• The Korean Journal of Physiology and Pharmacology
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• v.5 no.1
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• pp.33-40
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• 2001

The aim of present study was to define the cellular mechanisms underlying changes in delayed rectifier $K^+\;(K_{DR})$ channel function in isoproterenol-induced hypertrophy. It has been proposed that $K_{DR}$ channels play a role in regulation of vascular tone by limiting membrane depolarization in arterial smooth muscle cells. The alterations of the properties of coronary $K_{DR}$ channels have not been studied as a possible mechanism for impaired coronary reserve in cardiac hypertrophy. The present study was carried out to compare the properties of coronary $K_{DR}$ channels in normal and hypertrophied hearts. These channels were measured from rabbit coronary smooth muscle cells using a patch clamp technique. The main findings of the study are as follows: (1) the $K_{DR}$ current density was decreased without changes of the channel kinetics in isoproterenol-induced hypertrophy; (2) the sensitivity of coronary $K_{DR}$ channels to 4-AP was increased in isoproterenol-induced hypertrophy. From the above results, we suggest for the first time that the alteration of $K_{DR}$ channels may limit vasodilating responses to several stimuli and may be involved in impaired coronary reserve in isoproterenol-induced hypertrophy.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.1
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• pp.9-14
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• 2000

$K^+$ currents play multiple roles in the excitability of dorsal root ganglion (DRG) neurons. Influences on these currents change the shape of the action potential, its firing threshold and the resting membrane potential. In this study, whole cell configuration of patch clamp technique had been applied to record the blocking effect of capsaicin, a lipophilic alkaloid, on the delayed rectifier $K^+$ current in cultured small diameter DRG neurons of adult rat. Capsaicin reduced the amplitude of $K^+$ current in dose dependent manner, and the concentration-dependence curve was well described by the Hill equation with $K_D$ value of $19.1{\mu}M.$ The blocking effect of capsaicin was reversible. Capsaicin $(10 {\mu}M)$ shifted the steady-state inactivation curve in the hyperpolarizing direction by about 15 mV and increased the rate of inactivation. The voltage dependence of activation was not affected by capsaicin. These multiple effects of capsaicin may suggest that capsaicin bind to the region of $K^+$ channel, participating in inactivation process.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.2
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• pp.165-172
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• 1998

Under certain pathophysiological conditions, such as inflammation and ischemia, the concentration of H^+$ ion in the tissue surrounding neurons is changed. Variations in H^+$ concentration are known to alter the conduction and/of the gating properties of several types of ion channels. Several types of K^+$ channels are modulated by pH. In this study, the whole cell configuration of the patch clamp technique has been applied to the recording of the responses of change of external pH on the delayed rectifier K^+$ current of cultured DRG neurons of rat. Outward K^+$ currents were examined in DRG cells, and the Charybdotoxin and Mn^{2+}$ could eliminate Ca^{2+}-dependent$ K^+$ currents from outward K^+$ currents. This outward K^+$ current was activated around -60 mV by step depolarizing pulses from holding potential -70 mV. Outward K^+$ currents were decreased by low external pH. Activation and steady-state inactivation curve were shifted to the right by acidification, while there was small change by alkalization. These results suggest that H^+$ could be alter the sensory modality by changing and modifying voltage-dependent K^+$ currents, which participated in repolarization.

• Journal of Korean Society for Geospatial Information Science
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• v.2 no.1 s.3
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• pp.73-80
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• 1994

Most terrain information have been generally acquired by map. Because the map presents the real terrain, not by real figure but by contours, geometric figures, symbols, texts, and colors, it is not easy to interpret the real terrain by map. For this reason, aerial photos or terrestrial photos also have been used sometimes in the terrain analysis. But photos have geometrical displacement caused by the position of camera at the exposition time and the relief of the object. So, for accurate posional analysis, orthophoto maps produced by optical rectifier have been used. But, it is hard to produce orthophoto map by optical rectifier and the process is so slow. This study aims to present an accurate and rapid method to produce orthophoto map by generating digital elevation model from stereo aerial photos on common computer using the digital photogrammetric technique and producing orthophoto map digitally using the digital elevation model.

