• The Journal of Korean Academy of Prosthodontics
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• v.61 no.4
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• pp.379-385
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• 2023

With the recent development of digital dentistry, fully digitalized methods for fabricating dentures, using intraoral scans and computer-aided design/computer-aided manufacturing (CAD-CAM), are getting popular. Digital methods have the advantage of simplifying the fabrication process in the clinic and laboratory, supplementing digital data. This case report shows a fully digital fabrication method for interim removable dentures in a patient with anterior tooth loss in which implant placement is impossible or delayed. Interim removable dentures were fabricated using two methods. One method is printing tooth and base parts separately and combining, and the other method is printing the whole denture at one time and coloring on the base part. Afterward, dentures were delivered and adaptation was evaluated using the triple scan technique. The extracted site was scanned intraorally (first scan) and the interim removable denture was digitally scanned both intraorally (second scan) and, after removal extraorally (Third scan). In both method, denture adaptation was shown favorable. We report this case report as both the patient and the operator were satisfied with a simplified process using a fully digital method in the clinic.

• BMB Reports
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• v.56 no.10
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• pp.563-568
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• 2023

DNA methylation regulates gene expression and contributes to tumorigenesis in the early stages of cancer. In colorectal cancer (CRC), CpG island methylator phenotype (CIMP) is recognized as a distinct subset that is associated with specific molecular and clinical features. In this study, we investigated the genome-wide DNA methylation patterns among patients with CRC. The methylation data of 1 unmatched normal, 142 adjacent normal, and 294 tumor samples were analyzed. We identified 40,003 differentially methylated positions with 6,933 (79.8%) hypermethylated and 16,145 (51.6%) hypomethylated probes in the genic region. Hypermethylated probes were predominantly found in promoter-like regions, CpG islands, and N shore sites; hypomethylated probes were enriched in open-sea regions. CRC tumors were categorized into three CIMP subgroups, with 90 (30.6%) in the CIMP-high (CIMP-H), 115 (39.1%) in the CIMP-low (CIMP-L), and 89 (30.3%) in the non-CIMP group. The CIMP-H group was associated with microsatellite instability-high tumors, hypermethylation of MLH1, older age, and right-sided tumors. Our results showed that genome-wide methylation analyses classified patients with CRC into three subgroups according to CIMP levels, with clinical and molecular features consistent with previous data.

• BMB Reports
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• v.56 no.10
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• pp.569-574
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• 2023

Aberrant DNA methylation plays a pivotal role in the onset and progression of colorectal cancer (CRC), a disease with high incidence and mortality rates in Korea. Several CRC-associated diagnostic and prognostic methylation markers have been identified; however, due to a lack of comprehensive clinical and methylome data, these markers have not been validated in the Korean population. Therefore, in this study, we aimed to obtain the CRC methylation profile using 172 tumors and 128 adjacent normal colon tissues of Korean patients with CRC. Based on the comparative methylome analysis, we found that hypermethylated positions in the tumor were predominantly concentrated in CpG islands and promoter regions, whereas hypomethylated positions were largely found in the open-sea region, notably distant from the CpG islands. In addition, we stratified patients by applying the CpG island methylator phenotype (CIMP) to the tumor methylome data. This stratification validated previous clinicopathological implications, as tumors with high CIMP signatures were significantly correlated with the proximal colon, higher prevalence of microsatellite instability status, and MLH1 promoter methylation. In conclusion, our extensive methylome analysis and the accompanying dataset offers valuable insights into the utilization of CRC-associated methylation markers in Korean patients, potentially improving CRC diagnosis and prognosis. Furthermore, this study serves as a solid foundation for further investigations into personalized and ethnicity-specific CRC treatments.

