• Journal of the Korean Society for Library and Information Science
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• v.45 no.1
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• pp.11-27
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• 2011

This paper aims to seek ways of optimizing the operations of Collaborative Digital Reference Service(CDRS) in Korea. CDRS tries to specialize the reference service through world-wide collaborative service. In this study seven international CDRS services including "QuestionPoint" operated by ALA and one national service, "Ask a Librarian" by the National Library of Korea were surveyed. A focused analysis of CDRS in Korea shows not only a sharp increase in use by the public, but also much application in research and academic activities by university students and workers.

• Korean Journal of Clinical Laboratory Science
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• v.46 no.3
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• pp.79-84
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• 2014

Children and adolescents normally have higher Alkaline phosphatase levels than adults. This study was conducted to provide basic data about pediatric reference intervals for ALP. The data from the 2011 Korean National Health and Nutrition Examination Survey was used. Analysis was done for 847 Children and Adolescents (443 boys and 404 girls) aged 10 to 19. The method of p-NPP & EAE buffer was used to get the data. The highest ALP levels were found in boys aged 12 to 13, the reference interval being 653~1,518 IU/L; the levels decreased for those over 13 years old. In the case of girls, the highest ALP levels were found with those aged between 11 and 12, the reference interval being 463~1,598 IU/L; the levels decreased after 12 years of age. The mean difference in all age groups was statistically significant, except for those aged 10 to 11 and 11 to 12. Therefore, it is suggested that pediatric reference intervals should be divided into three groups according to gender. Complementing data about children and adolescents below 10 years old were not included in this study and will be much needed in the next trial.

• The Journal of Advanced Prosthodontics
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• v.14 no.2
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• pp.63-69
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• 2022

PURPOSE. The aim of this in vitro study was to investigate the accuracy (trueness and precision) of five intraoral scanners (IOS) using a novel reference model for standardized performance evaluation. MATERIALS AND METHODS. Five IOSs (Medit i500, Omnicam, Primescan, Trios 3, Trios 4) were used to digitize the reference model, which represented a simplified full-arch situation with four abutment teeth. Each IOS was used five times by an experienced operator, resulting in 25 STL (Standard Tessellation Language) files. STL data were imported into 3D software (Final Surface^®) and examined for inter- and intra-group analyses. Deviations in the parameter matching error were calculated. ANOVA F-test and Kruskal-Wallis test were applied for inter-group comparisons (α = .05); and the coefficient of variation (CV) was calculated for intra-group comparisons (in % ± SD). RESULTS. Primescan (matching error value: 0.015), Trios 3 (0.016), and Trios 4 (0.018) revealed comparable results with significantly higher accuracy compared to Medit i500 (0.035) and Omnicam (0.028) (P < .001). For intra-group comparison, Trios 4 demonstrated the most homogenous results (CV 15.8%). CONCLUSION. The novel reference model investigated in this study can be used to assess the performance of dental scanning technologies in the daily routine setting and in research settings.

• Publications of The Korean Astronomical Society
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• v.23 no.2
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• pp.53-63
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• 2008

Korea Astronomy and Space Science Institute (KASI), direct decendant of Korea National Astronomy Observatory, has been publishing Korean Astronomical Almanac since in 1976. The almanac contains essential data in our daily lives such as the times of sunrise, sunset, moonrise, and moonset, conversion tables between luni-solar and solar calendars, and so forth. So, we are planning to register Korean astronomical almanac data for national Standard Reference Data(SRD), which is a scientific/technical data whose the reliablity and the accuracy are authorized by scientific analysis and evalution. To be certificated as national SRD, reference data has to satisfy several criteria such as traceability, consistency, uncertainty, and so on. Based on similarity among calculation processes, we classified astronomical almanac data into three groups: Class I, II, and III. We are planning to register them for national SRD in consecutive order. In this study, we analyzed Class I data which is aimed to register in 2009, and presented the results. Firstly, we found that the traceability and the consistency can be ensured by the usage of NASA/JPL DE405 ephemeris and by the comparsion with international data, respectively. To evaluate uncertainty in Class I data, we solved the mathematical model and determined the factors influencing the calculations. As a result, we found that the atmospheric refraction is the main factor and leads to a variation of ${\pm}16$ seconds in the times of sunrise and sunset. We also briefly review the histories of astronomical almanac data and of standard reference data in Korea.