• Nuclear Engineering and Technology
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• v.53 no.7
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• pp.2334-2340
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• 2021

Radioactive particle tracking (RPT) is a minimally invasive nuclear technique that tracks a radioactive particle inside a volume of interest by means of a mathematical location algorithm. During the past decades, many algorithms have been developed including ones based on artificial intelligence techniques. In this study, RPT technique is applied in a simulated test section that employs a simplified mixer filled with concrete, six scintillator detectors and a¹³⁷Cs radioactive particle emitting gamma rays of 662 keV. The test section was developed using MCNPX code, which is a mathematical code based on Monte Carlo simulation, and 3516 different radioactive particle positions (x,y,z) were simulated. Novelty of this paper is the use of a location algorithm based on a deep learning model, more specifically a 6-layers deep rectifier neural network (DRNN), in which hyperparameters were defined using a Bayesian optimization method. DRNN is a type of deep feedforward neural network that substitutes the usual sigmoid based activation functions, traditionally used in vanilla Multilayer Perceptron Networks, for rectified activation functions. Results show the great accuracy of the DRNN in a RPT tracking system. Root mean squared error for x, y and coordinates of the radioactive particle is, respectively, 0.03064, 0.02523 and 0.07653.

• Proceedings of the KIEE Conference
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• 1991.07a
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• pp.451-455
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• 1991

The PWM control technique is proposed which can eliminate the harmonic components of the nonsinusoidal ac line current such as the current of 6-phase rectifier by injecting PWM current. TSC(Time-Sharing Control) is adopted to avoid the unbalance between three PWM injection currents at the three-phase system. Also a new power circuit for three-phase filter is suggested for realizing the proposed PWM control technique. The operation characteristics are investigated theoretically and experimentally to show the feasibility of the optimized injection method.

• Proceedings of the KIPE Conference
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• 2004.07b
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• pp.587-591
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• 2004

This paper proposes a novel current compensation technique that can eliminate the harmonic currents included in line currents without computation of harmonic current components. A current controller with fast dynamics for an active filter is described. Harmonic currents are directly controlled without the need for sensing and computing the harmonic current of the load current, thus simplifying the control system. Current compensation is done in the time domain, allowing a fast time response. The DC voltage control loop keeps the voltage across the DC capacitor constant. High power factor control by an active filter is described. All control functions are implemented in software using a single-chip microcontroller, thus simplifying the control circuit. Any current-controlled synchronous rectifier can be used as a shunt active filter through only the simple modification of the software and the addition of current sensors. It is shown through experimental results that the proposed controller gives good performance for the shunt active filter.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.41 no.3
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• pp.244-252
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• 1992

This paper describes a reactive power compensator using current-source delta modulation converter, which compensates the reactive power in the ac sides of 3-phase rectifier. In the conventional current control methods for the current-type reactive power compensators, it is usual to compare the reactive reference current signal with the triangular wave and hence to generate the ON-OFF signals for the reactive power compensator. To improve the response as well as the control capability, the delta modulated current control technique is used in this paper. As a result, the input power factor is improved close to unity and both simulation and experimental results show good compensating performances.

• Proceedings of the KIEE Conference
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• 1999.11b
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• pp.364-368
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• 1999

This paper suggests switching regulator technique to overcome the drawback of conventional variable linear power supply. Switching regulator technique can eliminate the extremely lossy operation and reduce the size and weight of variable linear power supply and provide nearly constant output power over the majority of output voltage range. The topology of variable switched mode power supply is employed active clamp forward converter with a current doubler rectifier and by using control of variable-frequency together with control of fixed-frequency, output voltage can be controled. Equivalent circuits pertinent to each operational mode of converter are derived, and an experimental 20V, 50A converter was designed and built. The converter operates from an output voltage of zero to 25 V, under 100 kHz switching frequency.

• Proceedings of the KIEE Conference
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• 1993.07b
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• pp.850-852
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• 1993

A buck-boost zero current switched(ZCS) series resonant AC to DC converter for the DC output voltage regulation together with high power factor is proposed. A dynamic model for this AC to DC converter is developed and an analysis for the internal operational characteristics is explored. With the proposed control technique, the unity power factor and the DC output voltage regulation without a current overshoot can be obtained.