• 대한임상약리학회:학술대회논문집
• /
• 대한임상약리학회 2001년도 제10차 추계학술대회
• /
• pp.31-31
• /
• 2001

• 응용화학
• /
• 제16권1호
• /
• pp.25-28
• /
• 2012

A determination method of cyanide ion (CN^-) using nickel complexation reaction by continuous monitoring system. The mechanical parameters and chemical conditions of the complexation reaction were investigated prior to application of continuous monitoring system for determination of cyanide. On the optimized conditions, the calibration curve was linear over the range from 5.0×10^-6 to 1.0×10^-4 M. In this range, 2.40% of the reproducibility (RSD, n=3) was obtained. The limit of detection (3σ/s) was calculated to be 1.8×10^-6 M.

• Industrial Engineering and Management Systems
• /
• 제4권2호
• /
• pp.176-183
• /
• 2005

The theory of signal detection has been applied to a wide range of practical situation for a long time, including sonar detection, air traffic control and so on. In general, in this theory, sensitivity parametric index d' and bias parametric index $\beta$ are used to evaluated the performance of vigilance. These indices use observer's response "hit" and "false alarm" to explain and evaluate vigilance, but not considering reaction time. However, the reaction time of detecting should be considered in measuring vigilance in some supervisory tasks such as unlimited monitoring tasks (e.g., supervisors in nuclear plant). There are some researchers have used the segments of reaction time to generate a pair of probabilities of hit and false alarm probabilities and plot the receiver operating characteristic curve. The purpose of this study was to develop a quantitative vigilance-measuring model by fuzzy sets, which combined the concepts of hit, false alarm and reaction time. The model extends two-values logic to multi-values logic by membership functions of fuzzy sets. A simulated experiment of monitoring task in nuclear plant was carried out. Results indicated that the new vigilance-measuring model is more efficient than traditional indices; the characteristics of vigilance would be realized more clearly in unlimited monitoring task.

• 센서학회지
• /
• 제29권5호
• /
• pp.342-347
• /
• 2020

In this study, a portable total-phosphorus (TP) monitoring system utilizing a photocatalytic-reaction-based pretreatment method is proposed, fabricated, and characterized. Commercial TP monitoring systems are only used in laboratories because of their complex monitoring procedure, bulk-size, and high-cost. In particular, pretreatment in commercial TP monitoring systems is performed at high temperatures (> 120 ℃) and pressure (> 1.1 kg cm^-2) making it difficult to minimize the scale of the systems. The proposed TP monitoring system employs a pretreatment method with a photocatalytic reaction; thus, its size can be reduced, as photocatalytic reactions occur at room temperature and atmospheric pressure. Analytes with various TP concentrations are pretreated using the proposed portable TP monitoring system and are quantitatively measured with an LED and a photodiode.

• 한국식품과학회지
• /
• 제28권2호
• /
• pp.212-219
• /
• 1996

Maillard 반응중 피질의 변화를 4차원 반응표면으로 나타내어 기질의 동적변화를 모니터링하고자 하였다. Total amino acids의 함량변화에 대한 회귀분석 결과 높은 $R^2$ (0.9470)를 나타내었으며, 각각의 amino acid또한 높은 R'를 나타내어 대부분 유의성이 인정되었다. 유리당의 함량에 대한 회귀분석에서 glucose의 함량에 대한 R'는 0.9250이었으나 fructose에 대한 $R^2$는 0.6490으로 낮은 값을 보였다. Maillard반응중 total amino acids의 함량은 반응온도가 높고 용매의 pH값 이 증가할수록 크게 감소되었다. 반응생성물의 갈색도는 반응온도가 증가할수록 증가하나 145‘C 내외에서 최대값을 나타내었다. 각각의 amino acid함량변화는 total amino acids 함량인화와 유사한 경향이었으며, 4차원 반응표면분석 결과 aspartic acid, threonine, glucose등의 기질들은 복합기질계 Maillard반응에 있어서 특이하게 반응온도가 증가할수록 크게 감소한 반면, 용매의 pH와 반응시간의 영향은 거의 받지 않는 것으로 나타났다.

• 한국도로학회논문집
• /
• 제17권2호
• /
• pp.13-20
• /
• 2015

PURPOSES: This paper describes the expansion caused by the alkali-aggregate reaction (AAR) in concrete pavement currently in service. It also discusses the effects of joints installed to release the stress induced by the AAR expansion. METHODS: The expansion effect on concrete pavement was verified by a visual inspection and long-term measurement of the joint width of a cut-section. The behaviors of 16 newly installed joints were monitored as part of the investigation and long-term monitoring was carried out for three years after cutting. RESULTS: The behavior of a bridge was affected when AAR occurred in the connected pavement. The newly installed joints shrank in the longitudinal direction of the bridge after cutting. The width of the joints decreased over the six months after cutting. A large portion of the joint width (8.5cm) was found to have closed nine months after cutting. It had ultimately shrunk by about 92 percent when the final measurement was taken. CONCLUSIONS : The expansion of the pavement due to AAR was quantitatively described by visual inspection and the long-term monitoring of the newly cut joints. However, the width of the new joints decreased over the six to nine months after cutting. Additional research should be conducted to determine a means of controlling the expansion due to AAR in the pavement.

