• Genomics & Informatics
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• 제16권3호
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• pp.71-74
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• 2018

Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.

• Advances in pediatric surgery
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• 제20권2호
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• pp.62-64
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• 2014

Gallbladder stones in children are not common without underlying hemolytic diseases or other risk factors like obesity. Ceftriaxone, a third generation cephalosporin, is known to make biliary precipitations that can be mistaken for biliary stones. We here report two children with biliary pseudolithiasis with different treatment modalities. One child was mistaken for symptomatic gallbladder stones and underwent elective laparoscopic cholecystectomy, while the other child, after thorough history taking on the ceftriaxone medication, was suspected of biliary pseudolithiasis and was treated conservatively. Both children had the history of usage of ceftriaxone in previous hospitals for infectious diseases. The ceftriaxone history of the first child was missed before the surgery. When gallbladder stones are found in children without any underlying diseases, specific history taking of the usage of ceftriaxone seems to be absolutely required. In this case, immediate interruption of the antibiotic could resolve the episode and avoid unnecessary surgical procedure.

• 한국통신학회논문지
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• 제27권6B호
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• pp.601-609
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• 2002

時變 多重經路 無線채널 環境下에서 移動局은 受信信號를 測定하여 網에 報告함으로써 綱이 핸드오버와 같은 網의 制御技能을 修行하도록 한다. 또한, 最大比結合利得 (maximum ratio combining gain, MRC gain)을 最大化하기 위해서 移動局은 信號세기가 가장 큰 經路를 찾아내고 그 時間옵셋 (time offset)을 빠르고 正確하게 測定해야 한다. 본 論文은 移動局이 채널經路의 信號세기를 測定하는 方法과 채널經路의 時間옵셋을 찾는 方法을 提案한다. 또한 W-CDMA 시스템에서는 次世代 高速 패킷 서비스를 目標로 하고 있으므로, 이 때의 性能 分析하기 위하여, 高速 패킷 서비스 環境에 맞도록 低速의 移動體 環境, 無電力制御, 送受信 안테나 다이버시터를 포함한 多重經路 環境下에서 컴퓨터 模擬實驗을 修行하여 最適의 設計 變數값을 導出하고 그 때의 性能 改善量을 비트誤率韻點에서 보인다.

• 디지털융복합연구
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• 제9권5호
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• pp.45-54
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• 2011

본 연구는 장기요양보험제도의 인식여부가 중장년층 성인자녀의 노부모 돌봄에 어떤 영향을 미치는지 살펴보는데 목적이 있다. 임의표집에 의해 A시에 거주하는 중장년층(55년생~63년생) 성인자녀 331명을 대상으로 장기요양보험제도 인식여부가 노부모 돌봄에 어떤 영향을 미치는지를 설문조사 하였다. 회귀분석을 통해 나타난 결과는 사회경제적 수준을 나타내는 학력과 소득수준이 높을수록, 노부모와의 정서적 친밀성이 높을수록, 장기요양보험제도를 인식할수록 노부모에 대한 전체적인 돌봄(경제적 돌봄, 정서적 돌봄, 신체적 돌봄)수준이 높게 나타났다. 특히, 장기요양보험제도를 인식할수록 노부모에 대한 신체적 돌봄이 높게 나타났다. 이는 지속적으로 노령인구가 증가하는 현상을 고려할 때, 장애노인을 돌보는 가족을 지원하는 제도적인 정책지원방안을 도입할 필요가 있음을 시사한다.

• Archives of Pharmacal Research
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• 제27권6호
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• pp.633-639
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• 2004

The expression of therapeutic transgenes in recombinant adenoviral vectors is a major cause of toxicity in dividing cancer cells as well as non dividing normal cells. To solve the problem of toxicity to normal cells, we have reported on a recombinant adenoviral vector system （AdLP-） in which the expression of the transgene is directed by the tumor-specific L-plastin promoter （LP） （Chung et al., 1999）. The object of this study was to generate a recombinant adenoviral vector system which would generate tumor cell specific expression of cytosine deaminase （CD） gene. We report the construction of a replication-incompetent adenoviral vector in which CD is driven by the L-plastin promoter （AdLPCD）. Infection of 293 cells by AdLPCD generated the functional CD protein as measured by HPLC analysis for the conversion of 5-Fluorocy-tosine （5-FC） to 5-Fluorouracil （5-FU）. HPLC analysis in conjunction with counting radioactivity for ［6-$^3$H］-5FC and ［6-$^3$H］-5FU demonstrated vector dose-dependent conversion of 5-FC to 5-FU in AdLPCD infected ovarian cancer cells. The results from present and previous studies（Peng et al., 2001； Akbulut et al., 2003） suggest that the use of the AdLPCD／5-FC system may be of value in the treatment of cancer including microscopic ovarian cancer in the peritoneal cavity.

