• World Technopolis Review
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• 제6권2호
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• pp.113-129
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• 2017

Universities are considered important actors and drivers of socio-economic development in the regional innovation eco-system. This article investigates the role Kenyan universities and research institutes play in the development of regional innovation eco-system in the context of triple and Quadruple helices. A model involving Government, Industry, Universities and Society (Public) linkages in the regional innovation eco-system and with Information and Communication Technology as an enabler is used as a framework for analysing the nature of linkages in Kenya. The article uses literature review and case study methods to examine how universities and research institutes can spur the development of the innovation eco-systems. The research question is: what is the role of Kenyan universities and research institutes in spurring innovation ecosystems? Six cases of Kenyan universities and research institutes are considered in the light of Government Policy on Science, Technology and Innovation (STI) which is underpinned in Kenyan constitution 2010. The study contributes to the understanding of how deep collaboration among universities, government, research institutes, Science Cities, local, regional, national and international players spurs the creation of world-class innovation ecosystems which can contribute to regional development in developing countries like Kenya.

• Journal of Ginseng Research
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• 제46권1호
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• pp.23-32
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• 2022

Panax polysaccharides are biopolymers that are isolated and purified from the roots, stems, leaves, flowers, and fruits of Panax L. plants, which have attracted considerable attention because of their immunomodulatory activities. In this paper, the composition and structural characteristics of purified polysaccharides are reviewed. Moreover, the immunomodulatory activities of polysaccharides are described both in vivo and in vitro. In vitro, Panax polysaccharides exert immunomodulatory functions mainly by activating macrophages, dendritic cells, and the complement system. In vivo, Panax polysaccharides can increase the immune organ indices and stimulate lymphocytes. In addition, this paper also discusses the membrane receptors and various signalling pathways of immune cells. Panax polysaccharides have many beneficial therapeutic effects, including enhancing or activating the immune response, and may be helpful in treating cancer, sepsis, osteoporosis, and other conditions. Panax polysaccharides have the potential for use in the development of novel therapeutic agents or adjuvants with beneficial immunomodulatory properties.

• Journal of Ginseng Research
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• 제45권2호
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• pp.228-235
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• 2021

Backgroud: Ginsenoside compound K (GK) is a major metabolite of protopanaxadiol-type ginsenosides and has remarkable anticancer activities in vitro and in vivo. This work used an ionic cross-linking method to entrap GK within O-carboxymethyl chitosan (OCMC) nanoparticles (Nps) to form GK-loaded OCMC Nps (GK-OCMC Nps), which enhance the aqueous solubility and stability of GK. Methods: The GK-OCMC Nps were characterized using several physicochemical techniques, including x-ray diffraction, transmission electron microscopy, zeta potential analysis, and particle size analysis via dynamic light scattering. GK was released from GK-OCMC Nps and was conducted using the dialysis bag diffusion method. The effects of GK and GK-OCMC Nps on PC3 cell viability were measured by using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. Fluorescent technology based on Cy5.5-labeled probes was used to explore the cellular uptake of GK-OCMC Nps. Results: The GK-OCMC NPs had a suitable particle size and zeta potential; they were spherical with good dispersion. In vitro drug release from GK-OCMC NPs was pH dependent. Moreover, the in vitro cytotoxicity study and cellular uptake assays indicated that the GK-OCMC Nps significantly enhanced the cytotoxicity and cellular uptake of GK toward the PC3 cells. GK-OCMC Nps also significantly promoted the activities of both caspase-3 and caspase-9. Conclusion: GK-OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the antiproliferative effects of GK.

