil study groups, 12 weeks after donepezil medication, neuropsychological test and EEG were rechecked. Results : After single donepezil challenge, forward digit span, Rey-Osterrieth Complex Figure Test copy, SVLT delayed recall were significantly improved, and beta spectra power in anterior, theta spectra power in posterior field were significantly decreased. According to linear regression analysis, forward digit span after single donepezil challenge was significantly positive correlated with long-term responders. Conclusions : This study suggests that single donepezil medication can significantly change cognitive functions and EEG in AD patients. Among these responsive items, forward digit span was significantly correlated with long-term responder.

• 정보교육학회논문지
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• 제14권3호
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• pp.461-468
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• 2010

동료평가는 학습자 중심의 평가로서, 평가를 통해 학습자간의 상호작용이 활발하게 일어나며, 교사 주도의 일방적인 평가보다 동료 학생들에 의한 평가가 학습자들에게 더 많은 영향을 미치게 된다. 본 연구에서는 초등학교 4학년 사회과를 중심으로 원격응답기를 활용한 수행평가 모형과 수행평가 과제를 개발하고, 실제 수업에 학생참여 수행평가를 적용하여 학생들의 학업성취도 및 학습태도에 어떠한 영향을 미치는지 알아보았다. 연구를 통해 나타난 결과는 다음과 같다. 원격응답기를 활용한 학생참여 수행평가는 사회과 학업성취도와 학습태도 향상에 긍정적인 영향을 주었으며 통계적으로 유의미한 결과를 나타냈다. 또한 원격응답기를 활용하여 학생참여 수행평가 후 학생들의 반응을 조사한 결과 교수.학습 과정에서 학생들의 학업 수행에도 긍정적인 영향을 미치는 것으로 나타났다.

• International journal of thyroidology
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• 제11권2호
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• pp.137-142
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• 2018

Background and Objectives: Radioactive iodine therapy (RAI) is an important treatment modality of Graves' disease (GD), but there is still not a consensus on the optimal dosage regimen. We studied the treatment success rate of different RAI doses, and examined which clinical markers were useful for determining the optimal RAI dosage for successful therapy in Korean patients. Materials and Methods: We retrospectively studied 123 patients with GD treated with RAI between 2004 and 2014 at Chonnam National University Hwasun Hospital. The responder group was defined as patients who developed hypothyroidism requiring levothyroxine replacement following RAI, regardless of the RAI dosage. Results: A total of 54 patients (43.9%) became hypothyroid after the first dose, and 31 needed two to four additional doses to achieve hypothyroidism. In the responder group as a whole (85 patients), the mean total dose of RAI was $15.5{\pm}7.0mCi$ and the mean thyroid volume (TV) was $35.4{\pm}23.4mL$. When divided into low dose (<15 mCi, n=46) and high dose (${\geq}15mCi$, n=39) responder groups, TV was significantly lower in the low-dose responder group ($25.7{\pm}11.4$ vs. $48.4{\pm}31.3$, p<0.001). The optimal cut-off TV for the low-dose responder group was <32.37 mL (sensitivity 80.9%, specificity 76.7%). Conclusion: TV had significant effects on the outcome of RAI in GD patients. The optimal fixed RAI dose for Korean GD patients with a large goiter (${\geq}33mL$) should be at least 15 mCi to achieve the best outcome.

• 대한미생물학회지
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• 제16권1호
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• pp.65-70
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• 1981

A microculture technique for the mixed lymphocyte culture test(MLC) in the sheep is described. The optimal incubation periods for the MLC are varied from 4 to 6 days depending on the sources of lymphocytes. It is found that a 2.5:1 stimulator-responder cell ratio and the responder cell concentration of $1{\times}10^5$ cells/well produce the highest($^3H$)-thymidine incorporation. Moreover cryopreservation of bovine lymphocytes results in satisfactory and reproducible MLC reaction. It is also evident that the MLC reactions of the sheep are under the control of histocompatibility matching between the stimulator cells and the responder cells. Significance of the technique as a too! for study on cell mediated immunity in sheep system, either normal or squamous cell carcinoma-bearing, are discussed.

• 동의생리병리학회지
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• 제21권5호
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• pp.1285-1290
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• 2007

The present study aims to identify and characterize genes that cause differen genes between non-responders and responders to electroacupuncture (EA) on mechanical allodynia following peripheral nerve injury. Under sodium pentobarbital anesthesia, animals were subjected to unilateral transection of the superior caudal trunk at the level between S1 and S2 spinal nerves. EA stimulation (2Hz, 0.3 ms, 0.2-0.3 mA) was delivered to Zusanli (ST36) for 30 min 2 weeks after the surgery. The degree of mechanical allodynia was assessed quantitatively by touching the tail with von Frey hair (2.0 g) at 10 min intervals. The rats, which showed an EA-induced decrease of response frequencies under 10 %, were classified as non-responders and those displaying an EA-induced decrease of response frequencies 20 % or more were classified as responders. Results from oligonucleotide microarray, to which cDNAs from the spinal dorsal horn (DH) were applied, showed that hemoglobin beta chain complex and chondroitin sulfate proteoglycan-5 decreased and limbic system-associated membrane protein increased in the non-responder group, whereas calcium-independent alpha-Iatrotoxin receptor homolog-3 increased in the responder group. These results suggest that The functional abnormality of molecules regulating cell adhesion, intracellular signal transduction and cell differentiation in the spinal DH may be involved in the anti-allodynic effect of EA.

