• Nuclear Engineering and Technology
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• 제54권3호
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• pp.1016-1023
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• 2022

In proton therapy, a highly conformal proton dose can be delivered to the tumor by means of the steep distal dose penumbra at the end of the beam range. The proton beam range, however, is highly sensitive to range uncertainty, which makes accurately locating the proton range in the patient difficult. In-vivo range verification is a method to manage range uncertainty, one of the promising techniques being prompt gamma imaging (PGI). In earlier studies, we proposed gamma electron vertex imaging (GEVI), and constructed a proof-of-principle system. The system successfully demonstrated the GEVI imaging principle for therapeutic proton pencil beams without scanning, but showed some limitations under clinical conditions, particularly for pencil beam scanning proton therapy. In the present study, we upgraded the GEVI system in several aspects and tested the performance improvements such as for range-shift verification in the context of line scanning proton treatment. Specifically, the system showed better performance in obtaining accurate prompt gamma (PG) distributions in the clinical environment. Furthermore, high shift-detection sensitivity and accuracy were shown under various range-shift conditions using line scanning proton beams.

• Nuclear Engineering and Technology
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• 제55권10호
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• pp.3700-3708
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• 2023

The stochastic origin ensembles method with resolution recovery (SOE-RR) has been proposed to reconstruct proton-induced prompt gammas (PGs), and the reconstructed PG image was used for range verification. However, due to low detection efficiency, the number of valid events is low. Such a low-count condition can degrade the accuracy of the SOE-RR method for proton range verification. In this study, we proposed two strategies to improve the reconstruction of the SOE-RR algorithm for low-count PG imaging. We also studied the number of iterations and repetitions required to achieve reliable range verification. We simulated a proton beam (10⁸ protons) irradiated on a water phantom and used a two-layer Compton camera to detect 4.44-MeV PGs. Our simulated results show that combining the SOE-RR algorithm with restricted volume (SOE-RR-RV) can reduce the error of the estimation of the Bragg peak position from 5.0 mm to 2.5 mm. We also found that the SOE-RR-RV algorithm initialized using a back-projection image could improve the convergence rate while maintaining accurate range verification. Finally, we observed that the improved SOE-RR algorithm set for 60,000 iterations and 25 repetitions could provide reliable PG images. Based on the proposed reconstruction strategies, the SOE-RR algorithm has the potential to achieve a positioning error of 2.5 mm for low-count PG imaging.

• Nuclear Engineering and Technology
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• 제51권2호
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• pp.533-538
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• 2019

The mechanical-collimation imaging is the most mature technology in prompt gamma (PG) imaging which is considered the most promising technology for beam range verification in proton therapy. The purpose of the present study is to compare the performances of two mechanical-collimation PG cameras, knife-edge (KE) camera and multi-slit (MS) camera. For this, the PG cameras were modeled by Geant4 Monte Carlo code, and the performances of the cameras were compared for imaginary point and line sources and for proton beams incident on a cylindrical PMMA phantom. From the simulation results, the KE camera was found to show higher counting efficiency than the MS camera, being able to estimate the beam range even for $10^7$ protons. Our results, however, confirmed that in order to estimate the beam range correctly, the KE camera should be aligned, at least approximately, to the location of the proton beam range. The MS camera was found to show lower efficiency, being able to estimate the beam range correctly only when the number of the protons is at least $10^8$. For enough number of protons, however, the MS camera estimated the beam range correctly, errors being less than 1.2 mm, regardless of the location of the camera.

• Nuclear Engineering and Technology
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• 제54권6호
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• pp.2213-2220
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• 2022

The maximum dose delivery at the end of the beam range provides the main advantage of using proton therapy. The range of the proton beam, however, is subject to uncertainties, which limit the clinical benefits of proton therapy and, therefore, accurate in vivo verification of the beam range is desirable. For the beam range verification in spot scanning proton therapy, a prompt gamma detection system, called as gamma electron vertex imaging (GEVI) system, is under development and, in the present study, the performance of the GEVI system in spot scanning proton therapy was predicted with Geant4 Monte Carlo simulations in terms of shift detection sensitivity, accuracy and precision. The simulation results indicated that the GEVI system can detect the interfractional range shifts down to 1 mm shift for the cases considered in the present study. The results also showed that both the evaluated accuracy and precision were less than 1-2 mm, except for the scenarios where we consider all spots in the energy layer for a local shifting. It was very encouraging results that the accuracy and precision satisfied the smallest distal safety margin of the investigated beam energy (i.e., 4.88 mm for 134.9 MeV).

