• ALGAE
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• v.17 no.1
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• pp.41-51
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• 2002

Three dominant rocky intertidal macroalgae, the fucoids Fucus gardneri and Pelvetiopsis limitata (Phaeophyta) and the red alga Mazzaella cornucopiae (= Iridaea cornucopiae) on the west coast of Vancouver Island, British Columbia, Canada were used in a series of field experiments to examine interspecific interactions. These experiments showed complex patterns which included an interchange of negative (inhibition) and positive (facilitation) interactions depending on neighbor distance. Less fucoid recruitment occurred in the plots with greater percent cover of a turfforming red alga, M. cornucopiae. However, experimentally removing Mazzaella turf (the turf was considered to be "blocking" fucoid recruits or "shading" growing recruits) did not increase recruitment. This result indicated that there may be another factor(s) involved in the survivorship of juvenile fucoids in the turf-removed plots. Morphological differences in adult plants between Mazzaella and the two fucoids resulted in another type of interaction; these began when fucoids successfully settled and grew nearby or within the red algal turf. By monitoring microhabitat at the individual plant level for two years, I found that survivorship of fucoid recruits showed different species-specific patterns. The patterns also varied as the microhabitat changed from Mazzaella turf edge to open space. For F. gardneri, longevity of P.limitata at all distances tested was similar. A reason for greater longevity of F. gardneri individuals at edge microhabitats may be that these sites have one side open to light and nutrients and another site that buffers them from desiccation and wave impact. In the Mazzaella-Fucus interaction, neighbor distance was a key factor in determining whether the outcome of the interaction would be competition or facilitation (or protection). This study provides experimental evidence that detectable biological interactions occur in this upper intertidal algal community where physical conditions are usually severe, and also indicates the importance of small scale examination in understanding macroalgal interactions in intertidal habitats.

• Parasites, Hosts and Diseases
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• v.49 no.3
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• pp.245-254
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• 2011

Many immune down-regulatory molecules have been isolated from parasites, including cystatin (cystain protease inhibitor). In a previous study, we isolated and characterized Type I cystatin (CsStefin-1) of the liver fluke, Clonorchis sinensis. To investigate whether the CsStefin-1 might be a new host immune modulator, we induced intestinal inflammation in mice by dextran sodium sulfate (DSS) and treated them with recombinant CsStefin-1 (rCsStefin-1). The disease activity index (DAI) increased in DSS only-treated mice. In contrast, the DAI value was significantly reduced in rCsStefin-1-treated mice than DSS only-treated mice. In addition, the colon length of DSS only-treated mice was shorter than that of rCsStefin-1 treated mice. The secretion levels of IFN-${\gamma}$ and TNF-${\alpha}$ in the spleen and mesenteric lymph nodes (MLNs) were significantly increased by DSS treatment, but the level of TNF-${\alpha}$ in MLNs was significantly decreased by rCsStefin-1 treatment. IL-10 production in both spleen and MLNs was significantly increased, and IL-$10^+F4/80^+$ macrophage cells were significantly increased in the spleen and MLNs of rCsStefin-1 treated mice after DSS treatment. In conclusion, rCsStefin-1 could reduce the intestinal inflammation occurring after DSS treatment, these effects might be related with recruitment of IL-10 secreting macrophages.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.1
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• pp.1-6
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• 2022

The tuber of Pinellia ternata (Thunb.) Brei (TPT) used in traditional Oriental medicine for the treatment of cough, sputum, vomiting, and insomnia, possesses antioxidant, antibacterial, and anti-inflammatory effects. Although recent studies have reported the anticancer effects of TPT in several cancer cells, it is still unclear whether TPT regulates tumor-associated macrophage (TAM) characterized by the immunosuppressive M2 macrophage phenotype. Our results showed that the ethanol extract of TPT (ETPT) suppressed the migration of RAW264.7 mouse macrophage cells and THP-1 human monocytes differentiated into macrophages towards the conditioned media (CM) collected from lung cancer cells, suggesting that ETPT would attenuate the recruitment of macrophages into tumors. In addition, ETPT suppressed the interleukin (IL)-4 or IL-6-induced M2 macrophage polarization in RAW264.7 cells. ETPT treatment not only downregulated the mRNA expression of M2 macrophage markers including arginase-1, mannose receptor C type 1 (MRC-1), and IL-10, but also inhibited the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and STAT6, general regulators of M2 macrophage polarization. Finally, the transwell assay results showed that the CM from M2-polarized RAW264.7 cells increased the migration of mouse lewis lung carcinoma (LLC) cells, while those from RAW264.7 cells co-treated with ETPT and IL-6 significantly reduced the migration of LLC cells. Taken together, our observations clearly demonstrate that ETPT suppressed the cancer cell migration by regulating macrophage recruitment and M2 macrophage polarization.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.5
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• pp.343-348
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• 2009