• The Korean Journal of Pain
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• 제30권3호
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• pp.214-219
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• 2017

Background: As herpes zoster progresses via postherpetic neuralgia (PHN) to well-established PHN, it presents its recalcitrant nature to the treatment. At this point, the well-established PHN is fixed as a non-treatable, but manageable chronic painful neuropathic disorder. This study evaluated the incidence of complete relief from PHN according to PHN duration at their first visit, and the other factors influencing it. Methods: A retrospective chart review was performed on patients with PHN at a university-based pain clinic over 7 years. The responders were defined as patients who had complete relief from pain after 1 year of active treatment. Age, sex, PHN duration at their first visit, dermatomal distribution, and underlying disorders were compared in the responder and non-responder groups. Responders were also compared according to these factors. Results: Among 117 PHN patients (M/F = 48/69), 35 patients (29.9%) had complete relief from PHN. Mean ages were $64.3{\pm}10.6$ and $66.9{\pm}10.7$ years, numbers of male to female patients were 11/24 and 37/45, and mean durations of PHN at their first visit were $8.5{\pm}6.3$ and $15.3{\pm}10.7$ months in the responder and non- responder groups, respectively. In addition, PHN patients who visited the clinic before 9 months showed a better result. Dermatomal distribution and underlying disorders did not show significant differences. Conclusions: Almost 30% of PHN patients received complete relief. Those who sought treatment in a pain clinic before 9 months received a better result.

• 한국간호교육학회지
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• 제14권1호
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• pp.138-146
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• 2008

Purpose: The first responder's role during a cardiac arrest scene is to initiate CPR. The AHA has recognized and included the first responder's role for improving the survival rate of cardiac arrest patients. Health personnel working in nursing, emergency care, dental hygiene, radiology, and ocular optics frequently confront sudden cardiac arrest while working. This study was to identify the relationship between the educational experience and recognition with the level of knowledge about CPR for college students. Method: Five hundred forty college students enrolled in the department of nursing science, radiological technology, ocular optics, emergency medical technician, or dental hygiene in Daejeon city were surveyed. The tool used was CPR knowledge developed by the authors based on a literature review including 2005 AHA's CPR guideline. Result: The higher educational experience of CPR was, the higher the level of knowledge. The knowledge of the students in nursing or emergency medical technician was higher than students in dental hygiene, radiology, and ocular optics. Conclusion: CPR class should be included in the curriculum for college students in order to improve their accuracy as a first responder to cardiac arresting patients.

• 한국인터넷방송통신학회논문지
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• 제16권5호
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• pp.49-54
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• 2016

디지털 증거를 다루는 범죄 사건 수사가 증가함에 따라 초동조치를 할 수 있는 인력과 개선된 수사절차 모델의 필요성이 증가하고 있다. 최근 들어 디지털 포렌식 분류(triage)와 예비분석 등의 개념이 수사 연구기관에 각광을 받고 있다. 하지만 초동조치 대응인력 및 예비분석관들이 구체적으로 어떤 훈련을 받아야 하는지에 대한 연구는 그다지 주목받지 못했다. 오히려 많은 조직에서 초동조치 대응인력이 전문적인 디지털 포렌식 분석관과 같은 실력을 갖추어야 한다고 여기고 있다. 본 연구에서는 '이상적인' 상황에서 디지털 수사의 초동조치 대응인력과 예비분석관들이 어떤 능력을 갖추어야 하며, 하드웨어 및 소프트웨어 측면에서의 필요사항과, 어쩌면 가장 중요하다 할 수 있는 교육훈련 조건에 대해 논하고자 한다.

• 사상체질의학회지
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• 제29권2호
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• pp.128-135
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• 2017

Objectives The purpose of this study is to investigate economic decision-making in accordance with Sasang Constitution through Ultimatum Game. Methods 84 subjects classified as Sasang Constitution played Ultimatum Game in two session which are firstly not facing their opponents(responders) and secondly facing ones. And they were also proposed unfair offers(9:1) in the same two session. Amount of proposal and whether they accept or reject to unfair offers were observed. Results and Conclusions Taeeumin tended to offer more to his/her responder in Ultimatum Game when facing the responder then not. Taeeumin seemed to feel more burnden when he/she was facing the responder while Soyangin or Soeumin didn't.

• 한국응급구조학회지
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• 제26권2호
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• pp.97-111
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• 2022

연구 목적: 병원 밖 심정지(OHCA)에서 자동제세동기(AED)의 사용은 환자의 생존율을 향상시킨다. 싱가포르는 절도를 막고자 공공 AED를 '브레이크 글래스' 기전의 잠금 박스로 보호하고 있는데 지역사회 대응자들은 AED를 회수하기 위해 유리를 깨면서 부상을 당하곤 했다. 최초로 시도한 본 연구는 성공적인 AED 회수에 영향을 미치는 요인들을 밝히고 만연한 부상을 문서화하고자 하였다. 연구 방법: 설문지를 작성, 배포하였다. 참가자는 지난 12개월 동안 OHCA에 대처한 자들이다. 비교 검정은 피셔-프리만-할턴 정확 검정 또는 피어슨 카이제곱 검정을 사용하여 5% 유의 수준에서 시행되었고, 로짓링크함수를 사용하여 다중로지스틱회귀분석을 시행하였다. 연구 결과: 88명의 참가자가 적격했다. 성공적인 AED의 회수는 직업, 연령, 성별 및 시간 영향을 받지 않았다. myResponder 앱의 활성화로 OHCA에 대응했던 참가자들은 성공적으로 AED를 회수할 가능성이 높았다. (AOR 11.111, 95% CI: 2.141-58.824) 결 론: 모바일 myResponder 앱을 활용할 경우 AED회수 성공률이 훨씬 높았다. AED의 성공적 회수는 시간 뿐만 아니라 이용자의 성별, 연령, 직업과 무관했다. 싱가포르에서 지역사회 대응자들은 부상 위험에도 불구하고 심정지에 대응할 적극적 자세가 되어 있다.