• Archives of Pharmacal Research
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• 제28권5호
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• pp.626-635
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• 2005

Liposome as a carrier of topotecan (TPT), a promising anticancer drug, has been reported in attempt to improve the stability and antitumor activity of TPT. However, the biodistr ibution pattern of TPT liposome in vivo and PEG-modified liposome containing TPT have not been studied systemically. In this paper, the in vitro stability and in vivo biodistribution behavior of several liposomes containing TPT with different lipid compositions and PEG-modification were studied. Compared with the 'fluid' liposome (S-Lip) composed of soybean phosphatidylcholine (SPC), the 'solid' liposome (H-Lip) composed of hydrogenated soybean phosphatidylcholine HSPC decreased the leaking efficiency of TPT from liposome and enhanced the stability of liposome in fetal bovine serum (FBS) or human blood plasma (HBP). The results of biodistribution studies in S$_{180}$ tumor-bearing mice showed that liposomal encapsulation increased the concentrations of total TPT and the ratio of lactone form in plasma. Compared with free TPT, S-Lip and H-Lip resulted in 5- and 19- fold increase in the area under the curve (AUC$_{0\rightarrow\propto}$), respectively. PEG- modified H-Lip (H-PEG) showed 3.7-fold increase in AUC$_{0\rightarrow\propto}$ compared with H-Lip, but there was no significant increase in t$_{1/2}$ and AUC$_{0\rightarrow\propto}$ for PEG-modified S-Lip (S-PEG) compared with S-Lip. Moreover, the liposomal encapsulation changed the biodistribution behavior, and H-Lip and H-PEG dramatically increased the accumulation of TPT in tumor, and the relative tumor uptake ratios were 3.4 and 4.3 compared with free drug, respectively. There was also a marked increase in the distribution of TPT in lung when the drug was encapsulated into H-Lip and H-PEG. Moreover, H-PEG decreased the accumulation of TPT in bore marrow compared with unmodified H-Lip. All these results indicated that the membrane fluidity of liposome has an important effect on in vitro stability and in vivo biodistribution pattern of liposomes containing TPT, and PEG-modified 'solid' liposome may be an efficient carrier of TPT.

• 마이크로전자및패키징학회지
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• 제12권2호
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• pp.105-109
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• 2005

본 논문은 LTCC 공정에 기반을 둔 GSM/DCS dual band 의 소형화된 antenna switch module을 공정변수 따른 특성의 왜곡을 안정화시키는 연구를 수행하였다. 특히 tape thickness의 변화에 따라 패턴간의 기생 커플링이 주된 변수로 작용한다. 두께 50um인 tape으로 제작된 시편의 사이즈는 $4.5{\times}3.2{\times}0.8 mm^3$이고 insertion loss는 Rx mode와 Tx mode 각각 ldB. 1.2dB 이하이다. 공정상에서 tape thickness의 변화에 따라 개발된 모듈의 특성 안정성을 검증하기 위해 각 블록-다이플렉서,필터, 바이어스 회로-을 probing method을 이용, 측정하였고, 각 블록간의 상호관계는 VSWR을 계산하여 비교하였다. 또한 회로적 관점에서 특성 개선을 위해 바이어스 회로부분의 집중소자형과 분포소자형을 구현하여 서로 비교 분석하였다. 이를 통해 각 블록의 측정과 계산된 VSWR의 데이터는 공정변수에 의해 변화된 전체 module의 특성과 안정성 거동을 파악하는데 좋은 정보를 준다. Tape thickness변화에도 불구하고 다이플렉스의 matching값은 연결되는 바이어스 회로와 LPF의 matching값과 상대 matching이 되면서, 낮은 VSWR을 유지하여 전체 insertion loss가 안정화되는 것을 확인하였다. 더불어 분포소자형 바이어스 회로보다는 집중소자형이 다른 회로블럭과의 관계에서 더 좋은 매칭을 이루어 loss개선에 일조하였다. Tape thickness가 6 um이상의 변화를 가져와도 집중소자형 바이어스 회로는 낮은 손실을 유지하여 더 넓은 안정 범위를 가져오기 때문에 양산에 적합한 구조가 될 수 있다 그리고, probing method에 의한 안정성 특성 추출은 세라믹에 임베디드된 수동회로들의 개발에 충분히 적용될 수 있다.