• The Journal of the Korea Contents Association
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• v.13 no.10
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• pp.574-583
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• 2013

The coastal area, which is managed by local governments, geographically, culturally and economically has been transformed into more influential space. In recent years, new type of fusion researches about coastal areas that have economic, cultural and engineering aspects, have been conducted. In this study, the multiple observations information was used to analyze change of Ilsan beach shoreline which is located in Dong-gu, Ulsan, Korea. For the shoreline analysis, we used VRS-RTK(Virtual Reference System by Real-Time Kinematic) GPS survey, aerial photograph, terrestrial LiDAR survey and fixed reference station survey. Specially fixed reference station method was suggested for shoreline observation and maintenance. In the case of Ilsan beach shoreline, according to the result of multiple observations information, coastline erosion(6~12m) appeared in medium and lower part and sedimentation(3~14m) in the upper part of coastline.

• Biomolecules & Therapeutics
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• v.15 no.2
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• pp.118-122
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• 2007

This study was performed to evaluate the bioequivalency between the Osmetone$^{TM}$ Tablet (Myeongmoon Pharm. Co., Ltd.) as a test formulation and the Relafen$^{TM}$ Tablet (Handok Pharm. Co., Ltd.) as a reference formulation. Twenty-four healthy male volunteers were administered the formulations by the randomized Latin square crossover design, and the plasma samples were determined by a high performance liquid chromatography (HPLC) with Ultra-Violet (UV) detector. AUC$_t$, C$_{max}$ and T$_{max}$ were obtained from the time-plasma concentration curves, and log-transformed AUC$_t$ and C$_{max}$ and log-untransformed T$_{max}$ values for two formulations were compared by statistical tests and analysis of variation. AUC$_t$ was determined to be 897.8${\pm}$431.1 ug.hr/ml for the reference formulation and 902.3${\pm}$408.4 ug.hr/ml for the test formulation. The mean values of C$_{max}$ for the reference and test formulations were 24.2${\pm}$8.9 and 24.0${\pm}$9.5 ug/ml, respectively. The AUC$_t$ and C$_{max}$ ratios of the reference Relafen$^{TM}$ Tablet to the test Osmetone$^{TM}$ Tablet were +5.01% and -0.83%, respectively, showing that the mean differences were satisfied the acceptance criteria within 20%. The results from analysis of variance for logtransformed AUC$_t$ and C$_{max}$ indicated that sequence effects between groups were not exerted and 90% confidence limits of the mean differences for AUC$_t$ and C$_{max}$ were located in ranges from log 0.80 to log 1.25, satisfying the acceptance criteria of the KFDA bioequivalence. The Osmetone$^{TM}$ Tablet as the test formulation was considered to be bioequivalant to the Relafen$^{TM}$ Tablet used as its reference formulation, based on AUC$_t$ and C$_{max}$ values.

• Spatial Information Research
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• v.8 no.1
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• pp.171-182
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• 2000

Random sampling or systematic sampling method is commonly used to assess the accuracy of classification results. In remote sensing, with these sampling method, much time and tedious works are required to acquire sufficient ground truth data. So , a more effective sampling method that can retain the characteristics of the population is required. In this study, fractal analysis is adopted as an index for reference sampling . The fractal dimensions of the whole study area and the sub-regions are calculated to choose sub-regions that have the most similar dimensionality to that of whole-area. Then the whole -area s classification accuracy is compared to those of sub-regions, respectively, and it is verified that the accuracies of selected sub regions are similar to that of full-area . Using the above procedure, a new kind of reference sampling method is proposed. The result shows that it is possible to reduced sampling area and sample size keeping up the same results as existing methods in accuracy tests. Thus, the proposed method is proved cost-effective for reference data sampling.

