• Development and Reproduction
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• v.17 no.2
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• pp.133-140
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• 2013

This study was performed to investigate the expression of cathepsin B mRNA and protein in eutopic and ectopic endometrial tissues of patients with endometriosis and in normal endometrial tissues and to clarify the association between the cathepsin B expression and endometriosis. A total of 40 women with histologically confirmed endometriosis were recruited for study group. For controls, 20 women undergoing operative treatment for uterine myoma, cervical intraepithelial neoplasia (CIN) or benign gynecologic conditions other than endometriosis were recruited. Eutopic endometrial tissues of both groups and ectopic endometrial tissue of study group were collected during the operations. We employed real time reverse transcriptase - polymerase chain reaction (RT-PCR) to quantify mRNA levels of cathepsin B in these tissues. Then, we performed western blot analysis to measure the protein levels of cathepsin B. The expressions of cathepsin B mRNA and protein were significantly higher in both eutopic and ectopic endometrial tissues of women with endometriosis than in endometrial tissues of controls. These data suggest that the higher expression of cathepsin B in the endometrial tissues might be associated with the development of endometriosis. In addition, eutopic endometrium itself with higher expression cathepsin B may play a pivotal role in the histogenesis of endometriosis.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.25 no.12
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• pp.1292-1299
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• 2014

Weather radar systems can provide weather information of the ground, sea, and air in extensive spatial coverage in near real time. However, it becomes problematic when ground clutter signal exists around precipitation because strong signals of ground can cause a false precipitation report. A large percentage of land coverage of Korea consists of mountainous regions where ground clutter needs to be mitigated for more accurate prediction. Thus, it is considered necessary to introduce a new suitable ground clutter removal technique specifically adequate for Korea. In this paper, the C-Map(Clutter Map) method using raw radar signals is proposed for removing ground clutter using a terrain-adaptive clutter map. A clutter map is generated using raw radar signals(I/Q) of clear days, then it is subtracted from received radar signals in frequency domain. The proposed method is applied to the radar data acquired from Sobaeksan rain radar and the result shows that the clutter rejection ratio is about 91.17 %.

• KIPS Transactions on Computer and Communication Systems
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• v.5 no.10
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• pp.311-318
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• 2016

IoT(Internet of Things areas) rich information based on the user easy access to service creation must be one of the power system of specificity due following: The IoT spread obstacle to the act be, and 'Smart Grid information of this is not easy under power plants approach the Directive on the protection measures, particularly when stringent security policies IoT technologies applied to Advanced Metering Infrastructure sector has been desired. This is a situation that occurs is limited to the application and use of IoT technologies in the power system. Power Information Network is whilst closed network operating is has a smart grid infrastructure, smart grid in an open two-way communication for review and although information security vulnerabilities increased risk of accidents increases as according to comprehensive security policies and technologies are required and can. In this paper, the IoT platform architecture design of information systems as part of the power of research and development IoT-based energy information platform aims. And to establish a standard framework for a connection to one 'Sensor-Gateway-Network-platform sensors Service' to provide power based on the IoT services and solutions. Framework is divided into "sensor-gateway" platform to link information modeling and gateways that can accommodate the interlocking standards and handling protocols variety of sensors Based on this real-time data collection, analysis and delivery platform that performs the role of the relevant and to secure technology.

• Korean Journal of Remote Sensing
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• v.34 no.2_1
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• pp.203-211
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• 2018

Dam discharge is carried out for the management of rivers and area around rivers due to rainy season or drought. Dam discharge should be based on an accurate understanding of the flow rate that can be accommodated in the river. Therefore, understanding the allowable storage capacity of river is an important factor in the management of the environment around the river. However, the methods using water level meters and images, which are currently used to determine the allowable flow rate of rivers, show limitations in terms of accuracy and efficiency. In order to solve these problems, this paper proposes a method to automatically calculate the allowable storage capacity of river based on the images taken by drone. In the first step, we create a 3D model of the river by using the drone images. This generation process consists of tiepoint extraction, image orientation, and image matching. In the second step, the allowable storage capacity is calculated by cross section analysis of the river using the generated river 3D model and the road and river layers in the target area. In this step, we determine the maximum water level of the river, extract the cross-sectional profile along the river, and use the 3D model to calculate the allowable storage capacity for the area. To prove our method, we used Bukhan river's data and as a result, the allowable storage volume was automatically extracted. It is expected that the proposed method will be useful for real - time management of rivers and surrounding areas and 3D models using drone.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.31 no.2
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• pp.202-209
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• 1998

