• Tuberculosis and Respiratory Diseases
• /
• 제41권6호
• /
• pp.651-657
• /
• 1994

저자들은 최근 석면분진에 11년간 폭로된 직업력이 있으며 작업중단 5년후 약3개월간의 호흡곤란을 주소로 입원하여 흉부X-선, 폐기능검사, 전산화단층촬영, 기관지경검사 및 석면소체검사, Gallium scan을 통하여 석면폐증, 늑막삼출액과 폐암으로 진단된 1예를 경험하였기에 문헌조사와 함께 이를 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
• /
• 제45권1호
• /
• pp.184-190
• /
• 1998

저자들은 발열, 체중감소 등의 증상과 흉부 X-선 사진상 폐경화의 소견이 있었던 환자에서 폐의 병변이 역형성 거대세포 림프종으로 추측되는 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
• /
• 제64권5호
• /
• pp.387-391
• /
• 2008

폐트리코모나스증은 인체에 기생하는 3가지 종류의 편모충류(구강편모충, 질편모충, 장세포편모충)에 의해 유발되는 매우 드문 기회 감염성 질환으로 대부분 만성 폐질환이나 화농성 또는 괴사성 폐질환을 앓고 있는 환자 및 면역저하를 동반하는 전신질환을 앓고 있는 사람에서 흡입 또는 직접 전파에 의해 발생된다. 일반적으로 질편모충을 제외한 구강 및 장세포편모충은 병원성이 없는 것으로 고려되어 치료가 필요하지 않지만, 정상적으로 분포하지 않는 장기에서 기회감염을 일으키는 경우 적극적인 치료가 고려되어야 한다. 저자들은 폐 및 전신적인 기저 질환이 없는 무증상의 건강한 남성에서 우연히 발견된 흉부 방사선 검사상 이상 소견에 대해 폐트리코모나스증을 진단하여 항균제 치료로 호전된 드문 예를 경험하여 보고하는 바이다.

• Journal of Microbiology
• /
• 제45권3호
• /
• pp.187-192
• /
• 2007

REOviruses (Respiratory Enteric Orphan viruses) are ubiquitous, non-enveloped viruses containing 10 segments of double-stranded RNA (dsRNA) as their genome. They are common isolates of the respiratory and gastrointestinal tract of humans but are not associated with severe disease and are therefore considered relatively benign. An intriguing characteristic of reovirus is its innate oncolytic potential, which is linked to the transformed state of the cell. When immortalized cells are transfected in vitro with activated oncogenes such as Ras, Sos, v-erbB, or c-myc, they became susceptible to reovirus infection and subsequent cellular lysis, indicating that oncogene signaling pathways are exploited by reovirus. This observation has led to the use of the virus in clinical trials as an anti-cancer agent against oncogenic tumors. In addition to the exploitation of oncogene signaling, reovirus may further utilize host immune responses to enhance its antitumor activity in vivo due to its innate interferon induction ability. Reovirus is, however, not entirely benign to immunocompromised animal models. Reovirus causes so-called "black feet syndrome" in immunodeficient mice and can also harm neonatal animals. Because cancer patients often undergo immunosuppression due to heavy chemo/radiation-treatments or advanced tumor progression, this pathogenic response may be a hurdle in virus-based anticancer therapies. However, a genetically attenuated reovirus variant derived from persistent reovirus infection of cells in vitro is able to exert potent anti-tumor activity with significantly reduced viral pathogenesis in immunocompromised animals. Importantly, in this instance the attenuated, reovirus maintains its oncolytic potential while significantly reducing viral pathogenesis in vivo.

