• YAKHAK HOEJI
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• v.46 no.6
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• pp.375-380
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• 2002

In this study, newly designed COX-2 inhibitors, synthetic derivatives of benzothiazine-3-carboxamide, were screened in vitro for selectivity of COX-1 and COX-2 inhibition properties. 7-Bromo-1,2-benzoisothiazine derivatives were obtained from 4-bromotoluene over the chlorosulfonation, amination and oxidation. And benzothiazine ring was synthesized through Gabriel-Colmann rearrangement reaction. To evaluate inhibitory effect of COX-2, synthetic derivatives of benzothiazine-3-carboxamide were tested with accumulation of prostaglandin by lipopolysaccharide in aspirin-treated murine macropharge cell. Some of the synthesized lead compounds have potentially shown the structure-activity relationship for selectivity of COX-2 inhibition activity.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.113-117
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• 2005

In comparative genome analyses, synteny blocks play important roles for finding ortholog genes, reconstructing phylogenetic tree and predicting genome rearrangement events. In this paper, we propose a novel method to search biologically plausible synteny blocks not only from the viewpoint of finding highly preserved regions but also from the viewpoint of analyzing genome rearrangements. We have applied the method to our experiments on four fungal organisms, and succeeded to obtain some biologically interesting results.

• Proceedings of the SAREK Conference
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• 2006.11a
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• pp.78-78
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• 2006

• Journal of the Korean Graphic Arts Communication Society
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• v.12 no.1
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• pp.17-34
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• 1994

Recently, the photopolymer made of novolak resin as the base and the naphthoquinonediazide(NQD) as the photoreactive compound is used for the presensitized plate(PS plate). The reaction mechanism of the NQD-novolak resin on light exposure is considered. Upon exposure it undergoes a Wolff rearrangement, via ketene intermediate which react with water ti form an 3-indene carboxylic acid. It was also found that NQD type resin in this experiment shows a high relative sensitivity compared with imported sample from Japan.

• 한국연소학회:학술대회논문집
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• 2004.06a
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• pp.133-137
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• 2004

The present study is focused on the small scale turbulent mixing processes in the scalar field. In order to deal with molecular mixing in turbulent flow, the linear eddy model is addressed. In each realization, the molecular mixing term is implemented deterministically, and turbulent stirring is represented by a sequence of instantaneous, statistically independent rearrangement event called by triplet map. The LEM approach is applied with relatively simple conditions. The characteristics of scalar mixing and PDF profiles are addressed in detail.

• Tuberculosis and Respiratory Diseases
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• v.75 no.6
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• pp.236-237
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• 2013

Many attempts have been made to find genetic abnormalities inducing carcinogenesis after the development of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor targeting EGFR in lung cancer. New target therapies have been already commercialized and studied along with the recent discovery of gene rearrangement involved in the carcinogenic process of non-small cell lung cancer. This study aims to investigate anplastic lymphoma kinase, c-ros oncogene 1, and receptor tyrosine kinase, in particular.

• Bulletin of the Korean Chemical Society
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• v.35 no.7
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• pp.1996-1998
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• 2014

Licochalcone C was synthesized from commercially available 2,4-dihydroxybenzaldehde by using regioselective $Al_2O_3$-mediated C-prenylation followed by conventional Claisen-Schmidt condensation in basic condition.

• YAKHAK HOEJI
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• v.30 no.6
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• pp.329-333
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• 1986

6-[3-(Hydroxymethyl)-2, 3-epoxybutyl]-3, 5-dimethoxyphenol was synthesized by means of the eight steps, such as allylether, Claissen rearrangement, tosylation, oxidation, Wittig reaction, reduction and epoxidation from 3, 5-dimethoxyphenol. The epoxidation of 6-[3- (hydroxymethyl)-2-butenyl]-3,5-dimethoxy phenol using the L-(+)-diethyltartrate(DET), titanium (IV) isopropoxide Ti[(O-iPr)$_4$] and t-butylhydroperoxide(TBHP) is described.

• Archives of Pharmacal Research
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• v.17 no.1
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• pp.39-41
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• 1994

Various N,N'-disubstituted ureas 5 were easily prepared from the corresponding primary amide 1 by tratment with N-Bromophthalimide $(NBP)-AgOAc-RNH$_{2}$ 4 in dry N,N-dimrthylformamide (DMF). This reaction envolved the intemediate formation of isocyanate 3 from amide 1 via Hofmann rearrangement by treatment with AgOAc and NBP and nucleophilic addition of amine 4 to this isocyante 3. This method is simple enough to be applied to the synthesis of various N,N'-disubstututed ureas scale conviently.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.82-82
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• 2002

Expression of phase II detoxifying genes is regulated by Nrf2-mediated antioxidant response element (ARE) activation. We previously showed that phosphatidylinositol 3-kinase (PI3-kinase) plays an essential role in ARE-mediated rGSTA2 induction by oxidative stress.(omitted)