• The KIPS Transactions:PartD
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• v.12D no.2 s.98
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• pp.289-302
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• 2005

The mobile agent has very various performance according to the element of communication number of times between hosts, quantity of transmission data agent's size, network state etc. specially, migration method is caused much effect in whole performance of distributed system. Most existing migration methods have simplicity structure that it moves doing to accumulate continuously result after achieving task by visiting host in the fixed order. Therefore, in case there are situation such as fault, obstacle, and service absence etc. This can be inefficient due to mobile agent increased network required time. In this paper, we design and implementation Multicast Migration Model for minimizing network required time by solving this problems. Multicast Migration Model includes components such as mobile agent including call module and naming agent, which provides object replication information and distributed server's location transparence. And we evaluate and compare with existing migration method applying prototype system to verify implemented migration model.

• Journal of IKEEE
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• v.26 no.4
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• pp.568-576
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• 2022

Automatic modulation classification(AMC) is a core technique in Software Defined Radio(SDR) platform that enables smart and flexible spectrum sensing and access in a wide frequency band. In this study, we propose a simple yet accurate deep learning-based method that allows AMC for variable-size radio signals. To this end, we design a classification architecture consisting of two Convolutional Neural Network(CNN)-based models, namely main and small models, which were trained on radio signal datasets with two different signal sizes, respectively. Then, for a received signal input with an arbitrary length, modulation classification is performed by augmenting the input samples using a self-replicating padding technique to fit the input layer size of our model. Experiments using the RadioML 2018.01A dataset demonstrated that the proposed method provides higher accuracy than the existing methods in all signal-to-noise ratio(SNR) domains with less computation overhead.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2005.05a
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• pp.1033-1039
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• 2005

Parallel and distributed simulation is concerned with the efficient execution of large-scale discrete event simulation models on multiprocessors and distributed platforms. After the development of WWW, many efforts in the parallel and distributed simulation have been made for modeling, particularly building simulation languages and creating model libraries that can be assembled and executed over WWW. However, web-based parallel and distributed simulation is restricted by heterogeneous computing environments. Recently, the advent of XML and web services technology has made these efforts enter upon a new phase. Especially, the web services as a distributed information technology have demonstrated powerful capabilities for scalable interoperation of heterogeneous systems. This paper aims to develop and evaluate the parallel and distributed simulation using the web services technology. In particular, a prototype multi-pass simulation framework is implemented using Java-based web services technology. It focuses on the efficiency of multi-pass simulation used for optimization through the distribution of simulation replication to several simulation service providers. The development of parallel and distributed simulation using web services will help solve efficiently large-scale problems and also guarantee interoperability among heterogeneous networked systems.

• Journal of Microbiology and Biotechnology
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• v.20 no.2
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• pp.375-382
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• 2010

The available techniques for heterologous protein secretion in Lactobacillus strains are limited. The aim of the present study was to develop an efficient protein-secretion system using recombinant lactobacilli for various applications such as live delivery of biotherapeutics. For the construction of expression vectors, the Lactobacillus brevis slpA promoter, Lactobacillus casei prtP signal sequence, and mouse IL-10 sequences were used as a model system. Interestingly, the slpA promoter exhibited strong activity in L. casei, contrary to previous observations. In order to stabilize replication of the plasmid in E. coli, a removable terminator sequence was built into the promoter region. For the improvement of secretion efficiency, a DTNSD oligopeptide was added to the cleavage site of signal peptidase. The resulting plasmids provided remarkably efficient IL-10 secretion. Accumulation of the protein in the culture supernatant varied widely according to the pH conditions. By analysis of the secreted protein, formation of homodimers, and biological activity, IL-10 was confirmed to be functional. The presently constructed plasmids could be useful tools for heterologous protein secretion in L. casei.

• Bulletin of the Korean Chemical Society
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• v.34 no.3
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• pp.837-850
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• 2013

Bovine viral diarrhea virus (BVDV), a major pathogen of cattle, is a well-characterized pestivirus which has been used as a good model virus for HCV. The RNA-dependent RNA polymerase (RdRp) plays a key role in the RNA replication process, thus it has been targeted for antivirus drugs. We employed two-dimensional quantitative structure-activity relationship (2D-QSAR) and molecular field analysis (MFA) to identify the molecular substructure requirements, and the particular characteristics resulted in increased inhibitory activity for the known series of compounds to act as effective BVDV inhibitors. The 2D-QSAR study provided the rationale concept for changes in the structure to have more potent analogs focused on the class of arylazoenamines, benzimidazoles, and acridine derivatives with an optimal subset of descriptors, which have significantly contributed to overall anti-BVDV activity. MFA represented the molecular patterns responsible for the actions of antiviral compound at their receptors. We conclude that the polarity and the polarizability of a molecule play a main role in the inhibitory activity of BVDV inhibitors in the QSAR modeling.