• Journal of Trauma and Injury
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• v.36 no.4
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• pp.441-446
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• 2023

Inferior vena cava (IVC) injuries, while accounting for fewer than 0.5% of blunt abdominal trauma cases, are among the most difficult to manage. Despite advancements in prehospital care, transportation, operative techniques, and perioperative management, the mortality rate for IVC injuries has remained at 20% to 66% for several decades. Furthermore, 30% to 50% of patients with IVC injuries succumb during the prehospital phase. A 65-year-old male patient, who had been struck in the back by a 500-kg excavator shovel at a construction site, was transported to a regional trauma center. Injuries to the right side of the infrarenal IVC and the right external iliac vein (EIV) were suspected, along with fractures to the right iliac bone and sacrum. The injury to the right side of the infrarenal IVC wall was repaired, and the right internal iliac artery was ligated. However, persistent bleeding around the right EIV was observed, and we were unable to achieve proximal and distal control of the right EIV. Attempts at prolonged manual compression were unsuccessful. To decrease venous return, we ligated the right superficial femoral vein. This reduced the amount of bleeding, enabling us to secure the surgical field. We ultimately controlled the bleeding, and approximately 5 L of blood products were infused intraoperatively. A second-look operation was performed 2 days later, by which time most of the bleeding sites had ceased. Orthopedic surgeons then took over the operation, performing closed reduction and external fixation. Five days later, the patient underwent definitive fixation and was transferred for rehabilitation on postoperative day 22.

• Journal of Trauma and Injury
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• v.36 no.4
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• pp.362-368
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• 2023

Purpose: Clinical reports on treatment outcomes of sternal fractures are lacking. This study details the clinical features, treatment approaches, and outcomes related to traumatic sternal fractures over a 10-year period at a single institution. Methods: A retrospective cohort study was conducted of patients admitted to a regional trauma center between January 2012 and December 2021. Among 7,918 patients with chest injuries, 266 were diagnosed with traumatic sternal fractures. Patient data were collected, including demographics, injury mechanisms, severity, associated injuries, sternal fracture characteristics, hospital stay duration, mortality, respiratory complications, and surgical details. Surgical indications encompassed emergency cases involving intrathoracic injuries, unstable fractures, severe dislocations, flail chest, malunion, and persistent high-grade pain. Results: Of 266 patients with traumatic sternal fractures, 260 were included; 98 underwent surgical treatment for sternal fractures, while 162 were managed conservatively. Surgical indications ranged from intrathoracic organ or blood vessel injuries necessitating thoracotomy to unstable fractures with severe dislocations. Factors influencing surgical treatment included flail motion and rib fracture. The median length of intensive care unit stay was 5.4 days (interquartile range [IQR], 1.5-18.0 days) for the nonsurgery group and 8.6 days (IQR, 3.3-23.6 days) for the surgery group. The median length of hospital stay was 20.9 days (IQR, 9.3-48.3 days) for the nonsurgery group and 27.5 days (IQR, 17.0 to 58.0 days) for the surgery group. The between-group differences were not statistically significant. Surgical interventions were successful, with stable bone union and minimal complications. Flail motion in the presence of rib fracture was a crucial consideration for surgical intervention. Conclusions: Surgical treatment recommendations for sternal fractures vary based on flail chest presence, displacement degree, and rib fracture. Surgery is recommended for patients with offset-type sternal fractures with rib and segmental sternal fractures. Surgical intervention led to stable bone union and minimal complications.

• Journal of Korean Society of Disaster and Security
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• v.16 no.3
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• pp.27-34
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• 2023

In Korea, safety inspections of bridges are conducted periodically in accordance with law. Bridges are classified according to type, length, etdc., and the content and frequency of safety inspections are different. Bridges safety evaluation is performed on relatively large bridges, and safety evaluation of small bridges, which account for the majority of all bridges, is not mandatory. Therefore, in this study, in order to confirm the safety of small-scale bridges, a correlation analysis study was conducted with the common load carrying rate for each safety evaluation indicator. For this purpose, inspection reports of bridges from local goverments were collected, and the values for each bridges for about 50 indicators in the report were converted into data. By performing cleaning on the collected data and analyzing the correlation with the common load carrying rate, the top indicators related to safety for each bridges type were derived.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.6
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• pp.55-61
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• 2023