• 대한본초학회지
• /
• 제36권1호
• /
• pp.97-102
• /
• 2021

Objectives : Virus infection through the respiratory tract causes various inflammatory diseases such as pneumonia, cystic fibrosis, and obstructive pulmonary disease, causing enormous social damage. Therefore, it is very important to develop a treatment and prevention of infectious diseases. In this study, we investigated the effect of water extracts of Liriope muscari (WELM), known to improve lung function, on the inflammatory response of lung carcinoma cell line A549 cells induced by the viral double stranded RNA mimetic Polyinosinic:polycytidylic acid (Poly I:C). Methods : The cell viability by WELM treatment was analyzed using MTS assay in A549 cells. After inducing an inflammatory response to WELM-treated A549 cells with Poly I:C, the degree of apoptosis was confirmed through bright field microscopy. Interferon beta (IFN-β) mRNA expression level in A549 cells was analyzed by quantitative reverse transcription PCR (qRT-PCR). Results : WELM treatment has no significant effect on cell viability of A549 cells. We confirmed that pre-treatment of WELM effectively reduces the Poly I:C-induced apoptotic cell death in A549 cells. In addition, it was confirmed that the mRNA expression level of IFN-β, a pro-inflammatory cytokine increased by Poly I:C treatment, was significantly suppressed by WELM treatment in A549 cells. Conclusions : These results provide the evidence that WELM is effective at inhibiting inflammation on respiratory viral infections and suggest that Liriope muscari might be a valuable natural substance in the prevention and treatment of infectious diseases.

• 한국환경보건학회지
• /
• 제47권6호
• /
• pp.513-520
• /
• 2021

Background: Benzalkonium chloride (BKC) has been extensively used as a preservative in industrial products and in hygiene, medical, and cosmetic applications. Humidifier disinfectant (HD) products containing BKC have been used in South Korea. Objectives: This study was aimed to review types of products containing BKC, to summarize the regulations in the US, EU, Japan, and South Korea, and to review the health effects associated with the use of HD. Methods: We reviewed and summarized documents which were searched through PubMed and Google Scholar with the key words: BKC and asthma/contact dermatitis, humidifier disinfectant-associated lung injury (HDLI), and more. Results: Regulations in most countries including South Korea do not allow its use as disinfectants in spray-type of products for medicine, cosmetics, and household products. Two types of HD containing BKC (800~1,270 ppm) were marketed in South Korea from 1996~2003. Health effects reported from people who used products containing BKC were allergic contact dermatitis, erythema, and respiratory disease, including asthma. Two people who responded as HD users containing BKC only were confirmed to have developed asthma. HD-associated lung injury (HDLI) was reported by consumers who used both HD containing polyhexamethylene guanidine (PHMG) and HD containing BKC. Conclusions: In conclusion, the use of BKC as a biocide has to be controlled considering the route and pattern of exposure. Products containing BKC as preservatives were reviewed with exposure routes and sites in the human body such as skin, eyes, and the respiratory tract. HD containing BKC was clinically evaluated to be associated with asthma.

• Journal of Oral Medicine and Pain
• /
• 제35권2호
• /
• pp.155-163
• /
• 2010

피부근염은 특발성의 염증성 결합조직 질환으로서 점진적인 근육의 쇠약과 특징적인 피부 발진의 증상을 보이는 전신적 자가 면역 질환의 일종이며 근력 약화와 함께 나타나거나 흔히 선행하는 특징적 발진에 의해 진단된다. 가장 특징적인 피부증상은 상안검의 부종과 함께 나타나는 푸르면서 보라색 발진인 heliotrophic rash, 안면부와 상부 흉부의 넓적하고 붉은 발진 (flat red rash), 피부의 인설(scaling)현상을 나타내는 손가락 관절(knuckle)부위의 두드러진 Gottron's papules (violaceous scaly eruption)등 이다. 근육 증상으로 주로 근위부 사지 근육의 약화를 동반한 근육의 염증성 및 퇴행성 변화를 보인다. 피부 근염은 종종 소화기계 (gastrointestinal tract)와 호흡기계 (respiratory system)를 침범하며 15%~25%에서 악성변화를 보인다. 치료는 피부증상뿐 아니라 근육 증상도 악화시킬 수 있는 자외선에 대한 노출을 피하고 일차적으로 전신적 corticosteroid를 사용하며 증상이 심하거나 steroid에 반응이 없을 때 다른 면역억제제를 사용할 수 있다. 피부근염에서 안면근은 침범되지 않으며 저작근의 이환 역시 거의 없다. 본 증례를 통해 피부근염을 앓고 있는 환자에서 개구장애가 발생할 수 있으며, 이는 근경축과 유사한 양상을 보임을 알 수 있었다. 따라서 피부근염 환자에서 발생할 수 있는 개구장애는 회복이 어려울 수 있으므로, 점진적으로 개구량이 줄어드는 것을 막고 정상적인 개구량을 확보 할 수 있도록 지속적인 개구운동 등의 치료가 필요하다고 사료된다.

