• Physical Therapy Korea
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• v.23 no.3
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• pp.21-28
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• 2016

Background: The toe-spread-out (TSO) exercise has been introduced as a strengthening exercise for the abductor hallucis muscle in subjects with hallux valgus. Visual biofeedback using ultrasound imaging during exercise, may increase the ability to selectively contract the abductor hallucis muscle, compared with exercise alone. Objects: The aim of this study was to investigate the effects of ultrasound imaging visual feedback during the TSO exercise with respect to its influence on the angle of the first metatarsophalangeal joint (1st MPJ) and the cross-sectional area (CSA) of the abductor hallucis muscle in subjects with hallux valgus. Methods: Twenty-five healthy young subjects with a mean average age of 22.5 years, and a standard deviation of 2.3 years, were recruited for this study. Hallux valgus was defined as an angles greater than $15^{\circ}$ angle of 1st MPJ. Goniometric measurement was used to determine the angle of 1st MPJ. In addition, an ultrasound system was used to collect the CSA of the abductor hallucis muscle in each foot. The angle of the 1st MPJ and CSA of the abductor hallucis were measured in three positions; the resting position, during TSO exercise, and during TSO exercise in conjunction with real-time ultrasound imaging feedback. All data analyzed using a repeated analysis of variance with Bonferroni correction in order to compare the dependent variables in all three positions. Statistical level of significance was set up as p<.05. Results: The angle of the 1st MPJ was noted to be significantly reduced and the CSA of the abductor hallucis to be significantly greater during TSO exercise used in conjunction with ultrasound imaging visual feedback, compared to when the values were recorded during TSO exercise alone (p<.05). Conclusion: Based on these findings, it can be concluded that the application of ultrasound imaging visual feedback during TSO exercise is more effective in contracting selectively the abductor hallucis than the use of exercise alone.

• Tuberculosis and Respiratory Diseases
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• v.71 no.1
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• pp.8-14
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• 2011

Background: MicroRNAs (miRNAs) have demonstrated their potential as biomarkers for lung cancer diagnosis. In recent years, miRNAs have been found in body fluids such as serum, plasma, urine and saliva. Circulating miRNAs are highly stable and resistant to RNase activity along with, extreme pH and temperatures in serum and plasma. In this study, we investigated serum miRNA profiles that can be used as a diagnostic biomarker of non-small cell lung cancer (NSCLC). Methods: We compared the expression profile of miRNAs in the plasma of patients diagnosed with lung cancer using an miRNA microarray. The data from this assay were validated by quantitative real-time PCR (qRT-PCR). Results: Six miRNAs were overexpressed and three miRNAs were underexpressed in both tissue and serum from squamous cell carcinoma (SCC) patients. Sixteen miRNAs were overexpressed and twenty two miRNAs were underexpressed in both tissue and serum from adenocarcinoma (AC) patients. Of the four miRNAs chosen for qRT-PCR analysis, the expression of miR-23a was consistent with microarray results from AC patients. Receiver operating characteristic (ROC) curve analyses were done and revealed that the level of serum miR-23a was a potential marker for discriminating AC patients from chronic obstructive pulmonary disease (COPD) patients. Conclusion: Although a small number of patients were examined, the results from our study suggest that serum miR-23a can be used in the diagnosis of AC.

• Journal of the Korean Institute of Landscape Architecture
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• v.18 no.3 s.39
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• pp.171-190
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• 1990

