• Journal of Microbiology and Biotechnology
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• v.31 no.10
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• pp.1358-1365
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• 2021

To clarify the role of long intergenic nonprotein-coding RNA 1232 (LINC01232) in the progression of gastric cancer and the potential mechanism, we analyzed the expression of LINC01232 in TCGA database using the GEPIA online tool, and the LINC01232 level in gastric cancer cell lines was detected by quantitative real time-polymerase chain reaction (qRT-PCR) as well. Cell proliferation assay, colony formation assay, transwell assay and tumor formation experiment in nude mice were conducted to observe the biological behavior changes of gastric cancer cells through the influence of LINC01232 knockdown. LncATLAS database and subcellular isolation assay were used for subcellular distribution of LINC01232 in gastric cancer cells. The interaction among LINC01232, zeste homolog 2 (EZH2) and kruppel-like factor 2 (KLF2) was clarified by RNA-protein interaction prediction (RPISeq), RNA immunoprecipitation (RIP), qRT-PCR and chromatin immunoprecipitation (ChIP) assay. Rescue experiments were further conducted to elucidate the biological function of LINC01232/KLF2 axis in the progression of gastric cancer. LINC01232 was upregulated in stomach adenocarcinoma (STAD) tissues and gastric cancer lines. LINC01232 knockdown inhibited the proliferative capacities of gastric cancer cells in vitro, and impaired in vivo tumorigenicity. LINC01232 was mainly distributed in the cell nucleus where it epigenetically repressed KLF2 expression via binding to the enhancer of EZH2, which was capable of binding to promoter regions of KLF2 to induce histone H3 lysine 27 trimethylation (H3K27me3). LINC01232 exerts oncogenic activities in gastric cancer via inhibition of KLF2, and therefore, the knockdown of KLF2 could reverse the regulatory effect of LINC01232 in the proliferative ability of gastric cancer cells.

• The Korean Journal of Emergency Medical Services
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• v.25 no.3
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• pp.145-162
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• 2021

Purpose: The 2018 General survey of emergency assistance was conducted to examine the working conditions and welfare, including educational direction, interests, and awareness of work, of the fire department emergency medical technicians (EMT). This would be used as basic data for future policy directions. Methods: Among the fire-fighting officers in 16 cities nationwide, emergency rescue workers engaged in first-aid activities were targeted. With prior consent, a survey was conducted through electronic documents. Of the total 1,227 people, responses from 1,151 were finally analyzed, excluding 76 who did not respond appropriately. Results: The working conditions and welfare of 119 firefighters were moderate, but in the fields of education and interest, the learning according to the regulations was high. In particular, satisfaction with the scope of work was found to be below average. However, it was positive that it will play a role as a social safety net in the future and will converge with cutting-edge science. Conclusion: Although this study was a total investigation of the EMT survey, conducting an EMT survey on all fire fighters in Korea is difficult. Further research is needed, particularly on first-class emergency medical personnel who play a major role in 119 paramedics.

• Journal of Positioning, Navigation, and Timing
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• v.7 no.4
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• pp.217-226
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• 2018

According to the Korea Coast Guard's maritime disaster statistics (Korea Coast Guard 2017, Korean Statistical information Service 2018), an average of 2,140 marine accidents occurred every year for the past 6 years and the number of accidents is increasing every year. Among them, maritime accidents of fishing vessels are the most frequent, and recently accidents involving fishing boat and leisure vessels are rapidly increasing as well. In particular, the number of accidents involving leisure vessels increased to about one-third of the accidents of fishing vessels, and emergency rescue requests are increasing every year accordingly. However, the number of crash accidents involving users of small vessels and marine leisure activities are increasing because of the difficulties of installing navigation equipment and electronic navigation charts. Recently, the demand for precise positioning using mobile devices is increasing in the fields of maritime safety, piloting support, and coastal survey. Although various applications of smart devices provide location-based services for users, the measurement results are discontinuous when using the position coordinates of the National Marine Electronics Association (NMEA) calculated by smartphone. Recently, Google announced that they will provide GPS raw data to developers from Android 7.0 Nougat. As a result, developers have an opportunity to receive precise carrier phase and code measurements to make more accurate positioning according to the performance of Android devices. This study analyzed GPS positioning performance using Android devices, and compared and analyzed the positioning performance at sea with high-performance GPS receivers.