53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage response proteins, including ${\gamma}$-H2AX, MDC1, and BRCA1. The recruitment of 53BP1 requires a tandem Tudor fold which associates with methylated histones H3 and H4. It has already been determined that the majority of DNA damage response proteins are phosphorylated by ATM and/or ATR after DNA damage, and then recruited to the break sites. 53BP1 is also phosphorylated at several sites, like other proteins after DNA damage, but this phosphorylation is not critically relevant to recruitment or repair processes. In this study, we evaluated the functions of phosphor-53BP1 and the role of the BRCT domain of 53BP1 in DNA repair. From our data, we were able to detect differences in the phosphorylation patterns in Ser25 and Ser1778 of 53BP1 after neocarzinostatin-induced DNA damage. Furthermore, the foci formation patterns in both phosphorylation sites of 53BP1 also evidenced sizeable differences following DNA damage. From our results, we concluded that each phosphoryaltion site of 53BP1 performs different roles, and Ser1778 is more important than Ser25 in the process of DNA repair.

• Physical Therapy Korea
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• v.13 no.4
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• pp.56-63
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• 2006

This study examined the effects of the abdominal drawing-in (ADI) maneuver using a pressure biofeedback on muscle recruitment pattern of erector spinae and hip extensors and anterior pelvic tilt during hip extension in the prone position. Fourteen able-bodied volunteers, who had no medical history of lower extremity or lumbar spine disease, were recruited for this study. The muscle onset time of erector spinae, gluteus maximus, and medial hamstring and angle of anterior pelvic tilt during hip extension in prone position were measured in two conditions: ADI maneuver condition and non-ADI maneuver condition. Muscle onset time was measured using a surface electromyography (EMG). Kinematic data for angle of anterior pelvic tilt were measured using a motion analysis system. The muscle onset time and angle of anterior pelvic tilt were compared using a paired t-test. The study showed that in ADI maneuver during hip extension in prone position, the muscle onset time for the erector spinae was delayed significantly by a mean of 43.20 ms (SD 43.12), and the onset time for the gluteus maximus preceded significantly by a mean of -4.83 ms (SD 14.10) compared to non-ADI maneuver condition (p<.05). The angle of anterior pelvic tilt was significantly lower in the ADI maneuver condition by a mean of 7.03 degrees (SD 2.59) compared to non-ADI maneuver condition (15.01 degrees) (p<.05). The findings of this study indicated that prone hip extension with the ADI maneuver was an effective method to recruit the gluteus maximus earlier than erector spinae and to decrease anterior pelvic tilting.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.36 no.4
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• pp.409-416
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• 2003

Marine populations are maintained through the processes of spawning, growth, recruitment, natural death and fishing in a marine ecosystem. Based upon each of these processes, a quantitative population dynamic model was developed to estimate damages in fishery production due to accidents in a fishing ground. This model was applied for the abalone culture grounds in Korean waters. Three components of damages were identified in the ecosystem of the abalone culture grounds, namely, physical damages in the substratum of the fishing ground, biological damages in the structure and function of the ecosystem, and damages in fishery production. Considering these three components the processes and durations of damages in fishery production were determined. Because the abalone population is composed of multiple year classes, damages influence all the year classes in the population, when they occur The model developed in this study is: $$y=(n_{\lambda}+1){\times}Y_E\;-\;\sum\limits^{n_\lambda-n_c}_{l=0}\;y_{n_c/i}$$ where, y is the expected damages in fishery production during the period of restoration of the damaged abalony population, $Y_E$ is the annual equilibrium yield, $n_{\lambda}$ is the maximum age in the population, $t_s$ is the year of damage occurrence, $n_c$ is the age at recruitment, and $\sum\limits^{n_\lambda-n_c}_{l=0}\;y\;_{n_c/i}$ is total expected lifetime catch of year classes which were recruited during the restoration period.