• Biomolecules & Therapeutics
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• v.1 no.1
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• pp.98-102
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• 1993

The therapeutic effectiveness of adenine arabinoside(tora-A) and its conjugate of prednisone(BR-8702-AP) was compared in Herpes simplex Virus Type 1 (HSV-1) infected BALB/C mice. The BALB/C mouse was infected with HSV-1(700 PFU/mouse) intranasally. Among mice infected intranasally with virus, a mortality rate of 100% was observed. On the oral administration of non-toxic doses of ara-A or BR-8702-AP(125 mg /kg/day) for 5 consecutive days 2 hours after virus infection, the tora-A was highly effective in reducing mortality to 0% (P<0.001) and BR-8702-AP was also effective in reducing mortality to 15% (P<0.01). In this model infection, the virus was first replicated in the lung and transmitted to the brain. Both arts-A and BR-8702-AP did not inhibit the viral replication in the lung, but they inhibited the viral transmission to the brain. However, the BR-8702-AP was less effective than the aria-A to prevent transmission of virus to brain. Therefore, the reduced mortality due to tora-A or BR-8702-AP therapy was associated with inhibition of viral transmission to brain.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.29 no.9 s.240
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• pp.1169-1174
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• 2005

Imprint lithography is a promising method for high-resolution and high-throughput lithography using low-cost equipment. In particular, ultraviolet-nanoimprint lithography (UV-NIL) is applicable to large area imprint easily. We have proposed a new UV-NIL process using an elementwise patterned stamp (EPS), which consists of a number of elements, each of which is separated by channel. Experiments on UV-NIL are performed on an EVG620-NIL using the EPS with 3mm channel width. The replication of uniform sub 70 nm lines using the EPS is demonstrated. We investigate the nonuniformity of residual layer caused by wafer deformation in experiment with varying wafer thickness. Severely deformed wafer works as an obstacle in spreading of dropped resin, which causes nonuniformity of thickness of residual layer. Numerical simulations are conducted to analyze aforementioned phenomenon. Wafer deformation in the process is simulated by using a simplified model, which is a good agreement with experiments.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.4
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• pp.291-297
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• 2014

A Design of Experiments(DOE) approach to an experimental study of fuselage drag and stability characteristics of a helicopter configuration was applied to achieve an accuracy improvement in the wind tunnel testing. The impact of blocking the test was assessed by comparing the ANOVA table for the blocked and unblocked cases. For a second-order response model, the role of blocking resulted in a substantial increase in the accuracy of test results. These accuracy improvement could be achieved through randomization, blocking, and replication of the data points i.e. a re-ordering of the test sequence where the data were acquired.

• Genomics & Informatics
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• v.14 no.3
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• pp.85-89
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• 2016

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. Although the etiology of SLE remains unclear, it is widely accepted that genetic factors could be involved in its pathogenesis. A number of genome-wide association studies (GWASs) have identified novel single-nucleotide polymorphisms (SNPs) associated with the risk of SLE in diverse populations. However, not all the SNP candidates identified from non-Asian populations have been validated in Koreans. In this study, we aimed to replicate the SNPs that were recently discovered in the GWAS; these SNPs have not been validated in Koreans or have only been replicated in Koreans with an insufficient sample size to conclude any association. For this, we selected five SNPs (rs1801274 in FCGR2A and rs2286672 in PLD2, rs887369 in CXorf21, rs9782955 in LYST, and rs3794060 in NADSYN1). Through the replication study with 656 cases and 622 controls, rs1801274 in FCGR2A was found to be significantly associated with SLE in Koreans (odds ratio, 1.26, 95% confidence interval, 1.06 to 1.50; p = 0.01 in allelic model). This association was also significant in two other models (dominant and recessive). The other four SNPs did not show a significant association. Our data support that FCGR polymorphisms play important roles in the susceptibility to SLE in diverse populations, including Koreans.

• International Journal of Industrial Entomology and Biomaterials
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• v.7 no.2
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• pp.139-144
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• 2003

Over 350 million people worldwide are chronic carriers of hepatitis B virus (HBV). Chronic viral infections of the liver can progress to cirrhosis, which may ultimately lead to hepatic failure or the development of hepatocellular carcinoma. There are two antiviral drugs on the market approved for clinical management of chronic HBV infections; interferon-alpha and the nucleoside analog lamivudine. However, they showed adverse side-effects. In the rational drug design for such therapies we would like to utilize antiviral drugs that inhibit the HBV replication in the liver. Investigation of natural extracts of silkworm exhibiting antiviral potential was held in the functional HBV polymerase activity and the release of virion particle in the HepG2.2.15 cell lines. HBV-producing transgenic mouse fed with silkworm DNJ molecule was shown as an inhibitor of serum HBV particles. We could represent this DNJ molecule as an antiviral potential complementing conventional therapies after preclinical tests against WHBV-infected animal model, woodchuck.