• 보존과학연구
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• 통권23호
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• pp.59-75
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• 2002

In this study human bones and teeth, excavated from the Myeongam-risite in Asan, Chungcheongnam-do Province, have been analysed by nuclear DNA typing and mitochondrial DNA sequencing methods. Twenty-one samples of long bones and twenty-seven samples of teeth from twenty-one individuals were collected and analysed. Among these thirteenteeth were successfully subjected to nuclear DNA extraction, quantification, and PCR(Polymerase Chain Reaction) amplification. Silver STR III (D16S539, D7S820, D13S317) multiplex PCR method was used in this study for a short tandem repeat (STR) analysis. Mitochondrial DNAs of tooth samples were also amplified and sequenced by a DNA sequencer. These analyses show that a sample from Burial no. 29 and one from Burial no. 38(right) possessed the same maternal inheritance. This may suggest that the Myeongam-ri cemetery was used by a kin group for a relatively long period of time.

• International Journal of Computer Science & Network Security
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• 제21권9호
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• pp.212-222
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• 2021

Multiple waves of COVID-19 highlighted one crucial aspect of this pandemic worldwide that factors affecting the spread of COVID-19 infection are evolving based on various regional and local practices and events. The introduction of vaccines since early 2021 is expected to significantly control and reduce the cases. However, virus mutations and its new variant has challenged these expectations. Several countries, which contained the COVID-19 pandemic successfully in the first wave, failed to repeat the same in the second and third waves. This work focuses on COVID-19 pandemic control and management in Saudi Arabia. This work aims to predict new cases using deep learning using various important factors. The proposed method is called Deep Learning and Dynamic Weighing-based (DLDW) COVID-19 cases prediction method. Special consideration has been given to the evolving factors that are responsible for recent surges in the pandemic. For this purpose, two weights are assigned to data instance which are based on feature importance and dynamic weight-based time. Older data is given fewer weights and vice-versa. Feature selection identifies the factors affecting the rate of new cases evolved over the period. The DLDW method produced 80.39% prediction accuracy, 6.54%, 9.15%, and 7.19% higher than the three other classifiers, Deep learning (DL), Random Forest (RF), and Gradient Boosting Machine (GBM). Further in Saudi Arabia, our study implicitly concluded that lockdowns, vaccination, and self-aware restricted mobility of residents are effective tools in controlling and managing the COVID-19 pandemic.

• 휴양 및 경관연구
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• 제12권4호
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• pp.11-16
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• 2018

The aim of this study is to obtain basic data to set the direction for construct and managing auto campsites. A survey was conducted with users of an auto campsite located in Jangsu Nuri Park in October 2018, and 32 copies of the questionnaire were used in the analysis. Auto camping is typically undertaken for a night or two with family or friends/colleagues. The adequacy of fees and location are important factors in choosing the campsite, so it is desirable to build one in the suburbs of the city and offer it at a reasonable price. Proximity to tourist spots and convenience in using facilities are also factors that must be considered. People are generally engaged in activities such as taking walks, relaxing, and looking around campsites, and they want to enjoy various other amenities like attractions, experiences, entertainment, and active leisure options, which is why there must be facilities to support these behaviors. The first-time visitors of the campsite showed high satisfaction with its individual facilities, while repeat visitors showed high overall satisfaction, which indicates that satisfaction with individual elements did not lead to overall satisfaction.

• 한국의류학회지
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• 제44권5호
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• pp.950-968
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• 2020

This study derives the modern characteristics of the paisley ornament through an analysis of the paisley ornament shown in fashion since the 2010s based on a theoretical review of the paisley ornament used in Kashmir India shawls for artistic inspiration in the fashion-textile field. It classified the paisley ornament in fashion since the 2010s into types of 'basic structure of body and coif', 'abnormal paisley ornament shapes', 'complex structure of paisley ornament', 'complex structure with other motif', 'a pair of symmetrical reflection motif', 'regular of repetitive arrangement', 'complex arrangement of irregularity and regularity' and 'free arrangement of irregularity'. A comparative analysis with the historical paisley ornament shows that paisley ornaments have contemporary characteristics like 'Bisector structure of centerline in criterion of the body', 'Composite structure of extended 1-repeat', and 'Free structure of engineered placement'. A modern design was inspired by the historical art forms; however, it was used in free utilization of motifs and patterns in terms of size, direction, proportion and space. These were the expression of a design identity that originated from the aesthetic ability and career of a designer as well as the technology of computer programs for the improvements in time and cost efficiency.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제47권3호
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• pp.209-215
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• 2021

