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Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/high-fructose diet-fed mice

  • Park, Miey;Yoo, Jeong-Hyun;Lee, You-Suk;Park, Eun-Jung;Lee, Hae-Jeung
    • Journal of Ginseng Research
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    • v.44 no.2
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    • pp.350-361
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    • 2020
  • Background: Black ginseng (BG) is a type of Korean ginseng prepared by steaming and drying raw ginseng to improve the saponin content. This study examined the effects of BG on nonalcoholic fatty liver disease (NAFLD) in HepG2 cells and diet-induced obese mice. Methods: HepG2 cells were treated with free fatty acids to induce lipid accumulation before supplementation with BG. NAFLD-induced mice were fed different doses (0.5%, 1%, and 2%) of BG for 8 weeks. Results: BG significantly reduced lipid accumulation and expression of lipogenic genes, peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein alpha, sterol regulatory element-binding protein-1c, and fatty acid synthase in HepG2 cells, and the livers of mice fed a 45% high-fat diet with 10% fructose in the drinking water (HFHF diet). BG supplementation caused a significant reduction in levels of aspartate aminotransferase and alanine aminotransferase, while antioxidant enzymes activities were significantly increased in 45% high-fat diet with 10% fructose in the drinking water diet-fed mice. Expression of proliferator-activated receptor alpha and carnitine palmitoyltransferase I were upregulated at the transcription and translation levels in both HepG2 cells and diet-induced obese mice. Furthermore, BG-induced phosphorylation of AMP-activated protein kinase and acetyl CoA carboxylase in both models, suggesting its role in AMP-activated protein kinase activation and the acetyl CoA carboxylase signaling pathway. Conclusion: Our results indicate that BG may be a potential therapeutic agent for the prevention of NAFLD.

Gender Differences in Bone Mineral Density-Related Factors among Adults: Based on the Korean National Health and Nutrition Examination Survey 2010-2011 (성인의 골밀도 관련요인에 대한 성별차이: 국민건강영양조사 자료[2010-2011년] 활용)

  • Kim, Hyejung;Lee, Haejung;Lim, Yeonjung
    • Journal of Korean Biological Nursing Science
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    • v.19 no.4
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    • pp.241-251
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    • 2017
  • Purpose: This study aimed to examine the factors related to the bone mineral density (BMD) in male and female adults aged 50 years or older. The factors included were socio-demographics, body mass index (BMI), blood pressure, blood lipids, and health habits. Methods: As a secondary data analysis, this study used raw data from the 5th Korean National Health and Nutrition Examination Survey, and selected 2,295 adults aged over 50 years who participated in the survey and had BMD values. The T-score of the femoral neck was evaluated for BMD. Data were analyzed using descriptive statistics, ANOVA and multiple regression. Results: The factors influencing the BMD in men were age (${\beta}=-.029$, p<.001), BMI (${\beta}=.100$, p<.001), triglyceride (${\beta}=-.001$, p=.001), and calcium (${\beta}=.001$, p=.003), and the suggested regression equation explained 25.6% of the variance in BMD (F=16.32, p<.001). The factors related to BMD in women were age (${\beta}=-.060$, p<.001), BMI (${\beta}=.091$, p<.001), total cholesterol (${\beta}=-.002$, p=.028), HDL cholesterol (${\beta}=.009$, p=.001), and calcium (${\beta}=.001$, p=.004), and the suggested regression equation explained 47.0% of the variance in BMD (F=61.72, p<.001). Conclusion: Based on the findings of this study, the modifiable factors, such as BMI, blood cholesterol, and calcium, should be targeted to improve the BMD in both men and women.

