• Journal of Families and Better Life
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• v.25 no.4
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• pp.113-137
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• 2007

This study examined the characteristics of total consumers' anti-sites on on-line and their changes according to the establishment year of consumers' anti-sites, the activities and the evaluation of consumers' anti-sites and their differences according to the characteristics of consumers' anti-sites. Total 649 consumers' anti sites were analyzed for examining the characteristics of total consumers' anti-sites and 18 anti sites were selected for examining the activities and the evaluations of consumers' anti site. The anti sites were evaluated by the index of using in preceding research. The result showed that about 90% of total consumers' anti-site were not activated, only a few consumers participated even in the activated sites, most activity of the anti-site were operated only on on-line not off-line, over half of anti-sites targeted to the company in the type of the subject of anti-site, and the majority of the external shape of anti-site were cafe. On the change of characteristics according to the opening year, the proportion of cafe and the sites acting on both on-line and off-line were increased year by year. The number of anti-sites was decreased since 2005 and the proportion of highly activated sites was lowest in 2005. On the activity of anti-sites, the number of providing the information were more than the number of presenting the complaint among the bulletin writings. The number of the bulletin writing were more in highly activated sites than in low activated sites. most of highly activated sites were problem solving type compared to the low activated sites. The number of the bulletin writings in company anti-sites were the most among three type of subject of anti-site. The number of the bulletin writings in cafe type were more than in home-page type. On the evaluation of consumers' anti-sites, most of the sites didn't update the notices and provided incomplete information how consumers participated in the protesting movements. The highly activated sites functioned better in most parts in providing a information, connection with other consumer and site manager, management of the site.

• KSBB Journal
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• v.27 no.6
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• pp.375-380
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• 2012

We previously reported that Ultra nattokinase$^{(R)}$ showed high fibrinolytic activity and revealed antithrombotic effect in rat blood plasma based on its ability to suppress collagen-induced platelet aggregation. This research was carried out to verify the clot lysing activity and blood flow enhancing effects of Ultra nattokinase$^{(R)}$ via monitoring and comparing the antithrombotic effects in rat artery between oral administration of Ultra nattokinase$^{(R)}$ and maltodextrin. SD rats were fed with 1.11 mg/kg of Ultra nattokinase$^{(R)}$ for 4 weeks. The effect on arterial thrombosis was then evaluated using an antithrombotic model after induction by $FeCl_3$. Detected fibrinolytic activity was proportional to the content of Ultra nattokinase$^{(R)}$ and statistical extents of the antithrombotic activity was enhanced strongly twice rather than control group. The PT and the aPTT, however, showed only a small difference between two groups. The results suggest that Ultra nattokinase$^{(R)}$ can effectively treat thromboembolism and enhance blood flow, and that Ultra nattokinase$^{(R)}$ can also prevent venous occlusion by aiding clot lysis.

• Nuclear Engineering and Technology
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• v.39 no.6
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• pp.747-752
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• 2007

The Proton Engineering Frontier Project (PEFP) has designed and developed a proton linear accelerator facility operating at 100 MeV - 20 mA. The radiological effects of such a nuclear facility on the environment are important in terms of radiation safety. This study estimated the production rates of radionuclides in the soil around the accelerator facility using MCNPX. The groundwater migration of the radioisotopes was also calculated using the Concentration Model. Several spallation reactions have occurred due to leaked neutrons, leading to the release of various radionuclides into the soil. The total activity of the induced radionuclides is approximately $2.98{\times}10^{-4}Bq/cm^3$ at the point of saturation. $^{45}Ca$ had the highest production rate with a specific activity of $1.78{\times}10^{-4}Bq/cm^3$ over the course of one year. $^3H$ and $^{22}Na$ are usually considered the most important radioisotopes at nuclear facilities. However, only a small amount of tritium was produced around this facility, as the energy of most neutrons is below the threshold of the predominant reactions for producing tritium: $^{16}O(n,\;X)^3H$ and $^{28}Si(n,X)^3H$ (approximately 20 MeV). The dose level of drinking water from $^{22}Na$ was $1.48{\times}10^{-5}$ pCi/ml/yr, which was less than the annual intake limit in the regulations.

• Microbiology and Biotechnology Letters
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• v.41 no.4
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• pp.469-471
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• 2013

In this study, we measured the anti-bacterial activity of radioisotope Lu-177 using a new laboratory instrument. The disk method used for the measurement of existing anti-bacterial antibiotics is drug diffusion into the medium. To measure the antimicrobial activity of a radioisotope, a new type of laboratory instrument is necessary to prevent the drug from spreading and the present invention was thus tested. In the medium, a space isolated separately for radioisotope injection was used to prevent the radioisotope from spreading and radioisotopes are actually injected by this system. We found that the antibacterial activity increased according to the radiation dose increases. It is expected that, through the present study, measuring the antibacterial activity of the other radioisotopes easily in the laboratory will be possible.

