• Pediatric Infection and Vaccine
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• v.4 no.2
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• pp.308-313
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• 1997

Ceftriaxone, an effective third generation cephalosporin with a wide range of antimicrobial activity, has become widely used by pediatricians for a variety of bacterial infections including meningitis. It has been associated with the development of sludge or stone in the gallbladder of some patients treated with this drug. Ceftriaxone associated biliary sludge has unusual acoustic characteristics and resembles gallstone. The sludge can cause symptoms such as cramping abdominal pain, and disappears after stopping ceftriaxone administration. Because of these seemingly confusing observations, it is important for the clinicians to recognize these findings that ceftriaxone treatment can cause. We report a case of ceftriaxone associated biliary sludge in Korean children. A 6-year-old girl who was treated for meningitis with ceftriaxone (100mg/kg/day) developed cramping upper abdominal pain from 5th hospital day. Physical examination, liver function tests and X-ray revealed no specific abnormal findings. But abdominal ultrasound revealed high amplitude echogenic sludge with prominent post-acoustic shadow in gallbladder and its diameter was 1.5cm. We stopped ceftriaxone administration and tried conservative care. Abdominal cramping pain subsided after 3 days of ceftriaxone removal. Second abdominal ultrasound confirmed the disappearance of sludge at 3 weeks later.

• Journal of Genetic Medicine
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• v.7 no.2
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• pp.119-124
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• 2010

More than 7,000 rare Mendelian diseases have been reported, but less than half of all rare monogenic disorders has been discovered. In addition, the majority of mutations that are known to cause Mendelian disorders are located in protein-coding regions. Therefore, exome sequencing is an efficient strategy to selectively sequence the coding regions of the human genome to identify novel genes associated with rare genetic disorders. The "exome" represents all of the exons in the human genome, constituting about 1.5% of the human genome. Exome sequencing is carried out by targeted capture and intense parallel sequencing. After the first report of successful exome sequencing for the identification of causal genes and mutations in Freeman Sheldon syndrome, exome sequencing has become a standard approach to identify genes in rare Mendelian disorders. Exome sequencing is also used to search the causal genes and variants in complex diseases. The successful use of exome sequencing in Mendelian disorders and complex diseases will facilitate the development of personalized genomic medicine.

• Journal of Genetic Medicine
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• v.17 no.1
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• pp.43-46
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• 2020

The Shprintzen-Goldberg syndrome (SGS) is an extremely rare genetic disorder caused by heterozygous variant in SKI. SGS is characterized by neurodevelopmental impairment with skeletal anomaly. Recognition of SGS is sometimes quite challenging in practice because it has diverse clinical features involving skeletal, neurological, and cardiovascular system. Here we report a case of a 6-month-old boy who initially presented with developmental delay and marfanoid facial features including prominent forehead, hypertelorism, high arched palate and retrognathia. He showed motor developmental delay since birth and could not control his head at the time of first evaluation. His height was above 2 standard deviation score. Arachnodactyly, hypermobility of joints, skin laxity, and pectus excavatum were also noted. Sequencing for FBN1 was negative, however, a novel missense variant, c.350G>A in SKI was identified by sequential whole exome sequencing. To our knowledge, this is the first case with SGS with phenotypic features of SGS overlapping with those of the Marfan syndrome, diagnosed by next generation sequencing in Korea.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.5.1-5.15
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• 2018

Targeting hair follicle regeneration has been investigated for the treatment of hair loss, and fundamental studies investigating stem cells and their niche have been described. However, knowledge of stem cell metabolism and the specific regulation of bioenergetics during the hair regeneration process is currently insufficient. Here, we report the hair regrowth-promoting effect of a newly synthesized novel small molecule, IM176OUT05 (IM), which activates stem cell metabolism. IM facilitated stemness induction and maintenance during an induced pluripotent stem cell generation process. IM treatment mildly inhibited mitochondrial oxidative phosphorylation and concurrently increased glycolysis, which accelerated stemness induction during the early phase of reprogramming. More importantly, the topical application of IM accelerated hair follicle regeneration by stimulating the progression of the hair follicle cycle to the anagen phase and increased the hair follicle number in mice. Furthermore, the stem cell population with a glycolytic metabotype appeared slightly earlier in the IM-treated mice. Stem cell and niche signaling involved in the hair regeneration process was also activated by the IM treatment during the early phase of hair follicle regeneration. Overall, these results show that the novel small molecule IM promotes tissue regeneration, specifically in hair regrowth, by restructuring the metabolic configuration of stem cells.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.198-198
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• 2016

