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The Meaning of P50 Suppression : Interaction of Gamma and Alpha Waves

  • Lee, Kyungjun;Kang, Ung Gu
    • Korean Journal of Biological Psychiatry
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    • v.21 no.4
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    • pp.168-174
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    • 2014
  • Objectives Sensory gating dysfunctions in patients with schizophrenia and bipolar disorder have been investigated through two similar methods ; P50 suppression and prepulse inhibition paradigms. However, recent studies have demonstrated that the two measures are not correlated but rather constitute as distinct neural processes. Recent studies adopting spectral frequency analysis suggest that P50 suppression reflects the interaction between gamma and other frequency bands. The aim of the present study is to investigate which frequency component shows more significant interaction with gamma band. Methods A total of 108 mood disorder patients and 36 normal subjects were included in the study. The P50 responses to conditioning and test stimuli with an intra-pair interval of 500 msec were measured in the study population. According to P50 ratio (amplitude to the test stimulus/amplitude to the conditioning stimulus), the subjects with P50 ratio less than 0.2 were defined as suppressed group (SG) ; non-suppressed group (NSG) consisted of P50 ratio more than 0.8. Thirty-five and 25 subjects were included in SG and NSG, respectively. Point-to-point correlation coefficients (PPCCs) of both groups were calculated between two time-windows : the first window (S1) was defined as the time-window of one hundred millisecond after the conditioning auditory stimulus and the second window (S2) was defined as the time-window of 100 msec after the test auditory stimulus. Spectral frequency analysis was performed to investigate which frequency band results in the difference of PPCC between SG and NSG. Results Significant reduction of PPCC between S1 and S2 was observed in the SG (Pearson's r = 0.24), compared to PPCC of the NSG (r = 0.58, p < 0.05). In spectral frequency analysis, gamma band showed "phase-reset" and similar responses after the two auditory stimuli in suppressed and non-suppressed group. However in the case of alpha band, comparison showed significantly low PPCC in SG (r = -0.14) compared to NSG (r = 0.36, p < 0.05). This may be reflecting "phase-out" of alpha band against gamma band at approximately 50 msecs after the test stimulus in the SG. Conclusions Our study suggests that normal P50 suppression is caused by phase-out of alpha band against gamma band after the second auditory stimulus. Thus it is demonstrated that normal sensory gating process is constituted with attenuated alpha power, superimposed on consistent gamma response. Implications of preserved gamma and decreased alpha band in sensory gating function are discussed.

A Study on the Improvement of Recommended Route in the Vicinity of Wando Island using Support Vector Machine (서포트 벡터 머신을 이용한 완도 인근해역 추천항로 개선안에 관한 연구)

  • Yoo, Sang-Lok;Jung, Cho-Young
    • Journal of Navigation and Port Research
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    • v.41 no.6
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    • pp.445-450
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    • 2017
  • It is necessary to set a route to reflect the traffic flow for the safety of the traffic vessels. This ongoing analysis is needed to ensure that the vessels comply with a route. The purpose of this study is to discover the problems of the recommended route vicinity for Wando Harbor and suggest an improvement plan. We used a support vector machine based on the ship's trajectory to establish an efficient route center line. Since the vessels should navigate to the starboard side, with reference to the center line of the recommended route, the trajectories of the vessels were divided into two clusters. The support vector machine is being used in many fields such as pattern recognition, and it is effective for this binary classification. As a result of this study, about 79.5 % of the merchant eastbound ships in a 2.4 NM distance to Jangjuk Sudo did not observe the recommended route, so the risk of collision always existed. The contraflow traffic rate of the route of the eastbound ships decreased from 79.5 % to 30.9 % when the recommended route was reset about 300 meters to the north, from its present position. The support vector machine applied in this study is expected to be applicable, to effectively set the route center line because the ship trajectories can be classified into two clusters.

A Survey on the Radiation Exposure Doses Reduction Plan through Dose Index Analysis in the Pediatric Brain Computed Tomography (소아 두부 컴퓨터단층촬영검사에서 선량지표 분석을 통한 방사선 피폭선량 감소 방안에 대한 연구)