• 혜화의학회지
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• 제26권1호
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• pp.68-72
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• 2017

Objectives: The purpose of this case study is to report the clinical effects of acupuncture and Korean medicine on antibiotics-induced functional dyspepsia. Methods: The patient, 79-year-old, who complained about nausea and vomiting after taking antibiotics was treated by acupuncture and Korean medicine. We measured the amount of meals eaten by patient and quantified the degree of nausea she felt. Results: After the treatment, the symptoms were decreased. Conclusion: Acupuncture and herb medicine may be effective therapy on antibiotic's side effects such as nausea and vomit.

• Genomics & Informatics
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• 제2권2호
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• pp.86-91
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• 2004

Even though it represents $6-13\%$ of human genomic DNA, Alu sequences are rarely found in coding regions. When in exon region, over $80\%$ of them are found in 3' untranslated region (UTR). Pseudogenes are an important component of human genome. Their functions are not clearly known and the mechanism of how they are generated is still debatable. Both the Alu and Pseudogenes are important research problems in molecular biology. mRNA is thought to be a prime source of pseudogene and active research is going on its molecular mechanism. We report, for the first time, that mRNAs containing Alu repeats at 3' UTR has a significantly high correlation with processed pseudogenes, suggesting a possibility that Alu containing mRNAs have a high tendency to become processed pseudogenes. It is known that about $10\%$ of all human genes have been transposed. Transposed genes at 3' UTR without Alu repeat have about two processed pseudogenes per gene on average while we found with statistical significance that a transposed gene with Alu had over three processed Pseudogenes on average. Therefore, we propose Alu repeats as a new and important factor in the generation of pseudogenes.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2010년도 제35회 추계학술대회논문집
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• pp.656-657
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• 2010

나로우주센터 발사장의 지상 추진제 공급시스템인 산화제 공급시스템은 2009년 5월 발사체와의 연계시험을 시작으로 2010년 6월 나로호 2차 발사 수행까지 총 9회의 시스템 운용을 하였다. 본 시스템은 두 차례의 나로호 발사 시 성공적으로 임무를 수행하였다. 지상설비의 성공적인 운용이란 기본적으로 재현성을 갖추어 신뢰도를 확보하는 것이며 본 논문에서는 산화제 공급시스템의 재현성 확보를 판단하기 위해 운용 시 액체산소 소모량을 분석하였으며 이는 시스템이 향후 한국형발사체의 발사 운용에 활용하기 위해서 적절한지 판단하는데 참고가 될 것이다.

• 대한두개안면성형외과학회지
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• 제18권4호
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• pp.282-286
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• 2017

Beta tricalcium phosphate (${\beta}-TCP$) is one of allogenic bone substitute which is known to have interconnected pores that draws cell and nutrients for bone generation. It has been resulted in good outcomes for bone defect coverage or augmentation. However, several studies have also reported negative outcomes and associated complications including unexpected formation of cystic mass, continuous pain and secretion. We present the case of a 36-year-old man with a right cheek cystic mass who had a history of right zygomaticomaxillary (ZM) complex fracture and surgical correction with ${\beta}-TCP$ powder insertion to ZM bone defect. Excisional biopsy under local anesthesia revealed calcified mass in a sinus tract which was found to be connected to the ZM bone defect site in postoperative computed tomography image. Further excision under general anesthesia was performed to remove the sinus tract and fine granules which filled the original defect site. Pathologic report revealed bony spicules and calcification materials with chronic foreign body reaction. Postoperative complications and recurrence were not reported.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.2
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• pp.317-320
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• 2006

Ships and their cargos have been managed safely by positioning report system. However, little attention has been paid to safety of crew's works with danger. The attempt that used PHS inboard was before by the present authors. However, the functions were just voice call and mail exchange. The data acquisition from the terminal by proper control was not possible. Thus the position of the terminal was not available. As for the cell phone of next generation, GPS receiver and wireless LAN are installed by manufacturers. Therefore, we propose a system which uses a cell-phone with GPS receiver on a ship in order to promote the safety of ship's crew. We checked the availability of cell-phone GPS receiver at thirty different points inboard. The positioning was not possible in the areas further than 4m from the window. Then, we proposed the system which follows the positions of the crews and confirms their safety inboard by using the VoIP (Voice over Internet Protocol) function by wireless LAN.