• Journal of the Korean Society for Precision Engineering
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• v.32 no.9
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• pp.807-813
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• 2015

In the present study, an interferometer system, which integrates the laser sensitivity control technique based on the theory of electronic speckle pattern interferometry, one of non-contact non-destructive analysis methods, was developed. This interferometry system receives an image from CCD cameras for each reference and object, and compares the photosensitivity of the object and reference images from imagification. For the purpose of this study, the photosensitivity of object and reference light is measured with power meters, and the amount of light was controlled with an ND filter with a reference light port matching photosensitivity. Using the plate specimen as the object, 0.6, 0.9, 1.2, and $1.5{\mu}m$ of out-plane deformation was made, and images were compared according to the difference in photosensitivity. After analysis, larger object deformations showed larger numbers of stripe patterns. Images became clearer and data error was reduced when the photosensitivity of object and reference light matched.

• Biomolecules & Therapeutics
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• v.14 no.1
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• pp.50-55
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• 2006

The objective of the study was to evaluate the bioequivalency between the $Rozid^{TM}$ Tablet (Ilhwa Pharm. Co., Ltd.) as a test formulation and the $Rulid^{TM}$ Tablet (Handok Pharm. Co., Ltd) as a reference formulation. Twenty-four healthy male volunteers were administered the formulations by the randomized Latin square crossover design, and the plasma samples were determined by a high performance liquid chromatography (HPLC) with fluorescence detector. $AUC_t,\;C_{max}\;and\;T_{max}$ were obtained from the time-plasma concentration curves, and log-transformed $AUC_t\;and\;C_{max}$ and log-untransformed $T_{max}$ values for two formulations were compared by statistical tests and analysis of variation. $AUC_t$ was determined to be $63.30{\pm}25.57{\mu}g.hr/ml$ for the test formulation and $64.02{\pm}29.27mg.hr/ml$ for the reference formulation. The mean values of $C_{max}$ for the test and reference formulations were $5.07{\pm}2.14\;and\;5.53{\pm}2.60{\mu}g/ml$, respectively. The $AUC_t,\;and\;C_{max}$ ratios of the test $Rozid^{TM}$ Tablet to the reference $Rulid^{TM}$ Tablet were -1.12% and -8.32%, respectively, showing that the mean differences were satisfied the acceptance criteria within 20%. The results from analysis of variance for log-transformed $AUC_t,\;and\;C_{max}$ indicated that sequence effects between groups were not exerted and 90% confidence limits of the mean differences for $AUC_t,\;and\;C_{max}$ were located in ranges from log 0.80 and log 1.25, satisfying the acceptance criteria of the KFDA bioequivalence. The RozidTM Tablet as the test formulation was considered to be bioequivalent to the RulidTM Tablet used as its reference formulation, based on $AUC_t,\;and\;C_{max}$ values.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.1
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• pp.1-10
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• 2018

During early pregnancy, before the development of a functioning thyroid gland, thyroid stimulating hormone (TSH) is a very sensitive marker of thyroid dysfunction during pregnancy. Normal values have been modified during gestation with a downward shift. The fetus is influenced by the TSH supplied by the mother. TSH and free thyroxine (FT4) concentrations vary during pregnancy and conventional units can vary between laboratories. A downward shift of the TSH reference range occurs during pregnancy, with a decrease in both the lower and upper limits of maternal TSH, relative to the typical non-pregnant TSH reference range. Each laboratory produces its own reference TSH and FT4 concentrations because there are many different assays that yield different results in pregnancy. Therefore, automated immunoassays used for serum FT4 analysis are still used widely, but the important considerations discussed above must be noted. The use of population-based, trimester-specific reference ranges remains the best way to handle this issue The slight downward shift in the upper reference range of TSH occurring in the latter first trimester (7~12 weeks) of pregnancy, typically not observed prior to 7 weeks. Their use indicates high or low levels in a quantitative manner independent of the reference ranges. These data highlight the importance of calculating population-based pregnancy-specific thyroid parameter reference intervals. A precision medicine initiative in this area will require the collection and analysis of a large number of genetic, biological, psychosocial, and environmental variables in large cohorts of individuals. Large prospective randomized controlled trials will be needed to resolve these controversies.