  • Kim, Hyeon-Jin;Lee, Hyo-Yeong;Im, In-Chul;Yu, Yun-Sik
    • Journal of the Korean Society of Radiology
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    • v.10 no.3
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    • pp.161-169
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    • 2016
  • In this study, the proposal to seek ways to reduce the amount of radiation is drawn by comparing and analyzing CT Dose Index(CTDI) on the pediatric head CT which was performed at the busan regional hospitals, to the national diagnostic reference levels. As a result, it was appeared to exceed the amount of the dose recommendation in order of hospital, general hospital and senior general hospital in the hospital-specific classification and from 2 to 5 year, from 1 month to 1 year and from 6 to 10 year in the age-specific classification. In addition, the amount of the dose recommendation was exceed in order of helical, axial and volume in the scan-specific classification. As the results of the scan range reset to match the diagnostic reference level, the dose reduction showed 11.68%, 15.79% and 20.66% in senior general hospital, general hospital and hospital respectively. In the results of analysing patient average scan ranges which does not deviate from the guideline of patient dose recommendation, there was age of 1 month to 1 year, 2 to 5 year and 6 to 10 year of $03.2{\pm}11.8mm$, $110.5{\pm}14.5mm$, and $117.8{\pm}17.2mm$ respectively.

Innovation Patterns of Machine Learning and a Birth of Niche: Focusing on Startup Cases in the Republic of Korea (머신러닝 혁신 특성과 니치의 탄생: 한국 스타트업 사례를 중심으로)

  • Kang, Songhee;Jin, Sungmin;Pack, Pill Ho
    • The Journal of Society for e-Business Studies
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    • v.26 no.3
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    • pp.1-20
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    • 2021
  • As the Great Reset is discussed at the World Economic Forum due to the COVID-19 pandemic, artificial intelligence, the driving force of the 4th industrial revolution, is also in the spotlight. However, corporate research in the field of artificial intelligence is still scarce. Since 2000, related research has focused on how to create value by applying artificial intelligence to existing companies, and research on how startups seize opportunities and enter among existing businesses to create new value can hardly be found. Therefore, this study analyzed the cases of startups using the comprehensive framework of the multi-level perspective with the research question of how artificial intelligence based startups, a sub-industry of software, have different innovation patterns from the existing software industry. The target firms are gazelle firms that have been certified as venture firms in South Korea, as start-ups within 7 years of age, specializing in machine learning modeling purposively sampled in the medical, finance, marketing/advertising, e-commerce, and manufacturing fields. As a result of the analysis, existing software companies have achieved process innovation from an enterprise-wide integration perspective, in contrast machine learning technology based startups identified unit processes that were difficult to automate or create value by dismantling existing processes, and automate and optimize those processes based on data. The contribution of this study is to analyse the birth of artificial intelligence-based startups and their innovation patterns while validating the framework of an integrated multi-level perspective. In addition, since innovation is driven based on data, the ability to respond to data-related regulations is emphasized even for start-ups, and the government needs to eliminate the uncertainty in related systems to create a predictable and flexible business environment.

Evaluation of Nursing Educational Objectives Achievement & Related Factors in Nurses Within Five Years After Graduation: Focusing on Critical Thinking Disposition and Clinical Competence (일개대학 간호학과 졸업 후 5년 이내 간호사의 교육목표 달성도와 영향요인 -비판적 사고 성향과 임상수행능력을 중심으로)

  • Han, Mi-Hyun;Jeong, Seung-Eun;Kim, Jee-Yoon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.12
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    • pp.836-846
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    • 2018
  • The purpose of this study was to evaluate nursing educational objectives achievement, critical thinking disposition, and clinical competence and their relationships in nurses within five years after graduation. Subjects were 82 nurses who graduated one nursing college within five years and 68 managers in nursing unit of hospital. Questions were given to nurses. They reported their achievement of educational objectives of the nursing college, critical thinking disposition and clinical competence. Nursing unit managers received the same questions to evaluate nurses working at their unit. Data were collected from January to march 2014 and analyzed by descriptive statistics, t-test, ANOVA, Pearson correlation and multiple regression with SPSS/WIN 23.0 program. Mean scores for achievement of educational objectives, critical thinking disposition, and clinical competence were $3.60{\pm}0.60$, $3.46{\pm}0.28$, and $4.17{\pm}0.56$, respectively. Educational objectives achievement showed significant correlations with critical thinking disposition (r = 0.52, p <. 001) and clinical competence (r = 0.52, p < .001). Regression analysis showed that critical thinking disposition (${\beta}=.30$, p = .018) and clinical competence (${\beta}=.26$, p = .029) were significant factors for predicting educational objectives achievement. Manager's evaluation score for educational objectives achievement and clinical competence was higher than graduated nurses' report (p < .001). This could be used as a feed- back to reset educational objectives and upgrade the curriculum. These study results could be used to, establish strategies to improve educational objectives achievement.