Objectives: Vascular malformation (VM) of the tongue can cause true macroglossia in children. Reduction glossectomy provides primary relief when sclerotherapy has failed or is not possible. In this study, we evaluated the surgical role in functional outcome of reduction glossectomy performed for VM of the tongue. Patients and Methods: We evaluated the functional and surgical outcomes of seven children who were treated at a tertiary care centre in Southern India between 2013 and 2018. Results: Six children underwent median glossectomy, while one child underwent lateral glossectomy. Functional assessment was performed at least 2 years after the date of surgery. At the time of assessment, speech was comprehensible for three children and was occasionally unintelligible in four children. Taste and swallowing were normal in all seven children. Six children exhibited a minimal residual lesion after surgery, of which only one was symptomatic. Residual lesions were managed with sclerotherapy (n=3), observation (n=2), or repeat surgery (n=1). Conclusion: Reduction glossectomy in children with macroglossia secondary to VMs has acceptable outcomes in terms of cosmesis and speech, with no gastronomic restriction.

• 대한한방부인과학회지
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• 제35권1호
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• pp.91-104
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• 2022

Objectives: The purpose of this study is to report the effect of combination treatment of Traditional Korean medicine (TKM) and chemotherapy on a ovarian cancer with lung metastasis patient. Methods: One ovarian cancer with lung metastasis patient was treated by TKM in conjunction with Carboplatin/paclitaxel since Feb. 2020. Repeat cycle every 3 weeks for 6 times. The patient has been treated with TKM at the same time. To evaluate the patient, symptoms were measured by Numeric Rating Scale (NRS), Eastern Cooperative Oncology Group (ECOG) and tumor size was measured by scanning with Computed Tomography (CT). Blood tests including cancer biomarker were conducted during treatment. Adverse events were evaluated by the National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), version 5.0. Results: After treatment with Carboplatin/paclitaxel and TKM during 2 months, the size of the ovarian cancer was decreased(Partial Response, PR), size and malignant pleural effusion at right lung disappeared. And no evidence of newly developed metastatic lesions. After 2 months, the tumor response was stable disease while improving the performance and other symptoms. Conclusions: This case provides us conjunctive treatment with Conventional and Eastern medicine may have substantial benefit for patients with end-stage ovarian cancer.

• 대한중풍순환신경학회지
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• 제18권1호
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• pp.1-11
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• 2017

It is difficult to combine oriental and western medicine. Each medicine has a different academic background, perspective on the world, and studying methodology. The claim that two paradigms can not be combined is not obtained from an actual verification, but this means it is so hard to combine two medicines having different backgrounds. The amalgamation of oriental and western medicine should be phased in on the basis of the continuous reciprocal understanding and commitment. First, the strength and weakness of each medicine over the treatment and research are required to be identified. Then, a few complementary areas can be chosen enabling a trial of fusion on a small scale. A cycle of problem solving and a new research can be set by analyzing research results obtained through the implementation over a period of time. In other words, the researchers of oriental and western medicine should repeat a continuous and gradual complementary research process by identifying issues to be improved and complemented through a consensus. Once the methodology obtained through the process of problem solving and proficient implementation is established in a stable condition, a method to widen the fusion area by expanding the operating area and implementation method can be chosen. However, the integral system of oriental medicine shouldn't be substituted by mechanical idea or reductionism. What should be done primarily for oriental medicine is to objectify things through quantification. In particular, the oriental treatment should accept the microscopic diagnosis to determine the structure and observe the biochemical change.

