• Journal of The Korean Association For Science Education
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• v.36 no.1
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• pp.113-123
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• 2016

The purpose of this study is to understand the elementary student's growth and its implications from the students' experience participating in the science fair by phenomenological study. The results are as follows. First, the students have various experiences. They acquire scientific knowledge and inquiry skills by conducting in-depth experiments, visiting several places, and interviewing experts. They have some experience in writing experiment journals to record the inquiry process in their own language, and presenting their results in public. Second, the students suffer several difficulties while preparing for the science fair. They have some difficulties when the results were not consistent with the hypothesis, or they had to repeat the experiment over and over. They feel burdened in writing the experiment journal. They had a few time to meet friends or for hobbies. Third, the students improve scientific attitude through the science fair, and they receive a positive effect on the affective side. They developed scientific interest, curiosity, cooperation, etc. And they also gained a sense of accomplishment, confidence, friendship, good relationship with teachers, career interest, etc. This study finds out that students participating in the science fair have a lot of experience that cannot be done easily in a normal science class. Even though students confront some difficulties in the inquiry process, they make good progression and feel accomplished. So the science fair is valuable experience for them.

• The Korean Journal of Malacology
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• v.30 no.4
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• pp.429-431
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• 2014

Since we reported a BLAST server for the mollusk in 2004, no work has reported the usability or modification of the server. To improve its usability, the BLAST server for the mollusk has been updated as version II (http://www.malacol.or.kr/blast) in the present study. The database was constructed by using the Intel server Platform ZSS130 dual Xeon 3.20 GHz CPU and Linux CentOS system and with NCBI WebBLAST package. We downloaded the mollusk nucleotide, amino acid, EST, GSS and mitochondrial genome sequences which can be opened through NCBI web BLAST and used them to build up the database. The updated database consists of 520,977 nucleotide sequences, 229,857 amino acid sequences, 586,498 EST sequences, 23,112 GSS and 565 mitochondrial genome sequences. Total database size is 1.2 GB. Furthermore, we have added repeat sequences, Escherichia coli sequences and vector sequences to facilitate data validation. The newly updated BLAST server for the mollusk will be useful for many malacological researchers as it will save time to identify and study various molluscan genes.

• Journal of KIISE:Databases
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• v.37 no.1
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• pp.1-11
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• 2010

Recently, there has been a growing interest in the processing of continuous queries over multiple data streams. When the arrival rates of tuples exceed the memory capacity of the system, a load shedding technique is used to avoid the system becoming overloaded by dropping some subset of input tuples. In this paper, we propose an effective load shedding algorithm for multi-way windowed joins over multiple data streams. Most previous load shedding algorithms estimate the productivity of each tuple, i.e., the number of join output tuples produced by the tuple, based on its "join attribute value" and drop tuples with the lowest productivity. However, the productivity of a tuple cannot be accurately estimated from its join attribute value when the join attribute values are unique and do not repeat, or the distribution of the join attribute values changes over time. For these cases, we estimate the productivity of a tuple based on its "arrival order" on data streams, rather than its join attribute value. The proposed method can effectively estimate the productivity of a tuple even when the productivity of a tuple cannot be accurately estimated from its join attribute value. Through extensive experiments and analysis, we show that our proposed method outperforms the previous methods in terms of effectiveness and efficiency.

• Journal of KIISE:Information Networking
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• v.36 no.1
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• pp.34-42
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• 2009

In this paper, we propose a practical hybrid transport error control scheme to provide SVC video streaming service over error-prone IP networks. Many error control mechanisms for various video coding standards have been proposed in the literature. However, there is little research result which can be practically applicable to the multilayered coding structure of SVC(the scalable extension of H.264/AVC). We present a new hybrid transport error control scheme that efficiently combines layered Forward Error Correction(FEC) and Automatic Repeat Request(ARQ) for better packet-loss resilience. In the proposed hybrid error control, we adopt ACK-based ARQ instead of NACK-based ARQ to maximize throughput which is the amount of effective data packets delivered over a physical link per time unit. In order to prove the effectiveness of the proposed hybrid error control scheme, we adopt NIST-Net network emulator which is a general-purpose tool for emulating performance dynamics in IP networks. It is shown by simulations over the NIST-Net that the proposed hybrid error control scheme shows improved packet-loss resilience even with much less number of overhead packets compared to various conventional error control schemes.

