• Interdisciplinary Bio Central
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• v.4 no.1
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• pp.2.1-2.7
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• 2012

Introduction: Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from ${\varepsilon}$-N-acetyl lysine amino acids of histone proteins. Their action is opposite to that of histone acetyltransferase that adds acetyl groups to these lysines. Only few HDAC inhibitors are approved and used as anti-cancer therapeutics. Thus, discovery of new and potential HDAC inhibitors are necessary in the effective treatment of cancer. Materials and Methods: This study proposed a method using support vector machine (SVM) to classify HDAC8 inhibitors and non-inhibitors in early-phase virtual compound filtering and screening. The 100 experimentally known HDAC8 inhibitors including 52 inhibitors and 48 non-inhibitors were used in this study. A set of molecular descriptors was calculated for all compounds in the dataset using ADRIANA. Code of Molecular Networks. Different kernel functions available from SVM Tools of free support vector machine software and training and test sets of varying size were used in model generation and validation. Results and Conclusion: The best model obtained using kernel functions has shown 75% of accuracy on test set prediction. The other models have also displayed good prediction over the test set compounds. The results of this study can be used as simple and effective filters in the drug discovery process.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.12
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• pp.8556-8562
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• 2015

The purpose of this study was to investigate the effectiveness of the Nursing Research Support Program on the attitudes and the barriers about nursing research. This study was conducted from July 1, 2012 to June 30, 2013. The subject was the 45 nurses who were worked two hospitals located in P city. Twenty-three nurses in A hospital were designated as experimental group and 22 nurses in B hospital were designated as control group. The process of this study included the nursing research support program for experimental group. It was conducted nine times with nursing research methods by the PPT and handouts and nursing research feedback and spent times for support. The results are as follows: Experimental group's attitude score was lower than the control group with an average 62.65 points, 70.18 points(t=-2.380, p=.022). It means that the experimental group had a positive attitude to nursing research than the control group. In conclusion, this study revealed that it had a significant effects on decreasing nurse's stress for clinical nursing reasearch activity.

• Journal of Korean Society for Atmospheric Environment
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• v.28 no.4
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• pp.396-410
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• 2012

The purpose of this study is to quantify the contribution of high emitting vehicles to mobile emission inventories. Analyzed emission data include $NO_x$, HC, and CO results, which were measured through the vehicle Inspection and Maintenance (I/M) program in Seoul metropolitan area. The high emitting vehicles were identified as the top 5% worst polluting cars of the fleet. We estimated that 5% of the gasoline passenger car fleet, which is high emitters, generated 25.5% of $NO_x$, 34.5% of HC, and 66.1% of CO emissions of total inventories for gasoline passenger car fleet in year 2010. In the study, we identified that the older vehicles (older than ten years) and high mileage vehicles (more than 120,000 km driven) comprised high emitter fleet with 70.9% and 71.2%, respectively. The emission contribution of high emitters became larger in younger fleet than in the older fleet. This is due to the reduced emission rates in newly manufactured vehicles, which were developed under the more stringent emission regulation limits. This analysis implies that high emitters could be responsible for an even larger fraction of total vehicular emissions as more advanced technology vehicles are being incorporated into the current vehicle fleet. The findings suggested that the high emitting vehicles should be primarily considered for in-use vehicle emission management program, such as I/M, accelerated vehicle retirement, or catalytic converter replacement, in order to enhance the effectiveness of selected program.

• Journal of Family Resource Management and Policy Review
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• v.18 no.4
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• pp.53-68
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• 2014

Increasing interest in family problems caused by social environment changes has elevated the importance of strong family policy. That is why Framework Act on Healthy Families has enacted in 2004 in Korea and it marked the 10th anniversary of establishing the law. This study finds out the meaning of enacting the law and an academic field of Family Resource Management through reviewing and analyzing the studies on the healthy families from 2000 to 2013 year in Journal of Korean Family Resource Management Association. The major findings of this study are as follows. First, we divide research themes into three parts: policy, practice(I)(center management), practice(II)(program development & efficiency), specialist area. The research trends have most focused on the issue of practice(II), that is, program analysis and development, contents review, because of the settlement of delivery system after the early of law establishment. But it is needed to rethink research themes because it has been dealt with not academical researches on theoretical basis but practical ones, for example, program development on Healthy Families Center and the tendency still lasts until now. Second, more than half of research methods have been concentrated on contents analysis and about 70% of research objects are focused on the center program. It needs to adopt various research methods and research objects. Lastly, it is necessary to make an academic identity clear that can be faithful to Family Resource Management Studies.