It is the purpose of this study to address how to manage the urban vegitation using the concept of Urban Forestry which is relatively new to Korea. When we consider the Urban Forestry as a science, We should understand it interdisciplinary subject which includes Forestry, Horticulture, Urban Planning, Landscape Design, Landuse Planning, Business and Humanities. It may say that people and tree are the fundermental components of Urban Forestry. So there are two ways of Urban Forestry Applications-How people care for trees and How trees care for People-. For the application, this study places the focus on the monetary valuation, tree inventory system and traditional forestry application to urban forest management. Pubic Relation, Communication, Ordinances and Budget are also mentioned as a part of Urban Forestry Policy. Monetary valuation of trees and forests is very important for the proper cognition of their real value. So that, they may be equated and weighed against conflicting uses which would cause to be removed or severely mutilated. A tree inventory system which is the essential part of urban tree management can provide the pertinent information about the present condition of urban tree resource. It may aid in reducing the subjectivity of tree management decisions and stimulate them to be made rapidly and can help reduce potential municipal liability by identifying serious problems in time for corrective maintenance practices to be applied for the maximize community benefits and minimimize public nuisances or hazards. Managers can derive the information from the inventory and use it for the various management plan. When we see the structure of tree inventory system as one of the data base management system, Computer is the best equipment for the efficient management plan. Public relation and communication is also important factors to care the people for urban vegetation management. Volunteer management system is a good example for the public relation and communication. Those skills are need to develop for using the priceless, valuable human resources. Budget holds the key to the execution of Urban Forestry. Good inventory can provide for efficient budgeting stratiges through it's scientific analysis for the way of maximum benefits and minimum costs. Forest can be play a vital role for the aesthetic improvement and recreation in the city. This study suggests that the traditional sivicultural application not only improve the quality of scenic beauty and recreation but also the products of timber. So it is more needed to study for strong and scientific application to urban forest management.

• Journal of the Korea Society of Computer and Information
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• v.17 no.6
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• pp.163-172
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• 2012

Collaborative filtering which is used explicit method in a existing recommedation system, can not only reflect exact attributes of item but also still has the problem of sparsity and scalability, though it has been practically used to improve these defects. This paper proposes the personalized recommendation system using RFM method and k-means clustering in u-commerce which is required by real time accessablity and agility. In this paper, using a implicit method which is is not used complicated query processing of the request and the response for rating, it is necessary for us to keep the analysis of RFM method and k-means clustering to be able to reflect attributes of the item in order to find the items with high purchasablity. The proposed makes the task of clustering to apply the variable of featured vector for the customer's information and calculating of the preference by each item category based on purchase history data, is able to recommend the items with efficiency. To estimate the performance, the proposed system is compared with existing system. As a result, it can be improved and evaluated according to the criteria of logicality through the experiment with dataset, collected in a cosmetic internet shopping mall.

• Korean Institute of Interior Design Journal
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• v.26 no.1
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• pp.33-42
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• 2017

Interior design especially the design developments for commercial spaces should ensure the economy of spaces. This is the marketing for space. It is necessary to understand the design elements of commercial space for the efficient using of digital media of space marketing. In this research decided to design application schemes for shopping mall by searching fashion shopping behaviors of users with persona-base scenario approach. Collected the information of users behavior base on case analysis of advance research to make personas. And develop scenario base personas for knowing the needs of users. And then made 4 schemes as the solution. Scheme 1. Customers can get the information and communication with the staff through with media screen in one room of shopping mall. The data of customers can be recorded for providing information or product recommendation personality. Forecast to preferred by group trip or customers that don't like walking around in shopping mall. Scheme 2. Install a media screen at entrance of a store in shopping mall and show special effect to raise customers' attention who walk through from the front of the store. Through with this customers will stay for long time and raise curiosity to get in the store. And the media screen also provide information of store and products. Scheme 3. Customers can get the information of products with using smart phone to scan QR cord in labels of products and record. Customers can finish whole shopping behaviors without the help of store staff. And can make buying decision even have left shopping mall as a online mode. Scheme 4. Store managers can record the products and the environment of store with 360 camera and update to website. Then customers can browse the virtual space with VR glasses. That make customers can have the real shopping experience without being in the store. In this study, have presented schemes of digital media in commercial space. But there are various of commercial space. In this study was presented schemes for shopping mall by searching fashion shopping behaviors of users. And look forward the researches about specific space setting and other type of commercial space for space development.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.691-695
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• 2012