• Physical Therapy Korea
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• v.13 no.4
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• pp.1-9
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• 2006

The purpose of this research was to analyze the effects of the increase of the femoral anteversion angle on the unbalanced quadriceps femoris muscle causing the increase of the valgus force on the knee joints and patellofemoral pain syndrome by comparing with the group that shows the smaller femoral anteversion angle. The method for the research was to compare the femoral muscle's activity while the subjects were maintaining the knee joint flexed isometrically for 10 seconds. The evaluation tool for femoral muscle's activity was QEMG-4 (model LXM 3204). The results were as followings. Firstly, in case of the experimental group, the muscle strength of the vastus lateralis muscle was strong while the rectus femoris and vastus medialis were weak. In these facts, we can see the statistically meaningful difference in vastus medialis muscle activity. Secondly, in the muscle activity analysis for vastus lateralis and medialis of the two groups, we could see the vastus lateralis muscle was strong in anteversion wider for experimental group while the vastus medialis muscle contracted far more stronger in anteversion smaller for control group. From these results, we can see the significant differences in muscle recruitment between the two groups. Above results show that if the anteversion becomes wider, vastus medialis muscle will become seriously weaker, on the other hand, vastus lateralis act stronger.

• Korean Journal of Pharmacognosy
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• v.44 no.3
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• pp.298-304
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• 2013

In this study, 64 Korean herbal medicines have been investigated with an in vitro evaluation systems using glycation end products (AGEs) formation inhibitory activity. Of these, 30 herbal medicines ($IC_{50}<50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Of these, four herbal medicines ($IC_{50}<5{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, Cornus controversa (branches and leaves), Acer ginnala (stems and leaves), Platycarya strobilacea (flowers) and Picrasma quassioides (stems), showed more potent inhibitory activity (approximately 17-27 fold) than the positive control aminoguanidine ($IC_{50}=77.04{\mu}g/ml$).

• Journal of Marine Bioscience and Biotechnology
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• v.10 no.2
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• pp.53-61
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• 2018

Sargassum fulvellum (gulfweed) is a widespread seaweed in the coastal areas of northeast Asia. In the present study, we identified the phenolic compounds present in aqueous and ethanolic extracts of S. fulvellum and evaluated their antioxidative properties and their abilities to block cell proliferation using in vitro assays: antioxidant activity was assessed by using a DPPH assay and superoxide anion scavenging activity, anti-tyrosinase activity, and anti-proliferative activity were assessed using MTT and lactate dehydrogenase [LDH] assays in vascular smooth muscle cells. The hot-water ($65^{\circ}C$) extract had a higher phenol content than the ethanolic extract. The hot-water extract showed a statistically significant increase in free radical scavenging activity and a greater ability to reduce proliferation of vascular smooth muscle cells stimulated with platelet-derived growth factor-BB. Taken together, hot-water extracts of S. fulvellum may be an important source of antioxidative and antiproliferative agents.

• Preventive Nutrition and Food Science
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• v.3 no.4
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• pp.324-328
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• 1998

We screened the methanol extracts from 133 plant species growing in Korea for antimicrobial activity against enterohemorrhagic Escherichia coli 0157 : H7. Those are selected from three plant grouping ; traditional medicinal herbs, edible plants, and flowers. They were tested by disk diffusion assay. From evaluation of the inhibition zone diameter of microbial growth, we found that the flower extract of Rhododendron Schilpenbachii Max had the most significant antimicrobial activity against this bacteria. Extracts from most of the vegetables and plants did not show antimicrobial activity except for the leaves of Ginkgo biloba L. and seeds of Prunus Dallicina L. did not show antimicrobial activity except for the leaves of Ginkgo biloba L. and the seeds of Prunus sallicina L.

• Archives of Pharmacal Research
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• v.22 no.5
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• pp.507-514
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• 1999

6-(1-azidoalkyl)-DMNQ derivatives compared to 2-(1-azidoalkyl)-DMNQ isomers, exhibited higher cytotoxic activity against L1210 mouse leukemia cells and stronger inhibition of DNA topoisomerase-I (TOPO-I), suggesting involvement of steric hindrance. However, similar antitumor activity against mice bearing S-180 cell was shown by 2-an 6-(1-azidoalkyl)-DMNQ derivatives.

• Archives of Pharmacal Research
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• v.20 no.1
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• pp.17-23
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• 1997

A saline suspension of Lumbricus rubellus earthworm powder (EWP) was administered to rats (1 g/kg/day) orally for 15 days to evaluate an oral effectiveness for thrombotic disorders. Blood was drawn at 2-day interval after the administration. Several parameters for antithrombotic, anticoagulant and fibrinolytic activities were measured, including platelet aggregation, clotting time, plasmin activity and the levels of FDP (fibrin/fibrinogen degradation products), D-dimer, and t-PA antigen. It did not affect platelet aggregation induced by ADP and collagen but anticoagulant activity (aPTT and TT) was gradually increased to two-folds for the first 5 days of administration and back to normal. Fibrinolytic activity of euglobulin fraction was highest on the 11 th day after the administration. The level of FDP was elevated to be comparable to the positve control$ (5-10 {\mu}g/ml)$ after 9-day treatment. Oral administration of the EWP could also reduce the formation of venous thrombus induced with viper venom. Complete blood count (CBC) profiles were within normal ranges except for a slight increase in white blood cells after the oral administration for 15 days. These results suggested that the EWP may be valuable for the prevention and/or treatment of thrombotic diseases.