• Journal of Ginseng Research
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• 제43권4호
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• pp.600-605
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• 2019

Background: The leaves and roots of Panax ginseng are rich in ginsenosides. However, the chemical compositions of the leaves and roots of P. ginseng differ, resulting in different medicinal functions. In recent years, the aerial parts of members of the Panax genus have received great attention from natural product chemists as producers of bioactive ginsenosides. The aim of this study was the isolation and structural elucidation of novel, minor ginsenosides in the leaves of P. ginseng and evaluation of their antiinflammatory activity in vitro. Methods: Various chromatographic techniques were applied to obtain pure individual compounds, and their structures were determined by nuclear magnetic resonance and high-resolution mass spectrometry, as well as chemical methods. The antiinflammatory effect of the new compounds was evaluated on lipopolysaccharide-stimulated RAW 264.7 cells. Results and conclusions: Two novel, minor triterpenoid saponins, ginsenoside $LS_1$ (1) and 5,6-didehydroginsenoside $Rg_3$ (2), were isolated from the leaves of P. ginseng. The isolated compounds 1 and 2 were assayed for their inhibitory effect on nitric oxide production in LPS-stimulated RAW 264.7 cells, and Compound 2 showed a significant inhibitory effect with $IC_{50}$ of $37.38{\mu}M$ compared with that of NG-monomethyl-L-arginine ($IC_{50}=90.76{\mu}M$). Moreover, Compound 2 significantly decreased secretion of cytokines such as prostaglandin $E_2$ and tumor necrosis factor-${\alpha}$. In addition, Compound 2 significantly suppressed protein expression of inducible nitric oxide synthase and cyclooxygenase-2. These results suggested that Compound 2 could be used as a valuable candidate for medicinal use or functional food, and the mechanism is warranted for further exploration.

• 청정기술
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• 제22권4호
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• pp.316-325
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• 2016

국내에 청정생산기술에 대한 개념이 도입된지 16년이 되었지만 아직도 청정생산기술에 대한 정의와 의미가 중소기업들에 확산이 되지 않은 상황이다. 본 연구에서는 청정생산기술에 대한 개념과 구분을 살펴보고, 환경기술과 녹색기술과의 관계 그리고 국내외에서 구분하고 있는 기술 종류 등을 비교분석하였다. 그리고 국내 중소기업들에 청정생산기술이 확산되기 위한 방안으로 현재 정부에서 지원하고 있는 지역에코혁신사업을 확대하는 정책 제안을 하였다.

• 한국지역지리학회지
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• 제15권5호
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• pp.537-553
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• 2009

혁신도시 건설이 자립형 지방화를 통한 국가경쟁력 강화라는 방향성에서 지역전략산업 중심의 연계방안 마련이 핵심적 과제가 될 수 있다. 본 연구는 경북 혁신도시를 사례로 혁신도시와 연계한 경북의 지역전략산업 중심의 산학연계 구축방안 모색을 통하여 지역산업 육성전략을 제시하고자 한다. 이전공공기관과 지역산업간 연계분석과 지역전략산업 중심의 혁신도시 연계방안을 제시하였다. 연계방안에서는 경북의 전략 및 선도산업인 전자정보기기, 신소재부품, 생물한방 문화관광, 친환경에너지 등의 산업별 특성에 기반한 클러스터 구축방안을 제시하였다. IT BT산업과 같이 기술발전 속도가 빠른 산업분야의 경우 구미 혁신클러스터 추진단 및 경북지역 주요 혁신지원기관과 연계한 관련 주체간 지리적 인접을 통한 상호 연계협력이 필요하며, 자동차부품 기계 철강산업과 같은 성숙 기술분야는 기존 클러스터의 육성을 위한 교통 물류지원 등 인프라 강화가 핵심과제이다. 경제권의 광역화와 광역클러스터화에 따른 광역경제권 단위의 산업클러스터 육성도 새로운 과제이다.

• International Journal of Computer Science & Network Security
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• 제22권1호
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• pp.7-14
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• 2022

The presented research is devoted to the problems of achieving the goals of sustainable development, which will contribute to the development of industrial parks and their transformation into eco-industrial parks. The importance of the functioning of industrial parks and their transformation into eco-industrial ones in the direction of achieving sustainable development goals is substantiated. The development of industrial parks and their transformation through the coordination of dynamic development processes and the establishment of a system of mutually beneficial relations, due to the peculiarities of their functioning aimed at achieving sustainable development goals ensure the achievement of sustainable spatial development. Transformation of industrial parks will contribute to: increasing tax revenues of local budgets, increasing employment in the regions, raising public awareness of the need for environmentally friendly, energy efficient production, increasing the balance and harmony of social, economic and environmental development, modernization of territorial communities and regional enterprises resources and increase entrepreneurial initiative, rational use of available resources, intensification of small and medium enterprises, including innovation. The authors' scientific achievements are the substantiation of the principles of functioning of industrial parks in order to achieve the goals of sustainable development, which are based on a systematic approach and provide for the transformation into eco-industrial parks.