• BMB Reports
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• 제57권1호
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• pp.40-49
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• 2024

Prokaryotes encode clustered regularly interspaced short palindromic repeat (CRISPR) arrays and CRISPR-associated (Cas) genes as an adaptive immune machinery. CRISPR-Cas systems effectively protect hosts from the invasion of foreign enemies, such as bacteriophages and plasmids. During a process called 'adaptation', non-self-nucleic acid fragments are acquired as spacers between repeats in the host CRISPR array, to establish immunological memory. The highly conserved Cas1-Cas2 complexes function as molecular recorders to integrate spacers in a time course manner, which can subsequently be expressed as crRNAs complexed with Cas effector proteins for the RNA-guided interference pathways. In some of the RNA-targeting type III systems, Cas1 proteins are fused with reverse transcriptase (RT), indicating that RT-Cas1-Cas2 complexes can acquire RNA transcripts for spacer acquisition. In this review, we summarize current studies that focus on the molecular structure and function of the RT-fused Cas1-Cas2 integrase, and its potential applications as a directional RNA-recording tool in cells. Furthermore, we highlight outstanding questions for RT-Cas1-Cas2 studies and future directions for RNA-recording CRISPR technologies.

• 공업화학
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• 제10권5호
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• pp.767-771
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• 1999

내열성 전기 절연 coating에 사용되는 기본 수지인 poly(ester-imide) (PEI)의 1단계 및 2단계 합성법을 비교하였으며 촉매의 영향도 조사하였다. Poly(ester-imide) 수지의 합성에 있어서 trimellitic anhydride(TMA)와 methylene dianiline(MDA)으로부터 imide 반복 단위를 구성하는 N,N'-(4,4'-diphenylmethane)bistrimellitimide(DID)를 먼저 합성하고 에스테르화 반응을 시키는 2단계법과 TMA, MDA, dimethyl terephthalate(DMT) 및 ethylene glycol(EG), 1,3,5-tris-(2-hydroxy ethyl)isocyanurate(THEIC)를 모두 m-cresol 용매에 넣고 반응시키는 1단계법이 동등한 PEI 수지를 생성함을 확인할 수 있었다. 합성된 poly(ester-imide) 수지 용액에 xylene, phenol-formaldehyde 수지인 P-5030K, TDI type blocked isocyanate인 TK-8 및 tetrapropyltitanate(TPT)를 첨가하여 경화 반응을 시키고 생성된 피막의 유연성 및 투명도를 조사한 결과 히드록실기의 함량, DMT의 첨가 및 imide 반복 단위의 함량이 내열성 절연 코팅의 물성에 중요한 인자로 작용함을 알 수 있었다.

• 한국안광학회지
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• 제20권1호
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• pp.75-81
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• 2015

목적: 본 연구는 안구에 존재하는 항산화효소인 superoxide dismutase(SOD)와 catalase(CAT)가 UV-A에 반복적으로 노출되었을 때 이들의 구조 및 활성의 변화가 유발되는지 알아보고 이들의 상관관계를 밝히고자 수행되었다. 방법: SOD와 CAT의 표준품으로 각각의 효소용액을 제조하고 하루 30분, 1시간 및 2시간씩 365 nm의 UV-A에 노출시키는 조건으로 1, 2, 3, 4 및 5일 동안 UV-A에 반복적으로 노출시켰다. UV-A 반복노출에 따른 SOD와 CAT의 구조변성은 전기영동분석으로 확인하였으며, 이들 효소의 활성은 분석키트를 이용하여 비색분석법으로 측정하였다. 결과: UV-A에 반복노출된 SOD는 일일 1시간 이상 조건으로 반복노출되었을 때 전기영동분석에서 효소의 다중화(polymerization)가 관찰되었으나 활성의 변화는 12% 이내로 나타났다. 반면 UV-A에 반복노출된 CAT는 전기영동 시 효소의 밴드크기가 감소하여 구조변성이 나타났음을 알 수 있었으며, 효소활성 또한 유의하게 감소됨을 확인하였다. 반복노출시간이 긴 경우 CAT은 전기영동분석에서는 효소밴드를 보임에도 불구하고 그 활성은 완전히 소실됨을 알 수 있었다. 결론: 이상의 결과로 UV-A 반복노출에 따른 항산화효소의 구조변성은 효소의 종류에 따라 그 정도와 양상이 다르게 나타나며, 구조변성이 효소활성의 감소정도와 반드시 일치하는 것은 아님을 알 수 있었다.