• Food Science and Industry
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• v.46 no.2
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• pp.8-22
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• 2013

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4458-4461
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• 2011

• Biomolecules & Therapeutics
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• v.22 no.6
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• pp.558-562
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• 2014

Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

• Journal of Nutrition and Health
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• v.50 no.2
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• pp.202-202
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• 2017

• Journal of the Korean Society of Propulsion Engineers
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• v.22 no.1
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• pp.89-97
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• 2018

The test results of a 7-tonf-class engine for the third-stage engine of KSLV-II are presented. Hot-firing tests performed with two engineering model engines are classified into ground tests and high-altitude tests according to the test conditions. The operability verification of the engines were carried out through short and long duration tests. The full duration test performed for the durability verification of the engines revealed a few of items to be improved. Synthetically, encouraging data of adding power to engine development were obtained from the test results. New engines based on these results will be manufactured and consistently verified through hot-firing tests.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.05a
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• pp.119-120
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• 2005

• Osong Public Health and Research Perspectives
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• v.9 no.6
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• pp.363-363
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• 2018

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.181-181
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• 2002

The herbal combination allergina has been used for the treatment of inflammatory diseases in South Korea. In this study, we investigated the immunosuppressive activities of allergina in more detail. Acute graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in patients undergoing allogeneic bone marrow transplantation.(omitted)

• Journal of Advanced Research in Ocean Engineering
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• v.4 no.4
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• pp.174-184
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• 2018

We herein propose a new design procedure of a flexible container ship model where the vertical bending and torsional vibration modes are similar to its prototype. To achieve similarity in torsional vibration mode shapes, the height of the shear center of the model must be located below the bottom hull, similar to an actual container ship with large opening decks. Therefore, we designed a ship model by imparting appropriate stiffness to the hull, using urethane foam without a backbone. We built a container ship model according to this design strategy and validated its dynamic elastic properties using a decay test. We measured wave-induced structural vibrations and present the results of tank experiments in regular and freak waves.

• Biomolecules & Therapeutics
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• v.23 no.6
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• pp.597-603
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• 2015

Synthetic cannabinoids JWH-018 and JWH-250 in 'herbal incense' also called 'spice' were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently there are not sufficient data on their adverse effects including neurotoxicity. There are only anecdotal reports that suggest their toxicity. In the present study, we evaluated the neurotoxicity of two synthetic cannabinoids (JWH-081 and JWH-210) through observation of various behavioral changes and analysis of histopathological changes using experimental mice with various doses (0.1, 1, 5 mg/kg). In functional observation battery (FOB) test, animals treated with 5 mg/kg of JWH-081 or JWH-210 showed traction and tremor. Their locomotor activities and rotarod retention time were significantly (p<0.05) decreased. However, no significant change was observed in learning or memory function. In histopathological analysis, neural cells of the animals treated with the high dose (5 mg/kg) of JWH-081 or JWH-210 showed distorted nuclei and nucleus membranes in the core shell of nucleus accumbens, suggesting neurotoxicity. Our results suggest that JWH-081 and JWH-210 may be neurotoxic substances through changing neuronal cell damages, especially in the core shell part of nucleus accumbens. To confirm our findings, further studies are needed in the future.