• Tribology and Lubricants
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• 제32권2호
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• pp.56-60
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• 2016

Sapphire has a high hardness and strength and chemical stability as a superior material. It is used mainly as a material for a semiconductor as well as LED. Recently, the cover glass industry used by a sapphire is getting a lot of attention. The sapphire substrate is manufactured through ingot sawing, lapping, diamond mechanical polishing (DMP) and chemical mechanical polishing (CMP) process. DMP is an important process to ensure the surface quality of several nm for CMP process as well as to determine the final form accuracy of the substrate. In DMP process, the material removal is achieved by using the mechanical energy of the relative motion to each other in the state that the diamond slurry is disposed between the sapphire substrate and the polishing platen. The polishing platen is one of the most important factors that determine the material removal characteristics in DMP. Especially, it is known that the geometric characteristics of the polishing platen affects the material removal amount and its distribution. This paper investigated the material removal characteristics and the effects of the polishing platen groove in sapphire DMP. The experiments were preliminarily carried out to evaluate the sapphire material removal characteristics according to process parameters such as pressure, relative velocity and so on. In the experiment, the monitoring apparatus was applied to analyze process phenomena in accordance with the processing conditions. From the experimental results, the correlation was analyzed among process parameters, polishing phenomena and the material removal characteristics. The material removal equation based on phenomenological factors could be derived. And the experiment was followed to investigate the effects of platen groove on material removal characteristics.

• 한국분말재료학회지
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• 제22권2호
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• pp.100-104
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• 2015

The porous metals are known as relatively excellent characteristic such as large surface area, light, lower heat capacity, high toughness and permeability. The Fe-Cr-Al alloys have high corrosion resistance, heat resistance and chemical stability for high temperature applications. And then many researches are developed the Fe-Cr-Al porous metals for exhaust gas filter, hydrogen reformer catalyst support and chemical filter. In this study, the Fe-Cr-Al porous metals are developed with Fe-22Cr-6Al(wt) powder using powder compaction method. The mean size of Fe-22Cr-6Al(wt) powders is about $42.69{\mu}m$. In order to control pore size and porosity, Fe-Cr-Al powders are sintered at $1200{\sim}1450^{\circ}C$ and different sintering maintenance as 1~4 hours. The powders are pressed on disk shapes of 3 mm thickness using uniaxial press machine and sintered in high vacuum condition. The pore properties are evaluated using capillary flow porometer. As sintering temperature increased, relative density is increased from 73% to 96% and porosity, pore size are decreased from 27 to 3.3%, from 3.1 to $1.8{\mu}m$ respectively. When the sintering time is increased, the relative density is also increased from 76.5% to 84.7% and porosity, pore size are decreased from 23.5% to 15.3%, from 2.7 to $2.08{\mu}m$ respectively.

• 한국터널지하공간학회 논문집
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• 제18권6호
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• pp.545-556
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• 2016

운영 중 해저 터널의 안정성 평가에 다양한 계측 정보를 사용해서 역해석하면, 효율적인 오차율 이내의 결과를 획득할 수 있다. 선행 연구에서 검증된 차분진화 알고리즘 기반의 역해석 수행 시 FLAC3D 등 범용 지반해석 프로그램을 사용했지만, 상대적으로 해석시간이 오래 걸리고, 제어가 어려운 단점이 있다. 이러한 이유로, 상대적으로 해석시간이 짧게 소요되는 beam-spring 모델기반의 FEM solver를 Python 언어로 개발하여, 기구축된 차분진화 알고리즘과 결합하였다. 계측 데이터로부터 실시간에 가깝게 운영 중 터널의 안정성 평가가 가능할 것으로 판단되며, 우선 솔버 개발에 용이한 종단방향 터널에 대해서 프로그램을 개발하였다.

• Journal of Animal Science and Technology
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• 제58권5호
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• pp.20.1-20.11
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• 2016

The present review has mainly focused on the specific parameters including aging (aging days, temperature, relative humidity, and air flow), eating quality (flavor, tenderness and juiciness), microbiological quality and economic (shrinkage, retail yields and cost) involved beef dry aging process. Dry aging is the process where beef carcasses or primal cuts are hanged and aged for 28 to 55 d under controlling environment conditions in a refrigerated room with $0^{\circ}$ to $4^{\circ}C$ and with relative humidity of 75 to 80 %. However there are various opinions on dry aging procedures and purveyors of such products are passionate about their programs. Recently, there has been an increased interest in dry aging process by a wider array of purveyors and retailers in the many countries. Dry aging process is very costly because of high aging shrinkage (6 to 15 %), trims loss (3 to 24 %), risk of contamination and the requirement of highest grades meat with. The packaging in highly moisture-permeable bag may positively impact on safety, quality and shelf stability of dry aged beef. The key effect of dry aging is the concentration of the flavor that can only be described as "dry-aged beef". But the contribution of flavor compounds of proteolysis and lipolysis to the cooked dry aged beef flavor is not fully known. Also there are limited scientific studies of aging parameters on the quality and palatability of dry aged beef.

