• Journal of mucopolysaccharidosis and rare diseases
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• 제4권1호
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• pp.21-25
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• 2018

Fabry disease is a hereditary lysosomal storage disorder caused by the reduction or absence of lysosomal enzyme alpha-galactosidase A and the accumulation of glycosphingolipids, such as globotriaosylceramide (Gb3), in various organs, including the heart. The prevention of cardiac involvement in Fabry disease can only be achieved by enzyme replacement therapy (ERT), and the method of assessing the efficacy of ERT should be confirmed. Changes in the electrocardiogram, such as the shortening of PQ interval, prolongation of QTc and repolarization abnormalities as well as left ventricular hypertrophy in voltage criteria, can be used to identify Fabry disease patients; however, the usefulness of electrocardiograms for evaluating the efficacy of ERT is limited. The assessment of left ventricular hypertrophy using echocardiography has been established to evaluate the efficacy of ERT during long-term period. A new technique involving speckled tracking method might be useful for detecting early cardiac dysfunction and identifying the effect of ERT for a relatively short period. The estimation of left ventricular hypertrophy using cardiac magnetic resonance (CMR) is also useful for assessing the efficacy of ERT. Identifying late gadolinium enhancement in CMR may affect the effectiveness of ERT, and the new technique of T1 mapping might be useful for monitoring the accumulation of Gb3 during ERT. Histopathology in cardiac biopsy specimens is another potentially useful method for identifying the accumulation of GB3; however, the use of histopathology to evaluate of the efficacy of ERT is limited because of the invasive nature of an endomyocardial biopsy.

• 유통과학연구
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• 제13권7호
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• pp.19-24
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• 2015

Purpose - This study attempts to identify the attributes of home meal replacements (HMR) from the perspective of consumers as well as suggest some directions for HMR. Research Design, Data, and Methodology - For the research, food and nutrition professors were interviewed and surveys were completed using the revised Delphi method to identify attributes of HMR. Subsequently, a total of 140 food and nutrition students already aware of HMR were asked to rate the attributes in terms of importance and satisfaction. In addition, Importance-Performance Analysis (IPA) was conducted. Results - According to the analysis results, a total of seven key factors were deduced from the attributes ratings and the Kaiser-Meyer-Olkin (KMO) criteria, which is used to verify the appropriateness of the selection of the variables. Conclusion - The findings could be helpful in the future as reference data for HMR producers and distributors to assist in the diagnosis of the status of HMR. Additionally, the data may point to some areas that need greater attention in terms of production as well as marketing.

• 상하수도학회지
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• 제25권5호
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• pp.707-717
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• 2011

Replacement of old water distribution pipes for protecting water quality induced by pipe corrosion requires enormous budget. Even after the replacement, however, corrosion can occur again at any times and, therefore, inhibitive measure of the corrosion will be not only economical but needed to diminish the consumers' distrust on tap water quality. In 2008, National Environmental Research Institute did a survey on 8 major drinking water source and proposed to establish the Langelier Saturation Index(LI) as a corrosion index in Drinking Water Quality Criteria. Among the water industries of Korea, K-Water is the only one that set up the level of pH over 7.0 and LI above -1.5 on yearly average basis. However, no systematic regulation including LI to inhibit the corrosive tendency has been established yet. In this paper, LI values out of 31 drinking water treatment plants were analyzed and two-stage control of LI value as a measure of corrosive tendency of water is proposed. Primarily, water treatment facilities may operate the system at a target LI value below -1.5. Following the investigation on the effect caused by adjusting the LI value on water quality and corrosiveness, it will be desirable to improve LI value below -1.0 in the long run. In addition to the LI, supplemental use of Larson's modified ratio (LMR) which incorporates hydraulic detention time will be necessary. Several methods to prove the inhibitive effect of improving the LI value on water quality have been also suggested.

