• The Korean Journal of Physiology and Pharmacology
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• v.22 no.5
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• pp.513-523
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• 2018

The tumor microenvironment greatly influences cancer cell characteristics, and acidic extracellular pH has been implicated as an essential factor in tumor malignancy and the induction of drug resistance. Here, we examined the characteristics of gastric carcinoma (GC) cells under conditions of extracellular acidity and attempted to identify a means of enhancing treatment efficacy. Acidic conditions caused several changes in GC cells adversely affecting chemotherapeutic treatment. Extracellular acidity did inhibit GC cell growth by inducing cell cycle arrest, but did not induce cell death at pH values down to 6.2, which was consistent with down-regulated cyclin D1 and up-regulated p21 mRNA expression. Additionally, an acidic environment altered the expression of atg5, HSPA1B, collagen XIII, collagen XXAI, slug, snail, and zeb1 genes which are related to regulation of cell resistance to cytotoxicity and malignancy, and as expected, resulted in increased resistance of cells to multiple chemotherapeutic drugs including etoposide, doxorubicin, daunorubicin, cisplatin, oxaliplatin and 5-FU. Interestingly, however, acidic environment dramatically sensitized GC cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Consistently, the acidity at pH 6.5 increased mRNA levels of DR4 and DR5 genes, and also elevated protein expression of both death receptors as detected by immunoblotting. Gene silencing analysis showed that of these two receptors, the major role in this effect was played by DR5. Therefore, these results suggest that extracellular acidity can sensitize TRAIL-mediated apoptosis at least partially via DR5 in GCs while it confers resistance to various type of chemotherapeutic drugs.

• Journal of Korean Society of Steel Construction
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• v.19 no.2
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• pp.139-146
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• 2007

The objective of the present study is to provide statistical resistance statistics for steel-concrete composite plate girder sections under positive and negative moments. Statistical properties on yield strength, tensile strength, elongation, and fracture toughness of domestic structural steel products, gathered from an analysis of over 16,000 samples, were evaluated. Using the steel samples for the plate girder, the bias factor and the coefficient of variation of the ultimate flexural resistance for representative composite plate girder sections under positive and negative flexures were presented. In calculating the ultimate flexural resistance of the composite section, the moment curvature relationships were developed using the incremental load approach considering material nonlinearity for the steel girder. The predicted statistics can be used in the future for the efficient calibration of LRFD code.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.129-136
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• 2005

The deterministic analysis method has generally used to evaluate the slope stability and it evaluates the slope stability with decision value that is a representative value of design variables. However, one of disadvantages in the deterministic approach is there is not able to consider the uncertainty of soil strength properties, even though it is the biggest influential parameter of the slope stability. On the other hand, the limit state design(LSD) can take a consideration of uncertainties and computes both the reliability index and the probability of failure. LSD method is capable of overcoming the disadvantages of deterministic method and evaluating the slope stability more reliably. In this study, both the mean value and standard deviation of the internal land's representative soil strength properties applied to process the LSD method. The major purpose of this study is to gauge the general applicability of the limit state design in soil slope and to weigh the comparative validity of the proposed partial safety factor. In order to reach the aim of this study, the partial safety factor and resistance factor which totally satisfied the slope's overall safety factor were calculated by the load and resistance safety factor design (LRFD).

• Journal of Surface Science and Engineering
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• v.47 no.5
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• pp.221-226
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• 2014

A low temperature plasma nitrocarburizng was implemented on the duplex stainless steel to achieve the enhancement of surface hardness without degradation of its corrosion resistance. Attempts were made to investigate the influence of Pulse frequency and Duty factor of pulsed power in a high Pulse frequency regime on the surface characteristics of the hardened layer. The hardened layer (S-phase) was formed on all of the treated surfaces. Surface hardness reached up to 1300 $HV_{0.1}$ which is about 4.6 times higher than that of the untreated material (280 $HV_{0.1}$). The thickness of the hardened layer tends to increase lightly with the higher Pulse frequency and the higher Duty factor. The corrosion resistance of nitrocarburized duplex stainless steel was almost similar to that of the untreated material. Both the Pulse frequency and the Duty factor do not have a significant influence on the corrosion property of plasma treated duplex stainless steel.

