• The Korean Journal of Physiology and Pharmacology
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• 제5권6호
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• pp.467-477
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• 2001

We examined astrocyte regional heterogeneity in their morphological changes in response to various stimuli. Astrocytes were cultured from six different neonatal rat brain regions including cerebral cortex, hippocampus, cerebellum, mid brain, brain stem and hypothalamus. Astrocyte stellation was induced by serum deprivation and the maximum stellation in different regional astrocytes was achieved after 2 h. After 24 h, in all astrocyte cultures, the level of stellation returned to their original level. Cerebellar or hypothalamic astrocytes were the most or the least sensitive, respectively, to serum deprivation. The order of maximum sensitivity to serum deprivation among different regional astrocytes was: cerebellum＞mid $brain{\ge}hippocampus,\;brain\;stem{\ge}cerebral$ cortex＞hypothalamus. Isoproterenol-induced astrocyte stellation was also examined in different regional astrocytes, and similar order of maximum sensitivity as in serum deprivation was observed. Next a possible developmental effect on astrocyte morphological changes was examined in cerebral cortex and cerebellum astrocytes cultured from postnatal day 1 (P1), P4 and P7 rat brains. A much higher sensitivity of cerebellum astrocytes to serum deprivation as well as isoproterenol treatment was consistently observed in P1, P4 and P7-derived astrocytes compared to cerebral cortex astrocytes. The present study demonstrates different regional astrocytes maintain different levels of morphological plasticity in vitro.

• 지역연구
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• 제36권3호
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• pp.3-16
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• 2020

도시 내 공간적 불평등은 꾸준한 관심을 받고 있는 연구주제다. 그러나 공간적 불평등이 주민에게 미치는 세부적인 영향과 공간적 불평등이 지속되고 재생산되는 방식에 대한 실증연구는 제한적이다. 본 연구는 공간적 수준에서의 박탈을 나타내는 개념인 지역박탈이 주민의 계층상승 가능성에 대한 인식에 미치는 영향을 확인하고자 하였다. 2015년 서울서베이 자료를 순서형 로지스틱 다층모형을 활용하여 분석한 결과, 지역박탈 수준이 높은 지역에 거주하는 주민일수록 자신의 계층상승 가능성을 부정적으로 인식하는 것으로 나타났다. 본 연구결과는 지역박탈이 주민의 계층상승에 대한 믿음을 저해함으로써 삶의 만족도와 기회 실현을 저해하는 것은 물론 지역 격차가 지속되는 데에 영향을 미칠 수 있음을 시사한다. 이와 같은 분석결과는 공간적 불평등을 해소하기 위한 도시정책에 함의를 제공할 수 있을 것으로 기대된다.

• Journal of Preventive Medicine and Public Health
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• 제48권4호
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• pp.195-202
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• 2015

Objectives: Receiving proper dental care plays a significant role in maintaining good oral health. We investigated the relationship between regional deprivation and dental care utilization. Methods: Multilevel logistic regression was used to identify the relationship between the regional deprivation level and dental care utilization purpose, adjusting for individual-level variables, in adults aged 19+ in the 2008 Korean Community Health Survey (n=220 258). Results: Among Korean adults, 12.8% used dental care to undergo examination and 21.0% visited a dentist for other reasons. In the final model, regional deprivation level was associated with significant variations in dental care utilization for examination (p<0.001). However, this relationship was not shown with dental care utilization for other reasons in the final model. Conclusions: This study's findings suggest that policy interventions should be considered to reduce regional variations in rates of dental care utilization for examination.

• 지적과 국토정보
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• 제48권2호
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• pp.197-211
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• 2018

본 연구에서는 건강에 대한 공간적 연구에서 통상적으로 사용되는 센서스에 기반한 지역 박탈지수의 대안으로 지역 주택가격이 사용될 수 있는지 평가하였다. 평가를 위해 개인을 1수준으로, 수도권의 보건소 구역을 2수준으로 하는 다수준 로지스틱 모델이 추정되었다. 다수준 모델에는 개인의 점심식사후 칫솔질과 치간실 사용을 설명하기 위한 개인수준의 변수들과 보건소 구역을 대표하는 사회적 박탈지수 및 지역주택가격 수준이 포함되었다. 추정된 모델들의 설명력은 Akaike Information Criterion (AIC)와 Bayesian Information Criterion (BIC)를 이용하여 평가되었다. 모델의 추정결과는 사회적 박탈지수 및 지역 주택가격이 모두 개인의 치아관리 행동을 설명하는 데 기여하나 지역 주택가격을 사용한 모델의 AIC 및 BIC가 통상적인 센서스 기반 지역 박탈지수를 사용한 경우 보다 낮은 것을 보여 주었다. 본 연구결과는 센서스에 기반한 박탈지수를 생성하는 데 사용된 센서스 변수가 시점의 차이 등의 이유로 적절하지 않을 경우 지역 주택가격이 지역의 사회경제적 수준을 대표하기 위해 대안적으로 사용될 수 있음을 보여준다.