• 한국철도학회논문집
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• 제17권3호
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• pp.193-200
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• 2014

본 연구에서는 도시철도 콘크리트궤도 장대레일에 대한 실내피로시험을 수행하였고, 장대레일 잔존수명을 표현한 파괴확률 50% S-N 선도는 적은 실험데이터에 대한 가중치 확률 해석기법을 사용하여 도출하였다. 여기서 피로시험에 사용된 레일들이 누적통과톤수가 서로 다르기 때문에 누적통과톤수를 평균하여 반복횟수를 수정하였다. 또한, 레일표면요철 및 열차속도를 고려한 레일 저부 휨응력은 기존 연구결과 도출된 레일휨응력 예측식을 사용하여 콘크리트궤도 장대레일의 잔존수명을 평가하였다. 레일 피로수명 평가결과, 레일 피로수명이 기준치에 비해 약 2억톤이상 높았다. 또한, 자갈궤도에 비해 콘크리트궤도 레일의 피로수명이 약 3억톤이상 높은 것으로 분석되었다. 따라서 도시철도에서 레일교체기준을 자갈궤도와 콘크리트궤도로 구분할 필요가 있으며, 레일연마를 통한 레일관리가 이루어진다면 기준치가 아닌 목표치로 관리할 수 있을 것으로 판단되었다.

• 유기물자원화
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• 제27권1호
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• pp.5-14
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• 2019

논 조건의 포트규모에서 유기질 비료로 화학비료 밑거름량을 대체하기 위해 벼의 정조수량, 쌀 품질 기준인 단백질 함량, 토양 화학적 특성에 미치는 영향을 조사하였다. 벼 생산에 적정인 유기물함량을 지닌 토양 1에서 벼의 생산량은 다른 처리구보다 70 %, 100 %에서 높았다. 벼 생산에 적정보다 높은 유기물함량을 지닌 토양 2에서 벼의 생산량은 NPK, 유기질비료 30%, 70%, 100%, 300%에서 차이가 없었다. 쌀 품질에 대한 단백질 기준이 7 % 이하를 적용할 때 유기질비료 3종(혼합유기질비료, 혼합유박, 유기복합)의 처리구 중에서 70 %, 100 % 처리구가 쌀 품질의 단백질 기준에 적합하였다. 유기질비료 30 %, 70 %, 100 %, 300 % 처리에서 유기물 함량, 암모늄태 질소 및 전기전도도는 NPK 처리와 유사한 경향을 보였다. 이러한 결과로부터 표준 질소 밑거름 시용량의 70 ~ 100 % 수준으로 유기질 비료 3종에 대해 투입하는 것이 농경지의 적절한 양분을 유지하고 쌀의 수확량과 품질을 유지하는 좋은 방법이라 판단된다.

• 한국지반환경공학회 논문집
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• 제4권4호
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• pp.25-34
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• 2003

본 논문에서는 일련의 실내실험을 통하여 하수회의 기본특성, 다짐, 압축강도, 압밀, 투수 및 CBR 특성을 분석하여 폐기물 매립장의 차수재 및 복토재 등의 건설재료로서 하수슬러지 소각재의 활용방안을 연구하였다. 특히, 하수슬러지 소각재의 치환률을 5, 10, 15, 20, 25, 30%로 변화시키면서 점토벽돌을 제작하여 품질시험을 실시하였다. 하수슬러지 소각재의 투수특성을 확보하기 위하여 혼합재로서 벤토나이트와 소석회를 사용하였다. 실험결과, 벤토나이트 혼합비가 증가함에 따라 투수계수는 감소하며 차수재로 사용가능한 투수계수가 $1{\times}10^{-7}cm/sec$ 이하로 되는 벤토나이트의 혼합비는 20% 정도로 나타났다. 일축압축시험결과 하수슬러지 소각재는 복토재의 일축압축강도 기준을 만족하는 것으로 평가되었다. 점토벽돌에 대한 품질시험 결과 하수슬러지 소각재의 치환률이 증가함에 따라 압축강도는 감소하였으며, 3종 점토벽돌의 품질기준을 만족하는 하수회의 최대치환률은 15% 정도로 나타났다.

• 한국농공학회지
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• 제36권4호
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• pp.103-116
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• 1994

The objective of this study was to determine the criteria for density and moisture content measurements made with a nuclear density meter on common materials in the construction field. The study also sought to test a full-type nuclear density meter in controlling the density of overlay layers( 2.5~5.0cm). In order to determine the accuracy and reliablility of nuclear guage measurements made on construction materials, laboratory and field tests were conducted. Wooden blocks( 65 x 45 ${\times}$ 50 cm) and a special steel compactor( 4.7kg) were constructed in order to carry out tests which were conducted on three different materials; coarse gramed soil, fine grained soil, and AC material. Throughout all laboratory and field tests, the nuclear density and moisture content were determined using Humboldt 5OOLP nuclear gauge. The tests on subgrade material entailed obtaining density measurements by means of both the sand replacement method and the nuclear density meter. The results of the sand replacement method were then compared to the readings recorded bu the meter. As in the subgrade material tests, density measurements made during AC pavement tests were also determined using the unclear meter in addition to a second means; through the core method. The meter readings and core densties were compared as was done in the tests on subgrade materials. The correlation between the results of the sand replacement test( also, the core method) and meter readings on subgrade material was then determined. Sirnilarly, the observed results were then analyzed through linear regression. The tests to determine thin-lift density by means of a full-type nuclear density meter also conducted on the overlay layers( about 4. 8cm thickness) above AC pavements at road construction sities in Korea.

