• Journal of applied mathematics & informatics
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• 제41권4호
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• pp.861-868
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• 2023

Nonlinear network creates complex homotopy structural communication in wireless network medium because of complex distribution approach. Due to this multicast topological connection structure, the queuing probability was non regular principles to create routing structures. To resolve this problem, we propose a Co-cluster homotopy queuing model (Co-CHQT) for Nonlinear Algebraic Topological Structure (NLTS-) for improving poison distribution network communication. Initially this collects the routing propagation based on Nonlinear Distance Theory (NLDT) to estimate the nearest neighbor network nodes undernon linear at x_(a,b)→ax²+bx² = c. Then Quillen Network Decomposition Theorem (QNDT) was applied to sustain the non-regular routing propagation to create cluster path. Each cluster be form with co variance structure based on Two unicast 2(n+1)-Z2(n+1)-Z network. Based on the poison distribution theory X_(a,b) ≠ µ(C), at number of distribution routing strategies weights are estimated based on node response rate. Deriving shorte;'l/st path from behavioral of the node response, Hilbert -Krylov subspace clustering estimates the Cluster Head (CH) to the routing head. This solves the approximation routing strategy from the nonlinear communication depending on Max- equivalence theory (Max-T). This proposed system improves communication to construction topological cluster based on optimized level to produce better performance in distance theory, throughput latency in non-variation delay tolerant.

• 한국정보과학회논문지:시스템및이론
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• 제31권9호
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• pp.514-526
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• 2004

최근 마이크로어레이 실험기술의 개발로 인해서 생물학자들은 한꺼번에 수천 혹은 수만 개의 유전자 발현실험이 가능하게 되었다. 마이크로어레이를 이용한 유전자 발현 패턴 분석에 필요한 이미지의 분석 작업은 사용자의 많은 수작업이 필요하며, 올바른 결과를 얻기 위해서 많은 주의가 필요하다. 그러므로 사용자의 수작업을 최소화하고 정확한 발현결과를 얻기 위해서 마이크로어레이 이미지의 자동 분석 방법이 필요하다. 일반적으로 마이크로어레이 데이타는 반점(spot) 위치의 변동이나 모양, 크기가 고르지 않는 것과 같은 다양한 문제로 인하여 자동 분석이 어렵다. 특히 블록과 반점의 주소를 결정하는 것은 마이크로어레이 분석 중 어려운 단계이며, 대부분 상용 프로그램에서는 수작업을 통해서 해결하거나, 수작업이 필요한 반자동시스템을 이용하고 있다. 본 논문에서는 균일 격자(regular grid) 구조 탐색을 이용하여 새로운 블록과 반점의 주소를 결정하는 알고리즘을 소개한다. 본 알고리즘에서는 입력된 반점들의 중심점을 이용하여, 균등 일직선 서열(equally spaced and collinear sequence)을 생성하고 이를 통하여 이미지의 기울기와 단위길이를 계산한다. 계산되어진 기울기와 단위길이를 이용하여 가상점을 허용한 균등 일직선서열을 다시 생성하고, 이를 이용하여 마이크로어레이의 주소를 결정한다. 실험 결과 다양한 실험 데이터에 대하여 매우 안정적이며, 신뢰성이 높은 결과를 얻을 수 있었다. 본 알고리즘에 대한 자세한 정보는 http://jade.cs.pusan.ac.kr/~autogrid에 정리되어 있다.

• 한국전자파학회논문지
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• 제23권9호
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• pp.1079-1086
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• 2012

본 논문에서는 반도체형 전력 증폭기의 바이어스를 개선하기 위하여 순차 제어 회로와 펄스 폭 가변 회로를 적용한 X-대역 60 W 고효율 전력 증폭 모듈을 설계하였다. 순차 제어 회로는 전력 증폭 모듈을 구성하는 각 증폭단의 GaAs FET의 드레인 전원을 순차적으로 스위칭하도록 회로를 구성하였다. 드레인 바이어스 전원의 펄스 폭을 RF 입력 신호의 펄스 폭보다 넓게 하여 전력 증폭 모듈의 입력 신호가 있을 때만 스위칭 회로를 순차적으로 구동시킴으로써 전력 증폭 모듈의 열화에 따른 출력 신호의 왜곡과 효율을 향상시킬 수 있다. 60 W 전력 증폭 모듈은 고출력 GaAs FET를 이용하여 전치 증폭단, 구동 증폭단과 주전력 증폭단으로 구성하였으며, 주전력 증폭단은 전력결합기를 이용한 평형증폭기 구조로 구현하였다. 설계된 전력 증폭 모듈은 9.2~9.6 GHz에서 듀티사이클 10 %로 동작시켰을 때 50 dB의 전력 이득, 펄스 주기 1 msec, 펄스 폭 100 us, 출력 전력 60 W에서 동작함에 따라 펄스-SSPA 형태로 반도체 펄스 압축 레이더 등에 적용할 수 있다.