A three-dimensional numerical method based on the Green's integral equation is developed to predict the motion response and drift force in waves for the ocean monitoring facilities. In this method, we use source and doublet distribution, and triangular and rectangular eliments. To eliminate the irregular frequency phenomenon, the method of improved integral equation is applied and the time-mean drift force is calculated by the method of direct pressure integration over the body surface. To conform the validity of the present numerical method, some calculations for the floating sphere are performed and it is shown that the present method provides sufficiently reliable results. As a calculation example for the real facilities, the motion response and the drift force of the vertical cylinder type ocean monitoring buoy with 2.6 m diameter and 3,77 m draft are calculated and discussed. The obtained results of motion response can be used to determine the shape and dimension of the buoy to reduce the motion response, and other data such as the effect of motion reduction due to a damper can be predictable through these motion calculations. Also, the calculation results of drift force can be used in the design procedure of mooring system to predict the maximum wave load acting on the mooring system. The present method has, in principle, no restriction in the application to the arbitrary shape facilities. So, this method can be a robust tool for the design, installation, and operation of various kinds of the floating-type ocean monitoring facilities.

• Restorative Dentistry and Endodontics
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• v.33 no.2
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• pp.141-147
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• 2008

This study was aimed to develop an instrument for real-time measurement of fluid conductance and to investigate the hydrodynamics of dentinal fluid. The instrument consisted of three parts; (1) a glass capillary and a photo sensor for detection of fluid movement, (2) a servo-motor, a lead screw and a ball nut for tracking of fluid movement, (3) a rotary encoder and software for data processing. To observe the blocking effect of dentinal fluid movement, oxalate gel and self-etch adhesive agent were used. BisBlock (Bisco) and Clearfil SE Bond (Kuraray) were applied to the occlusal dentin surface of extracted human teeth. Using this new device, the fluid movement was measured and compared between before and after each agent was applied. The instrument was able to measure dentinal fluid movement with a high resolution (0.196 nL) and the flow occurred with a rate of 0.84 to 15.2 nL/s before treatment. After BisBlock or Clearfil SE Bond was used, the fluid movement was decreased by 39.8 to 89.6%.

• The Journal of Industrial Distribution & Business
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• v.10 no.8
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• pp.45-53
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• 2019

Purpose - The purpose of this study was to clarify the factors to make an exclusive importation contract between foreign fashion brands and local retailers for successful business in Korea. Even though imported fashion brand market shows stead increasing in terms of sales amount, the number of store related study was very rare in fact. Meanwhile, as long as this business is glowing a lot of brands are suffering from bad business performance or getting in ruins thus these problems result in foreign currency loss. The local marketers therefore, strongly expect to know the solution for this matter. Research design, data, and methodology - For the qualitative research, 10 experts who are operating foreign brands with an exclusive contract at a department store or at duty free shop now and who had at least over 10 years of related working experience were included. The factors for the exclusive importation contract with foreign brands were drawn up through the one-to-one in-depth interview method from September 3, 2017 to January 15, 2018. The expert group for the validity analysis includes 2 professors and 5 postgraduate students. Results - As a result of qualitative study on the factors for imported fashion brand's launching with the exclusive importation contract, it turned out that there were 5 factors - safety, profitability, reliability, speed and global retailing. Safety, profitability, and reliability have been mentioned in most related surveys but some details are added and speed and global retailing have been newly highlighted and many unknown legal issues that it was not easy to get form common academic research are included. Speed simply means quick lead time and global retailing means stores where located in other countries. Conclusions - The reason that qualitative research should be done before the quantitative research is due to the scant theoretical background for this matter. Because the market of an imported fashion brand is steadily increasing, determining the factors to make exclusive importation contract is very meaningful from the point of academic and business. After this study, many marketers may get basic conditions to apply for real business and I hope the following quantitative research will give more effective results. The next study also will have extended range concerning industry area, product and distribution channel.