The Citarum River Basin is the biggest river basin in West Java Province, Indonesia and it plays strategic roles in providing water for irrigation, domestic and industrial uses, and power generation, besides controlling the flood during rainy season. Flowing through seven major cities makes the river flow and water demand are vulnerable to land use change around the river. The present water resources management has involved the regulator, operator, and users in deciding an appropriate water management plan for the entire basin. The plan includes an operation plan for three reservoirs, construction or maintenance of the river channel, and water allocation for all users along the river. Following this plan, a smaller operation group will execute and evaluates the plan based on the actual flow condition. Recently, a deforestation, environment degradation, river sedimentation, a rapid growth of population and industry, also public health become new issues that should be considered in water basin planning. Facing these arising issues, a new development program named ICWRMIP was established to advance the existing management system. This program includes actions to strengthen institutional collaboration, do the restoration and conservation of the river environment, improve water quality and public health, also advance the water allocation system. At present, the water allocation plan is created annually based on a forecasted flow data and water usage prediction report. Sometimes this method causes a difficulty for the operator when the actual flow condition is not the same as the prediction. Improving existing system, a lot of water allocation studies, including a development of the database and water allocation simulation model have been placed to help stakeholders decide the suitable planning schemes. In the future, this study also tries to contribute in advancing water allocation planning by creating an optimization model which ease stakeholders discover a suitable water allocation plan for individual users.

• Journal of the Optical Society of Korea
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• v.18 no.3
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• pp.207-216
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• 2014

In this work, we report detailed numerical analysis of the near-elliptic core index-guiding triangular-lattice and square-lattice photonic crystal fiber (PCFs); where we numerically characterize the birefringence, single mode, cut-off behavior and group velocity dispersion and effective area properties. By varying geometry and examining the modal field profile we find that for the same relative values of $d/{\Lambda}$, triangular-lattice PCFs show higher birefringence whereas the square-lattice PCFs show a wider range of single-mode operation. Square-lattice PCF was found to be endlessly single-mode for higher air-filling fraction ($d/{\Lambda}$). Dispersion comparison between the two structures reveal that we need smaller lengths of triangular-lattice PCF for dispersion compensation whereas PCFs with square-lattice with nearer relative dispersion slope (RDS) can better compensate the broadband dispersion. Square-lattice PCFs show zero dispersion wavelength (ZDW) red-shifted, making it preferable for mid-IR supercontinuum generation (SCG) with highly non-linear chalcogenide material. Square-lattice PCFs show higher dispersion slope that leads to compression of the broadband, thus accumulating more power in the pulse. On the other hand, triangular-lattice PCF with flat dispersion profile can generate broader SCG. Square-lattice PCF with low Group Velocity Dispersion (GVD) at the anomalous dispersion corresponds to higher dispersion length ($L_D$) and higher degree of solitonic interaction. The effective area of square-lattice PCF is always greater than its triangular-lattice counterpart making it better suited for high power applications. We have also performed a comparison of the dispersion properties of between the symmetric-core and asymmetric-core triangular-lattice PCF. While we need smaller length of symmetric-core PCF for dispersion compensation, broadband dispersion compensation can be performed with asymmetric-core PCF. Mid-Infrared (IR) SCG can be better performed with asymmetric core PCF with compressed and high power pulse, while wider range of SCG can be performed with symmetric core PCF. Thus, this study will be extremely useful for designing/realizing fiber towards a custom application around these characteristics.