• Journal of Ginseng Research
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• 제45권2호
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• pp.354-360
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• 2021

Background: Protopanaxatriol (PPT) is a secondary intestinal metabolite of ginsenoside in ginseng. Although the effects of PPT have been reported in various diseases including cancer, diabetes and inflammatory diseases, the skin protective effects of PPT are poorly understood. Methods: HaCaT cells were treated with PPT in a dose-dependent manner. mRNA and protein levels which related to skin barrier and hydration were detected compared with retinol. Luciferase assay was performed to explore the relative signaling pathway. Western blot was conducted to confirm these pathways and excavated further signals. Results: PPT enhanced the expression of filaggrin (FLG), transglutaminase (TGM)-1, claudin, occludin and hyaluronic acid synthase (HAS) -1, -2 and -3. The mRNA expression levels of FLG, TGM-1, HAS-1 and HAS-2 were suppressed under NF-κB inhibition. PPT significantly augmented NF-κB-luc activity and upregulated Src/AKT/NF-κB signaling. In addition, PPT also increased phosphorylation of the mitogen-activated protein kinases (MAPKs) ERK, JNK and p38 and upstream MAPK activators (MEK and MKK). Furthermore, transcriptional activity of AP-1 and CREB, which are downstream signaling targets of MAPK, was enhanced by PPT. Conclusion: PPT improves skin barrier function and hydration through Src/AKT/NF-κB and MAPK signaling. Therefore, PPT may be a valuable component for cosmetics or treating skin disorders.

• 기술혁신학회지
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• 제17권2호
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• pp.309-333
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• 2014

새로운 혁신활동에 대응하기 위해서는 혁신의 사회적 맥락과 사용자의 잠재적 니즈를 파악하여 기술과 사회를 동시에 구성하는 노력이 필요하다. 사용자 경험 활용, 사회 기술기획 등으로 표현되는 '수요 구체화' 활동이 효과적으로 이루어져야 새로운 궤적을 형성하는 탈추격 혁신을 수행할 수 있고 사회 문제를 해결할 수 있기 때문이다. 리빙랩(Living Lab)은 사용자가 혁신활동에 능동적으로 참여하는 "사용자 주도형 혁신" 모델로서 최근 유럽을 중심으로 부각되고 있다. 본 연구는 사용자 주도형 혁신모델로서 리빙랩의 이론적 논의와 주요 사례를 살펴보고 우리나라에서의 적용 가능성을 탐색하였다. 리빙랩은 특정 공간 또는 지역에서 최종 사용자들이 적극적으로 참여해 문제를 해결하는 개방형 혁신모델로 지역사회의 문제 해결력을 증대함과 동시에 새로운 사회 기술시스템을 구현하기 위한 선구적 활동이다. 더 나아가 리빙랩은 탈추격 혁신, 수요지향적 혁신, 지역혁신, 사회문제 해결형 혁신, 생태계 형성 지원, 사회 기술시스템 전환 등 최근에 등장하고 있는 혁신정책의 패러다임 변화를 반영한 정책 수단으로서 우리 사회의 변화를 탐색할 수 있는 기반이 된다.

• Transactions on Electrical and Electronic Materials
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• 제12권3호
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• pp.98-101
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• 2011

A 10 nm nano-silica was introduced to a conventional 3 ${\mu}M$ micro-silica composite to develop an eco-friendly new electric insulation material for heavy electric equipment. Thermal and mechanical properties, such as glass transition temperature (Tg), dynamic mechanical analysis, tensile and flexural strength, were studied. The mechanical results were estimated by comparing scale and shape parameters in Weibull statistical analysis. The thermal and mechanical properties of conventional epoxy/micro-silica composite were improved by the addition of nano-silica. This was due to the increment of the compaction via the even dispersion of the nano-silica among the micro-silica particles.