• Journal of Korean Biological Nursing Science
• /
• 제10권2호
• /
• pp.170-175
• /
• 2008

Purpose: The purpose of this study was to predict treatment outcome of chemotherapy compared with and bone marrow transplantation in acute leukemia patients. Methods: We respectively reviewed the characteristics of subjects, cytokine, complete remission time and survival time of 111 patients with acute leukemia, admitted in St. Mary's hospital, between July 2007 and August 2008. Results: The complete remission rate with chemotherapy group was 70.8% and bone marrow transplantation group was 54.3% but without statistically significance. The prognostic factors related with survival is classification of acute leukemia and complete remission time. Conclusion: This study suggests a need for nursing research and nursing intervention for acute leukemia patients.

• Korean Journal of Acupuncture
• /
• 제36권3호
• /
• pp.181-187
• /
• 2019

This case report details induction and maintenance of remission in a 34-year-old female patient with ulcerative colitis (UC) after Korean herbal medicine treatment. The patient diagnosed as UC after a series of examinations including endoscopy in a western medical hospital mainly presented bloody diarrhea and dyspepsia and symptoms were persistent even with medications. She was given individualized Korean herbal medicine prescriptions for 7 months and the symptoms were monitored during treatment and no adverse events were reported. After clinical remission, endoscopic remission was also confirmed by colonoscopy. Clinical remission was maintained for 30 months after treatment without Western medication for UC. This case report shows that Korean herbal medicine treatment may have the potential for complete remission of UC and further research is warranted.

• Journal of Chest Surgery
• /
• 제29권9호
• /
• pp.1010-1016
• /
• 1996

중증근무력증환자에 있어서 흉선 절제술은 대상이 되는 환자의 선택 기준이나 수술시기, 수술 방법에 있어서 아직까지 논란이 되고 있지만 긍정적으로 적용될 수 있는 치료 방법이다. 연세대학교흉부외과 학교실 신촌 세브란스병원에서는 1983년 1월부터 1994년 12월까지 중증근무력증으로 흉선 절제술을 시행한 82명의 환자를 대상으로 연구하였다. 수술 사망은 1명에서 발생하였고 수술 후 추적은 75명에서 가능하였고 평균 추적기간은 56.9개월 이었다. 완전관해된 28명(37.3%)을 포함하여 64명(85.3%)에서 수술로 인한 효과를 볼 수 있었다. 동반된 질환으로는 갑상선 질환이 8예로 가장 많았는데 이중 7명(87. 5%)이 완전관해를 보여 갑상선 질환을 동반하지 않은 환자 67명중 21명(31.3%)의 완전관해보다 높은 치료 성공율을 나타내었다. 수술 전 병력 기간이 2년 미만인 환자 32명중 16명(50%), 2년 이상인 환자 43명중 12명(27.4%)이 완전관해를 보여 수술전병력 기간이 2년 미만인 경우 높은 치료율을 보였다. 결론적으로 중증근무력증환자에 있어서 흉선 절제술 후 완전관해율은 갑상선 질환의 동반 여부와 수술 전 병력기간에의해 영향을 받음을 알 수 \ulcorner었으며 병의 발생 연령(40세 이상),흉선종의 동반,고령 및 남자의 경우 수술 후 완전관해율을 떨어뜨리는 것으로 나타났지만 통계적 의의는 없었다. 흉선의 조 직학적 소견으로 정상과 흉선 비후사이에 있어서 완전관해율의 차이는 보이지 않았다. 일반적으로 흉선 절제술은 대부분의 중증근무력증환자에 있어서 효과가 있었으나 임상증상적 분류로 기 속한 환자군은 수술로 인한 효과가 없었다.

• Journal of Yeungnam Medical Science
• /
• 제21권2호
• /
• pp.237-241
• /
• 2004

Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder that is characterized by cytopenia, splenomegaly, and mononuclear cells displaying cytoplasmic projections. We experienced a case of hairy cell leukemia that developed in a 38-year-old man. He showed marked splenomegaly without palpable lymphoadenopathy. A complete blood cell count revealed leukopenia ($3300/{\mu}{\ell}$ with 63% of lymphocyte) and the peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow smear revealed abnormal lymphocytes and severe myelofibrosis. Tartrate-resistant acid phosphatase reactivity was strongly positive in the hairy cells. The immunophenotyping results of lymphoid cells were CD5(-), CD10(-), CD19(+), CD25(+), CD103(+), CD20(+), lambda(+). The patient was treated with 2-Chlorodeoxyadenosine at a daily dose of 0.1mg/Kg by a continuous intravenous infusion for 7 days. The patient achieved complete remission.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권2호
• /
• pp.617-619
• /
• 2012

The aim of this study was to investigate the early outcome of the taxotere and cisplatin chemoradiotherapy for advanced cervical cancer. Fifty-six cases (FIGO II b to IVa) were divided randomly into two groups: radiotherapy alone (28 cases) and radiation plus chemotherapy (TP) group. There was no difference in radiotherapy between the two groups. The RT+C cases who received TP regimen during the radiation, and DDP once weekly injection of vain, according to 20$mg/m^2$ and taxotere once weekly iv according to 35 $mg/m^2$. These regimens were given for 4~5weeks, and some medicines to control vomiting were available for the RT+C cases. The two groups received an oral medicine MA 160mg every day during the treatment. Regarding early outcome, the complete remission rate was 64.3% and partial remission rate was 35.7% in RT+C. The complete remission rate was 32.1% and partial remission rate was 39.3% in RT. The total response rate and complete remission in the RT+C group were higher than that in the RT group. We conclude that taxotere and cisplatin chemoradiotherapy can improve the early outcome of the advanced cervical cancer, the adverse effects being endurable.