A Comparative Study on HSI and MaxEnt Habitat Prediction Models: About Prionailurus bengalensis (HSI와 MaxEnt를 통한 삵의 서식지 예측 모델 비교 연구)

  • Yoo, Da-Young;Lim, Tai-Yang;Kim, Whee-Moon;Song, Won-Kyong
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.24 no.5
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    • pp.1-14
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    • 2021
  • Excessive development and urbanization have destroyed animal, plant, habitats and reduced biodiversity. In order to preserve species diversity, habitat prediction studies are have been conducted at home and overseas using various modeling techniques. This study was conducted to suggest optimal habitat modeling research by comparing HSI and MaxEnt, which are widely used among habitat modeling techniques. The study was targeted on the endangered species of Prionailurus bengalensis in nearby areas (5460.35km2) including Cheonan City, and the same data were used for analysis to compare those models. According to the HSI analysis, Prionailurus bengalensis's habitat probability was 74.65% for less than 0.5 and 25.34% for more than 0.5 and the top 30% were forest (99.07%). MaxEnt's analysis showed that 56.22% of those below 0.5 and 43.79% of those above 0.5 were found to have a high explanatory power of 78.3% of AUC. The Paired Wilcoxn test, which evaluated the significance of thoes models, confirmed that the mean difference between the two models was statistically significant (p<0.05). Analysis of the differences in the results of those models using the matrix table shows that score 24.43% HSI and MaxEnt was accordance,12.44% of the 0.0 to 0.2 section, 7.22% of the 0.2 to 0.4 section, 2.73% of the 0.4 to 0.6 section, 1.96% of the 0.6 to 0.8, and 0.08% of the 0.9 to 1.0. To verify where the score difference appears, the result values of those models were reset to values from 1 to 5 and overlaid. Overlapping analysis resulted in 30.26% of the Strongly agree values, 56.77% of the agree values, and 11.92% of the Disagree values. The places where the difference in scores occurs were analyzed in the order of forest (45.23%), agricultural land (34.57%), and urbanization area (7.65%). This confirmed that the analysis of the same target species within the same target site also has differences in forecasts depending on the modelling method. Therefore, a novel analysis method combining the advantages of each modeling in habitat prediction studies should be developed, and future study may be used to select Prionailurus bengalensis and species-protected areas and species protection areas in the future. Further research is judged to require higher accuracy studies through the use of various modeling techniques and on-site verification.

Exploring Learning Progressions for Global Warming: Focus on Middle School Level (지구 온난화에 대한 학습발달과정 탐색: 중학교를 중심으로)

  • Yu, Eun-Jeong;Lee, Kiyoung;Kwak, Youngsun;Park, Jaeyong
    • Journal of Science Education
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    • v.46 no.1
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    • pp.1-16
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    • 2022
  • The purpose of this study is to explore learning progressions for global warming at middle school level. For this purpose, we conducted a construct modeling approach that specifies constructs, item designs, outcome spaces, and measurement model steps from April to October, 2021. In order to develop student assessment items, we analyzed the 2015 revised curriculum and textbooks of middle school and categorized a concept hierarchy for each construct to create a construct map. The assessment items were developed into multiple-choice, short answer, and essay questions according to the selected constructs to strengthen the linkage between the constructs and the items. Based on the three-step grading criteria for each item, an online assessment of 21 minor items developed for middle school students show that many students met 'high' level, but none met 'low' level. In this manner, the initial set lower anchor was reset to level 0, the original set upper anchor was lowered from level 4 to level 3, and the hypothetical learning progression for global warming was presented in the following order: phenomenal, conceptual, and mechanical understandings. The results of the research have raised implications for reorganizing the next science curriculum and improving the assessment system.