수위표의 영점에서 수면까지의 높이로 정의되는 해발수위는 유량 및 유사량 등과 같은 관련 수문자료를 생산하는데 기본이 되는 자료이며, 하천 및 수공구조물의 설계 등에 기초자료로 이용될 뿐만 아니라 수자원의 효율적인 관리 및 수문순환 해석을 위한 가장 중요한 기초자료로서 국가 차원의 올바른 수자원 계획과 정책을 수립하는데 널리 활용된다. 이와 같이 해발수위자료의 이용 분야가 다양하고 그 자체로서도 중요한 의미를 가지는 점을 고려할 때 무엇보다도 중요한 것은 자료의 품질이 확보되어야 하는 것이다. 그러나 영점표고검정수준점 및 기준 수위표의 설치 이후 오랜 시간이 경과됨에 따라 노후화와 수위관측소 주변의 환경변화가 발생하게 되어 자료의 정확도가 매우 낮아지고 있다. 본 연구에서는 해발수위 자료의 품질향상을 위해 수위관측소의 영점표고검정수준점 및 수위표 영점표고에 대하여 수준측량 및 RTK(Real Time Kinematic) GPS(Global Positioning System) 측량을 병행하여 수행하였으며, 조사측량된 값을 활용하여 기존에 측량된 영점표고검정수준점 및 수위표 영점표고에 대한 검토를 수행하였다. 금강 및 삽교천 수계에 위치한 50개 수위관측소 대하여 기존 측량값과 비교 검토한 결과 영점표고검정수준점은 0.10m 이하(54.0%), 0.10m 초과 ~ 0.50m 이하(26.0%), 0.50m 초과 ~ 1.00m 이하(6.0%), 1.00m초과 ~ 1.50m 이하(2.0%), 1.50m 초과 ~ 2.00m 이하(2.0%), 2.00m 초과 ~ 3.00m 이하(4.0%), 3.00m 초과(6.0%)의 값을 나타냈으며, 수위표 영점표고는 0.10m 이하(50.0%), 0.10m 초과 ~ 0.50m 이하(32.0%), 0.50m 초과 ~ 1.00m 이하(10.0%), 1.00m초과 ~ 1.50m 이하(2.0%), 1.50m 초과 ~ 2.00m 이하(2.0%), 2.00m 초과 ~ 3.00m 이하(2.0%), 3.00m 초과(2.0%)의 값을 가졌다. 이와 같이 기존과 금회 측량자료를 비교 검토한 결과 대부분이 안정적으로 유지되고 있으나 일부 수위관측소에서 변동량이 크게 발생한 원인은 영점표고검정수준점의 노후화, 기준 수위표의 교체 및 위치 변동, 인위적인 하천공사 등으로 인하여 발생한 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2935-2940
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• 2016

Breast cancer is the most frequent type of cancer diagnosed among women worldwide and also in Thailand. Estrogen and estrogen receptors exert important roles in its genesis and progression. Several cytokines have been reported to be involved in the microenvironment that promotes distant metastasis via modulation of immune and inflammatory responses to tumor cells. Estrogen receptor genetic polymorphisms and several cytokines have been reported to be associated with breast cancer susceptibility and aggressiveness. To investigate roles of genetic polymorphisms in estrogen receptor alpha (ESR1) and interleukin 6 (IL6), breast cancer patients and control subjects were recruited from the Division of Head, Neck and Breast Surgery (Siriraj Hospital, Bangkok, Thailand). Polymorphisms in ESR1 (rs3798577) and IL6 (rs1800795 and rs1800797) were evaluated by real-time PCR in 391 breast cancer patients and 79 healthy controls. Associations between genetic polymorphisms and clinicopathological data were determined. There was no association between genetic polymorphisms and breast cancer susceptibility. However the ESR1 rs3798577 CT genotype was associated with presence of lymphovascular invasion (OR=2.07, 95%CI 1.20-3.56, p=0.009) when compared to the TT genotype. IL6 rs1800795 CC genotype was associated with presence of extranodal extension (OR= 2.30, 95%CI 1.23-4.31, p=0.009) when compared to the GG genotype. Survival analysis showed that IL6 rs1800797 AG or AA genotypes were associated with lower disease-free survival. These findings indicate that polymorphisms in ESR1 and IL6 contribute to aggressiveness of breast cancer and may be used to identify high risk patients.

