• Tuberculosis and Respiratory Diseases
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• 제85권3호
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• pp.227-236
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• 2022

Background: The use of low-dose inhaled corticosteroid-formoterol as reliever monotherapy has recently been recommended in the asthma treatment guidelines. However, the efficacy of this treatment strategy has not yet been determined during the stepping-down period in moderate asthma. This study aimed to evaluate the feasibility of reducing treatment to as-needed budesonide-formoterol (BFM) in moderate asthma with complete remission. Methods: We randomly assigned 31 patients (8 males and 23 females with a mean age of 57.2 years) with complete remission of asthma by inhaled BFM (160/4.5 ㎍) twice daily to receive BFM (160/4.5 ㎍) as needed (16 patients), or budesonide (BUD) (200 ㎍) twice daily (15 patients). The study was an open-label study done for 48 weeks, with the primary outcome as the cumulative percentages of patients with treatment failure (asthma exacerbation or loss of asthma control or lack of satisfaction after using medications) in the two groups. Results: Six patients (42%) using as-needed BFM had treatment failure, as compared with three patients (21.4%) using BUD maintenance (hazards ratio for as-needed BFM, 1.77; 95% confidential interval, 0.44-7.12; p=0.41). The changes in forced expiratory volume in 1 second were -211.3 mL with as-needed BFM versus -97.8 mL with BUD maintenance (difference, 113.5 mL; p=0.75) and the change in fractional exhaled nitric oxide was significantly higher in both groups, at 8.68 parts per billion (ppb) in the as-needed BFM group and 2.5 ppb. in the BUD maintenance group (difference, 6.18 ppb; p=0.049). Conclusion: Compared with BUD maintenance, there were no significant differences in treatment failure rate in patients who received as-needed BFM during the stepping down period in moderate asthma. However, they showed reduced lung function and relapsed airway inflammation. The results are limited by imprecision, and further large RCTs are needed.

• 한국유체기계학회 논문집
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• 제7권3호
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• pp.14-22
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• 2004

Bileaflet mechanical valves have the complications such as hemolysis and thromboembolism, leaflet damage, and leaflet break. These complications are related with the fluid velocity and shear stress characteristics of mechanical heart valves. The first aim of the current study is to introduce fluid-structure interaction method for calculation of unsteady and three-dimensional blood flow through bileaflet valve and leaflet behavior interacted with its flow, and to overcome the shortness of the previous studies, where the leaflet motion has been ignored or simplified, by using FSI method. A finite volume computational fluid dynamics code and a finite element structure dynamics code have been used concurrently to solve the flow and structure equations, respectively, to investigate the interaction between the blood flow and leaflet. As a result, it is observed that the leaflet is closing very slowly at the first stage of processing but it goes too fast at the last stage. And the results noted that the low pressure is formed behind leaflet to make the cavitation because of closing velocity three times faster than opening velocity. Also it is observed some fluttering phenomenon when the leaflet is completely opened. And the rebounce phenomenon due to the sudden pressure change of before and after the leaflet just before closing completely. The some of time-delay is presented between the inversion point of ventricle and aorta pressure and closing point of leaflet. The shear stress is bigger and the time of exposure is longer when the flow rate is maximum. So it is concluded that the distribution of shear stress at complete opening stage has big effect on the blood damage, and that the low-pressure region appeared behind leaflet at complete closing stage has also effect on the blood damage.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2003년도 춘계학술발표논문집
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• pp.70-79
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• 2003

Paper coating can give smoothness surface and good printability to uncoated paper. Macro roughness of base paper would be decreasing its groove and grit in view of side. Nevertheless its improving effect for paper, some kind of problem is showing in the fine coated paper. Especially, back trap mottle is one of serious problems in printing with fine coated paper. Printers can not adjust conditions to overcome the problem. Also large amounts of paper can be rejected. There are many factors that influence back trap mottle. However it is not clear what the important parameters are in back trap mottle. Back trap mottle has some relationship with ink setting but good guidelines are not clear. Back trap mottle has been linked to non-uniform ink setting. We do not know how much variation in setting we can tolerate. Other mottle issues such as micro-picking and ink refusal are still common. This paper was prepared to identify correlation with ink setting and delta ink density obtained from experiment and then tried to find out some relationships with ink setting and back trap mottle. Basically fine calcium carbonate and ciay was used for main components and coarse calcium carbonate was mixed in two fine pigments to change its porosity and ink acceptance. Micro ink tack force at KRK printing tester was adapted to measure ink setting rate. KRK units were used for back trap mottle simulation and two printed samples were prepared to check delta ink density. Clay base coating has more fast ink setting time than calcium carbonate's though smoothness of clay was better than calcium carbonate. It could be explained by that clay has finer pore in its coating than calcium carbonate. DID(delta ink density) has shown a good correlation with ink setting time from micro ink tack. The total pore volume of coating layer did not match with ink setting and DID. From the results we might conclude coating that has fine pore size around 0.05 ${\mu}m$ can be exposed to high possibility of back trap mottle.