• Journal of the Korean Society for information Management
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• v.41 no.2
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• pp.47-69
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• 2024

Despite many changes occurring in the objects and methods of reading, the importance of reading as the most effective means of developing human intellectual ability is consistently emphasized. However, in Korea, reading tends to be perceived as a part of tedious and rigid education or learning activities rather than an act of giving pleasure and joy while accompanied by fun and interest. In addition, compared to the high interest and emphasis on reading, discussions on reading programs to systematically implement them are relatively insufficient, and it is difficult to find a study in Korea that grasp the overall research trend in the field of reading programs. Accordingly, in order to generally examine research trends in the field of domestic reading programs, an intellectual structure analysis method based on keyword profiling was applied. In particular, basic analysis, keyword analysis, research area analysis, and analysis by period and year were performed in stages based on the keywords of theses and academic journal articles in the domestic reading program field retrieved from the RISS database. In addition, future research tasks were presented by comprehensively reviewing the research trends of domestic reading programs identified as a result of this intellectual structure analysis.

• Imaging Science in Dentistry
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• v.32 no.1
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• pp.35-39
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• 2002

Purpose: The altered gantry angle during scanning for some multiplanar reconstruction CT program (CT/MPR) may cause distortion of the image. The aim of this study was to ascertain whether there is a image distortion in a reformatted image when the gantry and the object are equally inclined using ToothPix and DentaScan program. Materials and Methods: A resin block model with four cylindrical holes and a human dry mandible were used. Two MPR software packages, ToothPix and DentaScan program, were used for reformatted panoramic images. The block and the gantry were equally inclined at 0°, 15°, and 30°. Results: With ToothPix program, a resin block model with empty holes and a dry mandible showed inclined images in the reformatted panoramic image. Increasing the gantry angle, the depth and inclination of the holes were increased in the reformatted central panoramic images. However, a resin block model with gutta perch a in its holes and a dry mandible with a wire in its mandibular canal didn't show image distortion. With DentaScan program, image distortion was not seen in any situation. Conclusion: ToothPix program may distort the reformatted image when the gantry angle is not at zero degrees. However, with DentaScan program, the patient may be positioned comfortably and the gantry can be adjusted to the patient positioning.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.9 no.1
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• pp.123-132
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• 2002

Purpose: The purpose of this study was to develop an exercise intervention program based on stage of exercise using the Transtheoretical Model (TTM) for patients with type 2 diabetes mellitus (DM). Method : A methodological research design was used to develop the exercise intervention program based on stage of exercise using TTM. Result: The exercise intervention program consisted of theoretical background and goals of program, assessment tool for stage of change, and an exercise intervention program based on stage of exercise. Details for the exercise and a glossary are included, Conclusion : The exercise intervention based stage of exercise can apply for DM patients who are in any stages properly.

• The Mathematical Education
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• v.47 no.1
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• pp.61-74
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• 2008

The objective of this research is to verify the effect after development and application of a program for advance of number sense. This program presents an opportunity to explore suitable ways for the characteristics of problems by clarifying the meaning of number and operation through various thought processes, not focused on algorithm. To fulfill the objectives I developed the program for advance of number sense, and verify the effect on the improvement of number sense after applying to the developed program. As a result, it was confirm that this program was helpful to the improvement of the students' mathematical aptitude which resulted in a positive change in their attitude.

• Korean Journal of Human Ecology
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• v.21 no.3
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• pp.407-421
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• 2012

The purpose of this study is to plan out a university students' self-development program and to verify the effect of the students in adapting themselves to college life and coping with stress from it. The program was developed as the liberal arts course for a semester and comprised 12 sessions. Each secession of a 150 minutes workshop program. The pre-test, post test regarding students adaptation to college and stress coping methods conducts upon each experimental group and each control group. Each group consisted of 50 subjects. As a result of this research, this study could come to the following conclusions. Firstly, it was found that the university students' self-development program has effect on improving students adaptation to college. Secondly, it was found that the university students' self-development program has effect on improving stress coping methods.

• Journal of Families and Better Life
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• v.19 no.4
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• pp.69-83
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• 2001

The purpose of this study was to construct the new premarital relationship enrichment program and to examine the effects of it. Based on the review of the previous research and program, this program was composed. It included the realistic expectations of marriage and sex, understanding of themselves and accepting differences, role expectations and intimacy in the relationship, communication and conflict resolution skills. To perform this program, six sessions of time-limited(100-150 minutes) were carried out. And the subjects were assigned to experimental group(N=4 couples) and control group(N=4 couples). Scales of PREPARE and SEI(Self-Esteem Inventory) were used as the pre-post-follow instruments of this study. Major findings were as follows: 1. Premarital Relationship Enrichment Program had meaningful consequences for the improvement of the participants self-esteem. 2. Premarital Relationship Enrichment Program had meaningful consequences for the improvement of the participants equal role, communication and conflict resolution skills.