• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년 추계학술대회논문집
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• pp.359-366
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• 2008

Current state and perspective of DNS of turbulence and turbulent combustion are discussed with feature trend of the fastest supercomputer in the world. Based on the perspective of DNS of turbulent combustion, possibility of perfect simulations of IC engine is shown. In 2020, the perfect simulation will be realized with 30 billion grid points by 1EXAFlops supercomputer, which requires 4 months CPU time. The CPU time will be reduced to about 4 days if several developments were achieved in the current fundamental researches. To shorten CPU time required for DNS of turbulent combustion, two numerical methods are introduced to full-explicit full-compressible DNS code. One is compact finite difference filter to reduce spatial resolution requirements and numerical oscillations in small scales, and another is well-known point-implicit scheme to avoid quite small time integration of the order of nanosecond for fully explicit DNS. Availability and accuracy of these numerical methods have been confirmed carefully for auto-ignition, planar laminar flame and turbulent premixed flames. To realize DNS of IC engine with realistic kinetic mechanism, several DNS of elemental combustion process in IC engines has been conducted.

• 동의생리병리학회지
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• 제23권2호
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• pp.452-456
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• 2009

The purpose of this study was to investigate the anti-inflammatory effects and cellular mechanism of piperine on murine peritoneal macrophages. To evaluate the effects of piperine, we examined the production of nitric oxide (NO), interleukin (IL)-10 and IL-12. To investigate inhibitory mechanism of piperine, we examined the MAPKs and Ik-Ba in murine peritoneal macrophages, Piperine itself does not have any cytotoxic effect and reduced lipopolysaccharid (LPS), Poly(I:C), CpG-ODN -induced production of NO, IL-10 and IL-12 in peritoneal macrophages. Piperine inhibited the activation of extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK 1/2) not the activation of p38 and the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated murine peritoneal macrophages.ln conclusion, Piperine down-regulated LPS-induced production of NO, IL-10 and IL-12, which could provide a clinical basis for anti-inflammatory properties of piperine.

• Biomolecules & Therapeutics
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• 제22권4호
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• pp.341-346
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• 2014

Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This study investigated the mechanism by giving treatments of placebo, cyclophosphamide, paeonol of 150 and 300 mg/kg to 4 groups of mice bearing EMT6 breast cancer. Apoptosis in tumor cells were confirmed by morphology analysis, including hematoxylin, eosin staining and TUNEL staining. The results showed that the weight of EMT6 breast tumor was significantly reduced in the groups treated with both 150 and 300 mg/kg of paeonol. Immunohistochemical and Western blot results showed that the expression of Bcl-2 was down-regulated while the expression of Bax, caspase 8 and caspase 3 was up-regulated respectively. These results suggest that paeonol exhibits antitumor effects and the mechanism of the inhibition is via induction of apoptosis, regulation of Bcl-2 and Bax expression, and activation of caspase 8 and caspase 3.

• 한국터널공학회:학술대회논문집
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• 한국터널공학회 2005년도 학술발표회 논문집
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• pp.251-258
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• 2005

In this study, a new concept for simulating a long-term mechanical degradation mechanism of shotcrete in tunnels has been proposed. In fact, it is known that the degradation takes place mainly by internal cracks and reduced stiffness, which results mainly from volume expansion of shotcrete and corrosion of cement materials, respectively. This degradation mechanism of shotcrete in tunnels appears similar to those of the most kinds of chemical reactions in tunnels. Therefore, the mechanical degradation induced by a kinds of chemical reaction was generalized and mathematically formulated in the framework of thermodynamics. The numerical model was implemented to a 3D finite element code, which can be used to simulate behaviour of shotcrete structures undergoing external forces as well as chemical degradation in time. A number of illustrative examples were given to show the feasibility of the model in tunnel designs with consideration of long-term degradation effect of shotcrete quantitatively for increase of long-term safety of tunnels.

• 대한한방부인과학회지
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• 제21권2호
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• pp.152-165
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• 2008

Purpose: It is the purpose of this study to investigate the anti-inflammatory effects and mechanism of cheukbaekjurpihwan(CBJPH) extract on LPS (lipopolysaccharide)-induced inflammatory mediators in murine peritoneal macrophages. Methods: To evaluate anti-inflammatory effects of CBJPH extract, the production of cytokines(TNF-${\alpha}$(tumor necrosis factor-alpha), IL(interleukin)-6, IL-12) and NO(nitric oxide) was measured in vitro and in vivo. And western blot analysis has been done to look into the mechanism. Results: CBJPH extract reduced LPS-induced NO, TNF-${\alpha}$ and IL-6, IL-12 productions in peritoneal macrophages. CBJPH extract inhibited the activation of JNK(c-Jun N-terminal kinase), but didn't inhibit the activation of MAPKs (mitogen-activated protein kinases) such as p38, ERK1/2(extracelluar signal-regulated kinase1/2) and the degradation of $I_{\kappa}B-{\alpha}$(inhibitory kappa B-alpha) in the LPS-stimulated peritoneal macrophages. CBJPH extract suppressed LPS-induced endotoxin shock and the productions of TNF-${\alpha}$, but not of IL-6, after an oral administration of CBJPH extract Conclusion: CBJPH extract suppressed the productions of LPS-induced NO and cytokines by preventing JNK from phosphorylation, which may provide a clinical basis for anti-inflammatory properties of CBJPH.

