• BMB Reports
• /
• v.55 no.7
• /
• pp.360-360
• /
• 2022

• Journal of the Korean earth science society
• /
• v.27 no.7
• /
• pp.715-722
• /
• 2006

This study intended to find evidence of changes in teacher beliefs of teaching and learning and a case of infusing research experiences in teaching modules since their research participation. As part of this study, twenty three science and math teachers in Korea were provided with science research labs and field experiences in the University of Iowa for three weeks. The research units that teachers participated in for three weeks covered seven fields of subjects such as: geology, astronomy, chemistry, physics, mathematics, computer science, and environmental engineering. In the course of this study, the effectiveness of science research participation program was explored in terms of changing teacher beliefs and their production of teaching modules based on their research. This study especially focused on identifying changes of beliefs on science teaching and learning after participating in the research. A case study of a participant teacher was also conducted by comparing descriptively teaching modules before and after experiencing the program. It was found that the program affected the new modules and the research experiences affected participants' beliefs toward student centeredness.

• Bulletin of the Korean Chemical Society
• /
• v.30 no.5
• /
• pp.1152-1156
• /
• 2009

Silent information regulator 2 (Sir2) or sirtuins are NAD(+)-dependent deacetylases, which hydrolyze the acetyllysine residues. In mammals, sirtuins are classified into seven different classes (SIRT1-7). SIRT1 was reported to be involved in age related disorders like obesity, metabolic syndrome, type II diabetes mellitus and Parkinson’s disease. Activation of SIRT1 is one of the promising approaches to treat these age related diseases. In this study, we have used HipHop module of CATALYST to identify a series of pharmacophore models to screen SIRT1 enhancing molecules. Three molecules from Sirtris Pharmaceuticals were selected as training set and 607 sirtuin activator molecules were used as test set. Five different hypotheses were developed and then validated using the training set and the test set. The results showed that the best pharmacophore model has four features, ring aromatic, positive ionization and two hydrogen-bond acceptors. The best hypothesis from our study, Hypo2, screened high number of active molecules from the test set. Thus, we suggest that this four feature pharmacophore model could be helpful to screen novel SIRT1 activator molecules. Hypo2-virtual screening against Maybridge database reveals seven molecules, which contains all the critical features. Moreover, two new scaffolds were identified from this study. These scaffolds may be a potent lead for the SIRT1 activation.

• Bulletin of the Korean Chemical Society
• /
• v.31 no.3
• /
• pp.611-614
• /
• 2010

Substituted imidazolidin-2-ones deduced as potential inhibitors of IleRS by docking simulations were synthesized from an aziridine-2-carboxaldehyde. Reductive amination of an aziridine-2-carboxaldehyde with dipeptides for the substituents at N1 and followed by aziridine-ring expansion with triphosgene afforded 4-chloromethylimidazolidin-2-ones whose chloride were further manipulated towards phenylurea, pyrimidin-2-yl-urea or benzenesulfonamide at C4.

• Journal of Korean Academy of Nursing
• /
• v.39 no.2
• /
• pp.249-258
• /
• 2009

Purpose: The purpose of this study was to develop a multimedia learning program for patients with diabetes mellitus (DM) diet education using standardized patients and to examine the effects of the program on educational skills, communication skills, DM diet knowledge and learning satisfaction. Methods: The study employed a randomized control posttest non-synchronized design. The participants were 108 third year nursing students (52 experimental group, 56 control group) at K university in Seoul, Korea. The experimental group had regular lectures and the multimedia learning program for DM diet education using standardized patients while the control group had regular lectures only. The DM educational skills were measured by trained research assistants. Results: The students who received the multimedia learning program scored higher for DM diet educational skills, communication skills and DM diet knowledge compared to the control group. Learning satisfaction of the experimental group was higher than the control group, but statistically insignificant. Conclusion: Clinical competency was improved for students receiving the multimedia learning program for DM diet education using standardized patients, but there was no statistically significant effect on learning satisfaction. In the nursing education system there is a need to develop and apply more multimedia materials for education and to use standardized patients effectively.

• Plant Biotechnology Reports
• /
• v.4 no.4
• /
• pp.311-319
• /
• 2010

Lettuce is an economically important leafy vegetable that accumulates a milk-like sap called latex in the laticifer. Previously, we conducted a large-scale lettuce latex proteomic analysis. However, the identified proteins were obtained only from lettuce ESTs and proteins deposited in NCBI databases. To extend the number of known latex proteins, we carried out an analysis identifying 302 additional proteins that were matched to the NCBI non-redundant protein database. Interestingly, the newly identified proteins were not recovered from lettuce EST and protein databases, indicating the usefulness of this hetero system in MudPIT analysis. Gene ontology studies revealed that the newly identified latex proteins are involved in many processes, including many metabolic pathways, binding functions, stress responses, developmental processes, protein metabolism, transport and signal transduction. Application of the non-redundant plant protein database led to the identification of an increased number of latex proteins. These newly identified latex proteins provide a rich source of information for laticifer research.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.25 no.3
• /
• pp.101-112
• /
• 2021

SpaceX shows various strategies such as constructing various payload portfolio through the reuse of Falcon 9 and Falcon Heavy, constructing the launch vehicles using one type of engine, the transition from kerosene engine to methane engine, and the use of 3D printing. In this study, launch vehicle proposals that can cover a variety of payloads and trajectories from KOMPSAT to GEO-KOMPSAT were constructed, and ten launch vehicles using kerosene gas generator cycle engine, kerosene staged-combustion cycle engine, and methane staged-combustion cycle engine were reviewed. Of the ten launch vehicles, the reusable launch vehicle using a 35-ton methane engine was rated as the best in terms of development potential.

• Journal of Fisheries and Marine Sciences Education
• /
• v.27 no.5
• /
• pp.1318-1333
• /
• 2015

The research aim of this investigation was to present implications and supplements in policy research middle school which has implemented free learning semester for 3 years from 2013 to now, through identifying and analyzing education program. In this study, the results were as follows. Firstly, it was needed to generalize career education programs. I was required to make a specialized program which was suitable for a characteristic of school and community rather than department-store-like program. Secondly, in considering career development stage of middle school students, it seemed that implementation of free learning semester was suitable for second grades. Thirdly, teacher interns should be used appropriately in order to manage efficiently free learning semester. Lastly, it was needed to develop a specialized program for career education through studying with expert groups.

• Rapid Communication in Photoscience
• /
• v.4 no.4
• /
• pp.79-81
• /
• 2015

The influence of the grain size of the $CH_3NH_3PbI_3$ on the solar cell performance is investigated by controlling the ratio between $CH_3NH_3I$ and $PbI_2$ precursors. As the concentration of the precursors increased from 1.0M to 2.0M, the $CH_3NH_3PbI_3$ grain size increased from ~100nm to ~400nm. The solar cell utilizing the $CH_3NH_3PbI_3$ with large grain size shows improved photocurrent compared to the solar cell utilizing $CH_3NH_3PbI_3$ with small grain size, which is ascribed to the reduced recombination at the boundaries of grains.

• Proceedings of the Korean Society of Plant Biotechnology Conference
• /
• 2005.04a
• /
• pp.58-58
• /
• 2005