In this study, a basic research was conducted to establish a maintenance plan considering the environmental factors and deterioration characteristics of port facilities. The precise safety diagnosis reports for Incheon and Busan port facilities were referenced to examine the extent of deterioration and damage. The relationship with the degradation environmental assessment presented in the current guidelines was also analyzed. The analysis of the damage level of Incheon and Busan port facilities revealed that Incheon Port exhibited approximately three times higher damage rate compared to Busan Port. In the case of Incheon Port, reinforcement corrosion and external damage showed similar proportions, while in Busan Port, reinforcement corrosion had a higher proportion compared to external damage. On the other hand, when comparing with the degradation environmental assessment presented in the guidelines, it was found that there were some limitations in performing quantitative evaluation based on the guidelines for assessing port facilities. Therefore, an analysis based on tidal range was conducted by referring to existing literature. The analysis of tidal range in Incheon and Busan regions showed that Incheon had approximately five times higher difference compared to Busan. It is considered that this can be utilized as a differentiated item from existing degradation environmental assessment criteria.

• Journal of Internet Computing and Services
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• v.24 no.6
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• pp.127-135
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• 2023

With the development of information and communication technology, the amount of information produced and shared in the battlefield and stored and managed in the system dramatically increased. This means that the amount of information which cansupport situational awareness and decision making of the commanders has increased, but on the other hand, it is also a factor that hinders rapid decision making by increasing the information overload on the commanders. To overcome this limitation, this study proposes a method to automatically search, select, and summarize documents that can help the commanders to understand the battlefield situation reports that he or she received. First, named entities are discovered from the battlefield situation report using a named entity recognition method. Second, the documents related to each named entity are discovered. Third, a language model and collaborative filtering are used to select the documents. At this time, the language model is used to calculate the similarity between the received report and the discovered documents, and collaborative filtering is used to reflect the commander's document reading history. Finally, sentences containing each named entity are selected from the documents and sorted. The experiment was carried out using academic papers since their characteristics are similar to military documents, and the validity of the proposed method was verified.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.843-848
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• 2023

The purpose of this study is to understand in detail the development of infants in the 18-24-month period when language develops the most, and to prepare new standards for developmental evaluation that can promote appropriate intervention design at an early time. We divided sub-items such as screening tests and standardized test tools to know the language development ability indicators of infants aged 18-24 months were divided into syntax/phonology, meaning, and speech, and each question was classified and a checklist was made on a five-point scale to conduct a survey on parents with infants aged 18-24 months. Low sensitivity to screening of infants with language delays in nationally implemented infant health checkups, and domestic test tools are standardized for at least six to as many as 10 years, which is always possible in questionnaires related to acceptance and expression, with many reports from parents or teachers.The proportion of "wow" and "started to do" was more than 50-60%. Based on the results of this study, it is hoped that new standards for developmental evaluation will be developed to promote the design of appropriate interventions in detail at a short time.

• Journal of the Korea Institute of Building Construction
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• v.23 no.6
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• pp.785-796
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• 2023

The adoption of Environmental, Social, and Governance(ESG) practices in domestic construction firms is predominantly driven by major corporations. These companies not only publish reports on their ESG management but also engage in a meticulous process of identifying key issues and setting priorities. This process entails an in-depth evaluation of the severity of various issues and the gathering of insights from experts in the field. Interestingly, a comparative analysis of ESG assessments for construction companies, both domestically and internationally, reveals significant discrepancies in outcomes. These differences stem from the varied evaluation methodologies and criteria employed by different assessing bodies. Addressing this gap, our study proposes a suite of strategies aimed at bolstering ESG management within the construction sector. We advocate for enhanced policy support and financial backing, especially targeting small and medium-sized enterprises(SMEs) to facilitate their engagement in ESG practices. A critical step forward involves the standardization and transparent disclosure of ESG evaluation criteria, tailored to reflect the unique aspects of the construction industry. Moreover, the standardization and publication of ESG assessments for subcontractors are essential, equipping them with the necessary tools for effective ESG management and evaluation. Given the global nature of construction projects, particularly those commissioned by the European Union in regions like Africa and East Asia, adherence to ESG standards is imperative. Our long-term vision includes the development of a comprehensive database detailing ESG regulations and their impacts, segmented by region and country. This repository will serve as a valuable resource for companies venturing into international construction projects.