• Journal of Chest Surgery
• /
• v.15 no.2
• /
• pp.222-229
• /
• 1982

The aneurysmal dilatation of ascending aorta with the aortic regurgitation presents typical surgical problems. Over the years, various surgical procedures had been used for the management of the dilated segment of sending aorta and the aortic regurgitation. The surgical technique Is still in the state of evolution. The one method is the super coronary replacement of the ascending aorta with vascular graft and replacement of the aortic valve with preservation of the coronary ostia as advocated by Miller and his colleague at Stanford University, so called conventional technique". The other is the replacement of aortic valve and the dilated segment of the ascending aorta using a composite graft and transplantation of the coronary ostia as described by Bentall and DeBono in 1968. The controversy appears to evolve around 3 technical problems. One is bleeding from the grafted area. Two is later development of the aneurysmal dilatation of the subcoronary aortic wall when non-composite graft is employed. Three is a management of the coronary arteries. The purpose of this article is to present our experience with 7 cases of annuloaortic ectasia in whom both of these surgical techniques at that employed and to review some of the problems that encountered during the management of these patients .

• The Korean Journal of Physiology and Pharmacology
• /
• v.10 no.3
• /
• pp.123-129
• /
• 2006

In several experimental models, estrogens protect neurons against ischemic insults. However, the recent clinical studies of hormone replacement showed negative results to prevent stroke. Therefore, optimal models to study estrogen replacement for neuroprotection are needed before its clinical ap-plication. Organotypic hippocampal slice under oxygen-glucose deprivation (OGD) has been established as a model of cerebral ischemia and has advantages to study drug effects. We investigated whether estrogen protected CAI neurons and affected activation of Akt (pAkt) in CAI region under OGD. Thus, rat hippocampal slices on day 7 of culture were treated with $17-{\beta}$ estradiol (E, 1 nM) for 7 days before 30 min OGD, and cell death of CAI neurons was quantified by propidium iodide (PI) staining and expression of pAkt was studied by Western blot and immunofluorescence. PI intensity in slices treated with E was significantly reduced 72 hour after OGD compared to that of non-treated slices (p < 0.05). E pretreatment also increased the expression of pAkt 72 hour after OGD compared to that of no treatment (p<0.01). These data suggest that estrogen pretreatment may rescue neurons from ischemic insults through the activation of Akt and also indicate that our model would be a useful alternative method to study the mechanisms and effects of estrogen replacement treatment for neuroprotection.

• Asian Journal of Business Environment
• /
• v.9 no.3
• /
• pp.21-26
• /
• 2019

Purpose - This study aims to investigate the effect of brand image and trust of a home meal replacement (HMR) industry on customer satisfaction and repurchase during online shopping. Research design, data, and methodology - With 217 questionnaires, this study was conducted by AMOS 20.0, and the Structural Equation Model (SEM) as statistical method was used for examining the hypotheses in this study. Factors such as brand image and brand trust in customer shopping for HMR products online were tested, and relationships between satisfaction and repurchase were studied. Results - Brand image and brand trust in terms of online shopping for HMR were found to affect satisfaction significantly; in addition, the path where satisfaction leads to repurchase was found to be significant. However, brand image and brand trust for HMR in online shopping differed depending on customer age groups. The path-coefficients from brand image of HMR in online shopping to satisfaction were more significant in the older age group; meanwhile, the path-coefficient from brand trust to satisfaction was significant in the younger age group. Conclusions - Results of the study suggested the importance of the attributes for buying HMR products online and provided meaningful implications of difference between age groups when they choose the products.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2010.05a
• /
• pp.373-374
• /
• 2010

This study is to search for recycling method of the WCP(waste concrete powder). From the experiment analysis on the chemical composition, we confirmed that $SiO_2$ was occupied about 60% of WCP. To investigate the applicability of WCP as replacement material of Quartz, we tested the properties of autoclaved light weight concrete containing WCP. As a results, when increasing the replacement of WCP, compressive strength decreased and pore diameter did not change. On the other hand, when increasing curing times, compressive strength and pore diameter increased.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.24 no.11
• /
• pp.2777-2785
• /
• 2000

In cementless total hip replacement(THR), an initial stability of the femoral component is important to long term fixation of femoral stem. The intial stability has close relationship with the relative displacement of prosthessis and sponge bone at the proximal of femur. After implantation of the proshesis, the surrounding bone is partially shielded from load carrying and starts to resorb. Stress shielding is the cause of the loss of proximal bone. Assessing stress distribution of femur is important to predict stress shielding. The initial stability and the stress shielding were investigated for two loading conditions approximating a single leg stance and a stair climbing. Three types of stems were studied by the finite element method to analyze the biomechanical effects of distal filling of cementless femoral stems. Three types of stems empolyed are a distal filling stem, a distal flexible stem, and a distal tapered stem.