• Journal of Ginseng Research
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• v.39 no.1
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• pp.46-53
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• 2015

Background: Glucocorticoids (GCs) are commonly used in many chemotherapeutic protocols and play an important role in the normal regulation of bone remodeling. However, the prolonged use of GCs results in osteoporosis, which is partially due to apoptosis of osteoblasts and osteocytes. In this study, effects of Korean Red Ginseng (KRG) on GC-treated murine osteoblastic MC3T3-E1 cells and a GC-induced osteoporosis mouse model were investigated. Methods: MC3T3-E1 cells were exposed to dexamethasone (Dex) with or without KRG and cell viability was measured by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Realtime polymerase chain reaction was performed to evaluate the apoptotic gene expression; osteogenic gene expression and alkaline phosphatase (ALP) activity were also measured. Western blotting was performed to evaluate the mitogen-activated protein kinase (MAPK) proteins. A GC-induced osteoporosis animal model was used for in vivo study. Results and conclusion: The MTT assay revealed that Korean Red Ginseng (KRG) prevents loss of cell viability caused by Dex-induced apoptosis in MC3T3E1 cells. Real-time polymerase chain reaction data showed that groups treated with both Dex and KRG exhibited lower mRNA levels of caspase-3 and -9, whereas the mRNA levels of Bcl2, IAPs, and XIAP increased. Moreover, groups treated with both Dex and KRG demonstrated increased mRNA levels of ALP, RUNX2, and bone morphogenic proteins as well as increased ALP activity in MC3T3-E1 cells, compared to cells treated with Dex only. In addition, KRG increased protein kinase B (AKT) phosphorylation and decreased c-Jun N-terminal kinase (JNK) phosphorylation. Moreover, microcomputed tomography analysis of the femurs showed that GC implantation caused trabecular bone loss. However, a significant reduction of bone loss was observed in the KRG-treated group. These results suggest that the molecular mechanism of KRG in the GC-induced apoptosis may lead to the development of therapeutic strategies to prevent and/or delay osteoporosis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.379-386
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• 2021

This study was undertaken to develop a cascade-type continuous culture system (CCCS) that combines both ICT and biotechnology (BT), for the mass production of microalgae. This system is capable of maintaining the essential culture conditions of pH, temperature, carbon dioxide, and illuminance control, which are key parameters for the growth of microalgae, and is economical for producing microalgae regardless of the season or location. It has the added advantage of providing stable and high productivity. In the current study, this system was applied to culture microalgae for 71 days, with subsequent analysis of the experimental data. The initial O.D. of the culture measured from incubator 1 was 0.006. On the 71st day of culture, the O.D.s obtained were 0.399 (incubator 1), 0.961 (incubator 2), 0.795 (incubator 3), and 0.438 (incubator 4), thereby confirming the establishment of continuous culture. Thus, we present a smart-farm based on ISMC (in-situ monitoring and control) for a mass culture method. We believe that this developed technology is suitable for commercialization, and has the potential to be applied to hydroponics-based cultivation of microalgae and cultivation of high-value-added medicinal plants as well as other plants used in functional foods, cosmetics, and medical materials.

• Journal of Internet Computing and Services
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• v.22 no.2
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• pp.59-68
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• 2021

As artificial intelligence(AI) technologies, which have made rapid growth recently, began to be applied to the marine environment such as ships, there have been active researches on the application of CNN-based models specialized for digital videos. In E-Navigation service, which is combined with various technologies to detect floating objects of clash risk to reduce human errors and prevent fires inside ships, real-time processing is of huge importance. More functions added, however, mean a need for high-performance processes, which raises prices and poses a cost burden on shipowners. This study thus set out to propose a method capable of processing information at a high rate while maintaining the accuracy by applying Quantization techniques of a deep learning model. First, videos were pre-processed fit for the detection of floating matters in the sea to ensure the efficient transmission of video data to the deep learning entry. Secondly, the quantization technique, one of lightweight techniques for a deep learning model, was applied to reduce the usage rate of memory and increase the processing speed. Finally, the proposed deep learning model to which video pre-processing and quantization were applied was applied to various embedded boards to measure its accuracy and processing speed and test its performance. The proposed method was able to reduce the usage of memory capacity four times and improve the processing speed about four to five times while maintaining the old accuracy of recognition.