• Molecules and Cells
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• 제41권5호
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• pp.381-389
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• 2018

ARF is a tumor suppressor protein that has a pivotal role in the prevention of cancer development through regulating cell proliferation, senescence, and apoptosis. As a factor that induces senescence, the role of ARF as a tumor suppressor is closely linked to the p53-MDM2 axis, which is a key process that restrains tumor formation. Thus, many cancer cells either lack a functional ARF or p53, which enables them to evade cell oncogenic stress-mediated cycle arrest, senescence, or apoptosis. In particular, the ARF gene is a frequent target of genetic and epigenetic alterations including promoter hyper-methylation or gene deletion. However, as many cancer cells still express ARF, pathways that negatively modulate transcriptional or post-translational regulation of ARF could be potentially important means for cancer cells to induce cellular proliferation. These recent findings of regulators affecting ARF protein stability along with its low levels in numerous human cancers indicate the significance of an ARF post-translational mechanism in cancers. Novel findings of regulators stimulating or suppressing ARF function would provide new therapeutic targets to manage cancer- and senescence-related diseases. In this review, we present the current knowledge on the regulation and alterations of ARF expression in human cancers, and indicate the importance of regulators of ARF as a prognostic marker and in potential therapeutic strategies.

• Transactions of the Korean Society of Automotive Engineers
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• 제10권5호
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• pp.9-14
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• 2002

The durability prediction of emission control components, especially 02 sensor and catalytic converter, is getting more important as emission regulation is getting stricter and vehicle durability mileage requirement is also extended from 80,000 ㎞ to 160,000 km in Korean market. And the duration of vehicle mileage accumulation to get vehicle exhaust emission deterioration factor for certification is required to be shorter in order to reduce the vehicle development time. Since most of the vehicle emission development tests are done on chassis dynamometer and aging bench by using vehicle aging modes, real road condition and in-use driving patterns must be reflected into them to predict the vehicle emission level and to meet emission regulation especially at high mileage. In order to get the frequent driving pattern of vehicle and the aging characteristic of emission components, a vehicle was tested by changing drivers and driving roads around Seoul. Real road driving patterns were analyzed and compared with those of the certification modes which are well known in automotive industry.

• Molecules and Cells
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• 제45권4호
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• pp.243-256
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• 2022

Transcriptional regulation, a core component of gene regulatory networks, plays a key role in controlling individual organism's growth and development. To understand how plants modulate cellular processes for growth and development, the identification and characterization of gene regulatory networks are of importance. The SHORT-ROOT (SHR) transcription factor is known for its role in cell divisions in Arabidopsis (Arabidopsis thaliana). However, whether SHR is involved in hypocotyl cell elongation remains unknown. Here, we reveal that SHR controls hypocotyl cell elongation via the transcriptional regulation of XTH18, XTH22, and XTH24, which encode cell wall remodeling enzymes called xyloglucan endotransglucosylase/hydrolases (XTHs). Interestingly, SHR activates transcription of the XTH genes, independently of its partner SCARECROW (SCR), which is different from the known mode of action. In addition, overexpression of the XTH genes can promote cell elongation in the etiolated hypocotyl. Moreover, confinement of SHR protein in the stele still induces cell elongation, despite the aberrant organization in the hypocotyl ground tissue. Therefore, it is likely that SHR-mediated growth is uncoupled from SHR-mediated radial patterning in the etiolated hypocotyl. Our findings also suggest that intertissue communication between stele and endodermis plays a role in coordinating hypocotyl cell elongation of the Arabidopsis seedling. Taken together, our study identifies SHR as a new crucial regulator that is necessary for cell elongation in the etiolated hypocotyl.

• Journal of Auto-vehicle Safety Association
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• 제14권2호
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• pp.90-95
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• 2022

Composite material is widely used in the automotive industries because it has excellent mechanical properties and is possible to reduce weight due to the low density. However, there is a new obstacle to meet environment regulation like Cu less or Cu free regulation for the friction material. Although it is strongly demanded, there are few research results about that unfortunately. Unless this problem is not solved properly, it is impossible to apply composite brake system to vehicle. In this paper, a new eco-friendly friction material for composite brake system is represented to respond these regulations. To do this, friction characteristics between existing low steel friction material and new eco-friendly friction material are verified to secure performances for brake system such as effect characteristic, fade characteristic and wear characteristic. And composite brake gets the equivalent or better performance compared to a low steel friction material. Finally, this result contributes to the study of major principles for the development of eco-friendly friction material in the future.

• BMB Reports
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• 제51권6호
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• pp.280-289
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• 2018

Previously considered as a component of transcriptional noise, long noncoding RNAs (lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and post-transcriptional regulation. In this review, we discuss the fundamental functions of lncRNAs at different regulatory levels and their roles in metabolic balance. Typical examples are introduced to illustrate their diverse molecular mechanisms. The comprehensive investigation and identification of key lncRNAs will not only contribute to insights into diseases, such as breast cancer and type II diabetes, but also provide promising therapeutic targets for related diseases.

• Journal of Applied Reliability
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• 제10권3호
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• pp.161-169
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• 2010

Automobiles have become part of our lives in modern society. But since they can be detrimental once problems occur on the road safety requirements are stringent. In this paper DFSS procedure is applied to the establishment of headliner safety. Specifically, IDDOV is employed where problems are identified, areas for development clarified, optimization realized, and finally optimal conditions verified at the final stage.

• Proceedings of the KIPE Conference
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• 전력전자학회 1999년도 전력전자학술대회 논문집
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• pp.333-337
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• 1999

This paper presents the DQ transfomation space space vector modulation method to devel control algorithm of distribu STATCON(STATic CONdenser) for line volt regulation, dc link voltage regulation harmonics compensation. The Performance an of a PI with ramp comparision and synchro reference frame current controller is carried Based on these analysis, the control perform are desirable to compensate the harmonics a regulate dc link and line voltage of Distrib line.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2012년도 제44회 KOSCO SYMPOSIUM 초록집
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• pp.69-74
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• 2012

Looming global environmental pollution problems around the world movement to minimize the environmental pollution is actively taking place. International Maritime Organization (IMO) a significant portion of the marine pollution by exhaust gases emitted from vessel considered, and accordingly developed around the ship and ship-related environmental regulations, emission standards are going to strengthen gradually, the development of environmentally friendly vessels and equipment is proceeding actively.

• 한국항공운항학회:학술대회논문집
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• 한국항공운항학회 2015년도 추계학술대회
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• pp.42-46
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• 2015

This paper is written about the UAS DAA(Detect and Avoidance) of EU MIDCAS project. This project has been performed from 2009 to 2014. The main mission of this project was supporting the certification agency which is ICAO, EASA, and so on. The result of this project would be the base of the UAS operation regulation in the non segregated airspace. UAS usage demand is expanding rapidly, so we also start the development of the regulation, the research of SAA technologies and LRU.

• KSBB Journal
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• 제8권1호
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• pp.1-9
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• 1993

The acetone-butanol fermentation by C. acetobutylicum has gained increasing attention for the following reasons. First, the finite supply of petrochemical resources, combined with increasing concern over global environmental effects and the unstable nature of the price of petroleum has renewed interest in the development of fermentation technology that allows utilzation of biomass wastes for the production of alcohol. Second, it serves as excellent model system for understading the regulation and molecular biology of tightly regulated complex primary metabolism, and for applications of metabolic engineering. In this review various aspects of acetone-butanol fermentation by C. acetobutylicm including strain and fermentation characteristics, enzyme regulation, and solvent formation mechanism, and product recovery and summarized.