• Maxillofacial Plastic and Reconstructive Surgery
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• 제30권6호
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• pp.529-539
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• 2008

Background and Purpose : Oral squamous cell carcinoma (OSCC) is one of the most aggressive tumors of the head and neck area. OSCC is known to preferentially metastasize via lymphatic system, and resulting cervical lymph node metastasis is the most reliable of treatment failure. But the biological mechanism of the regional nodal metastasis is not clear. So, we determined metastasis-related factors in orthotopic nude mouse models of OSCC. Experimental Design : Two cell lines-KB and YD-10B cells, established from human oral mucosal squamous cell carcinoma, were xenografted into the tissue space of athymic murine mouth floor. The mice were followed for tumor development and growth, the murine tumors were examined histopathologically for local invasion or regional or distant metastasis. Finally, we performed immunohistochemical assays with antiepithelial growth factor (EGF), EGF receptor (EGFR), phosphorylated EGFR (pEGFR), and anti-vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-2, phosphorylated VEGFR-2/3 (pVEGFR-2/3) antibodies. We also determined the microvessel density. Results : Transplantation of human OSCC tumor cells into the mouth floor successfully resulted in the formation of orthotopic tumors. KB cell line showed significantly higher tumor proliferation and higher nodal metastatic potential than YD-10B cell line. Furthermore, immunohistochemical staining demonstrated higher expression of EGFR/pEGFR, VEGF, and pVEGFR-2/3 as well as higher microvessel density in KB murine tumors than in YD-10B murine tumors. Conclusion : An orthotopic model of OSCC in athymic mice was established which copies the cervical lymph nodal metastasis of human OSCC. Our mouth floor model should facillitate the understanding of the molecular pathogenesis of cervical nodal metastasis of OSCC.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제22권1호
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• pp.17-28
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• 2016

Purpose: The purpose of this paper is to analyze the spatial configurations of a sample of Korean regional emergency medical centers (REMCs) to explore its underlying genotypes and thus produce a base line data for the analysis and evaluations of future REMCs designs using space syntax theory. Methods: Space syntax analysis was used as a major tool for the analysis and exploration of Genotype. The measures of Integration(overall integration with exterior and without exterior as well as the integration of individual clinical spaces for each center), base difference factor (DF) and Space link ratio were calculated for a sample of seven Korean REMCs. Results: The result shows a strikingly similar pattern of Syntactic measures across the sample, the mean integration of sample ranges from 0.82-0.99 with exterior (while considering the exterior space as a root) and 0.81-1.01 without exterior (considering the connections of interior spaces only with no outside connection). The base difference factor (DF) of the sample varies from 0.60-0.81 with exterior and from 0.59-0.82 without exterior. Case number-1 was identified as non-genotype with differing order of Syntactic values. Although the genotype had different forms, layouts and even sizes, these results cannot be explained by Phenotypical comparisons. Implications: This study will contribute to the configurational analysis and evaluation of existing and future Korean REMCs design and practice of emergency healthcare delivery system in Korea.

• 한국지역지리학회지
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• 제20권3호
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• pp.245-255
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• 2014

지형경관을 단순한 기호로 사용하여 지도화하면 지형의 형태와 내재된 형성과정에 대한 표현에 한계가 있다. 지형경관 지도화에 대한 문제해결을 위한 대안 중에 하나가 지도를 통해 실제 경관을 상상할 수 있도록 연상기호를 제작하는 방법이다. 본 연구는 지형경관을 효과적으로 표현할 수 있는 지형 연상기호 제작 방안을 제시하고자 하였다. 지형은 정태적인 경관이 아니고 토양형성 작용과 지형형성 작용으로 변화하는 대상이다. 지형을 지도화하기 위해 형태, 변화, 그리고 물질이 표현될 수 있도록 기호가 설계가 되어야 하며, 축척에 따라 점/면, 선/면, 점/선의 축척 가변성을 고려하여 지형기호를 제작해야 한다. 본 연구는 지형학적 연구뿐만 아니라 환경, 생태학, 고고학, 토목 분야에 활용될 수 있을 것으로 본다.