• Women's Health Nursing
• /
• v.9 no.4
• /
• pp.369-378
• /
• 2003

Purpose: To identify factors influencing women's intention to take hormone replacement therapy(HRT). Method: A cross-sectional survey design was utilized. A total of 116 married women aged 40 to 60 were recruited from women's groups in communities. They completed a structured questionnaire containing demographic characteristics, Orientation to Life Questionnaire, Menopausal Symptom Checklist, Health Belief of Korean Adult, Sexrole Idea of Kim, Dong-il, chronic illnesses, and a single item measuring marital satisfaction. Result: Thirteen percents of the women were currently taking HRT and 28.4% had intention to take HRT. Education, sense of coherence, and sex role attitude were related to women's susceptibility to menopause. Hysterectomy status and the level of sense of coherence explained women's perception of seriousness regarding menopause. In addition, chronic health conditions accounted for the variances of benefits and barriers to HRT. Factors influencing women's intention to take HRT were education, menopausal symptoms, and perceived benefits of HRT. Conclusion: Women's chronic health conditions, psychosocial characteristics as well as menopausal discomforts were associated with women's choice regarding HRT. Other factors related to decision making process of women's health seeking behaviors need to be explored.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2016.10a
• /
• pp.115-116
• /
• 2016

This study applied BS replacement mortar's ERCO to see what impact it has on moisture evaporation and contraction changes, and resulted in the following. Depending on the rate of change in length according to the cure method of BS replacement mortar, high-strength areas were shown to have a bigger increase in the rate of change in length than regular or low-strength areas, and differences in rate of change in length due to ERCO cure methods were shown to be slight. For rate of changes in mass, on the whole there was an increase in the order of dry curing, cover curing, 7-day water curing, and28-day water curing. A comprehensive view says that after removal of test piece specimens, ERCO application did not expect a sufficient curing effect in the BS area.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.6 no.1
• /
• pp.58-62
• /
• 2006

Gaucher disease is an inherited disorder due to a deficiency in the activity of glucocerebrosidase (EC. 3.2.1.45) by genetic mutation which resulted from missense, nonsense, frameshift, deletion in long arm 21 of chromosome 1 (1q21). Gaucher disease is classified into the main three types as type 1 (nonneuronopathic), type 2 (acute neuronopathic) and type 3 (subacute neuronopathic) according to the progressive phase of manifestations and nervous system involvement. Gaucher disease patients had been treated by using the method as splenectomy and bone marrow transplantation. But enzyme replacement therapy as a more effective treatment has been available since the early 1990's. In order to treat Gaucher disease efficiently by using ERT, it is necessary to chase the progress of the therapy. In this study, therefore, we tried to chase the progress of the ERT by using the measurement of chitotriosidase activity in Gaucher disease patients.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2007.04a
• /
• pp.43-46
• /
• 2007

This study dealt with the influence of the replacement ratio of rapidly-chilled steel slag on fluidity and compressive strength of unsaturated polyester polymer concretes. The rapidly-chilled steel slag used in this study, a by-product which is produced by refining pig iron during the manufacture of steel, was controled by a air-jet method which rapidly cools substance melted at a high temperature. Experimental results show that fluidity and compressive strength of unsaturated polyester polymer concretes increase with increasing replacement ratio of rapidly-chilled steel slag. Use of rapidly-chilled steel slag was found to be effective for improving fluidity and compressive strength of rapidly-chilled steel slag.

• Molecules and Cells
• /
• v.19 no.3
• /
• pp.365-374
• /
• 2005

To find potential targets of novel antimicrobial agents, we identified essential genes of Streptococcus pneumoniae using comparative genomics and allelic replacement mutagenesis. We compared the genome of S. pneumoniae R6 with those of Bacillus subtilis, Enterococcus faecalis, Escherichia coli, and Staphylococcus aureus, and selected 693 candidate target genes with > 40% amino acid sequence identity to the corresponding genes in at least two of the other species. The 693 genes were disrupted and 133 were found to be essential for growth. Of these, 32 encoded proteins of unknown function, and we were able to identify orthologues of 22 of these genes by genomic comparisons. The experimental method used in this study is easy to perform, rapid and efficient for identifying essential genes of bacterial pathogens.