Resetting the Evaluation Indicators for School Garden Education Service

  • Hong, In-Kyoung;Yun, Hyung-Kwon;Jung, Young-Bin;Lee, Sang-Mi;Lee, Choon-soo
    • Journal of People, Plants, and Environment
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    • v.24 no.3
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    • pp.245-256
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    • 2021
  • Background and objective: The vitalization of urban agriculture has increased various forms of experience-based education using school gardens, which raised the importance of school gardens in terms of value as well as the need to develop an implementation system for education-based agricultural experience service using school gardens. Thus, we reset the evaluation indicators from the previous study to establish objective evaluation indicators that enable quantitative comparison of school garden education services. Methods: Analytic hierarchy process (AHP) and direct question (DQ) surveys were conducted on 20 experts from October 12 to 19, 2020 after establishing the purpose and subjects of evaluation, and then the weights were calculated using the Expert Choice 2010 program. Results: First, we analyzed the problems of the previous indicators by categorizing the performance indicators and comparing and verifying them with six requirements of valuation. Then, we added 'welfare values' and established sub-indicators accordingly. The importance of value indicator in AHP was in the order of education values (0.544), health values (0.182), welfare values (0.164), environmental values (0.062), and economic values (0.049). The importance of environmental and economic values was relatively low, less than 0.1. The importance of sub-indicators was highest in cultivating character (0.144), followed by enhancing ecological sensitivity (0.141) > promoting mental health (0.134) > cultivating agricultural literacy (0.120) > improving social skills (0.104). And mitigating climate change in environmental values was lowest (0.009). Increase in income was the lowest (0.036). This can be regarded as the expression of change to increase the educational effect based on collective life and the connotative meaning of 'school'. In the case of DQ, the AHP weight and order were the same, but the environmental and economic values were relatively low, and the result was different from AHP weight. For sub-indicators, the importance in DQ was highest in promoting mental health (0.136), followed by promoting physical health (0.085), ]cultivating character (0.082), social integration (0.072), and enhancing ecological sensitivity (0.071). After reviewing related experts, we came up with 5 evaluation indicators and 16 sub-indicators for school garden education service, which are objective evaluation indicators that enable quantitative comparison. Conclusion: In the future, we will validate the socioeconomic values of school garden education services and contribute to revitalizing school gardens by establishing policy alternatives for effective operation and management of school gardens.

Criminal Law Issues and Challenges Due to Changes in the Healthcare Paradigm (헬스케어 패러다임 변화에 따른 형사법적 쟁점과 과제)

  • Sun, JongSoo
    • The Korean Society of Law and Medicine
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    • v.24 no.1
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    • pp.43-65
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    • 2023
  • The healthcare industry is a digital healthcare that combines technology based on the 4th Industrial Revolution, dealing with information on individual health and medical care, and is a fusion of health care services and medical science and technology. It is questionable whether digital healthcare according to the paradigm change can be discussed by the concept of medical practice under the existing Medical Act. There is no clear definition of the concept of medical practice in the Medical Service Act, but the concept is established through precedents. In addition, under the Medical Service Act, the subject of medical practice is limited to medical personnel. However, digital healthcare sometimes diagnoses and treats diseases using digital technology by medical personnel. On the other hand, what is possible by non-medical personnel is digital healthcare. This is because digital healthcare is understood as a concept that includes health care such as exercise, eating habits, and weight control. For this reason, if the concept of medical practice under the "Medical Act" on digital healthcare is included, it is subject to criminal punishment for "unlicensed medical practice" prescribed in Article 27 of the "Medical Act". In the health and medical industry, digital transformation and convergence with information and communication technology are rapidly progressing. As a result, there is a need to newly define it as 'digitalized medical practice' or 'information and communication technology (ICT)-based medical practice' separately from existing medical practices. The concept of medical practice has variability, not a fixed and invariable concept. However, in response to this demand, it is not an infinite expansion of the concept of medical practice, but a request to reset its scope. Therefore, the concept of medical practice should be legislated by reflecting the demand of consumers for the medical service system.

Evaluation of Dynamic X-ray Imaging Sensor and Detector Composing of Multiple In-Ga-Zn-O Thin Film Transistors in a Pixel (픽셀내 다수의 산화물 박막트랜지스터로 구성된 동영상 엑스레이 영상센서와 디텍터에 대한 평가)

  • Seung Ik Jun;Bong Goo Lee
    • Journal of the Korean Society of Radiology
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    • v.17 no.3
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    • pp.359-365
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    • 2023
  • In order to satisfy the requirements of dynamic X-ray imaging with high frame rate and low image lag, minimizing parasitic capacitance in photodiode and overlapped electrodes in pixels is critically required. This study presents duoPIXTM dynamic X-ray imaging sensor composing of readout thin film transistor, reset thin film transistor and photodiode in a pixel. Furthermore, dynamic X-ray detector using duoPIXTM imaging sensor was manufactured and evaluated its X-ray imaging performances such as frame rate, sensitivity, noise, MTF and image lag. duoPIXTM dynamic X-ray detector has 150 × 150 mm2 imaging area, 73 um pixel pitch, 2048 × 2048 matrix resolution(4.2M pixels) and maximum 50 frames per second. By means of comparison with conventional dynamic X-ray detector, duoPIXTM dynamic X-ray detector showed overall better performances than conventional dynamic X-ray detector as shown in the previous study.