• 대한임상검사과학회지
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• 제37권1호
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• pp.1-7
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• 2005

The purpose of this study was to verify (i) a consistent calibration verification for the assessment of method linearity and (ii) calibration agreement with calibration settings. We validated calibration verification through method linearity with different lot number of individual calibrators that span the working range for 9 tests except salicylate with control sample in test. We evaluated that it covered broad analyte range to assay from near zero to the top of the measuring range with 5 or 6 points every three times for 10 analytes in TDM test. Target values were plotted on X-axis with assigned or observed values on the Y-axis. Working range were as follows. Calibration verification of the measuring range (maximum to minimum values) has been validated asetaminophen 0.1 to $304.6_{\mu}g/mL$, salicylate 0 to $1005_{\mu}g/mL$, valproic acid 3.2 to $154.19_{\mu}g/mL$, digoxin 0.17 to 5.65 ng/mL, vancomycine 1.3 to $80.51_{\mu}g/mL$, carbarmazepine 0.1 to $22.3_{\mu}g/mL$, phenytonin 0.6 to $40.21_{\mu}g/mL$, theophyline 0.2 to $40.21_{\mu}g/mL$, primidone 0 to $24.07_{\mu}g/mL$, phenobarbital 0.6 to $60.0_{\mu}g/mL$. Drawing a straight line through five or six points of these data showed good linearity. We are sure that it is important to assess the calibration verification of a test method to ascertain the lowest and highest test results that are reliable.

• 음성과학
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• 제9권4호
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• pp.253-263
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• 2002

In this paper, we propose new algorithm of speaker recognition which identifies the speaker using the information obtained by the intensive speech feature analysis such as pitch, intensity, duration, and formant, which are crucial parameters of individual voice, for candidates of high percentage of wrong recognition in the existing speaker recognition algorithm. For testing the power of discrimination of individual parameter, DTW (Dynamic Time Warping) is used. We newly set the range of threshold which affects the power of discrimination in speech verification such that the candidates in the new range of threshold are finally discriminated in the next stage of sound parameter analysis. In the speaker verification test by using voice DB which consists of secret words of 25 males and 25 females of 8 kHz 16 bit, the algorithm we propose shows about 1% of performance improvement to the existing algorithm.

• 한국수자원학회논문집
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• 제39권3호
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• pp.215-226
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• 2006

본 연구에서는 경안천 유역에 대해 초단시간 강수예보모델인 VSRF(Very Short Range Forecast of precipitation) 모델에서 생산되는 예측강우량의 검증을 실시하고, 이를 NWSPC(National Weather Service PC) 강우-유출 모형에 적용하였다. 강수는 기상학적 검증과 수문학적 검증으로 구분하여 검증하였다. 기상학적 검증은 유역 내에 존재하는 AWS 강수량과 VSRF모델 강수량의 정성적 관계를 객관적으로 제시하였고, 수문학적 검증은 AWS 면적 가중치를 고려한 유역평균 강우량과 VSRF유역평균 강우량과의 정량적 검증결과를 제시하였다. 또한 예보모델에서 생산된 6시간 예측강수량을 NWSPC 모형에 적용해 강수예보모델의 수문연계 가능성을 검토해 본 결과 0.6 이상의 높은 상관관계를 보여 예보모델의 수자원 활용 가능성을 제시하였다.

• 대한임상검사과학회지
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• 제39권1호
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• pp.31-36
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• 2007

