• Geomechanics and Engineering
• /
• v.15 no.3
• /
• pp.879-888
• /
• 2018

Probability-based design codes have been developed to sufficiently confirm the safety level of structures. One of the most acceptable probability-based approaches is Load Resistance Factor Design (LRFD), which measures the safety level of the structures in terms of the reliability index. The main contribution of this paper is to calibrate the load and resistance factors of the design code for tunnels. The load and resistance factors are calculated using the available statistical models and probability-based procedures. The major steps include selection of representative structures, consideration of the limit state functions, calculation of reliability for the selected structures, selection of the target reliability index and calculation of load factors and resistance factors. The load and resistance models are reviewed. Statistical models of resistance (load carrying capacity) are summarized for strength limit state in bending, shear and compression. The reliability indices are calculated for several segments of a selected circular tunnel designed according to the tunnel manual report (Tunnel Manual). The novelty of this paper is the selection of the target reliability. In doing so, the uniform spectrum of reliability indices is proposed based on the probability paper. The final recommendation is proposed based on the closeness to the target reliability index.

• Progress in Superconductivity and Cryogenics
• /
• v.6 no.4
• /
• pp.17-21
• /
• 2004

The butt joint was verified to satisfy the thermal stability of the ITER magnet system through the ITER CS model coil test. Since the contact area in the butt joint is limited to the cross section of the cable, it is necessary to analyze and control the joining parameters precisely for improving the DC resistance. It is difficult to simulate the cables, which are composed of a lot of strands, as three-dimensional models using the commercial code. The random numbers were used to simulate many kinds of contact patterns of the strands on the bonding surface for calculating the bonding area and the DC resistance of the butt joint. The calculated DC resistance decreases with an increase of cable filling factor in terminal. The calculated DC resistance of a 0.9 cable filling factor is about 0.48 n-Ohm, which is about one-tenth of that in the CS model coil test when not considering the electrical contact resistance. From this difference, the electrical contact resistance between the strands and copper sheet was calculated.

• Genomics & Informatics
• /
• v.19 no.1
• /
• pp.2.1-2.10
• /
• 2021

BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in the majority of cases. Although secondary mutations in the mitogen-activated protein kinase signaling pathway are known to be responsible for this phenomenon, the molecular mechanisms governing acquired resistance are not known in more than half of patients. Here we report a genome- and transcriptome-wide study investigating the molecular mechanisms of acquired resistance to BRAF inhibitors. A microfluidic chip with a concentration gradient of vemurafenib was utilized to rapidly obtain therapy-resistant clones from two melanoma cell lines with the BRAF V600E mutation (A375 and SK-MEL-28). Exome and transcriptome data were produced from 13 resistant clones and analyzed to identify secondary mutations and gene expression changes. Various mechanisms, including phenotype switching and metabolic reprogramming, have been determined to contribute to resistance development differently for each clone. The roles of microphthalmia-associated transcription factor, the master transcription factor in melanocyte differentiation/dedifferentiation, were highlighted in terms of phenotype switching. Our study provides an omics-based comprehensive overview of the molecular mechanisms governing acquired resistance to BRAF inhibitor therapy.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.31 no.6C
• /
• pp.259-266
• /
• 2011

Conducting statistical analysis of foundation resistance using sufficient number of well-performed load test results is prerequisite for the calibration of reliable resistance factors for foundation LRFD. In this study, a rational analysis method is proposed so that the proof pile load test results can be reflected in update of resistance statistical characteristics based on Bayesian theory. Then, resistance factors for driven steel pipe piles compatible with Korea foundation practices are updated by implementing this rational analysis method. To accomplish the resistance factor updates, (1) prior pile resistance distribution is constructed based on the results of pile load tests, which loads are imposed at least up to their ultimate limit loads. (2) likelihood function is obtained from the results of proof pile load tests, and (3) posterior pile resistance distribution is updated by combining these prior pile resistance distribution and likelihood function. The resistance factors are updated using the posterior pile resistance following the first-order reliability method (FORM). From the possible results of five consecutive proof pile load tests, the updated resistance factors vary within ranges of 0.27-0.96 and 0.19-0.68 for target reliability indices of 2.33 and 3.0, respectively. Consequently, it was found that the Bayesian theory-implemented method enables the updates of resistance factors in an efficient way when reliable resistance factors are not available due to the lack of well-performed pile load test results.