• Journal of Gastric Cancer
• /
• 제16권2호
• /
• pp.115-119
• /
• 2016

We report the case of a patient with gastric adenocarcinoma with multiple liver metastases. This patient showed complete remission for more than 68 months after S-1/cisplatin combination chemotherapy and radical total gastrectomy. The patient, a 63-year-old man, presented with dyspepsia and difficulty in swallowing. Endoscopic findings showed a huge ulcero-infiltrative mass at the lesser curvature of the mid-body, extending to the distal esophagus. Biopsy revealed a poorly differentiated tubular adenocarcinoma. An abdominal computed tomography scan demonstrated multiple hepatic metastases. S-1/cisplatin combination chemotherapy was initiated, and following completion of six cycles of chemotherapy, the gastric masses and hepatic metastatic lesions had disappeared on abdominal computed tomography. Radical total gastrectomy and D2 lymphadenectomy combined with splenectomy were performed. The patient underwent three cycles of S-1/cisplatin combination chemotherapy followed by tegafur-uracil therapy for 1 year. He remained in complete remission for more than 68 months after surgery.

• Journal of Digestive Cancer Research
• /
• 제5권1호
• /
• pp.70-72
• /
• 2017

A 41-year old woman with dysphagia visited, which was aggravated after eating. On physical examination, there was a palpable mass on the left supraclavicular area. Endoscopic examination revealed a mass on the distal esophagus with irregular mucosa, erythema and a whitish plaque with luminal narrowing. The patient was diagnosed with unresectable esophageal cancer (squamous cell carcinoma, T3N2M1, Stage IV). The patient received CCRT (total 63 Gy) with cisplatin and 5-fluorouracil (5-FU). After CCRT, the patient took an additionally 2 cycles of chemotherapy for consolidation (cisplatin and 5-FU every 4 weeks). After additional chemotherapy, endoscopic examination showed no residual tumor, a chest CT scan revealed that the mass in the distal esophagus had decreased and there was no enlargement of the lymph nodes around the left supraclavicular area. The patient has been in complete remission for 5 years.

• 대한영상의학회지
• /
• 제82권4호
• /
• pp.903-913
• /
• 2021

목적 악성 종양의 완전 관해 후 발생한 흉강 내 림프절병증 환자에서 사르코이드증 유사 반응을 시사할 수 있는 영상의학적 특징을 알아보고자 한다. 대상과 방법 이 연구는 악성 종양의 완전 관해 상태에서 발생한 조직병리학적으로 확인된 사르코이드증 유사 반응을 보인 5명의 환자의 임상적 특징과 CT 및 ¹⁸F-fluorodeoxyglucose(이하 FDG) PET/CT 소견을 분석하였다. 결과 기저 악성 종양으로는 유방암, 비인두암, 자궁내막암 및 림프종이 포함되며. 악성 종양의 완전 관해와 사르코이드증 유사 반응 진단 사이의 시간 간격은 6~78개월이었다. CT 소견으로는 양측 폐문 및 종격동 림프절병증(n = 5), 기관지혈관주위, 엽간열주위 또는 흉막하 폐결절(1~15 mm) 및 소엽내 간질비후가 포함되었다(n = 4). ¹⁸F-FDG PET/CT는 흉강 외 FDG 흡수 없이 양측 폐문 및 종격동 림프절의 대사항진을 나타냈다(n = 3). 모든 환자에서 코르티코스테로이드 치료 후 사르코이드증 유사 반응이 호전되었다. 결론 악성 종양의 완전 관해를 달성한 환자에서, 원발성 종양의 재발과 흉강 외 원격 전이 없는 상태에서 새로 발견된 양측 폐문 및 종격동 림프절병증은 림프관주위 폐결절의 유무에 관계없이 사르코이드증 유사 반응의 가능성을 시사할 수 있으며 불필요한 전신 화학요법을 예방하기 위해 림프절의 조직병리학적 확인이 필요하다.

• 대한기관식도과학회지
• /
• 제11권1호
• /
• pp.21-24
• /
• 2005

Acute lymphocytic leukemia(ALL) is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. Currently, only $20-30\%$ of adults with ALL are cured with standard chemotherapy regimens. It is very important risk factor whether to failure to achieve complete remission within 4 weeks or not. The relapse of leukemia is usually classified as hematologic and extramedullary relapse, and extramedullary leukemic infiltration is rarely observed in patients with ALL. In October 2004, a 23-year-old man presented with painless enlargement of both parotid glands. He was diagnosed as ALL(L2 subtype) one month ago, and he gained complete remission with induction chemotherapy. Fine needle aspiration cytology and bone marrow biopsy revealed extramedullary and hemtologic remission. To our knowledge this is the first report of extramedullary relapse in the parotid in ALL.

• 한국임상수의학회지
• /
• 제34권2호
• /
• pp.119-122
• /
• 2017

Calcinosis cutis is a chronic condition characterized by insoluble calcified deposits in the skin and subcutaneous tissue. Although there is no uniformly effective treatment for calcinosis cutis, minocycline therapy has demonstrated varying degrees of benefit in humans. Five client-owned dogs with calcinosis cutis were included. Minocycline was administered orally in a dose of 10 mg/kg bodyweight twice a day. Treatment was repeated every day until complete remission. The efficacy of minocycline was evaluated within this period. The side effects of minocycline were monitored and reported by the owners and veterinarians. Of the 5 dogs with calcinosis cutis, which was classified as the dystrophic form, four dogs had a complete remission of calcinosis cutis and one dog had a partial response. The major improvement was a reduction in the size of the calcified deposits and reduction in inflammation associated with them. The duration of remission was $9.1{\pm}2.2$ weeks. The adverse effects, observed in one dog, were anorexia and vomiting. Minocycline may be effective in the control of calcinosis cutis in dogs.