• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.37C no.10
• /
• pp.915-924
• /
• 2012

Though a mobile device is equipped with a number of wireless communication interfaces in general such as Zigbee, Bluetooth, Wi-Fi, 3G, it uses only one interface for a specific service. In this paper, we propose a mechanism of adaptive switching between wireless communication interfaces in order to efficiently use various communication interfaces. Depending on the application service and the characteristics of wireless communication interface, mobile devices select an appropriate wireless communication interface and may switch to another interface during the service. As a result, power consumption can be reduced and the utilization of communication interface can be improved by using this mechanism.

• Journal of Radiation Industry
• /
• v.4 no.3
• /
• pp.227-231
• /
• 2010

The purpose of this study was to investigate the expression mechanism of MCP-1 in gamma-irradiated RAW 264.7 macrophage cells. MCP-1 plays an important role in attracting monocyte to injured site at the early inflammation stage. However the production mechanism of MCP-1 by gamma-irradiation in RAW 264.7 macrophage cells was almost undiscovered. We found that MCP-1 was produced in RAW 264.7 macrophage cells by irradiation with 5 Gy. And these inceases were attenuated by specific inhibitors treatment, such as $NF-{\kappa}B$, JNK, ERK, JAK2, and Pyk2. These results indicate that radiation-induced MCP-1 production is mediated by MyD88- and TRIF-dependent pathways in RAW 264.7 macrophage cells. Furthermore, gamma-irradiation induced heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophage cells. However this induction level was reduced before MCP-1 and $IFN-{\beta}$ production.

• Bulletin of the Korean Chemical Society
• /
• v.21 no.12
• /
• pp.1217-1221
• /
• 2000

L-alanine dehydrogenase from Bacillus subtilis exhibits allosteric kinetic properties in the presence of $ZN^{2+}$. $ZN^{2+}$ induces the binding of substrate (L-alanine) to be cooperative at pH 8.0. The effect of pH variation between pH 7.0 and pH 10.0 on the inhibition by $ZN^{2+}$ correlates with the pH effect on the $K_m$ values for L-alanine within these pH range indicating that $ZN^{2+}$ and substrate compete for the same site. No such cooperativity is induced by $ZN^{2+}$ when the reaction is carried out at pH 10. At this higher pH, $ZN^{2+}$ binds with the enzyme with lower affinity and noncompetitive with respect to L-alanine. Inhibition of L-alanine dehydrogenase by $ZN^{2+}$ depends on the ionic strength. Increase in KCI concentration reduced the inhibition, but allosteric property in $ZN^{2+}$ binding is conserved. A model for the regulatory mechanism of L-alanine dehydrogenase as a noncooperative substrate-cooperative cofactor allosteric enzyme, which is compatible in both concerted and the sequential allosteric mechanism, is proposed.

• Molecules and Cells
• /
• v.45 no.4
• /
• pp.169-176
• /
• 2022

A primary cilium, a hair-like protrusion of the plasma membrane, is a pivotal organelle for sensing external environmental signals and transducing intracellular signaling. An interesting linkage between cilia and obesity has been revealed by studies of the human genetic ciliopathies Bardet-Biedl syndrome and Alström syndrome, in which obesity is a principal manifestation. Mouse models of cell type-specific cilia dysgenesis have subsequently demonstrated that ciliary defects restricted to specific hypothalamic neurons are sufficient to induce obesity and hyperphagia. A potential mechanism underlying hypothalamic neuron cilia-related obesity is impaired ciliary localization of G protein-coupled receptors involved in the regulation of appetite and energy metabolism. A well-studied example of this is melanocortin 4 receptor (MC4R), mutations in which are the most common cause of human monogenic obesity. In the paraventricular hypothalamus neurons, a blockade of ciliary trafficking of MC4R as well as its downstream ciliary signaling leads to hyperphagia and weight gain. Another potential mechanism is reduced leptin signaling in hypothalamic neurons with defective cilia. Leptin receptors traffic to the periciliary area upon leptin stimulation. Moreover, defects in cilia formation hamper leptin signaling and actions in both developing and differentiated hypothalamic neurons. The list of obesity-linked ciliary proteins is expending and this supports a tight association between cilia and obesity. This article provides a brief review on the mechanism of how ciliary defects in hypothalamic neurons facilitate obesity.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1997.04a
• /
• pp.119-119
• /
• 1997