• 통합자연과학논문집
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• 제16권4호
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• pp.139-145
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• 2023

Due to changes in the distribution system and increased demand for renewable energy, interest in technology to increase the limit capacity of distributed energy grid connection using grid flexible resources is also increasing. Recently, the distribution system system is changing due to the increase in distributed power from renewable energy, and as a result, problems with the limited capacity of the distribution system, such as waiting for renewable energy to connect and increased overload, are occurring. According to the power generation facility status report provided by the Korea Power Exchange, of the total power generation capacity of 134,020 MW as of 2021, power generation capacity through new and renewable energy facilities is 24,855 MW, accounting for approximately 19%, and among them, power generation through solar power accounts for a total portion of the total. It was analyzed that the proportion of solar power generation facilities was high, accounting for 75%. In the future, the proportion of new and renewable energy power generation facilities is expected to increase, and accordingly, an efficient operation plan for the distribution system is needed. Advanced country-type NWAs that can integrate the operation and management of load characteristics for each line of the distribution system, power distribution, regional characteristics, and economic feasibility of distributed power in order to improve distribution network use efficiency without expanding distribution facilities due to the expansion of renewable energy. An integrated operating system is needed. In this study, in order to improve the efficiency of distribution network use without expanding distribution facilities due to the expansion of renewable energy, we developed a method that can integrate the operation and management of load characteristics for each line of the distribution system, power distribution, regional characteristics, and economic feasibility of distributed power. We want to develop an integrated operation system for NWAs similar to that of advanced countries.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권2호
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• pp.81-93
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• 2007

Purpose: Adenoid cystic carcinoma (ACC) is a relatively rare tumor that arises in glandular tissues of the head and neck region and sometimes has a protracted clinical course with perineural invasion and delayed onset of distant lung metastasis. Treatment failure of salivary ACC is most often associated with perineural and hematogenous tumor spread. However, very little has been known about the cellular and molecular mechanisms of perineural invasion and hematogenous distant metastasis of parotid ACC. This study was designed to develop an orthotopic tumor model of parotid adenoid cystic carcinoma in athymic nude mice. Experimental Design: A melanoma cell line was injected into the parotid gland of athymic mice to determine whether such implantation was technically feasible. A parotid ACC cell line was then injected into the parotid gland or the subcutaneous tissue of athymic mice at various concentrations of tumor cells, and the mice were thereafter followed for development of tumor nodule. The tumors were examined histopathologically for perineural invasion or regional or distant lung metastasis. We used an oral squmous cell carcinoma cell line as control. Results: Implantation of tumor(melanoma) cell suspension into the parotid gland of nude mice was technically feasible and resulted in the formation of parotid tumors. A parotid ACC cell line, ACC3 showed no significantly higher tumorigenicity, but showed significantly higher lung metastatic potential in the parotid gland than in the subcutis. In contrast, mucosal squmous cell carcinoma cell line doesn’t show significantly higher lung metastatic potential in the parotid gland than in the subcutis. The ACC tumor established in the parotid gland seemed to demonstrate perineural invasion of facial nerve, needs further study. Conclusion: An orthotopic tumor model of salivary ACC in athymic nude mice was successfully developed that closely recapitulates the clinical situations of human salivary ACC. This model should facilitate the understanding of the cellular and molecular mechanisms of tumorigenisis and metastasis of salivary ACC and aid in the development of targeted molecular therapies of salivary ACC.

• 토지주택연구
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• 제8권4호
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• pp.285-294
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• 2017

Recently, as the paradigm of regional development has been transformed into characterization, decentralization and cooperation, small and medium scale development is in the spotlight. In particular, as the transfer of planning authority to local governments accelerates, LH is in the process of seeking to transform itself into a system that is in line with local government demand. The purpose of this study is to elaborate the regional pending projects that meet the demand of the region. The Jeju Special Self-Governing Province is the area where land and housing prices have increased more than three times recently, which is the area of interest in recent years due to the various demand for development projects. Another objective is to establish a local government based on LH's system, it is aimed to derive a collaboration method with local government, province corporation and local researchers. The criteria for deriving the cooperation projects between the local government and LH are basically the ones that can be carried out by LH and future-oriented projects. The process of deriving has undergone the process of statutory planning, unscrupulous plan analysis, and consultation of experts' advisory committees. In order to derive the regional cooperation project, four criteria such as local uniqueness, future possibility, business promotion efficiency, and local cooperation project were set. Major projects of the Jeju Special Self-Governing Province are improvement of the surrounding traffic system, construction of the hinterland due to the construction of the second airport, and establishment of Cruise Port(Jeju Port, Seogwipo Port). The role of each entity in the implementation of regional cooperation projects is as follows. Local government should request subsidies for the projects in case of lack of budget support and secure them through competition with other regions. In addition, it should be responsible for the operation and management of the facility once it has been supported and completed smoothly. The Ministry of Land, Infrastructure and Transport affects each region through approval and subsidy of the development plan. After the development project is completed, it evaluates the development project through monitoring and plays a role of continuously improving the system. As a business operator, the provincial corporation will carry out small-scale projects including non-physical projects such as community participation. In the case of LH regional headquarters, the general manager of the region will establish a comprehensive business plan, secure development availability, and carry out large-scale growth promotion projects.