• Journal of Power System Engineering
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• v.13 no.2
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• pp.36-41
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• 2009

An experimental investigation was conducted to examine the fluid flow resistance in the rectangular channel with two inclined wire screen baffles. Two different types of wire screens; dutch weave and plain weave, were used as baffle devices in this experiment. Three kinds of baffles with different mesh specifications were made up of dutch type and four different kinds of baffles were made up of plain weave type. The stainless steel wire screen baffles were mounted on the bottom wall with varied angle inclination. Reynolds numbers were varied from 23,000 to 57,000. Results show that the mesh number of baffles plays an important role on friction factor behaviour. It is found that the baffle with the most number of meshes (type SA) has the highest fluid flow resistance.

• Journal of the Korean Society of Safety
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• v.23 no.4
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• pp.25-29
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• 2008

Recently, new functionally graded material(FGM) that has a spatial variation in composition and properties is developed because of its good quality. This material yields the demands for resistance to corrosion and high temperature in turbine blade, wear resistance as in gears and high strength machine parts. Especially coating treatment in FGM surface brings forth a mechanical weak at the interface due to discontinuous stress resulting from a steep material change. It often, leads cracks or spallation in a coating area around an interface. The behavior of propagation cracks in FGMs was here investigated. The interface stresses were reduced because of graded material properties. Also graded material parameter with exponential equation was founded to influence the stress intensity factor. And the resistance curve with FGM coating was slightly increased.

• Journal of the Korea Concrete Institute
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• v.16 no.2 s.80
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• pp.269-275
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• 2004

Factorial design method is applied to investigate the effects of various factors simultaneously rather than to conduct a series of single-factor experiment. As the results, frost resistance of the concrete specimens, in both W/C ratio of 0.28 and 0.35, was highly affected by the type of coarse aggregate that is, andesite produced more durable concrete than the limestone. Durability factor of the specimens, with W/C ratio of 0.28, which were demolded after I day and transferred to the curing room was higher than those demolded after 2 days. This stated the efficiency of the high early curing in high strength concrete.

• Journal of the Korea Concrete Institute
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• v.12 no.5
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• pp.141-151
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• 2000

Compressive strength, sulfate deterioration factor(SDF) and length change of 5 types of mortars immersed in sodium sulfate solution were observed. As the results of tests, it was found that the sulfate resistance of blended cement mortars were superior to that of portland cement mortars. Pore volume with diameter larger than 0.1 $\mu\textrm{m}$ of 5 types of pastes indicated that the micro-structures of blended cement pastes were denser, due to pozzolan reaction and latent hydraulic properties, than those of portland cement pastes. The XRD, ESEM, EDS and TG analyses demonstrated that the reactants such as ettringite and gypsum were significantly formed in portland cement pastes. Besides, compared with the $Ca(OH)_2$ content of ordinary portland cement pastes immersed in water and sodium sulfate solution, the $Ca(OH)_2$ contents of fly ash blended cement and ground granulated blast-furnace slag cement paste were about 58% and 28% in water, and 55% and 20% in sodium sulfate solution, respectively.

• Selected Papers of The Society of Naval Architects of Korea
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• v.1 no.1
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• pp.65-75
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• 1993

Hull form development for an AFRAMAX tanker characterized by the form parameters of $C_B\simeq0.8$, $L/B\simeq5.5$, $B/T\simeq3.5$, han been carried out by the application of ‘Composite Stern Frameline Concept’. The viscous resistance of the new form was much smaller than that of the conventional form. Form factor of the new form was only 0.18 compared to 0.30 for the conventional hull form, Nevertheless the propulsive efficiency was slightly lower and thus the required propulsion power was smaller by 5~6% at both full load and ballast condition. In addition, it is confirmed that introduction of the form factor method such as ITTC’78 method is highly advisable because there is a great risk of the underperdicting full scale resistance of the hull form whose form the extrapolation of moel resistance to full scale is to be based on Froude method with the correlation allowances usually applied to conventional hull forms.

• Journal of the Semiconductor & Display Technology
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• v.22 no.3
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• pp.67-72
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• 2023

In this paper, a dye-sensitized solar cell (DSSC), one of the representative third-generation solar cells with eco-friendly materials and processes compared to other solar cells, was modeled using MATLAB/Simulink. The simulation was conducted by designating values of series resistance, parallel resistance, light absorption coefficient, and thin film electrode thickness, which are directly related to the efficiency of dye-sensitized solar cells, as arbitrary experimental values. In order to analyze the performance of dye-sensitized solar cells, the optimal value among each parameter experimental value related to efficiency was found using formulas for fill factor (FF) and conversion efficiency.