• Korean Journal of Environmental Agriculture
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• v.12 no.3
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• pp.264-280
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• 1993

The environmental pollutions were a serious problem in Korea recently. So many researcher have studied the effect of environmental pollution on plants and agro-ecosystem, but the basic mechanisms of environmental stresses were various. One of the important mechanisms was oxidative stress caused by active toxic oxygen. The toxic oxygen was generated by several stresses, abnormal temperature, many xenobiotics, air pollutants, water stress, fugal toxin, etc. In the species of toxic oxygen which is primary inducer of oxidative stresses, superoxide, hydrogen peroxide, hydroxyl radical and singlet oxygen were representative species. The scavenging systems were divided into two groups. One was nonenzymatic system and the other enzymatic system. Antioxidants such as glutathione, ascorbic acid, and carotenoid, have the primary function in defense mechanisms. Enzymatic system divided into two groups; First, direct interaction with toxic oxygen(eg. superoxide dismutase). Second, participation in redox reaction to maintain the active antioxidant levels(eg. glutathione reductase, ascorbate peroxidase, etc.).

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.188-194
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• 2009

Consolidation settlement, a crucial parameter in geotechnical design of soft ground, has not been computed in a unique way due to different computation methods in practice. To improve computational error in calculating consolidation settlement, a number of researches has been attempted. Conventional 1-dimensional consolidation theory assumes the center of the clay layer as the representative point to obtain effective stress in calculation, which could resort to erroneous results. To calculate exact solutions considering initial distribution of effective stress, diving a stratum into multi-layers could resort to wasting time and effort. In the study, a novel methodology for calculating consolidation settlement via Guassian quadrature is developed. The method generally is capable of computing settlements in any case of the stress conditions encountered in fields.

• Tuberculosis and Respiratory Diseases
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• v.85 no.3
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• pp.221-226
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• 2022

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has various antioxidant mechanisms for efficiently coping with such oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) is a representative system. Dysregulation of the Nrf2-ARE pathway is responsible for the development and promotion of COPD. Furthermore, COPD severity is also closely related to this pathway. There has been a clinical impetus to use Nrf2 for diagnostic and therapeutic purposes. Therefore, in this work, we systematically reviewed the clinical significance of Nrf2 in COPD patients, and discuss the value of Nrf2 as a potential COPD biomarker.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.162-167
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• 2020

In this study, a fatigue analysis of an external fuel tank and pylon for fixed-wing aircraft was carried out as part of the domestic development of fixed-wing aircraft. Through structural analysis, the analysis areas were selected, and the transfer function for unit loads was established in the selected parts. For each of the continuous load profiles, stress components in the selected areas were calculated using the load of each profile and the transfer function, and the Von Mises equivalent stress was employed as the representative stress of each profile. In addition, the rainflow counting technique was used to extract individual profiles obtained from the initial large load profiles and to calculate their amplitude and average values. For life evaluation, the S-N diagram of the Metallic Materials Properties Development and Standardization (MMPDS) was applied, and the damage value was calculated by Miner's rule to assess the life of the selected area. As a result of the life assessment, the life span requirement for the selected area of the external fuel tank and the pylon was assessed as being satisfied.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.32 no.8
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• pp.660-667
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• 2008

During the last two decades, lots of efforts have been devoted to resolve thermal stratification phenomenon and primary water environment issues. While several effective methods were proposed especially in related to thermally stratified flow analyses and corrosive material resistance experiments, however, lack of details on specific stress and fatigue evaluation make it difficult to quantify structural behaviors. In the present work, effects of the thermal stratification and primary water are numerically examined from a structural integrity point of view. First, a representative austenitic nuclear piping is selected and its stress components at critical locations are calculated in use of four stratified temperature inputs and eight transient conditions. Subsequently, both metal and environmental fatigue usage factors of the piping are determined by manipulating the stress components in accordance with NUREG/CR-5704 as well as ASME B&PV Codes. Key findings from the fatigue evaluation with applicability of pipe and three-dimensional solid finite elements are fully discussed and a recommendation for realistic evaluation is suggested.

• Safety and Health at Work
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• v.11 no.1
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• pp.1-9
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• 2020

Background: As the impact of climate change intensifies, exposure to heat stress will grow, leading to a loss of work capacity for vulnerable occupations and affecting individual labor decisions. This study estimates the future work capacity under the Representative Concentration Pathways 8.5 scenario and discusses its regional impacts on the occupational structure in the Republic of Korea. Methods: The data utilized for this study constitute the local wet bulb globe temperature from the Korea Meteorological Administration and information from the Korean Working Condition Survey from the Occupational Safety and Health Research Institute of Korea. Using these data, we classify the occupations vulnerable to heat stress and estimate future changes in work capacity at the local scale, considering the occupational structure. We then identify the spatial cluster of diminishing work capacity using exploratory spatial data analysis. Results: Our findings indicate that 52 occupations are at risk of heat stress, including machine operators and elementary laborers working in the construction, welding, metal, and mining industries. Moreover, spatial clusters with diminished work capacity appear in southwest Korea. Conclusion: Although previous studies investigated the work capacity associated with heat stress in terms of climatic impact, this study quantifies the local impacts due to the global risk of climate change. The results suggest the need for mainstreaming an adaptation policy related to work capacity in regional development strategies.