• Tuberculosis and Respiratory Diseases
• /
• 제61권2호
• /
• pp.171-177
• /
• 2006

MALT림프종은 질병의 진행이 느리고, 진단 당시 국소적인 병변이 대부분이며, 폐와 위장관을 동시에 침범하는 경우는 매우 드물다. 저자들은 흉부 단순촬영에서 고립성 폐결절이 발견된 73세 남자 환자에서 위, 폐, 골수를 침범한 파종성 MALT림프종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
• /
• 제59권5호
• /
• pp.497-503
• /
• 2005

연구배경 : 호흡기 바이러스 감염은 천식 및 만성폐쇄성폐질환의 악화와 관련이 있다고 알려져 있지만 국내의 자료는 충분치 않다. 방 법 : 급성 악화로 한림대학교 성심병원에 내원한 천식환자 20명과 COPD 환자 24명을 대상으로 비강 분비물과 객담에서 PCR과 배양을 통해 호흡기 바이러스를 검출하였다. rhinovirus, coronavirus는 PCR을, influenza A, B, RSV, parainfluenza virus는 배양을 통해 바이러스를 검출하였다. 결 과 : 천식의 급성 악화로 내원한 환자의 평균 연령은 45.4(${\pm}16.7$)세였고, 평소 $FEV_1/FVC$는 1.9/2.9L(65.5%)였다. 급성 악화 시 13예(13/20, 65%)에서 바이러스가 검출되었으며 rhinovirus 9예, coronavirus 2예, influenza A 2예, RSV 1예, parainfluenza virus가 1예였다. rhinovirus와 coronavirus, rhinovirus와 RSV가 동시에 검출된 예가 각각 1예가 있었다. COPD 환자의 평균 연령은 71.5(${\pm}8.4$)세였으며, 평소 $FEV_1/FVC$는 1.1/2.6L(42.3%)였고, 악화 시 14예(14/24, 58.3%)에서 바이러스가 검출되었다. rhinovirus 10예, coronavirus 3예, influenza A가 4예였으며 2예에서 rhinovirus와 coronavirus가 동시에 검출되었고, 1예에서 rhinovirus와 influenza A가 동시에 검출되었다. 결 론 : 호흡기 바이러스 감염은 국내에서도 천식 및 COPD 악화의 주요한 요인이 될 것으로 생각되며, 천식 및 COPD 환자의 악화에서 치료에 있어서 항생제 사용에 주의하여야 할 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
• /
• 제85권1호
• /
• pp.37-46
• /
• 2022

Background: Although respiratory tract infection is one of the most important factors triggering acute exacerbation of chronic obstructive pulmonary disease (AE-COPD), limited data are available to suggest an epidemiologic pattern of microbiology in South Korea. Methods: A multicenter observational study was conducted between January 2015 and December 2018 across 28 hospitals in South Korea. Adult patients with moderate-to-severe acute exacerbations of COPD were eligible to participate in the present study. The participants underwent all conventional tests to identify etiology of microbial pathogenesis. The primary outcome was the percentage of different microbiological pathogens causing AE-COPD. A comparative microbiological analysis of the patients with overlapping asthma-COPD (ACO) and pure COPD was performed. Results: We included 1,186 patients with AE-COPD. Patients with pure COPD constituted 87.9% and those with ACO accounted for 12.1%. Nearly half of the patients used an inhaled corticosteroid-containing regimen and one-fifth used systemic corticosteroids. Respiratory pathogens were found in 55.3% of all such patients. Bacteria and viruses were detected in 33% and 33.2%, respectively. Bacterial and viral coinfections were found in 10.9%. The most frequently detected bacteria were Pseudomonas aeruginosa (9.8%), and the most frequently detected virus was influenza A (10.4%). Multiple bacterial infections were more likely to appear in ACO than in pure COPD (8.3% vs. 3.6%, p=0.016). Conclusion: Distinct microbiological patterns were identified in patients with moderate-to-severe AE-COPD in South Korea. These findings may improve evidence-based management of patients with AE-COPD and represent the basis for further studies investigating infectious pathogens in patients with COPD.