• The KIPS Transactions:PartD
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• v.8D no.4
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• pp.313-326
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• 2001

The XML that was proposed as a next-generation standard for describing Web documents is widely used in various Web-based applications. In addition, XML documents on the Web link each other by hyperlinks. The current works on XML focus on the XML storage system that can efficiently store, manage, and retrieve XML documents. However, the research on the query language that supports the XML links and on the XML retrieval systems to process the XML links, is little conducted until now. In this paper, we propose an extension of an XML query language for expressing the XML link query and its processing scheme. A link query is to retrieve contents from an XML document (a query document) and from the XML documents (referenced documents) that are referred to by the links in the query document. As far as retrieving from the referenced documents is concerned, the current practice is to manually generate queries to get the partial results, and to repeat such a procedure. The purpose of link query processing in this paper is to eliminate the manual work altogether in getting the complete query result. The performance analysis shows that our link query processing strategy outperforms the conventional approach including the manual tasks. The more links to the referenced documents and the more referenced documents there are in the site storing the query document, the more query processing time decreases.

• KIPS Transactions on Software and Data Engineering
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• v.6 no.2
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• pp.103-116
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• 2017

In this paper, we present the design and implementation of a large-scale qualitative spatial reasoner, which can derive new qualitative spatial knowledge representing both topological and directional relationships between two arbitrary spatial objects in efficient way using Aparch Spark SQL. Apache Spark SQL is well known as a distributed parallel programming environment which provides both efficient join operations and query processing functions over a variety of data in Hadoop cluster computer systems. In our spatial reasoner, the overall reasoning process is divided into 6 jobs such as knowledge encoding, inverse reasoning, equal reasoning, transitive reasoning, relation refining, knowledge decoding, and then the execution order over the reasoning jobs is determined in consideration of both logical causal relationships and computational efficiency. The knowledge encoding job reduces the size of knowledge base to reason over by transforming the input knowledge of XML/RDF form into one of more precise form. Repeat of the transitive reasoning job and the relation refining job usually consumes most of computational time and storage for the overall reasoning process. In order to improve the jobs, our reasoner finds out the minimal disjunctive relations for qualitative spatial reasoning, and then, based upon them, it not only reduces the composition table to be used for the transitive reasoning job, but also optimizes the relation refining job. Through experiments using a large-scale benchmarking spatial knowledge base, the proposed reasoner showed high performance and scalability.

• KIPS Transactions on Computer and Communication Systems
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• v.2 no.9
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• pp.381-392
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• 2013

During the last decade, the multitude of advances attained in terminal computers, along with the introduction of mobile hand-held devices, and the deployment of high speed networks have led to a recent surge of interest in Quality of Service (QoS) for video applications. The main difficulty is that mobile devices experience disparate channel conditions, which results in different rates and patterns of packet loss. One way of making more efficient use of network resources in video services over wireless channels with heterogeneous characteristics to heterogeneous types of mobile device is to use a scalable video coding (SVC). An SVC divides a video stream into a base layer and a single or multiple enhancement layers. We have to ensure that the base layer of the video stream is successfully received and decoded by the subscribers, because it provides the basis for the subsequent decoding of the enhancement layer(s). At the same time, a system should be designed so that the enhancement layer(s) can be successfully decoded by as many users as possible, so that the average QoS is as high as possible. To accommodate these characteristics, we propose an efficient transmission scheme which incorporates SVC-aware dual-channel repetition to improve the perceived quality of services. We repeat the base-layer data over two channels, with different characteristics, to exploit transmission diversity. On the other hand, those channels are utilized to increase the data rate of enhancement layer data. This arrangement reduces service disruption under poor channel conditions by protecting the data that is more important to video decoding. Simulations show that our scheme safeguards the important packets and improves perceived video quality at a mobile device.

• Parasites, Hosts and Diseases
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• v.56 no.2
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• pp.135-145
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• 2018

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little is known about the signaling events in RPE involved in Toxoplasma gondii infection and development. The aim of the study is to screen the host mRNA transcriptional change of 3 inflammation-related gene categories, PI3K/Akt pathway regulatory components, blood vessel development factors and ROS regulators, to prove that PI3K/Akt or mTOR signaling pathway play an essential role in regulating the selected inflammation-related genes. The selected genes include PH domain and leucine- rich-repeat protein phosphatases (PHLPP), casein kinase2 (CK2), vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), glutamate-cysteine ligase (GCL), glutathione S-transferase (GST), and NAD(P)H: quinone oxidoreductase (NQO1). Using reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), we found that T. gondii up-regulates PHLPP2, $CK2{\beta}$, VEGF, GCL, GST and NQO1 gene expression levels, but down-regulates PHLPP1 and PEDF mRNA transcription levels. PI3K inhibition and mTOR inhibition by specific inhibitors showed that most of these host gene expression patterns were due to activation of PI3K/Akt or mTOR pathways with some exceptional cases. Taken together, our results reveal a new molecular mechanism of these gene expression change dependent on PI3K/Akt or mTOR pathways and highlight more systematical insight of how an intracellular T. gondii can manipulate host genes to avoid host defense.