• Journal of Ginseng Research
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• v.43 no.4
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• pp.499-507
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• 2019

Background: Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root, exhibits neuroprotective functions in many neurological diseases. This study was intended to investigate whether Rb1 can attenuate cisplatin-induced memory impairments and explore the potential mechanisms. Methods: Cisplatin was injected intraperitoneally with a dose of 5 mg/kg/wk, and Rb1 was administered in drinking water at the dose of 2 mg/kg/d to rats for 5 consecutive wk. The novel objects recognition task and Morris water maze were used to detect the memory of rats. Nissl staining was used to examine the neuron numbers in the hippocampus. The activities of superoxide dismutase, glutathione peroxidase, cholineacetyltransferase, acetylcholinesterase, and the levels of malondialdehyde, reactive oxygen species, acetylcholine, tumor necrosis factor-${\alpha}$, interleukin-$1{\beta}$, and interleukin-10 were measured by ELISA to assay the oxidative stress, cholinergic function, and neuroinflammation in the hippocampus. Results: Rb1 administration effectively ameliorates the memory impairments caused by cisplatin in both novel objects recognition task and Morris water maze task. Rb1 also attenuates the neuronal loss induced by cisplatin in the different regions (CA1, CA3, and dentate gyrus) of the hippocampus. Meanwhile, Rb1 is able to rescue the cholinergic neuron function, inhibit the oxidative stress and neuroinflammation in cisplatin-induced rat brain. Conclusion: Rb1 rescues the cisplatin-induced memory impairment via restoring the neuronal loss by reducing oxidative stress and neuroinflammation and recovering the cholinergic neuron functions.

• The Journal of the Korea institute of electronic communication sciences
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• v.17 no.1
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• pp.139-146
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• 2022

Mountain accidents such as forest fires and missing people are increasing as hikers increase due to indoor activities restrictions caused by the prolonged COVID-19 incident. If a dangerous situation occurs at outside where rescue workers cannot reach, the search time for person can be reduced using a quadcopter. Considering this, in this paper, Multiwii is used to smoothly hover the quadcopter by setting optimized PID values of the x-axis, y-axis, and z-axis (Yaw) according to the change in the inclination of the gas. In addition, after installing Open CV on Raspberry Pie, the camera uses HSV color space to filter the color such as the description of the person, and uses a thermal imaging camera to receive thermal sensing images in real time in environments where color extraction is difficult. As a result, it was confirmed that hovering was possible at a height of 2 to 8 m, blue extraction was possible at a height of 5 m, and heat detection was possible at a distance of less than 10 cm.

• Journal of Aerospace System Engineering
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• v.17 no.6
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• pp.9-15
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• 2023

In order to effectively prevent and respond to disasters, several techniques have been developed in which the pilot wearing a see-through Head Mounted Display (HMD) performs disaster-related rescue activities using images transmitted from an Unmanned Aerial Vehicle (UAV). However, these techniques have limitations in quickly determining and executing tasks appropriate to the on-site situation because the pilot cannot recognize the entire field in an integrated manner. In order to overcome these problems, we propose an AR based-interface technique that allows the rescuer wearing a see-through HMD to operate a UAV efficiently. Simulation results show that the proposed interface technique allows the rescuer wearing a see-through HMD to control the gimbal and flight of the UAV at a high speed based on finger gestures in a visibility situation.

• Fire Science and Engineering
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• v.31 no.3
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• pp.106-118
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• 2017

The purpose of this study was to realize volunteer fire departments' historical identity through a review of the transition process from the quickening period of volunteer fire departments to the enactment of the volunteer fire department act in 2014, establish it newly from the viewpoint of changing the basic theoretical concepts, and seek a development plan. For this, the technical approach method was used based on the research method of literature searches. The result of the study established the definition as 'volunteer fire departments are legal auxiliary organizations composed by local residents who volunteer and understand one another with their independent and voluntary will to prepare for all kinds of disasters as well as fire suppression, rescue, and first aid.' and the installation ideology as 'leading service organizations of safety as a form of community involvement', 'resident-friendly organizational activities based on autonomous operational operation' and 'the activities of supplementing their demands according to the realization of social welfare and regional conditions'. Regarding the characteristics, the basic theoretical concept was newly established by 'voluntary participation', 'social expandability', 'the realization and complementation of social welfare', and 'professionalism and possibilities'. In addition it is expected that the results of this study can be utilized as the basic materials in studies of volunteer fire departments in the future.