The purpose of the clinically reportable range (CRR) in clinical chemistry is to estimate linearity in working range. The reportable range includes all results that may be reliably reported, and embraces two types of ranges: the analytical measurement range (AMR) is the range of analyte values that a method can directly measure on the specimen without any dilution, concentration, or other pretreatment not part of the usual assay process. CAP and JCAHO require linearity on analyzers every six months. The clinically reportable range is the range of analyte values that a method can measure, allowing for specimen dilution, concentration, or other pretreatment used to extend the direct analytical measurement range. The AMR cannot exceed the manufacturer's limits. Establishing AMR is easily accomplished with Calibration Verification Assessment and experimental Linearity. For example: The manufacturer states that the limits of the AST on their instrument are 0-1100. The lowest level that could be verified is 2. The upper level is 1241. The verified AMR of the instrument is 2-1241. The lower limit of the range is 2, because that is the lowest level that could be verified by the laboratory. The laboratory could not use the manufacturer's lower limit of 2 because they have not proven that the instrument values below 2 are valid. The upper limit of the range is 1241, because although the lab has shown that the instrument is linear to 1241, the manufacturer does not make that claim. The laboratory needs to demonstrate the accuracy and precision of the analyzer, as well the validation of the patient AMR. Linearity requirements have been eliminated from the CLIA regulations and from the CAP inspection criteria, however, many inspectors continue to feel that linearity studies are a part of good lab practice and should be encouraged. If a lab chooses to continue linearity studies, these studies must fully comply with the calibration/calibration verification requirements of CLIA and/or CAP. The results of lower limit and upper limit of clinically reportable range were total protein (2.1 - 79.9), albumin (1.3 - 39), total bilirubin (0.2 - 106.2), alkaline phosphatase (13 - 6928.2), aspartate aminotransferase (24 - 7446), alanine aminotransferase (13 - 6724.2), gamma glutamyl transpeptidase (16.64 - 9904.2), creatine kinase (15.26 - 4723.8), lactate dehydrogenase (127.66 - 13231.8), creatinine (0.4 - 129.6), blood urea nitrogen (8.67 - 925.8), uric acid (1.6 - 151.2), total cholesterol (48.52 - 3162), triglycerides (36.91 - 3367.8), glucose (31 - 4218), amylase (21 - 6694.2), calcium (3.1 - 118.2), inorganic phosphorus (1.11 - 108), HDL (11.74 - 666), NA (58.3 - 1800), K (1.0 - 69.6), CL (38 - 1230).

• ETRI Journal
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• 제33권3호
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• pp.423-433
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• 2011

This paper introduces an adaptive and integrated utterance verification (UV) framework using minimum verification error (MVE) training as a new set of solutions suitable for real applications. UV is traditionally considered an add-on procedure to automatic speech recognition (ASR) and thus treated separately from the ASR system model design. This traditional two-stage approach often fails to cope with a wide range of variations, such as a new speaker or a new environment which is not matched with the original speaker population or the original acoustic environment that the ASR system is trained on. In this paper, we propose an integrated solution to enhance the overall UV system performance in such real applications. The integration is accomplished by adapting and merging the target model for UV with the acoustic model for ASR based on the common MVE principle at each iteration in the recognition stage. The proposed iterative procedure for UV model adaptation also involves revision of the data segmentation and the decoded hypotheses. Under this new framework, remarkable enhancement in not only recognition performance, but also verification performance has been obtained.

• 기록학연구
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• 제77호
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• pp.5-36
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• 2023

강력한 대통령중심제를 채택하고 있는 대한민국에서 대통령이 인사권을 가진 직위에 대하여 업무 능력, 평판, 비위 여부 등을 종합적으로 인사검증하는 것은 국가운영의 기본일 뿐만 아니라 민주주의 체계의 유지를 위해서도 매우 중요하다. 그 과정에서 생산된 인사검증 관련 기록물 또한 국가의 중요 인물들에 대한 광범위한 자료를 담고 있어, 그 자체로 매우 중요한 국가적 차원의 정보이며, 후세에 현재의 국가운영을 연구하는 데 유용한 사료로 활용될 가능성이 매우 높다. 그렇기 때문에 2007년 「대통령기록물 관리에 관한 법률」 제정 이후, 인사검증 업무를 담당한 대통령비서실 민정수석비서관실은 광범위한 인사검증기록물을 대통령지정기록물로 지정하여 대통령기록관으로 이관하였을 것으로 추정된다. 그런데 제20대 정부가 출범하면서 2022년 6월부터 인사검증 담당기관이 대통령비서실 민정수석비서관실에서 법무부 '인사정보관리단'으로 변경됨에 따라 그간 유지된 인사검증 프로세스와 관련된 기록물의 보존에 커다란 변화가 생겼다. 이에 이 연구에서는 우선 인사검증기록물이 무엇이며 그간 어떻게 보존되고 관리되어 왔는지를 살펴 보았다. 그리고 이번 인사검증 담당기관의 변화로 인해 기록관리 차원에서 어떠한 쟁점이 생겨났는지, 그 쟁점들을 어떤 방식으로 해결해야 하는지에 대하여 실무적· 제도적 차원에서 개선 방안을 제안하였다.