• Journal of Society of Preventive Korean Medicine
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• v.17 no.2
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• pp.139-155
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• 2013

Purpose : This study was aim to evaluate effects of pharmacodynamics and toxicity in combination therapy of donepezil with Gongjindan. The effects of Gongjindan co-administration on the pharmacokinetics (PK) of donepezil were observed after single and 7-day repeated oral co-administration with 1.5hr-intervals, to evaluate synergic pharmacodynamics and reduce toxicity of combination therapy of donepezil with Gongjindan. Materials and Methods : After 10mg/kg of donepezil treatment, Gongjindan100mg/kg was administered with 1.5hr-intervals. The plasma were collected at 30min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24hrs after end of first and last 7th donepezil treatment, and plasma concentrations of donepezil were analyzed using LC-MS/MS methods. Results : Gongjindan markedly inhibited the absorption of donepezilregardless of sample time, from 30min to 8hrs after end of first 1.5hr-interval co-administration as compared with donepezil single treated rats. Especially the absorption of donepezil was significantly decreased at 2, 4, 6 and 8hrs after co-administration as compared with donepezilsingle treated rats. Accordingly, the Cmax (-26.236%), $AUC_{0-t}$(-26.02%) and $AUC_{0-inf}$(-25.90%) of donepezil in 1.5hr-interval co-administered rats were dramatically decreased as compared with donepezilsingle treated rats, respectively. However, no meaningful changes on the plasma donepezil concentrations and pharmacokinetic parameters were detected after end of last 7th 1.5hr-interval co-administration as compared with donerezil single treated rats, except for non-significant slight increases of Tmax(16.67%) detected in co-administered rats as compared with donepezil single treated rats. Conclusion : These findings are considered as direct evidences that Gongjindan also decreased oral bioavailability of donerezil as inhibited the absorptions, when they were co-administered with 1.5hr-intervals, but they may be adapted after 7 days continuous repeated l.5hr-interval co-administration.

• Journal of Korean Neurosurgical Society
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• v.48 no.3
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• pp.240-243
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• 2010

Objective : Radiofrequency (RF) medial branch neurotomy is an effective management of lumbar facet syndrome. However, pain may recur after period of time. When pain recurs, it can be repeated, but the successful outcome and duration of relief from repeated procedures are not clearly known. The objective of this study was to determine the success rate and duration of pain relief from repeated radiofrequency medial branch neurotomy for lumbar facet syndrome. Methods : A retrospective review of medical records was done on 60 consecutive patients, from March of 2006 to February of 2009, who had an initial successful RF neurotomy but subsequently underwent repeated procedures due to recurrence of pain. All procedures were done in carefully selected patients after at least two responsive medial branch nerve blocks. C-arm fluoroscopic guide, impedance, sensory and motor threshold monitoring tools were used for the precise placement of electrodes. Responses of repeated procedures were compared with initial radiofrequency neurotomy for success rates and duration of pain relief. Results : There were 48 females and 12 males. Mean age was 52.4 years (range, 26-83). RF medial branch neurotomy was done on one side in 38 and both sides in 22 patients, each covering at least three segments. Average visual analog scale at last procedure was 6.8. Twelve patients had previous lumbar operations, including 4 patients with instrumentations. Fifty-five patients had two procedures and five patients had three procedures. Mean duration of successful pain relief (> 50% of previous pain for at least 3 months period) after initial radiofrequency neurotomy was 10.9 months (range, 3-28) in 51 (85%) patients. From repeated procedures, successful pain relief was seen in 50 (91%) patients with average duration of 10.2 months (range, 3-24). Five patients had third procedure, which was successful in 4 (80%) patients with mean duration of 9.8 months (range, 5-16). This was not statistically different from initial results. There were no permanent neurological complications from the procedures. Conclusion : Results of this study indicate that the frequency of success and durations of relief from repeated RF medial branch neurotomy for lumbar facet syndrome are similar to initial results that provided relatively prolonged period of pain relief without major side effects Each procedure seems to provide successful pain relief for about 10 months in more than 85% of carefully selected patients when properly done.