DOI QR코드

DOI QR Code

A study on Hair Bundle Feature Estimation Based on Negative Stiffness Mechanism Using Integrated Vestibular Hair Cell Model

전정 유모세포 통합 모델을 이용한 반강성 기전 기반 섬모번들 특성 추정에 관한 연구

  • Kim, Dongyoung (Department of Electronic Engineering, Inha University) ;
  • Hong, Kihwan (Institute for Information and Electronics Research, Inha University) ;
  • Kim, Kyu-Sung (Institute for Information and Electronics Research, Inha University) ;
  • Lee, Sangmin (Department of Electronic Engineering, Inha University)
  • 김동영 (인하대학교 전자공학과) ;
  • 홍기환 (인하대학교 정보전자공동연구소) ;
  • 김규성 (인하대학교 정보전자공동연구소) ;
  • 이상민 (인하대학교 전자공학과)
  • Received : 2013.10.31
  • Accepted : 2013.12.16
  • Published : 2013.12.31

Abstract

In this paper hair bundle feature model and integration method for hair cell models were proposed. The proposed hair bundle feature model was based on spring-damper-mass model. Input of integrated vestibular hair cell model was frequency and output was interspike interval of hair cell that was reflected the feature of hair bundles. Irregular afferents that had a great gain variation showed reduction of negative stiffness section. Regular afferents that had a small gain variation, however, showed same feature with base negative stiffness feature. As a result, integrated vestibular hair cell model showed almost the same modeling data with experimental data in the modeled eleven frequency bands. It is verified that the proposed model is a good model for hair bundle feature modeling.

Keywords

References

  1. I. Nazareth, S. Landau, L. Yardley, L. Luxon, "Patterns of presentations of dizziness in primary care-a cross-sectional cluster analysis study," J. Psychosom. Res., vol. 60, pp. 395-401, 2006. https://doi.org/10.1016/j.jpsychores.2005.07.011
  2. M. Karatas, "Central vertigo and dizziness: epidemiology, differential diagnosis, and common causes," Neurologist., vol. 14, pp. 355-364, 2008. https://doi.org/10.1097/NRL.0b013e31817533a3
  3. T. F. Youssef, D. S. Poe, "Intratympanic gentamicin injection for the treatment of Meniere's disease," Am. J. Otol., vol. 19, no. 4, pp. 435-42, 1998.
  4. A. G. Pfleiderer, "The current role of local intratympanic gentamicin therapy in the management of unilateral Meniere's disease," Clin. Otolaryngol Allied Sci., vol. 23, no. 1, pp. 34-41, 1998. https://doi.org/10.1046/j.1365-2273.1998.00092.x
  5. A. J. Ayres. L. Tickle, "Hyper-responsivity to touch and vestibular stimulation as a predictor of responsivity to sensory integrative procedures by autistic children," Journal of Occupational Therapy, vol. 34, pp. 375-381, 1980. https://doi.org/10.5014/ajot.34.6.375
  6. B. Hermelin, "Development of hemispheric specialization for speech perception," Cortex., vol. 12, pp. 337-346, 1976. https://doi.org/10.1016/S0010-9452(76)80037-8
  7. C. E. Smith, J. M. Goldberg, "A Stochastic Afterhyperpolarization Model of Repetitive Activity in Vestibular Afferents," Biol. Cybern., vol. 54, no. 1, pp. 41-51, 1986. https://doi.org/10.1007/BF00337114
  8. P. Martin, D. Bozoviz, Y. Choe, J. Hudspeth, "Spontaneous oscillation by hair bundles of the bullfrog's sacculus," J. Neurosci., vol. 23, no. 11, pp. 4533-48, 2003.
  9. L. Le Goff, D. Bozovic, A. J. Hudspeth, "Adaptive shift in the domain of negative stiffness during spontaneous oscillation by hair bundles from the internal ear," PNAS., vol. 102, pp. 16996-17001, 2005. https://doi.org/10.1073/pnas.0508731102
  10. A. C. Crawford, R. Fettiplace, "The mechanical properties of ciliary bundles of turtle cochlear hair cells," J. Physiol. (Lond.), vol. 364, pp. 359-379, 1985. https://doi.org/10.1113/jphysiol.1985.sp015750
  11. P. Martin, A. D. Mehta, A. J. Hudspeth, "Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell," Proc. Natl. Acad. Sci. USA., vol. 97, pp. 12026-12031, 2000. https://doi.org/10.1073/pnas.210389497
  12. R. E. Marquis, A. J. Hudspeth, "Effects of extracellular $Ca^{2+}$ concentration on hair-bundle stiffness and gating-spring integrity in hair cells," Proc. Natl. Acad. Sci. USA., vol. 94, pp. 11923-11928, 1997. https://doi.org/10.1073/pnas.94.22.11923
  13. R. A. Eatock, D. P. Corey, A. J. Hudspeth, "Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus," J Neurosci., vol. 7, pp. 2821-2836, 1987.
  14. P. Martin, A. J. Hudspeth, "Compressive nonlinearity in the hair bundle's active response to mechanical stimulation," Proc. Natl. Acad. Sci. USA., vol. 98, pp. 14386-14391, 2001. https://doi.org/10.1073/pnas.251530498
  15. R. W. Baloh, V. Honrubia, "The peripheral vestibular system. Clinical neurophysiology of the vestibular system. 2nd ed," Philadelphia: FA Davis Company, 1990.
  16. D. Kernell, "The repetitive impulse discharge of a simple neurone model compared to that of spinal motoneurones," Brain Res., vol. 11, pp. 685-687, 1968. https://doi.org/10.1016/0006-8993(68)90157-1
  17. D. Kernell, "The early phase of adaptation in repetitive impulse discharges of cat spinal motoneurones," Brain Res., vol. 41, pp. 184-186, 1972. https://doi.org/10.1016/0006-8993(72)90626-9
  18. I. M. Purcell, S. D. Newlands, A. A. Perachio, "Responses of gerbil utricular afferents to translational motion," Brain Res., vol. 152, pp. 317-322, 2003. https://doi.org/10.1007/s00221-003-1530-5