• Journal of Korean Neurosurgical Society
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• 제60권6호
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• pp.676-683
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• 2017

Objective : The purpose of this study is to evaluate the efficacy and safety of 3-level hybrid surgery (HS), which combines fusion and cervical disc replacement (CDR), compared to 3-level fusionin patient with cervical spondylosis involving 3 levels. Methods : Patients in the anterior cervical discectomy and fusion (ACDF) group (n=30) underwent 3-level fusion and the HS group (n=19) underwent combined surgery with fusion and CDR. Clinical outcomes were evaluated using the visual analogue scale for the arm, the neck disability index (NDI), Odom criteria and postoperative complications. The cervical range of motion (ROM), fusion rate and adjacent segments degeneration were assessed with radiographs. Results : Significant improvements in arm pain relief and functional outcome were observed in ACDF and HS group. The NDI in the HS group showed better improvement 6 months after surgery than that of the ACDF group. The ACDF group had a lower fusion rate, higher incidence of device related complications and radiological changes in adjacent segments compared with the HS group. The better recovery of cervical ROM was observed in HS group. However, that of the ACDF group was significantly decreased and did not recover. Conclusion : The HS group was better than the ACDF group in terms of NDI, cervical ROM, fusion rate, incidence of postoperative complications and adjacent segment degeneration.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2016년도 춘계 학술논문 발표대회
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• pp.87-88
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• 2016

In order to assess the design value of engineering work from the point of view of LCC (Life Cycle Cost) in Korea, it is mandatory for all construction works that the total construction costs are over 10 billion won. The LCC includes initial construction costs, maintenance & operation costs, energy costs, end-of-life costs, and so on. Among these, the portion for maintenance & operation costs for a building is sizeable, as compared to the initial construction costs. Furthermore, the paradigm for construction industry has rapidly shifted from 2D to BIM, which includes design planning and data management. However, the study of BIM-based LCC analysis is not adequate today, even though all domestic construction projects ordered by the Public Procurement Service have to adopt BIM. Therefore, this study suggests a methodology of BIM-based LCC analysis that is particularly focused on repair and replacement (R&R) cost. For this purpose, we defined requirements of calculating R&R cost and extracted X from the relevant IFC data. Thereafter, we input them to the ontology of calculating the initial construction costs to obtain an objective output. Finally, in order to automatically calculate R&R cost, mapping with R&R criteria was performed. We expect that our methodology will contribute to more efficiently calculate R&R cost and, furthermore, that this methodology will be applicable to all range of total LCC. Thus, the proposed process of automatic BIM-based LCC analysis will contribute to making LCC analysis more fast and accurate than it is at present.

• Journal of Advanced Marine Engineering and Technology
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• 제38권4호
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• pp.456-462
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• 2014

본 논문에서는 시설물의 효율적인 유지보수를 지원하기 위하여 시설물을 구성하는 부품의 고장 영향 및 교체 주기 알람 기능을 제공하는 시설물 관리 시스템의 개발에 관한 내용을 다룬다. 이를 위해 시설물의 BOM을 활용하여 시설물을 구성하는 각 부품에 가중치를 부여하여 부품별 중요도를 계산하고 부품 간의 관계를 구조화하였다. 또한 BOM에 FMECA 기법을 도입하여 시설물을 구성하는 각 부품별 고장 원인 및 영향 등을 도출하였으며, 시설물에서의 위험 우선순위를 구하기 위한 심각도, 발생도, 검출도에 관한 기준을 정의하였다. 이러한 내용을 반영하여 웹 기반 시설물 관리 시스템을 개발하였으며 이를 통해 제안하는 방법의 유용성을 실험하였다. 개발한 시스템은 향후 시설물의 관리뿐만 아니라 선박 및 해양플랜트의 유지보수 등 여러 분야에 적용될 수 있을 것으로 기대된다.