• Journal of Preventive Medicine and Public Health
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• 제39권1호
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• pp.46-52
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• 2006

Objectives: This study was performed to investigate the relationship between regional material deprivation and the standardized mortality ratios(SMRs) of community residents aged 15-64 in Korea. Methods: SMRs were investigated using the registered death data from 1995 to 2000 that was obtained from the Korean National Statistics Office with the denominators being drawn from the 1995 to 2000 census. Material deprivation was measured using the Townsend score that was calculated from the 1995 to 2000 census. The relationship between the regional material deprivation and the SMRs of the community residents aged 15-64 was investigated by using ANOVA, Spearman's rank correlation analysis and Pearson's correlation analysis. The trends in mortality inequality were investigated using the concentration index. Results: On the ANOVA, the SMRs of the men and women residents in the least deprived areas were the smallest and those in the most deprived areas were the largest. Spearman's rank correlation analysis, Pearson's correlation analysis and the concentration index revealed that significant positive relationships exist between the regional material deprivation and the SMRs of the community residents aged 15-64. Conclusions: This study suggests that there are mortality inequalities among the communities in Korea and part of this difference is due to the material deprivation of the community. Strategies aimed at reducing mortality inequalities among the communities will be needed to address economic inequalities. Further studies are needed to explore the mechanisms of how the regional deprivation influences on health and how the other factors of the community influence on the health of the community residents.

• 보건교육건강증진학회지
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• 제32권2호
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• pp.27-37
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• 2015

Objectives: As the increasing of the length of the lifespan, more recent policy interest are concerned with how many years of life are lived without functional disability or activity limitation. We investigated the relationship between deprivation and activity limitation at the 251 local authority level. Methods: The data were derived from the 2010 Census 10% sample data. Crude and age-standardized activity limitation rates by gender at the ages of 50 or over and deprivation index were calculated. Mapping and multiple linear regression analysis were applied to explore relationship between area activity limitation and area deprivation. Results: There were considerable differences in activity limitation rate across the 251 local authorities. Age-standardized activity limitation rate in both male and female were strongly associated with the level of area deprivation. Especially, low social class, male unemployment, or non-apartment residents at the local level were strong positive association with local authorities' age-standardized activity limitation. Conclusion: More policy attention is needed for tackling regional inequality in activity limitation among older adults.

• Journal of Preventive Medicine and Public Health
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• 제56권1호
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• pp.88-94
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• 2023

Objectives: This study examined how deprivation differed by region and the effect those differences had on suicidal ideation among the local population. Methods: Data collected over 10 years (2012-2021) in the Korea Welfare Panel Study were organized into 3 categories: metropolitan, city, and rural. A panel analysis was conducted on the impact of deprivation indices, socio-demographic characteristics, and life satisfaction on suicidal ideation in each category. Results: Income, divorce status, family relationship satisfaction, and medical deprivation had a significant impact on suicidal ideation in metropolitan areas, whereas these variables did not have significant effects in rural areas. In other words, income, family, and medical support were more impactful in city areas. Conclusions: Although the deprivation index was higher in rural areas than in city areas due to an aging population and reduced income levels, the mental health of rural residents was found to be generally better than that of city residents. The possibility that this is related to the strength of relationships within the respective communities should be considered in light of recent discussions on relational welfare.

• 한국지역지리학회지
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• 제20권2호
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• pp.217-229
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• 2014

본 연구는 건강을 설명하는 지역 박탈 지표를 선별하고 이러한 지표들이 근린사회의 인구구성효과와 구분되는 독립적인 맥락효과를 지니는지 검증해 보았다. 이를 위하여 서울시를 대상으로 행정동 단위의 표준화사망비를 산출하여 소지역 건강불평등 실태를 분석하였고, 표준화사망비 격차를 설명하는 지역박탈 지표들을 선정하였다. 그리고 다수 준 모형을 통해 개인의 사회경제적 지위를 통제한 후 지역박탈 효과를 검증하였다. 분석 결과는 건강불평등의 지역 격차가 대부분 사회경제적 지위 요인을 반영할 뿐이며, 거주지 지역사회의 독립된 맥락효과는 미미한 것으로 나타났다. 분석에서 행정동별 표준화사망비 분포가 취약근린지수의 분포와 유사하고 더 나아가 공시지가, 하위교육수준, 복지수급자 비율, 여성가구주 가구의 개별 지표 분포와 유사한 패턴을 보이고 있는 것으로 나타나 전반적으로 인구집단의 취약성을 반영하는 것으로 보인다. 반면 빈곤 지역이 내생적으로 형성하는 건강문화나 보건의료접근성 등의 가능한 매개 요인들의 가능성은 인구 구성에 따른 빈곤과 결핍보다 상대적으로 저조할 것으로 보인다. 즉 건강의 지역별 격차는 다름 아닌 계층간 격차로 해석될 수 있다.

