• 제목/요약/키워드: Research and Development Department

검색결과 20,363건 처리시간 0.05초

The in vitro antioxidant activities of the bromophenols from the red alga Tichocarpus crinitus and phenolic derivatives

  • Lee, Ji-Hye;Lee, Taek-Kyun;Kang, Rae-Seon;Shin, Hee-Jae;Lee, Hyi-Seung
    • 한국자기공명학회논문지
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    • 제11권1호
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    • pp.56-63
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    • 2007
  • A series of bromophenols and corresponding debrominated phenolic compounds was prepared by isolation from red alga Tichocarpus crinitus and by structural modification of natural bromophenols. Their structures were determined by extensive NMR analysis and the antioxidant activities were established through the determination of their abilities to inhibit free radicals using DPPH as the stable radical. The most active free radical scavengers were the debrominated phenolic derivatives 3,4-dihydroxybenzyl alcohol and 3,3',4,4'-tetrahydroxydiphenylmethane.

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Antioxidant and Anti-Obesity Activities of Polygonum cuspidatum Extract through Alleviation of Lipid Accumulation on 3T3-L1 Adipocytes

  • Choi, Da-Hye;Han, Joon-Hee;Yu, Keun-Hyung;Hong, Min;Lee, Sun-Yeop;Park, Ka-Hee;Lee, Soo-Ung;Kwon, Tae-Hyung
    • Journal of Microbiology and Biotechnology
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    • 제30권1호
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    • pp.21-30
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    • 2020
  • Natural products are widely used due to their various biological activities which include anti-inflammatory, antioxidant, and anti-obesity effects. In this study, we determined the antioxidative and anti-obesity effects of Polygonum cuspidatum 50% ethanol extract (PEE). The antioxidative effect of PEE was evaluated using its radical scavenging activity, total phenolic content, and reducing power. The anti-obesity effect of PEE was investigated using 3T3-L1 adipocytes. The antioxidative activity of PEE was progressively increased in various concentrations, mainly due to the presence of phenolic compounds. PEE also alleviated lipid accumulation on 3T3-L1 adipocytes and downregulated the mRNA and protein production of adipogenesis-related (SREBP-1c, PPARγ, C/EBPα) and lipogenesis-related (aP2, FAS, ACC) markers. Furthermore, we found that the inhibitory effect on lipid accumulation via PEE was caused by the alleviation of NF-κB, p38 MAPK, ERK1/2, and JNK at the protein level. Taken together, our results imply that PEE is a potential antioxidant that can prevent obesity-associated disorders.

한국 환경 영향평가제도의 변천 (Regulatory Development of Environmental Impact Assessment in Korea)

  • 장준기;이재운;권명희;정동환
    • 환경영향평가
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    • 제2권2호
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    • pp.95-103
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    • 1993
  • EIA has been introduced as a tool for environment protection into promulgation of the Environment Preservation Act in 1977, which replaced the Pollution Control Act in Korea. EIA system has been improved with the enlargement of project type, public participation, guideline improvement, and regulatory development. Recently, Environmental Impact Assessment(EIA) Act will have an important role for sustainable development. This article deals with regulatory development, implementation order, EIA project type, and EIS preparation guidelines by Act promulgated and amended, also it explains comparison analysis of Environmental Policy Act and Environment Impact Assessment Act Major results are summarized in the table.

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Analysis of the chloroplast genome and SNP detection in a salt tolerant breeding line in Korean ginseng

  • Jo, Ick-Hyun;Bang, Kyong-Hwan;Hong, Chi Eun;Kim, Jang-Uk;Lee, Jung-Woo;Kim, Dong-Hwi;Hyun, Dong-Yun;Ryu, Hojin;Kim, Young-Chang
    • Journal of Plant Biotechnology
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    • 제43권4호
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    • pp.417-421
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    • 2016
  • The complete chloroplast genome sequence of Panax ginseng breeding line 'G07006', showing higher salt tolerance, was confirmed by de novo assembly using whole genome next-generation sequences. The complete chloroplast (CP) genome size is 156,356 bp, including two inverted repeats (IRs) of 52,060 bp, separated by the large single-copy (LSC 86,174 bp) and the small single-copy (SSC 18,122 bp) regions. One hundred fourteen genes were annotated, including 80 protein-coding genes, 30 tRNA genes, and 4 rRNA genes. Among them, 18 sites were duplicated in the inverted repeat regions. By comparative analyses of the previously identified CP genome sequences of nine cultivars of P. ginseng and that of G07006, five useful SNPs were defined in this study. Since three of the five SNPs were cultivar-specific to Chunpoong and Sunhyang, they could be easily used for distinguishing from other ginseng accessions. However, on arranging SNPs according to their gene location, the G07006 genotype was 'GTGGA', which was distinct from other accessions. This complete chloroplast DNA sequence could be conducive to discrimination of the line G07006 (salt-tolerant) and further enhancement of the genetic improvement program for this important medicinal plant.