• Fire Science and Engineering
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• v.28 no.1
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• pp.64-70
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• 2014

A Volunteer Fire Brigade is a voluntary social services organization that performs various assistance works in fire fighting activities such as fire fighting and rescue of human lives on a part-time basis. Recently, it has also assumed an important role in the creation of security culture of local society. Besides, it provides diverse service activities related to security of local society. However, as this kind of volunteer fire brigade organization is not in a vigorous state, research for an improvement is being carried out in earnest. As part of a vitalization plan of the volunteer fire brigade, an attempt was made in this research to present an activation plan of the volunteer fire brigade through formation of social capital. Accordingly, efforts were made in this research to investigate and analyze an awareness of social capital among the volunteers and to present on this basis a plan for formation of social capital for the volunteer fire brigade of local society. As a result of the research, it turned out that social norm has the major effect on the formation of social capital for volunteer fire brigade. Therefore, it is our belief that an independent statute should be established to nurture and develop volunteer fire brigades. And when strong mutual trust among the volunteers are formed and efforts for devotion to local society are made on this basis, the security level of local society will be enhanced further.

• The Korean Journal of Air & Space Law and Policy
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• v.28 no.2
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• pp.145-181
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• 2013

General aviation is an integral part of civil aviation and involves the widest range of aviation segments except commercial aviation. Featured with different operational procedures and practices to satisfy the economic needs and safety requirements of a sovereign state, general aviation tends to be regulated by an individual state. The last three decades have seen exponential growth of commercial air transport in China, but its general aviation sector has remained disproportionally underdeveloped. With the deepening of the reform of low-altitude airspace, the sector is poised for a radical change and rapid growth. However, legislation governing general aviation activities in China is distorted causing inconsistency and confusions in their application and implementation. This paper aims to analyse China's prevailing legislation regulating general aviation activities. It first discusses the various definitions adopted by ICAO and its member states and reviews the development of general aviation in the US, EU, Australia and China. It then examines the sources of China's general aviation laws, e.g. Chicago Convention and its annexes, and Chinese domestic legislature which covers legislation, laws, directives, rules and procedures. The paper continues to analyse and establish the deficiencies of its prevailing legal framework by pointing out the following: variation of definitions in different regulations, inconsistency of principles in existing laws and regulations, legal vacuum concerning government subsidy, environment protection, safety and security, and other operational areas such as aerial club, sightseeing, and search and rescue. In this process, the paper argues that a coherent, consistent and systematic legal framework is required in order to ensure fair competition and safety for a healthy, progressive and sustainable general aviation growth. Suggestions for rectification and improvement are proposed.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.4
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• pp.423-432
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• 2019

Along with an increase in marine activities every year, the frequency of marine accidents is on the rise. Accordingly, various research activities and policies for marine safety are being implemented. Despite these efforts, the number of accidents are increasing every year, bringing their effectiveness into question. Preliminary studies relying on annual statistical reports provide precautionary measures for items that stand out significantly, through the comparison of statistical provision items. Since the 2000s, large-scale marine accidents have repeatedly occurred, and case studies have examined the "accident response." Likewise, annual statistics or accident cases are used as core data in policy formulation for domestic maritime safety. However, they are just a summary of post-accident results. In this study, limitations of current marine research and policy are evaluated through a literature review of case studies and analyses of marine accidents. In addition, the ontology of the marine accident information classification system will be revised to improve the current limited usage of the information through an attribute analysis of boating accident status reports and text mining. These aspects consist of the reporter, the report method, the rescue organization, corrective measures, vulnerability of response, payloads, cause of oil spill, damage pattern, and the result of an accident response. These can be used consistently in the future as classified standard terms to collect and utilize information more efficiently. Moreover, the research proposes a data collection and quality assurance method for the practical use of ontology. A clear understanding of the problems presently faced in marine safety will allow "suf icient quality information" to be leveraged for the purpose of conducting various researches and realizing effective policies.