Valacyclovir is a L-valyl ester prodrug of acyclovir which is a highly effective and selective antiviral agent in the treatment of herpes virus diseases. Valacyclovir is rapidly and almost completely converted to acyclovir and increases the oral bioavailability of acyclovir three to five fold. However, the intestinal absorption mechanism of valacyclovir is not clear. If the improved absorption mechanism of valacyclovir is fully understood, it will provide a rationale of designing the amino acid ester prodrugs of polar drugs containing hydroxyl group. The main objective of our present study is to characterize the membrane transport mechanism of valacyclovir. Methods : Intestinal absorption of valacyclovir was investigated by using in-situ rat perfusion study and its wall permeability was estimated by modified boundary layer model. The membrane transport mechanism was also investigated through the uptake study in Caco-2 cells and in CHO-hPepTl cells. Results : In the rat perfusion study, the wall permeability of valacyclovir was ten times higher than acyclovir and showed concentration dependency, Valacyclovir also demonstrated a D,L stereo-selectivity with L-isomer having an approximately five-fold higher permeability than D-isomer. Mixed dipeptides and cephalexin, which are transported by dipeptide carriers, strongly competed with valacyclovir for the intestinal absorption, while L-valine did not show any competition with valacyclovir. This indicated that the intestinal absorption of valacyclovir could be dipeptide carrier-mediated. In addition, the competitive uptake study in Caco-2 cells presented that dipeptides reduced the valacyclovir uptake but valine did not. Also, in IC$\sub$50/ study, valacyclovir showed strong inhibition on the $^3$H-gly-sar uptake in CHO-hPepTl cells over-expressing a human intestinal peptide transporter. Taken together, the result from our present study indicated that valacyclovir utilized the peptide transporter for the intestinal absorption.

• Journal of KIISE:Information Networking
• /
• v.29 no.2
• /
• pp.197-203
• /
• 2002

This paper proposes a new agent based mechanism called a Multicast Handoff Agent (MHA) to reduce handoff latency for IP multicast. The MHA acts as a proxy for an Internet Group Management Protocol (IGMP) of Mobile Nodes (MNs) at each Base Station (BS) and keeps information for members of multicast groups in a cell. When an MN moves to a next cell, the MHA immediately sends unsolicited reports without waiting for the IGMP query. The mechanism was evaluated through simulation and analysis and compared with the IGMPv2 for micro-mobility and the IGMP traffic. Simulation results show that handoff latency for micro-mobility can be largely reduced and the IGMP control traffic on the wireless links during the duration of membership can be eliminated. Thus, this mechanism is superior to the existing mechanism in both micro-mobility and battery duration, as the need not to reply to a query conserves battery power.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.24 no.12
• /
• pp.1581-1587
• /
• 2020

With the emergence of convolutional neural network in the field of machine learning, the model for solving image processing problems has seen rapid development. However, the computing resources required are also rising, making it difficult to learn from a typical environment. Attention mechanism is originally proposed to prevent the gradient vanishing problem of the recurrent neural network, but this can also be used in a direction favorable to learning of the convolutional neural network. In this paper, attention mechanism is applied to convolutional neural network, and the excellence of the proposed method is demonstrated through the comparison of learning time and performance difference at this time. The proposed model showed that both learning time and performance were superior in object detection based on YOLO compared to models without attention mechanism, and experimentally demonstrated that learning time could be significantly reduced. In addition, this is expected to increase accessibility to machine learning by end users.

• Archives of Pharmacal Research
• /
• v.9 no.3
• /
• pp.169-174
• /
• 1986

Bilateral lesion of nucleus accumbens septi (N, AB), one of the mesolimbic nuclei, resulted in hyperirritability and muricide including mouse eating behavior in rats. The effects of various drugs on hyperirritability and muricide induced by NAB lesion were investigated in rats. Hyperirritability in NAB rats were significantly reduced by L-DOPA L-5-HTP major and minor tranquilizers but not reduced by MA, ATP and imipriamine-like antidepressants. On the other hand, muricide in NAB rats was significantly suppressed by L-DOPA, L-5-HTP, major and minor tranquilizers, furthermore, selectively suppressed by MA, ATP and antidepressants. These results suggested that the neural mechanism for inducing muricide is distinct from for hyperirritability in NAB rats, and that muricide in NAB rats is resulted from the increasing of cholinergic activity and reduction of dopaminergic and serotonergic activity.

• International Journal of Concrete Structures and Materials
• /
• v.8 no.2
• /
• pp.173-182
• /
• 2014

An experimental investigation was carried out to evaluate the mechanical properties of concrete mixtures in which coarse aggregate was partially (30, 50 or 70 %) replaced with pre-washed municipal solid waste incineration (MSWI) bottom ash. Results indicated that bottom ash reduced the compressive strength, elastic modulus, and levels of heavy metals in leachate when used as a replacement for gravel, and that the maximum amount of MSWI bottom ash in concrete should not exceed 50 %. To analyze the effect mechanism of bottom ash in concrete, the degree of hydration and the following pozzolanic reaction characterized by the pozzolanic activity index, and the porosity distribution in cement mortar. The study indicates that improved properties of concrete are not solely later strength gain and reduced levels of heavy metals in leachate but also the progression of pozzolanic reactions, where a dense structure contains a higher proportion of fine pores that are related to durability.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2002.10a
• /
• pp.641-646
• /
• 2002

FRP-concrete composite slab is consisted of brittle materials and then shows brittle failure mechanism. This study suggests a new design approach that FRP-concrete composite slab leads to ductile failure, and investigates their failure behaviors for two types of section by numerical analysis. Box-type section is higher than I-type section in load capacity to required FRP quantity. Each section was designed so that the strain of FRP plate is 50% to its ultimate strain on initiation of concrete crushing, and it is verified that displacement ductility is more than two. Ductility capacity can be improved by reducing the strain of FRP on initiation of concrete crushing, but as the strain of FRP is reduced load capacity to required FRP quantity is also reduced. Therefore section optimization study is needed considering safety and economical efficiency.