• 지역과문화
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• 제4권2호
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• pp.1-23
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• 2017

'3대 문화권 문화·생태·관광 기반조성 사업' 중 안동시 사업(2010-2020)은 선도사업 2개(세계 유교선비문화공원, 한국문화테마파크)와 전략사업 3개(유림문학유토피아, 선성현 문화단지. 전통 빛타래 길쌈마을)로 구성되어 있다. 지역간 투입산출모형을 이용하여 사업 예산 4,432억 원이 경북지역 내 창출한 생산유발액은 6,068억 원(유발계수 1.37), 부가가치유발액은 1,965억 원(유발계수 0.44), 소득유발액은 1,331억 원(유발계수 0.30), 고용유발인수는 2,851명(유발계수 10억 원당 6.43명)이었고 경북을 제외한 타 지역에 창출시킨 생산유발액은 3,834억 원(유발계수 0.877), 부가가치유발액은 1,617억 원(유발계수 0.27), 소득유발액은 546억 원(유발계수 0.12), 고용유발인수는 1,849명(유발계수 10억 원당 4.17명)이었으며 전국에서 유발된 경제적 파급효과는 생산 9,902억 원(유발계수 2.23), 부가가치 3,182억 원(유발계수 0.72), 소득 1,877억 원(유발계수 0.42), 고용 4,701명(유발 계수 10억 원당 10.6명)이었다. 그러나 현재 진행되고 있는 사업은 여러 가지 문제로 인해 사업이 지연되고 있고 당초 목적인 유교문화의 생활화·산업화·세계화를 달성하기에 많은 한계에 도달하게 되었다. 이와 같은 문제점을 극복하기 위한 방안으로 기존 사업과 연계한 한문화 ICT융합 체험단지, 전통문화와 ICT융합 콘텐츠 개발, 안동호 주변연계관광지 조성, 안동호 관광인프라 구축, 전통문화체험단지 조성 등을 신성장 동력 사업으로 제안하였다.

• 한국지역지리학회지
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• 제15권3호
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• pp.317-327
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• 2009

본 연구는 환경부의 전국자연환경조사를 통하여 수집된 비무장지대와 그 인접 지역의 지형분야 조사의 결과를 분석하고, 활용 방안을 모색하는데 그 목적이 있다. 조사된 총 356개의 지형 중 가장 많이 관찰된 지형은 하안단구였으며, 전체 지형 중 1 등급은 57개(16.01%)로 나타났다. 본 지형 조사는 북방한계선까지 접근하여 비무장지대 및 그 인접 지역의 지형을 파악하는데 큰 의의가 있다. 이러한 비무장지대 및 그 인접지역의 지형경관은 비무장지대라는 세계에서 유일한 공간적 특성과 함께 유네스코에서 지정하는 지오파크로 활용될 수 있는 가능성이 매우 높다.

• 지역연구
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• 제14권2호
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• pp.1-33
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• 1998

Whereas previous researches on land policy after unification dealt with principally the problem of land confiscation under the communist reign, this research tried to propose a scheme of long-term land reform which was based on case studies on ex-socialist societies' experiences during their transformation, analysis on North Korea's institution related to land ownership and use. To reform North Korea's land ownership and use by the principle of market economy, North Korean should accumulate their commencing asset necessary for private ownership of land and housing. Therefore much focus should be put on the accumulation of the commencing asset at the early state of unification. On the extension of that line, the government of the Unified Korea should try to solve the problem of land confiscation by the communist party and land privatization in the region of North Korea. For the purpose, gradual land reform is more desirable than rapid one according to the case studies on ex-socialist societies. The government should avoid policies than can result in serious fiscal burden. Active participation of local government is highly recommendable in land tax and development. On the direction of land policy, this research proposed a four step long-term scheme of land reformation in North Korea. However, later researches should put more Korea. However, later researches should put more emphasis to the unification of land institution of North and South Korea which this research couldn't deal with sufficiently.

• 자원환경지질
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• 제24권1호
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• pp.63-69
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• 1991

Gravity study was carried out to investigate the structure and total mass of the Bupyeong silver deposits closely related to formation of the Bupyeong caldera. Survey region covers $3.3{\times}6.6km^2$ over silver deposits and is comprised of 334 gravity measurement stations. An apparent regional gravity trend parallel to the west coast line is mainly attributed to isostasy. A least square isostasy model was used for the regional correction. A Fortan subroutine was coded to calculate 3-dimensional subsurface model. The calculated gravity values from the 3-dimensional model of the caldera with silver deposits agree with observed anomalies relatively well. Gravity anomaly due to Bupyeong silver deposits reaches to +3.5 mgal from the background value and anomaly due to the caldera reaches to -4 mgal. But the maximum negative anomaly of the caldera would be much greater at its center. The total mass of silver deposits calculated from the subsurface model is $4.19{\times}10^9$ tons. Although the economic part of silver deposits depends on the grade of orebody, we expect that there are still large amount of silver reserves in Bupyeong area.