Synthesis of Cement Raw Materials by Melting of Industrial Wastes (폐기물의 용융처리에 의한 시멘트원료의 합성)

  • Hwang, Yeon;Sohn, Yong-Un;Chung, Hun-Saeng;Lee, Hong-Ki;Park, Hyun-Suh
    • Resources Recycling
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    • v.5 no.1
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    • pp.3-8
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    • 1996
  • CZS(2Ca0 , SiO\ulcorner) phase of cement clinkcr was obtaincd by melting mixcd four indnstrial wasles of limestone sludge, waste Foundry sand, coal lly ash fiorn power plants and chernicas glasses. The effect ot mixing ratio of four rvastc mater~als ou the composnlg phascs in melled slag was investigated. Thc mixed wastes were meltcd to slag by heat under a constant basicity at 1370C. The shg consisted of p -CIS and C,AS(2CaO - A I P , . SiO,). The ratio of two phases was varied with mixing ~atioo f the waste materials. In order Lo increasc the amount ot j -C2S phase, the coal fly ash content should be reduced, while amount of the chemical glass be increased. The coal fly ash contcnt was the most imporlant factor in controlling phases of thc melted-slag.

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Swimming speed measurement of Pacific saury (Cololabis saira) using Acoustic Doppler Current Profiler (음향도플러유향유속계를 이용한 꽁치어군의 유영속도 측정)

  • Lee, Kyoung-Hoon;Lee, Dae-Jae;Kim, Hyung-Seok;Park, Seong-Wook
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.46 no.2
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    • pp.165-172
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    • 2010
  • This study was performed to estimate the swimming velocity of Pacific saury (Cololabis saira) migrated offshore Funka Bay of Hokkaido using an acoustic Doppler current profiler (OceanSurveyor, RDI, 153.6kHz) established in T/S Ushio-maru of Hokkaido University, in September 27, 2003. The ADCP's doppler shift revealed as the raw data that the maximum swimming velocity was measured 163.0cm/s, and its horizontal swimming speed and direction were $72.4{\pm}24.1\;cm/s$, $160.1^{\circ}{\pm}22.3^{\circ}$ while the surrounding current speed and direction were $19.6{\pm}8.4\;cm/s$, $328.1^{\circ}{\pm}45.3^{\circ}$. To calculate the actual swimming speed of Pacific saury in each bins, comparisons for each stratified bins must be made between the mean surrounding current velocity vectors, measured for each stratified bin, and its mean swimming velocity vectors, assumed by reference (threshold > -70dB) and 5dB margin among four beams of ADCP. As a result, the actual averaged swimming velocity was 88.6cm/s and the averaged 3-D swimming velocity was 91.3cm/s using the 3-D velocity vector, respectively.

The Physical, Mechanical, and Sound Absorption Properties of Sandwich Particleboard (SPb)

  • ISWANTO, Apri Heri;HAKIM, Arif Rahman;AZHAR, Irawati;WIRJOSENTONO, Basuki;PRABUNINGRUM, Dita Sari
    • Journal of the Korean Wood Science and Technology
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    • v.48 no.1
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    • pp.32-40
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    • 2020
  • While the utilization of wood as a raw material in related industries has been increasing with the population increasing, the availability of wood from natural forests has continued to decline. An alternative to this situation is the manufacture of particleboard from non-wood lignocellulose materials through the modification of sandwich particleboard (SPb) using bamboo strands as reinforcement. In this study, strandsof belangke bamboo (Gigantochloa pruriens W) and tali bamboo (Gigantochloa apus) were utilized. The non-wood particles included sugar palm fibers, cornstalk, and sugarcane bagasse. The board was made in a three-layer composition of the face, back, and core in a ratio of 1: 2: 1. The binder used was 8% isocyanate resin. The sheet was pressed at a temperature of 160℃ for 5 min under a pressure of 3.0 N/㎟. Testing included physical and mechanical properties based on the JIS A 5908 (2003) standard, while acoustic testing was based on ISO 11654 (1997) standards. The results showed that using bamboo strands as reinforcement has an effect on the mechanical and physical properties of SPb. Almost all the types of boards met the JIS A 5908 (2003) standards, with the exception of thickness swelling (TS) and internal bond (IB) parameters. Based on the thickness swelling parameter, the C-type board exhibited the best properties. Overall, the B-type board thatused a belangke bamboo strand for the surface and sugarcane bagasse as the core underwent the best treatment. Based on the acoustical parameter, boards using a tali bamboo strand for the surface and sugar palm fiber as the core (E-type board) exhibited good sound absorption properties.