• Journal of Microbiology and Biotechnology
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• v.27 no.8
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• pp.1529-1538
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• 2017

Klebsiella pneumoniae is an opportunistic and clinically significant emerging pathogen. We investigated the relative roles of Toll-like receptor (TLR) 2 and TLR4 in initiating host defenses against K. pneumoniae. TLR2 knockout (KO), TLR4 KO, TLR2/4 double KO (DKO), and wild-type (WT) mice were inoculated with K. pneumoniae. Mice in each group were sacrificed after either 12 or 24h, and the lungs, liver, and blood were harvested to enumerate bacterial colony-forming units (CFU). Cytokine and chemokine levels were analyzed using enzyme-linked immunosorbent assay and real-time PCR, and pneumonia severity was determined by histopathological analysis. Survival was significantly shortened in TLR4 KO and TLR2/4 DKO mice compared with that of WT mice after infection with $5{\times}10^3CFU$. TLR2 KO mice were more susceptible to infection than WT mice after exposure to a higher infectious dose. Bacterial burdens in the lungs and liver were significantly higher in TLR2/4 DKO mice than in WT mice. Serum $TNF-{\alpha}$, MCP-1, MIP-2, and nitric oxide levels were significantly decreased in TLR2/4 DKO mice relative to those in WT mice, and TLR2/4 DKO mice showed significantly decreased levels of $TNF-{\alpha}$, IL-6, MCP-1, and inducible nitric oxide synthase mRNA in the lung compared with those in WT mice. Collectively, these data indicate that TLR2/4 DKO mice were more susceptible to K. pneumoniae infection than single TLR2 KO and TLR4 KO mice. These results suggest that TLR2 and TLR4 play cooperative roles in lung innate immune responses and bacterial dissemination, resulting in systemic inflammation during K. pneumoniae infection.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.1C
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• pp.26-35
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• 2006

In this paper, an automatic mobile robot system for a intelligent path planning using the detection scheme of the spatial coordinates based on stereo camera is proposed. In the proposed system, face area of a moving person is detected from a left image among the stereo image pairs by using the YCbCr color model and its center coordinates are computed by using the centroid method and then using these data, the stereo camera embedded on the mobile robot can be controlled for tracking the moving target in real-time. Moreover, using the disparity map obtained from the left and right images captured by the tracking-controlled stereo camera system and the perspective transformation between a 3-D scene and an image plane, depth information can be detected. Finally, based-on the analysis of these calculated coordinates, a mobile robot system is derived as a intelligent path planning and a estimation. From some experiments on robot driving with 240 frames of the stereo images, it is analyzed that error ratio between the calculated and measured values of the distance between the mobile robot and the objects, and relative distance between the other objects is found to be very low value of $2.19\%$ and $1.52\%$ on average, respectably.

• Journal of Life Science
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• v.20 no.2
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• pp.213-218
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• 2010

In the present study, we investigated anti-proliferative activities of capsaicin and gene expression changes in response to capsaicin treatment in human colorectal HCT116 cells. The results showed that capsaicin decreased cell viabilities in a dose dependent manner and induced global gene expression changes. We found that 103 genes were up-regulated more than twofold, whereas 153 genes were down-regulated more than twofold by $100\;{\mu}M$ capsaicin treatment. Among the up-regulated genes, we selected 4 genes (NAG-1, DDIT3, GADD45A and PCK2) and performed RT-PCR to confirm the microarray data. We found that $100\;{\mu}M$ of capsaicin increased tumor suppressor p53 gene expression. In addition, the results showed that NAG-1, DDIT3 and GADD45A expressions were not dependent on p53 presence, whereas PCK2 expression. The results of this study may help to increase our understandings of the molecular mechanism of anti-proliferative activity mediated by capsaicin in human colorectal cancer cells.