• 한국초전도ㆍ저온공학회논문지
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• 제17권4호
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• pp.30-33
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• 2015

We report the synthesis of Ni-doped $BaFe_2Se_3$ single crystals by using a flux method. X-ray diffraction (XRD) of $Ba(Fe_{1-x}Ni_x)_2Se_3$ shows a gradual peak shift with an increase in the nominal Ni-doping rate, x = 0, 0.05, and 0.10, due to a decrease in unit-cell volume. All samples show a spin glass transition, and temperature dependence of magnetic susceptibility shows a negligible change in the spin-glass transition temperature ($T_g$) with Ni concentration x. The temperature dependence of electrical resistivity for $BaFe_2Se_3$ shows an insulating behavior, and the resistivity value at 295 K and the activation energy ($E_a$) obtained from the Arrhenius plot decrease with increasing x. These results suggest that the Ni doping can be effectively worked as a dopant for electron charge carriers, but is less efficient in controlling the magnetic property, such as spin glass transition, in the $BaFe_2Se_3$ compound.

• 대한기계학회논문집B
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• 제39권10호
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• pp.779-786
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• 2015

이 연구의 목적은 열수력 성능을 향상시키기 위하여 PCHE의 새로운 유로 형상을 제안하는 것이다. 기존의 Zigzag 유로는 굽힘점에서 유동 박리와 역류 영역의 발생으로 높은 압력손실을 가지고 있다. 이 단점을 개선하기 위하여 굽힘점에 직관영역을 삽입하였다. 또한 직관의 길이 변화가 열전달 및 압력손실에 미치는 영향을 분석하였다. 새로운 형상과 기존 Zigzag 유로의 열수력 성능을 Goodness Factor를 사용하여 정량적으로 비교하였다. 질량유량은 $1.41{\times}10^{-4}$에서 $2.48{\times}10^{-4}kg/s$까지 변화 하였다. 1mm 직관길이에서 평균 Goodness Factor는 Zigzag보다 약 25% 정도 증가되었다.

• 공업화학
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• 제8권2호
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• pp.286-291
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• 1997

항암제로 탁월한 효능이 있는 taxol을 정상 액체 크로마토그래피를 이용하여 주목나무의 추출물에서 분리하였다. Taxol을 분리하기 위해 시료 주입량은 $5{\mu}l$에서 $100{\mu}l$로 변화시키고, 이동상 유속은 1ml/min로 고정하여 일정 용매법으로 실험을 하였다. 실험에 사용된 이동상은 헥산, 에탄올, 메탄올, 1-프로판올, 이소프로판올이었다. Taxol과 유사한 성질를 갖는 표준시료 cephalomannine, taxol, 10-deacetyltaxol의 혼합물에서 taxol을 분리하였다. Cephalomannine, taxol, 10-deacetyltaxol 혼합물의 분리 실험 결과로 taxol의 분리 최적 조건은 2성분계에서 헥산/에탄올의 부피 조성비가 96/4이며, 3성분계에서는 헥산/1-프로판올/메탄올의 부피 조성비가 96/2/2이었다. 분리시간은 2성분계에서 80분인데 비해 3성분계에서는 50분으로 적은 용매를 사용하여 분리할 수 있었다. 위에서 얻는 실험조건으로 실제 주목나무의 추출물 $1{\mu}g$에서 taxol를 분리할 수 있었다.