Velocity Estimation of Moving Targets on the Sea Surface by Azimuth Differentials of Simulated-SAR Image

  • Yang, Chang-Su;Kim, Youn-Seop;Ouchi, Kazuo
    • Korean Journal of Remote Sensing
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    • v.26 no.3
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    • pp.297-304
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    • 2010
  • Since the change in Doppler centroid according to moving targets brings alteration to the phase in azimuth differential signals of synthetic aperture radar (SAR) data, one can measure the velocity of the moving targets using this effect. In this study, we will investigate theoretically measuring the velocity of an object from azimuth differential signals by using range compressed data which is the interim outcome of treatment from the simulated SAR raw data of moving targets on the background of sea clutter. Also, it will provide evaluation for the elements that affect the estimation error of velocity from a single SAR sensor. By making RADARSAT-1 simulated image as a specific case, the research includes comparisons for the means of velocity measurement classified by the directions of movement in the four following cases. 1. A case of a single target without currents, 2. A case of a single target with tidal currents of 0.5 m/s, 1 m/s, and 3 m/s, 3. A case of two targets on a same azimuth line moving in a same direction and velocity, 4. A case of a single target contiguous to land where radar backscatter is strong. As a result, when two moving targets exist in SAR image outside the range of approximately 256 pixels, the velocity of the object can be measured with high accuracy. However, when other moving targets exist in the range of approximately 128 pixels or when the target was contiguous to the land of strong backscatter coefficient (NRCS: normalized radar cross section), the estimated velocity was in error by 10% at the maximum. This is because in the process of assuming the target's location, an error occurs due to the differential signals affected by other scatterers.

Effect of Chamomile Flower Extract on Septic Arthritis due to Candida albicans (카모마일 꽃 추출물의 Candida albicans 기인성 감염성 관절염에 대한 효과)

  • Kim, Jeonghyeon;Kim, Songyi;Hong, Yuna;Kim, Yeong Shik;Han, Yongmoon
    • YAKHAK HOEJI
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    • v.58 no.5
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    • pp.343-348
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    • 2014
  • In the present studies, we examined effect of chamomile flowers extract (CH-Ex), which has traditionally been used as antiphlogistics in Europe for many centuries, against Candida albicans-caused septic arthritis. Candida albicans is a major etiological agent among fungal septic arthritis. This effect was investigated in a murine model of the septic arthritis. That is, mice that were given an emulsion form of C. albicans cell wall (CACW) via footpad route were treated intraperitoneally with the CH-Ex for 3 times every 3 days. Degrees of the footpad-swellings were measured with dial gauger. Data showed that the CH-Ex resulted in the reduction of swelling. For instance, at Day 9 when swelling reached the highest peak, there was up to app. 60% reduction of edema in mice injected with the CH-Ex, compared to that of the control mice that received no treatment (P<0.05). This therapeutic anti-arthritic activity appeared to be mediated by inhibitions of NO (nitric oxide) production from activated RAW264.7 macrophages and proliferation of Con A-treated T lymphocytes. Analysis by HPLC revealed that the CH-Ex contained eight polyphenolic compounds including chlorogenic acid (CRA) and rutin. We have reported the CRA and rutin respectively have the anti-arthritic activity. This correlation implicates that CRA and rutin in the CH-Ex may be responsible for the activity. Combined all together, the CH-Ex has anti-arthritic activity against C. albicans-caused septic arthritis, possibly by inhibiting NO production and proliferation of T cells. This activity seems to be contributed by, at least, CRA and rutin among the compounds in the CH-Ex.

The Effect of Pre-Treated Black Garlic Extracts on the Antioxidative Status and Quality Characteristics of Korean Ginseng Chicken Soup (Samgyetang)