• Mass Spectrometry Letters
• /
• 제5권3호
• /
• pp.79-83
• /
• 2014

Three different dutasteride extraction methods were compared and a method based on liquid-liquid extraction (LLE) using methyl tert-butyl ether and methylene chloride was proved to be more effective than others for the extraction of dutasteride and finasteride, the internal standard (IS), from rat plasma. Additionally, a method composed of the LLE extraction, liquid chromatography, and multiple reaction monitoring (MRM) to target dutasteride and IS was validated by assessing specificity, linearity ($r^2$ = 0.9993, 5 - 400 ng/mL), sensitivity (the limit of detection: 4.03 ng/mL; the limit of quantitation: 12.10 ng/mL), accuracy (intra-day: 89.4 - 105.9%; inter-day: 84.9 - 100.9%), precision (intra-day: 0.8 - 6.9%; inter-day: 2.9 - 15.9%), and recovery (84.7 - 107.8%). Since the validated method was successfully applied to a pharmacokinetic study of dutasteride, it can be useful for the pharmacokinetic evaluation of newly developed dutasteride formulations.

• 한국임상약학회지
• /
• 제32권4호
• /
• pp.303-312
• /
• 2022

Objective: The purpose of the study was to analyze the difference in the importance and performance of the educational content of the community pharmacy practice and find the factors that influence it. Methods: A 5-point Likert scale questionnaire asked about the importance and performance of the pharmacy practice education items to community pharmacy preceptors, current students, and professors. Data were analyzed using Microsoft office 365 Excel and IBM SPSS 21.0. Results: A total of 117 people participated. The averages of importance and performance were 4.34±0.34 and 3.71±0.45, respectively. Except for the computational entry of prescriptions and medication history, the average score for the importance of all educational items was statistically significantly higher than the one for performance. Importance Performance Analysis (IPA) identified over-the-counter medication counseling, over-the-counter drug selection consultation, pharmacy management, adverse drug reaction monitoring, and understanding and implementation of drug use evaluation as the items that needed focused effort. Borich's needs were highest in the adverse drug reaction monitoring. Conclusions: Overall, high importance and low performance indicate a need for improvement in community pharmacy practice education. Since the demand for education was high in over-the-counter medication counseling, adverse drug reaction monitoring, and OTC drug selection consultation, various supports are urgently needed to strengthen pharmacy practice education in this area in the future.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2003년도 추계학술대회 논문집 전기물성,응용부문
• /
• pp.89-91
• /
• 2003

The determination of DNA hybridization reaction can apply the molecular biology research, clinic diagnostics, bioengineering, environment monitoring, food science and other application area. So, the improvement of DNA detection system is very important for the determination of this hybridization reaction. In this study, we report the characterization of the probe and target oligonucleotide hybridization reaction using the evanescent field microscopy. First, we have fabricated DNA chip microarray. The particles which were immobilized oligonucleotides were arranged by the random fluidic self-assembly on the pattern chips, using hydrophobic interaction. Second, we have detected DNA hybridization reaction using evanescent field microscopy. The 5'-biotinylated probe oligonucleotides were immobilized on the surface of DNA chip microarray and the hybridization reaction with the Rhodamine conjugated target oligonucleotide was excited fluorescence generated on the evanescent field microscopy. In the foundation of this result, we could be employed as the basis of a probe olidonucleotide, capable of detecting the target oligonucleotide and monitoring it in a large analyte concentration range and various mismatching condition.

• KIEE International Transactions on Electrophysics and Applications
• /
• 제11C권3호
• /
• pp.85-90
• /
• 2001

The determination of DNA hybridization reaction can apply the molecular biology research, clinic diagnostics, bioengineering, environment monitoring, food science and other application area. So, the improvement of DNA detection system is very important for the determination of this hybridization reaction. In this study, we report the characterization of the probe and target oligonucleotide hybridization reaction using the evanescent field microscopy. First, we have fabricated DNA chip microarray. The particles which were immobilized oligonucleotides were arranged by the random fluidic self-assembly on the pattern chips, using hydrophobic interaction. Second, we have detected DNA hybridization reaction using evanescent field microscopy. The 5'-biotinylated probe oligonucleotides were immobilized on the surface of DNA chip microarray and the hybridization reaction with the Rhodamine conjugated target oligonucleotide was excited fluorescence generated on the evanescent field microscopy. In the foundation of this result, we could be employed as the basis of a probe olidonucleotide, capable of detecting the target oligonucleotide and monitoring it in a large analyte concentration range and various mismatching condition.