• Journal of Magnetics
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• v.21 no.4
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• pp.509-515
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• 2016

We report on development of a ground-based bi-axial Search-Coil Magnetometer (SCM) designed to measure time-varying magnetic fields associated with magnetosphere-ionosphere coupling processes. The instrument provides two-axis magnetic field wave vector data in the Ultra Low Frequency or ULF (1 mHz to 5 Hz) range. ULF waves are well known to play an important role in energy transport and loss in geospace. The SCM will primarily be used to observe generation and propagation of the subclass of ULF waves. The analog signals produced by the search-coil magnetic sensors are amplified and filtered over a specified frequency range via electronics. Data acquisition system digitizes data at 10 samples/s rate with 16-bit resolution. Test results show that the resolution of the magnetometer reaches $0.1pT/{\sqrt{Hz}}$ at 1 Hz, and demonstrate its satisfactory performance, detecting geomagnetic pulsations. This instrument is scheduled to be installed at the Korean Antarctic station, Jang Bogo, in the austral summer 2016-2017.

• Journal of Adhesion and Interface
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• v.22 no.4
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• pp.153-157
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• 2021

Graphene, a two-dimensional carbon allotrope, has outstanding mechanical and electrical properties. In particular, the charge carrier mobility of graphene is known to be about 100 times higher than that of silicon, and it has received attention as a core material for next-generation electronic devices. However, graphene is very sensitive to environmental conditions, especially vulnerable to moisture or oxygen. It becomes a disadvantage in that the stability of the graphene-based electronic device, so various attempts are being made to solve this problem. In this work, we report a method to greatly improve the stability by controlling the surface energy of the polymer layer used for transferring the insulating layer of the graphene field-effect transistor. As the surface energy of the polymer used as the insulating layer was lowered, the stability could be improved by effectively controlling the adsorption of impurities in the atmosphere such as water molecules or oxygen.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.41 no.4
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• pp.248-255
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• 2018

Ensuring the quality of molds is one of the major issues in mass production. In general, securing the quality of the molds is achieved by repeating grinding and die spotting after machining the molds based on engineer's decision. However, this heuristic method is affected by the engineer's skill and working environment. Therefore, a lot of time and resources are needed in order to ensure quality. In this study, ensuring the quality of molds using grinding map which is generated using automatic measurement is proposed. An automatic measuring system based on CMM (Coordinate Measuring Machine) is developed for measuring the molds. This system generates the measurement path automatically using the 3D CAD model of products. CAD (ComputerAided-Design), CAM (Computer-Aided-Manufacturing), and CAQ (Computer-Aided-Quality) technology is integrated using DMIS (Dimensional Measuring Interface Standard) format in the automatic measuring system. After measuring the molds, a grinding map is generated using the gap between the CAD model and measured values of mold. The grinding map displays the machining tendency and the required amount of grinding with values on a 3D map. Therefore, the quality of molds can be ensured with exactness and quickness based on the grinding map. This study shows that integrating the planning, measuring, and analyzing based on computer technology can solve the problem of quality assurance of mold using the proposed method, therefore the productivity can be increased.

• Restorative Dentistry and Endodontics
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• v.44 no.3
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• pp.27.1-27.12
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• 2019

This case report describes a technique in which endodontic treatment and permanent indirect restoration were completed in the same clinical appointment with the aid of a computer-aided design/computer-aided manufacturing (CAD/CAM) system. Two patients were diagnosed with irreversible pulpitis of the mandibular first molar. After access preparation, root canals were located, irrigation was performed until bleeding ceased, and the coronal tooth structure was prepared for indirect restoration. Then, utilizing an interim 3-mm build-up of the endodontic access cavity, a hemi-arch digital scan was performed with an intraoral scanner. Subsequent to digital scanning, restoration design was performed simultaneously with the endodontic procedure. The root canals were shaped using the Race system under irrigation with 2.5% sodium hypochlorite followed by root canal filling. The pulp chamber was subsequently filled with a 3-mm-thick composite resin restoration mimicking the interim build-up previously utilized to facilitate block milling in the CAD/CAM system. Clinical try-in of the permanent onlay restoration was followed by acid etching, application of a 5th generation adhesive, and cementation of the indirect restoration. Once the restoration was cemented, rubber dam isolation was removed, followed by occlusal adjustment and polishing. After 2 years of follow-up, the restorations were esthetically and functionally satisfactory, without complications.