• The Journal of Korean Medicine
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• v.29 no.4
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• pp.146-160
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• 2008

Objectives: The present study was designated to evaluate the direct effects of Fructus Liquidambaris on suppression of eosinophil activity and on suppression of chemokines such as eotaxin, IL-8, ICAM-1, and VCAM-1, in vitro. Methods: A549 cells were stimulated with TNF-$\alpha$ (100 ng/ml), IL-4 (100 ng/ml) or IL-$1{\beta}$(10 ng/ml) to induce chemokines and adhesion molecules involved in eosinophil chemotaxis. Then after treatment of Fructus Liquidambaris, inhibition effect assay such as ELISA, real-time RT-PCR, and chemotaxis assay was performed. Results: Eotaxin level was suppressed in both protein secretion and mRNA expression. Eosinophil recruitment to lung epithelial cells was also reduced by Fructus Liquidambaris, implying the role of eotaxin in eosinophil recruitment. In addition, expression of IL-8 was also suppressed by Fructus Liquidambaris (p<0.05). However, expression of adhesion molecules (ICAM-1, VCAM-1) related to eosinophil was not affected. The eosinophil migration was inhibited at high concentration of Fructus Liquidambaris (p<0.05). Conclusion: These results suggest that Fructus Liquidambaris may regulate a common signaling pathway of eotaxin and IL-8. FS might be of therapeutic value in diseases such as asthma.

• The Journal of Information Systems
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• v.28 no.2
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• pp.25-52
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• 2019

Purpose Despite the recent increase in the use of selection tools using artificial intelligence (AI), far less is known about the effectiveness of them in recruitment and selection research. Design/methodology/approach This paper tests the impact of AI-based initial screening and interview on intentions to apply. We also examine the moderating role of individual difference (i.e., reliability on technology) in the relationship. Findings Using policy-capturing with undergraduate students at a large university in South Korea, this study showed that AI-based interview has a negative effect on intentions to apply, where AI-based initial screening has no effect. These results suggest that applicants may have a negative feeling of AI-based interview, but they may not AI-based initial screening. In other words, AI-based interview can reduce application rates, but AI-based screening not. Results also indicated that the relationship between AI-based initial screening and intentions to apply is moderated by the level of applicant's reliability on technology. Specifically, respondents with high levels of reliability are more likely than those with low levels of reliability to apply for firms using AI-based initial screening. However, the moderating role of reliability was not significant in the relationship between the AI interview and the applying intention. Employing uncertainty reduction theory, this study indicated that the relationship between AI-based selection tools and intentions to apply is dynamic, suggesting that organizations should carefully manage their AI-based selection techniques throughout the recruitment and selection process.

• The Journal of the Convergence on Culture Technology
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• v.9 no.2
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• pp.207-213
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• 2023

Korea is facing a population cliff and a decline in the fertility rate, and the competition rate for recruiting officers in our military is rapidly decreasing every year. This situation is a serious problem in terms of national security and requires efforts to obtain excellent manpower. To this end, it is necessary to understand their occupational values through consideration of the MZ generation, which is the main recruitment target of the military, and to find diagnosis and solutions for each problem by closely analyzing the military's internal and external environment based on their understanding of soldiers as a job. Therefore, we diagnose the current situation in consideration of military specificity, examine the occupational values of the MZ generation, which is a resource for military officers recruitment. Since the subject of military officer acquisition is the MZ generation, efforts are needed to focus on occupational values of MZ generations.

• Journal of the Korean Society of Marine Environment & Safety
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• v.19 no.5
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• pp.511-517
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• 2013

Maritime police recognize that the organizational culture of various acting as a member of the organization. Also, marine policing and security activities to determine the number of build. The overall culture of maritime police who share the organization sub-culture may take place. Maritime police organizational culture and a variety of types of group culture, hierarchical culture, development culture, rational culture examined the differences in perceptions. Maritime police aware of the general results of the analysis are as follows; First, the maritime police officers of the age group of 20 was the highest recognition in hierarchy culture and rational culture. Second, the maritime police officers of the rank of captain was the highest recognition in development culture and rational culture. Third, differences in the perception of organizational culture by recruitment analysis show the difference in cultural groups showed, in particular, the special recruitment group of police officers, and maritime police culture can be seen tend to appear low.