• 한국가스학회지
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• 제11권4호
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• pp.17-22
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• 2007

비예혼합 대향류화염에서 산소부화에 따른 NOx 생성특성에 관한 수치해석이 수행되었다. 순산소의 연소과정에서 공기침투에 의한 부득이한 질소 유입의 상황을 체계적으로 고려하기 위하여, 산화제의 $O_2$는 체적비 21%에서 100%까지 변화되었다. 결과적으로 NO 배출지수$(EI_{NO})$는 산소부화율 75%까지 증가하다가 급격히 감소하는 경향을 보여준다. 이러한 경향은 화염온도, 화염두께 및 체류시간 보다는 NOx 생성과 관련된 $N_2$ 소모율 변화에 의해 설명될 수 있음을 확인하였으며, 특히 N+NO=$N_2+O$ 반응이 가장 크게 기여함을 알 수 있었다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2019년도 추계학술대회
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• pp.19-19
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• 2019

It is necessary to maintain stable crop productions under the unsuitable environments, because the drought and flood may be frequently caused by the global warming. Therefore, it is agent to improve the crop growth model corresponded to soil moisture status. Chili pepper (Capsicum annuum) is one of the useful crop in Asia, and then it is affected by change of precipitation in consequence drought and flood occur however crop model to evaluate water stresses on chili pepper is not enough yet. In this study, development of crop model under different soil moisture status was attempted. The experiment was conducted on the slope fields in the greenhouse. The water level was kept at 20cm above the bottom of the container. Habanero (C. chinense) was used as material for crop model. Sap bleeding rate, SPAD value, chlorophyll content, stomatal conductance, leaf water potential, plant height, leaf area and shoot dry weight were measured at 10 days after treatment (DAT) and 13 DAT. Moreover, temperature and RH in the greenhouse, soil volume water contents (VWC) and soil water potential were measured. As a result, VWC showed 4.0% at the driest plot and 31.4% at the wettest plot at 13 DAT. The growth model was calculated using WVC and the growth analysis parameters. It was considered available, because its coefficient of determination showed 0.84 and there are significant relationship based on plants physiology among the parameters and the changes over time. Furthermore, we analyzed the important factors for higher accuracy prediction using multiple regression analysis.

• 한국기계가공학회지
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• 제18권3호
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• pp.66-73
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• 2019

Recently, FDM-type 3D printer technology has been developed, and efforts have been made to improve the output formability and characteristics further. Through this, 3D printers are used in various fields, and printer technologies are suggested according to usage, such as FDM, SLA, DLP, and SLM. In particular, the FDM method is the most widely used, and the FDM method technology is being developed further. The characteristics of the output are produced by the FDM-type 3D printer, which is determined by various factors, and particularly the perspective of the Inter-Layer Fill Factor, which is the volume ratio of the laminated material that exerts a direct influence. In this study, the Inter-Layer Fill Factor is theoretically obtained by presenting the internal space between each layer according to the laminate thickness as a cross-sectional shape model, and the cross section of the actual laminated sample is compared with the theoretical model through experiments. Then, the equation for the theoretical model is defined, and the strength change according to each condition (tensile strength of material, reduction slope, strength reduction rate, and output strength) is confirmed. In addition, we investigated the influence on the correlation and strength between laminate thickness and the Inter-Layer Fill Factor.

• 자원환경지질
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• 제47권3호
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• pp.247-254
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• 2014

불균질한 자연균열 저류층에서 암체의 압축률은 매우 작은 값을 가지는 반면에 균열의 압축률은 상대적으로 큰 값을 갖는다. 균열의 압축률을 포함한 유효 압축률을 고려하지 않을 경우에는 균열의 간극 변화로 인한 공극 부피의 변화를 반영할 수 없기 때문에 정확한 오일 회수를 예측할 수 없다. 본 연구에서는 기존의 연구들에서 암체의 압축률만을 고려하여 오일 회수를 분석했던 것과 달리, 암체와 균열의 압축률을 모두 고려한 유효 압축률을 적용해서 오일 회수량을 분석하였다. 폴리머 공법에서 균열의 압축률이 폴리머의 주입에 미치는 영향을 이해하기 위해, 폴리머의 분자량, 농도, 주입속도에 따른 오일 회수량을 분석하였다. 유효 압축률을 고려할 경우 폴리머 분자량, 농도, 주입속도가 높아질수록 유효 압축률을 고려하지 않은 경우가 고려한 경우보다 누적 오일 생산량이 높게 나타났다. 또한 공저 압력의 경우에도 유효 압축률을 고려하지 않은 경우가 고려한 경우보다 빠르게 급감하여 오일 생산량에 영향을 주는 것을 확인할 수 있다.