  • Barido, Farouq Heidar;Jang, Aera;Pak, Jae In;Kim, Yeong Jong;Lee, Sung Ki
    • Food Science of Animal Resources
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    • v.41 no.6
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    • pp.1036-1048
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    • 2021
  • This study investigated the possible improvement in the antioxidative status and quality characteristics of ready-to-eat (RTE) Samgyetang after adding various black garlic (BG) extracts. The antioxidant activity, total phenolic content (TPC), total flavonoid content (TFC), meat quality indexes, and lipid oxidation rates were measured after receiving one of five different treatments consisting of conventional Samgyetang broth as a negative control, raw garlic (RG) extract as a positive control, BG, oven-dried BG, and maltodextrin-encapsulated BG extract as treatments. Employing retort cooking, fat trimmed carcasses were added to the initially prepared broth together with a phenolic extract that was set at 5% (w/w). A significant intensification of red and yellow color was observed in breast and thigh meat treated with BG extracts, regardless of pretreatment, compared to the negative control and RG. The moisture percentage was affected by the addition of BG extracts, where the encapsulation group retained the highest water content after retorting. In terms of antioxidative status, maltodextrin-encapsulated BG extract was as effective as an oven-dried extract to scavenge free radicals and showed the highest score among samples (p<0.01). The concentration of TFC was found to be the highest and did not differ between encapsulation and oven-dried groups, followed by BG, RG, and the negative control. However, the addition of encapsulated BG extract was the most effective in delaying the formation of malondialdehyde among the samples. Therefore, pre-treatment of BG extract through encapsulation is recommended to develop a higher antioxidative status and quality characteristics of Samgyetang.

A Study on the Material Characteristics of Stone Tools Excavated from the Remain Point of Paleolithic Age in Osong Site, Cheongju

  • Kim, Jae Hwan;Han, Min Su
    • Journal of Conservation Science
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    • v.35 no.1
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    • pp.41-49
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    • 2019
  • This study analyzes the material characteristics of stone tools of the Paleolithic period excavated from the Osong site, located at the project site for the creation of the Osong 2nd Life Science Complex, and estimates the provenance of the stone materials. Because the stones had been buried for a long time, their surfaces had become heavily weathered yellow or yellowish-brown, and the magnetic susceptibility values varied from 0 to 15(${\times}10^{-3}SI$). The excavated stone tools were rocks with various magnetic susceptibility values that could not be specified. Five stone tools subjected to destructive analysis were divided into two groups, one with a value of 1-3(${\times}10^{-3}SI$) and the other with a value of 5-9(${\times}10^{-3}SI$), both based on visible characteristics. The results of the thin-section analysis showed that most of the stone tools were basaltic rocks comprising plagioclase, quartz, and pyroxene, and some had iron content as high as 20 wt.%. These findings and the present geological map suggest that the stone tools were not made from the surrounding rocks because there are no areas containing basaltic rocks surrounding Bongsan-ri in Osong-eup. Andesite and tuff are distributed along with basaltic rocks in the Doan-myeon area in Jeongpyeong-gun, Chungcheongbuk-do Province, but the distance from the excavation site is too far. To determine whether this region is actually related to the provenance of the raw rock, it is necessary to conduct additional field surveys and comprehensive and precise analyses.

Characteristics of Health Masks Certified by the Ministry of Food and Drug Safety (식품의약품안전처에서 허가된 보건용 마스크의 특성 분석)

  • Ham, Seunghon;Choi, Won-Jun;Lee, Wanhyung;Kang, Seong-Kyu
    • Journal of Environmental Health Sciences
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    • v.45 no.2
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    • pp.134-141
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    • 2019
  • Objectives: The study aimed to investigate the characteristics of health masks and to suggest the proper selection and use of protecting the respiratory system from particulate matters. Methods: The National Standard of masks promulgated by the Ministry of Food and Drug Safety (MFDS) and the Ministry of Employment and Labor (MOEL) were reviewed. The raw data of certified health masks were obtained from the MFDS database. Descriptive statistical analysis was performed. Results: Overall, 543 masks were certified by MFDS as of March 2019. Numbers of certified masks as KF80 (Korea Filter), KF94 and KF99 were 257 (47.3%), 281 (51.8%), and 5 (0.9%), respectively. Names of health masks, which were yellow sand, communicable diseases, health or its combination, were diverse that made customers be confused in selection. Health masks were also classified by particulate size, however, detailed information was not available. Conclusions: We investigated the status of health mask certification in Korea. Appropriate information on KF grade of health masks is required for customers to use them properly. MFDS should update the certification system of health masks periodically.