• Title/Summary/Keyword: Research of Dentistry

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Oral manifestation and root canal therapy of the patient with mucopolysaccharidosis

  • Yoon, Ji-Hye;Lee, Hyo-Il;Jang, Ji-Hyun;Choi, Sung-Hyeon;Chang, Hoon-Sang;Hwang, Yun-Chan;Hwang, In-Nam;Lee, Bin-Na;Oh, Won-Mann
    • Restorative Dentistry and Endodontics
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    • v.44 no.2
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    • pp.14.1-14.7
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    • 2019
  • Mucopolysaccharidosis (MPS) is an inherited metabolic disorder caused by a deficiency in enzymes that participate in the degradation of glycosaminoglycans (GAGs) such as heparin sulfate and dermatan sulfate. Left untreated, patients show progressive mental and physical deterioration due to deposition of GAGs in organs. Death often occurs due to cardiac or respiratory failure before patients reach their early twenties. MPS has several oral and dental manifestations. An enlarged head, short neck, and open mouth associated with a large tongue are major characteristics of MPS patients. Dental complications can be severe, including unerupted dentition, dentigerous cyst-like follicles, malocclusions, condylar defects, and gingival hyperplasia. A 21-year-old female patient with MPS was described in this article, with special emphasis on oral manifestations and dental treatment.

Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry

  • Kim, Jia;Song, Young-Sang;Min, Kyung-San;Kim, Sun-Hun;Koh, Jeong-Tae;Lee, Bin-Na;Chang, Hoon-Sang;Hwang, In-Nam;Oh, Won-Mann;Hwang, Yun-Chan
    • Restorative Dentistry and Endodontics
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    • v.41 no.1
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    • pp.29-36
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    • 2016
  • Objectives: The purpose of this study was to assess the ability of two new calcium silicate-based pulp-capping materials (Biodentine and BioAggregate) to induce healing in a rat pulp injury model and to compare them with mineral trioxide aggregate (MTA). Materials and Methods: Eighteen rats were anesthetized, cavities were prepared and the pulp was capped with either of ProRoot MTA, Biodentine, or BioAggregate. The specimens were scanned using a high-resolution micro-computed tomography (micro-CT) system and were prepared and evaluated histologically and immunohistochemically using dentin sialoprotein (DSP). Results: On micro-CT analysis, the ProRoot MTA and Biodentine groups showed significantly thicker hard tissue formation (p < 0.05). On H&E staining, ProRoot MTA showed complete dentin bridge formation with normal pulpal histology. In the Biodentine and BioAggregate groups, a thick, homogeneous hard tissue barrier was observed. The ProRoot MTA specimens showed strong immunopositive reaction for DSP. Conclusions: Our results suggest that calcium silicate-based pulp-capping materials induce favorable effects on reparative processes during vital pulp therapy and that both Biodentine and BioAggregate could be considered as alternatives to ProRoot MTA.

Epigenetics: general characteristics and implications for oral health

  • Seo, Ji-Yun;Park, Yoon-Jung;Yi, Young-Ah;Hwang, Ji-Yun;Lee, In-Bog;Cho, Byeong-Hoon;Son, Ho-Hyun;Seo, Deog-Gyu
    • Restorative Dentistry and Endodontics
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    • v.40 no.1
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    • pp.14-22
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    • 2015
  • Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.

A study on the North Korea°Øs clinical dentistry system and research tendency of dentistry (북한문헌을 통한 북한의 연구경향 고찰)

  • Kim, Seong-Hwan;Kim, Min-Gyun;Myoung, Hoon;Kim, Jong-Chul
    • The Journal of the Korean dental association
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    • v.53 no.10
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    • pp.712-725
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    • 2015
  • The clinical dentistry system and research tendency of dentistry in North Korea has a difference with South Korea. In North Korea, preventive dentistry has been developed, and government of North Korea clame a free medical service to all the people. And there are tendency that Korean medicine(Oriental medicine) is applied to clinical dentistry in North Korea. Research tendency of dentistry in North Korea have a difference from South Korea. Articles of dentistry in North Korea have some freatures. Terminology of dentistry is writtened in original Korean developed uniquely in North Korea. Recent articles of dentistry in North Korea have a reference from english articles, and it is different that reference articles in the past were from Chinese or Russian articles. In order to get ready for the United Korea, we need to know the feature of dentistry in North Korea, and increase an academic exchange between South and North Korea.