• 한국전산유체공학회지
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• 제13권1호
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• pp.57-62
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• 2008

Laminar flows over a cube and a cuboid (cube extended in the streamwise direction) are numerically investigated for the Reynolds numbers between 50 and 350. First, vortical structures behind a cube and lift characteristics are scrutinized in order to understand the variation in vortex shedding characteristics with respect to the Reynolds number. As the Reynolds number increases, the flow over a cube experiences the steady planar-symmetric, unsteady planar-symmetric, and unsteady asymmetric flows. Similar to the sphere wake, the planar-symmetric flow over a cube can be divided into two different regimes: single-frequency regime and multiple-frequency regime. The former has a single frequency due to regular shedding of vortices with the same strength in time, while the latter has multiple frequency components due to temporal variation in the strength of shed vortices. Second, the effect of the length-to-height ratio of the cuboid on the flow characteristics is investigated for the Reynolds number of 270, at which planar-symmetric vortex shedding takes place behind a cube. With the ratio smaller than one, the flow over the cuboid becomes unsteady asymmetric flow, whereas it becomes steady flow for the ratios greater than one. With increasing the ratio, the drag coefficient first decreases and then increases. This feature is related to the flow reattachment on the side faces of the cuboid.

• 대한의용생체공학회:의공학회지
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• 제34권4호
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• pp.218-225
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• 2013

In this paper hair bundle feature model and integration method for hair cell models were proposed. The proposed hair bundle feature model was based on spring-damper-mass model. Input of integrated vestibular hair cell model was frequency and output was interspike interval of hair cell that was reflected the feature of hair bundles. Irregular afferents that had a great gain variation showed reduction of negative stiffness section. Regular afferents that had a small gain variation, however, showed same feature with base negative stiffness feature. As a result, integrated vestibular hair cell model showed almost the same modeling data with experimental data in the modeled eleven frequency bands. It is verified that the proposed model is a good model for hair bundle feature modeling.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2004년도 춘계학술대회 학술발표 논문집 제14권 제1호
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• pp.97-100
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• 2004

The identification of the DNA structure as a double-stranded helix consting of two nucleotide chain molecules was a milestone in modern molecular biology. The DNA chip technology is based on reverse hybridization that follows the principle of complementary binding of double-stranded DNA. DNA chip can be described as the deposition of defined nucleic acid sequences, probes, on a solid substrate to form a regular array of elements that are available for hybridization to complementary nucleic acids, targets. DNA chips based on cDNA clons, oligonucleotides and genomic clons have been developed for gene expression studies, genetic variation analysis and genomic changes associated with disease including cancers and genetic diseases. DNA chips for gene expression profiling can be used for functional analysis in human eel Is and animal models, disease-related gene studies, assessment of gene therapy, assessment of genetically modified food, and research for drug discovery. DNA chips for genetic variation detection can be used for the detection of mutations or chromosomal abnormalities in cnacers, drug resistances in cancer cells or pathogenic microbes, histocompatibility analysis for transplantation, individual identification for forensic medicine, and detection and discrimination of pathogenic microbes. The DNA chip will be generalized as a useful tool in clinical diagnostics in near future. Lab-on-a chip and informatics will facilitate the development of a variety of DNA chips for diagnostic purpose.

• Water Engineering Research
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• 제2권1호
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• pp.49-61
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• 2001

A grid-based KIneMatic wave soil-water EROsion and deposition Model(KIMEROM) that predicts temporal variation and spatial distribution of sediment transport in a watershed was developed. This model uses ASCII-formatted map data supported from the regular gridded map of GRASS (U.S. Army CERL, 1993)-GIS(Geographic Information Systems), and generates the distributed results by ASCII-formatted map data. For hydrologic process, the kinematic wave equation and Darcy equation were used to simulated surface and subsurface flow, respectively (Kim, 1998; Kim et al., 1998). For soil erosion process, the physically-based soil erosion concept by Rose and Hairsine (1988) was used to simulate soil-water erosion and deposition. The model adopts single overland flowpath algorithm and simulates surface and subsurface water depth, and sediment concentration at each grid element for a given time increment. The model was tested to a 162.3 $\textrm{km}^2$ watershed located in the tideland reclaimed ares of South Korea. After the hydrologic calibration for two storm events in 1999, the results of sediment transport were presented for the same storm events. The results of temporal variation and spatial distribution of overland flow and sediment areas are shown using GRASS.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2001년도 학술발표회 논문집(I)
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• pp.25-34
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• 2001