• 보건행정학회지
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• 제31권1호
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• pp.114-124
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• 2021

Background: In this study, we aimed to investigate the interaction effects of individual socioeconomic status and regional deprivation on the onset of diabetes complications and diabetes-related hospitalization among type 2 diabetes patients. Methods: Korean National Health Insurance Service National Sample Cohort data from 2002 to 2013 were used. A total of 50,954 patients newly diagnosed with type 2 diabetes from 2004 to 2012 and aged 30 years or above were included. We classified patients into six groups according to individual income level and neighborhood deprivation: 'high in advantaged,' 'high in disadvantaged,' 'middle in advantaged,' 'middle in disadvantaged,' 'low in advantaged,' and 'low in disadvantaged.' We calculated hazard ratios (HR) of onset of diabetes complication and diabetes-related hospitalization using the Cox proportional hazard model, with the reference group as diabetes patients with high income in advantaged regions. Results: In terms of the interaction effects of individual income level and regional socioeconomic level, even with the same low individual income level, the group with a high regional socioeconomic level (low in advantaged) showed low HRs for the onset of diabetes complication (HR, 1.04; 95% confidence interval [CI], 1.00-1.08) compared to the 'low in disadvantaged' group (HR, 1.10; 95% CI, 1.05-1.16). In addition, the 'high in advantaged' group showed slightly higher HRs for the onset of diabetes complication (HR, 1.06; 95% CI, 1.00-1.11) compared to the 'low in advantaged' and it appeared to be associated with slight mitigation of the risk of diabetes complication. For the low-income level, the patients in disadvantaged regions showed the highest HRs for diabetes-related hospitalization (HR, 1.29; 95% CI, 1.19-1.41) compared to the other groups. Conclusion: Although we need to perform further investigations to reveal the mechanisms that led to our results, interaction effects individual socioeconomic status and regional deprivation might be associated with on onset of diabetes complications and diabetes-related hospitalization among type 2 diabetes patients.

• Journal of Korean Neurosurgical Society
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• 제29권8호
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• pp.1008-1018
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• 2000

Objective : Glutamate induced excitotoxicity is one of the leading causes of cell death under pathologic condition. However, there is controversy whether excitotoxicity may also participate in the neuronal death under low intensity insult such as simple hypoxia or hypoglycemia. To investigate the role of NMDA receptor in low intensity insult, we chose anoxia as the method of injury and used organotypically cultured hippocampal slice as the material of experiment. Materials & Methods : The hippocampal slices cultured for 2-3 weeks were exposed to 60 minutes of complete oxygen deprivation(anoxia). Neuronal death was assessed with Sytox stain. Corrected optical density of fluorescence in gray scale, used as cellular death indicator, was obtained from pictures taken at 24 and 48 hours following the insult. The well-known in vivo phenomenon of regional difference in susceptibility of hippocampal sub-fields to ischemic insult was reproduced in HOSC(hippocampal organotypic slice culture) by complete oxygen deprivation injury. Results : $CA_1$ was the most vulnerable to complete oxygen deprivation in hippocampus while $CA_3$ was resistant. Oxygen deprivation for 10 and 20 minutes with glucose(6.5g/l) present was insufficient to induce neuronal death in the cultured hippocampal slice. However, after 30 minutes exposure under anoxic condition, neuronal death was able to be detected in the center of $CA_1$ area. The intensity and area of fluorescence indicating cell death correlated with the duration of oxygen deprivation. NMDA receptor and non-NMDA receptor blocking with MK-801(30 & $60{\mu}M$) and CNQX($100{\mu}M$) did not provide cellular protection to HOSC against damage induced by oxygen deprivation, but increased intracellular calcium buffering capacity with BAPTA-AM($10{\mu}M$) was effective in preventing neuronal death (p=0.01, Student's t-test). Cycloheximide($1{\mu}g/ml$, $10{\mu}g/ml$) provided no protection to HOSC against insult of complete oxygen deprivation for 60 minutes and combined therapy of MK-801(30 & $60{\mu}M$) and cycloheximide(1 & $10{\mu}g/ml$) was also ineffective in preventing neuronal death. Conclusion : The results of this study show that the another mechanism not associated with glutamate receptor(NMDA & non NMDA) may play major role in cell death mechanisms induced by complete oxygen deprivation and increased intracellular calcium during anoxia may participate in the neuronal death mechanism of oxygen deprivation. Further investigation of the calcium entry channel activated during oxygen deprivation is necessary to understand the neuronal death of anoxia.