• Bulletin of the Korean Chemical Society
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• 제32권9호
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• pp.3372-3376
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• 2011

We have studied the relative stability and atomic structures of five $C_{20}X_2$ regioisomers obtained as diadducts of a $C_{20}$ cage (X = H, F, Cl, Br, and OH). All the regioisomers are geometric isomers, i.e., they differ in their spatial arrangement. Full-geometry optimizations of the regioisomers have been performed using the hybrid density-functional (B3LYP/6-31G(d, p)) method. Our results suggest that the cis-1 regioisomer (the 1,2-diadduct) is the most stable and that the second most stable is the trans-2 (1,13-diadduct) regioisomer, implying that the long-range interaction between the two adducts and the resonance effect are more pronounced than the diadduct-induced strain in the $C_{20}$ cage. The HOMO and LUMO characteristics of each regioisomer with the same symmetry of structural regioisomers except $C_{20}(OH)_2$ are topologically same. This suggests that by using an entirely different set of characteristic chemical reactions for each regioisomer, we can distinguish between the five regioisomers for each $C_{20}$ diadduct derivative.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.117-120
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• 2008

교량받침은 활하중, 크리프, 온도변화, 건조수축 등에 의한 상부구조의 변위를 흡수하는 역할을 수행한다. 국내 탄성받침 설계기준인 KS F 4420은 전단변형을 탄성받침 총 고무 높이의 70% 이내로 제한하고 있는데, KS F 4420에 의해 설계된 탄성받침이 요구되는 전단성능을 발휘하기 위해서는 허용 전단변형률이 전단파괴에 대하여 충분한 안전성을 보유해야 한다. 더욱이 탄성받침이 지진격리장치와 함께 내진설계에 사용될 수 있는 상황을 고려할 경우, 탄성받침은 KS F 4420의 허용전단변형률보다 높은 수준의 전단성능을 확보해야 한다. 이 논문에서는 국내 탄성받침의 전단성능을 확인하기 위하여 극한전단실험을 실시하였다. 실험 결과 탄성받침은 200% 이상의 전단변형률에서 파괴가 발생하여 KSF 4420의 허용전단변형률 규정이 안전 측이라는 사실을 알 수 있었다. 하지만 일체화된 거동을 할 것이라 기대 되었던 탄성받침이 200% 전단변형률 내외에서 받침 분리현상을 보였다. 관측된 받침분리 현상은 탄성받침의 내진설계 적용성을 고려할 경우 교량 시스템에 예기치 못한 충격 또는 집중 응력을 발생 시킬 수 있기 때문에 이러한 현상이 방지될 수 있도록 관련 규정이 필요하다고 판단된다.

• E2M - 전기 전자와 첨단 소재
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• 제9권6호
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• pp.605-615
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• 1996

In this paper, the effect of alkaline oxide addition such as Li$_{2}$O and Na$_{2}$O on the microstructure and humidity sensitivity of V$_{2}$O$_{5}$(2 mol%)-doped TiO$_{2}$(98 mol%) was investigated as a function of amount (0, 1, 2, 5, 10 mol%) of Li$_{2}$O and Na$_{2}$O additives. The pores in the alkaline free sample were distributed mostly in the range between 0.16 and 1.0.mu.m in diameter and its porosity was 23.29%. Li$_{2}$O caused grain overgrowth and reduced the porosity with a narrow distribution of the pore size, leading to poor humidity sensitivity. Na$_{2}$O helped to enlarge the distribution of the pore size through the formation of small soluble phases. The pore sizes of the sample containing Na$_{2}$O 2mol% were distributed mostly in the range between 1.0 and 2.5.mu.m in diameter and its porosity and intrusion volume of mercury were 31.13 % and 0.1155 mL/g respectively, which consequently improved the humidity sensing characteristics such as the sensitivity and temperature-stability. Especially, the addition of 2mol% of Na$_{2}$O improved the humidity-sensing characteristics such as sensitivity and linearity in the whole range between 30 and 90 %RH (Percentage Relative Humidity)y)

• Journal of Advanced Marine Engineering and Technology
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• 제36권6호
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• pp.780-787
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• 2012

일반적으로 파력진동발전기는 부양 체, 진동시스템, 선형발전시스템으로 구성된다. 기존의 파력 진동발전기는 진동시스템과 파도에너지가 갖는 주파수를 일치시켜 공진현상을 이용하여 에너지효율을 극대화하였다. 그러나 파도에너지가 갖는 주파수는 시시각각 변하기 때문에 공진을 이용하여 파도에너지를 효율적으로 얻는 것은 어렵다. 본 논문에서는 이러한 단점을 해결하기위해 파력 발전기를 구성하는 부양 체와 진동시스템에 대하여 연구하였다. 먼저 파도에너지가 갖는 중심주파수에서 공진이 발생되도록 바다에 떠있는 부양 체를 설계하였고, 진동시스템과도 공진이 발생되도록 진동시스템을 설계하였다. 그 결과 일정 주파수대역에서 파력진동발전기를 구성하는 부양 체와 영구자석사이의 상대속도는 증가한 반면 부양 체와 바닷물사이의 상대변위는 작아짐을 알 수 있다. 따라서 본 논문에서 제안한 방법은 기존 방법에 비해 부양 체와 바닷물사이의 상대변위가 작기 때문에 극한 바다 주변 환경으로부터 부양 체의 안정성을 확보할 수 있고, 시시각각 변하는 주파수를 갖는 파도에너지로부터도 더 많은 운동에너지를 얻을 수 있는 장점을 가진다.