A grid-based KIneMatic wave soil-water EROsion and deposition Model (KIMEROM) that predicts temporal variation and spatial distribution of sediment transport in a watershed was developed. This model uses ASCII-formatted map data supported from the regular gridded map of GRASS (U.S. Army CERL, 1993)-GIS (Geographic Information Systems), and generates the distributed results by ASCIIl-formatted map data. For hydrologic process, the kinematic wave equation and Darcy equation were used to simulate surface and subsurface flow, respectively (Kim, 1798; Kim et al., 1993). For soil erosion process, the physically-based soil erosion concept by Rose and Hairsine (1988) was used to simulate soil-water erosion and deposition. The model adopts sing1e overland flowpath algorithm and simulates surface and subsurface water depth, and sediment concentration at each grid element (or a given time increment. The model was tested to a 162.3 km$^2$ watershed located in the tideland reclaimed area of South Korea. After the hydrologic calibration for two storm events in 1999, the results of sediment transport were presented for the same storm events. The results of temporal variation and spatial distribution of overland flow and sediment areas are shown using GRASS.

• Archives of Pharmacal Research
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• 제26권11호
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• pp.967-973
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• 2003

Cytochrome P4502C9(CYP2C9) is largely responsible for terminating anticoagulant effect by hydroxylation of S-warfarin to inactive metabolites. Mutations in the CYP2C9 gene result in the expression of allelic variants, CYP2C9*2 and CYP2C9*3 with reduced enzyme activity compared to wild type CYP2C9 *1. The aim of this study was to assess relationship between requirement of warfarin dose and polymorphism in CYP2C9 in Korean population. Patients on warfarin therapy for longer than 1 year were included from July 1999 to December 2000 and categorized as one of four groups; regular dose non-bleeding, regular dose bleeding, low dose non-bleeding and low dose bleeding. Low dose was defined as less than 10 mg/week for 3 consecutive monthly follow-ups. Bleeding complications included minor and major bleedings. Blood samples were processed for DNA extraction, genotyping and sequencing to detect polymorphism in CYP2C9. Demographic data, warfarin dose per week, prothrombin time (INR), indications and co-morbid diseases were assessed for each group. Total 90 patients on warfarin were evaluated; The low dose group has taken warfarin 7.6$\pm$1.7 mg/week, which was significantly lower than 31.4$\pm$0.9 mg/week in the regular dose group (p<0.0001). The measured INR in the low dose group was similar to that of the regular dose group (2.3$\pm$0.7 vs. 2.3$\pm$0.6, p=0.9). Even though there was a higher possibility of CYP2C9 variation in the low dose group, no polymorphism in CYP2C9 was detected. All patients were homozygous C416 in exon 3 for CYP2C9*2 and A1061 in exon 7 for CYP2C9*3. The DNA sequencing data confirmed the homozygous C416 and A 1061 alleles. In conclusion, polymorphism in CYP2C9 is not a critical factor for assessing warfarin dose requirement and risk of bleeding complications in a Korean population.

• 한국해안·해양공학회논문집
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• 제28권6호
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• pp.332-349
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• 2016

OLAFOAM은 파동역학의 시뮬레이션을 위하여 $OpenFOAM^{(R)}$을 확장한 강력한 CFD코드이며, $OpenFOAM^{(R)}$은 다양한 분야에서 각각 수치계산의 목적에 대응할 수 있도록 많은 Solver를 제공하고 있다. OLAFOAM의 기본방정식은 VARANS식에 기초하고, 수치기법으로는 유한체적법을 적용하며, 프로그램은 C++로 코딩되어 Linux운영체제에서 실행된다. 본 연구는 OLAFOAM을 이용하여 먼저 1) 단파와 규칙파하 투과성구조물에서 파의 변형, 2) 규칙파하 잠제에 의한 파의 변형 및 3) 흐름하 규칙파의 변형과 연직유속분포에 대해 기존의 각 실험결과와 비교 검토하여 OLAFOAM의 타당성을 검증하였다. 이로부터 지금까지 거의 검토되지 않은 규칙파와 흐름의 공존장에 설치된 투과성잠제에 대해 배후경사면을 불투과성 혹은 투과성으로 고려한 경우 흐름방향 등의 변화에 따른 잠제 주변에서 수위, 파고, 주파수스펙트럼, 쇄파, 평균유속 및 난류운동에너지 등의 변동특성을 면밀히 검토하였다. 결과로부터 흐름방향(순방향과 역방향)에 따른 파고변화는 난류운동에너지와 밀접한 관계를 가지는 것 등을 알 수 있었다.