• Journal of the Society of Naval Architects of Korea
• /
• v.54 no.3
• /
• pp.171-186
• /
• 2017

This paper introduces a study on ship performance in waves to consider the effects of added resistance in the early stage of hull-form design. A ship experiences a loss of speed in actual seaways, hence this study proposes the overall procedure of a new design concept that takes into account the hydrodynamic performance of ship in waves. In the procedure, the added resistance is predicted using numerical methods: slender-body theory and Maruo's far-field formulation, since these methods are efficient in initial design stage, and an empirical formula is adopted for short waves. As computational models, KVLCC2 hull and Supramax bulk carrier are considered, and the results of added resistance and weather factor for test models are discussed. The computational results of vertical motion response and added resistance of KVLCC2 hull are compared with the experimental data. In addition, the sensitivity analysis of added resistance and weather factor for KVLCC2 hull to the variations of ship dimensions are conducted, and the change of the added resistance and propulsion factors after hull form variations are discussed.

• Journal of the Society of Naval Architects of Korea
• /
• v.50 no.5
• /
• pp.291-297
• /
• 2013

Generally, form factor is determined through ITTC method. Determining the form factor from ITTC method includes the assumption that the form factor of a full-scale ship is the same value as its model ship. In other words, the form factor is independent on Reynolds number. However, for the more appropriate prediction of the resistance performance of a full-scale ship, the form factor must be determined with the consideration of the variation attendant on Reynolds number. In this research, several Geosim ship models are adopted to investigate the scale effect, and correlation lines of form factor are improved to suggest the better extrapolation method for the prediction of the form factor of full-scale ship. The corrected form factors using the correlation lines are compared with those determined from the results of low-speed resistance tests. To consider the influence of hull form, the correlation lines are determined for the group of high-speed ships and the group of low-speed ships, respectively. The corrected form factors have shown good agreement among the prediction results from each Geosim ship model to the full-scale ship.

• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.66 no.4
• /
• pp.219-223
• /
• 2017

In this paper, we calculated the losses in the high voltage lines of power distribution system. The losses caused by high voltage lines are calculated using maximum current, resistance, loss factor, and dispersion loss factor. The accurate extraction of these factors are very important to calculate the losses exactly. Thus, the maximum loads are subdivided to regions and calculated monthly for more accurate maximum current calculation. Also, the composite resistance is calculated according to the ratio of the used wire types. In order to calculate the loss factor, the load factors according to the characteristics of each region were calculated. Finally, the losses of the distribution system is calculated by adding the losses by the transformers and the low voltage lines.

• Proceedings of the KIEE Conference
• /
• 2004.11a
• /
• pp.153-156
• /
• 2004

An electric power efficiency of electrodeless fluorescent lamp has big relative property of gas in lamp, gas pressure, lamp formation, ingredients of magnetic substance and shape and action frequency etc. We used magnetic substance that open self examination material of electrodeless fluorescent lamp antenna. Ferrite that is used in this experiment was Mn-Zn type. We have examined resistance kind, impedance, Q-factor's frequency characteristic by ferrite. Impedance, resistance and capacitance did not show difference in start frequency 2.65 [MHz] but there was difference quantity. We could know Q-factor's difference according to material, and Q-factor's is important part of antenna design.

• 한국신재생에너지학회:학술대회논문집
• /
• 2009.11a
• /
• pp.360-363
• /
• 2009

In order to improve the overall power conversion efficiency, it is very important to reduce the interface resistance of dye-sensitized solar cells (DSSCs). In this approach, tiny $TiO_2$ nanoparticles with the primary size of 10~20nm were synthesized and deposited between FTO glass and preformed $TiO_2$ layer by $TiOCl_2$ treatment, and also Pt catalysts were deposited on the counter electrode by both ion-sputter and thermal deposition to reduce the electrolyte-counter electrode interface resistance. The influence of these processes on the performace of DSSCs were discussed in terms of fill factor, short circuit current, and conversion efficiency.

• Proceedings of the KWS Conference
• /
• 2007.11a
• /
• pp.26-28
• /
• 2007

This research is concerned with a study of failure strength evaluation on heat element gap at resistance welding. The failure strength of resistance welded joint is changed by welding factor like as current(power level), welding time(total energy), pressure etc. and another heat element factor like as number of element line, element gap etc. Tensile-shear tests were carried out with the single-lap specimen using polypropylene(PP). The failure mechanism and optimization of gap was discussed in order to explain the tensile-shear strength evaluation on heat element gap at resistance welding. Orthogonal array was used by fractional factorial design for efficient experiments.