• 한국정밀공학회지
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• 제34권1호
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• pp.53-58
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• 2017

A fine stage is developed for the 3-DOF error compensation of a linear axis in order to improve the positioning accuracy. This stage is designed as a planar parallel mechanism, and the joints are based on a flexure hinge to achieve ultra-precise positioning. Also, the effect of Abbe's offsets between the measuring and driving coordinate systems is minimized to ensure an exact error compensation. The mode shapes of the designed stage are analyzed to verify the desired 3-DOF motions, and the workspace and displacement of a piezoelectric actuator (PZT) for compensation are analyzed using forward and inverse kinematics. The 3-DOF error of a linear axis is measured and compensated by using the developed fine stage. A marked improvement is observed compared to the results obtained without error compensation. The peak-to-valley (PV) values of the positional and rotational errors are reduced by 92.6% and 91.3%, respectively.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.843-846
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• 2004

Cavity tone is generated due to the feedback between flow and acoustic wave. It is recognized that the period is determined by the time required for the flow convection in one direction, the time required for the acoustic propagation in the other direction and the time for phase shift depending on the flows and mode. Most of the phenomena have been investigated by experiments and a simple but fundamental theory. But the cause of the phase shift and the correctness of the theory have not been clearly explained so far. In this paper, the phenomena are calculated numerically to obtain detail information of flow and acoustic wave to explain the mechanism including the phase. High order high resolution scheme of optimized high order compact is used to resolve the small acoustic quantities and large flow quantities at the same time. The data are reduced using cross correlation function in space and time and cross spectral density function which has phase information. Abrupt change in pressure near corner in cavity is observed and is relate to phase variation. The time required for the feedback between the flow and acoustic wave is calculated after the numerical simulation f3r various modes. The periods based on the time calculated using the above method and direct observation from the acoustic waves generated and propagated in the numerical simulation are compared. It is found that no phase shift is required if we examine the time required carefully. Rossiter's formula for the cavity tone used for quick estimation needs to be modified far some modes.

• Ocean Systems Engineering
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• 제10권3호
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• pp.333-357
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• 2020

International Maritime Organisation (IMO) regulations insist on reduced emission of CO₂, noxious and other environmentally dangerous gases from ship, which are usually let out while burning fossil fuel for running its propulsive machinery. Contrallability of ship during sailing has a direct implication on its course keeping and changing ability, and tries to have an optimised routing. Bad coursekeeping ability of a ship may lead to frequent use of rudder and resulting changes in the ship's drift angle. Consequently, it increases vessels resistance and also may lead to longer path for its journey due to zigzag movements. These adverse effects on the ship journey obviously lead to the increase in fuel consumption and higher emission. Hence, IMO has made it mandatory to evaluate the manoeuvring qualities of a ship at the designed stage itself. In this paper a numerical horizontal planar motion mechanism is simulated in CFD environment and from the force history, the hydrodynamic derivatives appearing in the manoeuvring equation of motion of a ship are estimated. These derivatives along with propeller thrust and rudder effects are used to simulate different standard manoeuvres of the vessel and check its parameters against the IMO requirements. The present study also simulates these manoeuvres by using numerical free running model for the same ship. The results obtained from both these studies are presented and discussed here.

• 한국콘텐츠학회논문지
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• 제2권3호
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• pp.119-126
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• 2002

이동망에서의 서비스 품질은 중요한 망 설계 요소중의하나이다. 특히, All-IP망에서 VoIP와 같은 실시간 응용은 망 링크간에 이동 호스트의 전이시 발생할 수 있는 패킷 손실을 최소로하는 smooth handoff가 필요하다. 본 논문에서는 MH가 All-IP를 지원하는 다른 망으로 이동시에 패킷 손실을 줄일 수 있는 동적 버퍼링 기반의 새로운 멀티캐스트 알고리즘을 제안한다. 새로운 프로토콜의 핵심 요소는 동적 버퍼링과 멀티캐스트 데이터그램 전달 경로를 줄이기 위해 멀티캐스트 라우팅 에이젼트(MRA) 개념을 도입한 것이다. 제안된 프로토콜은 짧은 라우팅 경로 및 이동 호스트에 근접한 노드에서 이동 호스트로의 직접 데이터그램 전송을 통하여 성능 향상을 기대할 수 있다.

• 한국자동차공학회논문집
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• 제22권3호
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• pp.97-104
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• 2014

Automobile trunk latches enable trunks to be opened and closed by a latch mechanism, which can be selectively positioned between a locked condition and an open condition. To maintain structural and electronic performance of the trunk latch, the latch needs to endure impact load that occurs in its open and close motion, and a dynamic mechanism needs to be electronically controled by a contact switch connected with a small DC motor. A base plate, which is the most important component relating to the structural safety, commonly uses a high stiffness material SAPH440-P with high manufacturing cost. In this paper, through structural analysis and optimization, production cost is significantly reduced by replacing SAPH440-P used in some region of the base plate with engineering plastic PBT GF 20%. The optimized contact switch reduces difference between distributed pressures of its two legs, which leads to improve the electronic performance of the trunk latch.