• Korean Journal of Applied Biomechanics
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• v.19 no.2
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• pp.197-204
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• 2009

It bas been hypothesized that foot ulceration might be internally initiated. Current instruments which merely allow superficial estimate of plantar loading acting on the foot, severely limit the scope of many biomechanical/clinical studies on this issue. Recent studies have suggested that peak plantar pressure may be only 65% specific for the development of ulceration. These limitations are at least partially due to surface pressures not being representative of the complex mechanical stress developed inside the subcutaneous plantar soft-tissue, which are potentially more relevant for tissue breakdown. This study established a three-dimensional and nonlinear finite element model of a human foot complex with comprehensive skeletal and soft-tissue components capable of predicting both the external and internal stresses and deformations of the foot. The model was validated by experimental data of subject-specific plantar foot pressure measures. The stress analysis indicated the internal stresses doses were site-dependent and the observation found a change between 1.5 to 4.5 times the external stresses on the foot plantar surface. The results yielded insights into the internal loading conditions of the plantar soft-tissue, which is important in enhancing our knowledge on the causes of foot ulceration and related stress-induced tissue breakdown in diabetic foot.

• Journal of the Ergonomics Society of Korea
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• v.25 no.3
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• pp.77-83
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• 2006

The purpose of this study is to assess the organizational types and the job stress factors that affect the procedure-based job performances in nuclear power plants(NPPs). We derived 24 organizational factors affecting to the job stress in NPPs from the job stress analysis models of NIOSH(1989), Cooper(1990), and Karasek(1990). onsidering the safety characteristic in operating tasks of NPPs, we individuate among the tasks in NPPs through the division of duty and the analysis of cost activity. Through the questionnaire survey, a structured interview with the responsible employees, and expert panels, we assess 70 tasks among 777 tasks managed officially under the procedures. They are the representative tasks to the duties of each division and are directly related to the safety. We utilize the OPTI(organizational personality type indicators) to characterize the personality type of each organization in NPPs.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.1
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• pp.145-150
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• 2008

One of the unresolved questions in articular cartilage biomechanics is the magnitude of the dynamic modulus and tissue compressive strains under physiological loading conditions. The objective of this study was to characterize the dynamic modulus and compressive strain magnitudes of bovine articular cartilage at physiological compressive stress level and loading frequency. Four bovine calf shoulder joints (ages 2-4 months) were loaded in Instron testing system under load control, with a load amplitude up to 800 N and loading frequency of 1 Hz, resulting in peak engineering stress amplitude of ${\sim}5.8\;MPa$. The corresponding peak deformation of the articular layer reached ${\sim}27%$ of its thickness. The effective dynamic modulus determined from the slope of stress versus strain curve was ${\sim}23\;MPa$, and the phase angle difference between the applied stress and measured strain which is equivalent to the area of the hystresis loop in the stress-strain response was ${\sim}8.3^{\circ}$. These results are representative of the functional properties of articular cartilage in a physiological loading environment. This study provides novel experimental findings on the physiological strain magnitudes and dynamic modulus achieved in intact articular layers under cyclical loading conditions.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.570-575
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• 2022

Stress breaks body balance, which can cause diverse physiological disorders and worsen preexisting diseases. However, recent studies have reported that controllable stress and overcoming from stress reinforce resilience to resist against more intense stress afterwards. In this study, we investigated the protective effect of corticosterone (CORT), a representative stress hormone against hydrogen peroxide (H₂O₂)-induced neuronal cell death and its underlying molecular mechanism in SH-SY5Y cells, a human neuroblastoma cell line. The decreased cell viability by H₂O₂ was effectively restored by the pretreatment with low concentration of CORT (0.03 μM for 72 h) in the cells. H₂O₂-increased expression of apoptotic markers such as PUMA and Bim was decreased by CORT pretreatment. Furthermore, pretreatment of CORT attenuated H₂O₂-mediated oxidative damages by upregulation of antioxidant enzymes via activation of nuclear factor erythroid 2-related factor 2 (Nrf2). These findings suggest that low concentration of CORT with eustressed condition enhances intracellular self-defense against H₂O₂-mediated oxidative cell death, suggesting a role of low concentration of CORT as one of key molecules for resilience and neuronal cell survival.