• Journal of Chest Surgery
• /
• v.31 no.7
• /
• pp.650-659
• /
• 1998

Between August 1996 and August 1997, 22 patients underwent extracardiac Fontan operations. The basic diagnoses included univentricular heart of the right ventricular type (n=12); univentricular heart of the left ventricular type (n=4); tricuspid atresia (n=4); left isomerism, transposition of great arteries, ventricular septal defect and pulmonary stenosis (n=1); and criss-cross heart with uneven ventricle (n=1). The median age of the 14 men and 8 women was 29 months (range from 21 months to 26 years). Previous procedures included bidirectional cavopulmonary shunt (n=15, interval=15.6$\pm$3.4 months), Kawashima operation (n=4, interval=37.5$\pm$20 months), and classic Glenn shunt (n=1, interval=14 years). In 2 patients, extracardiac Fontan operations were done without any previous procedures. A 16- to 22-mm flexible Gore-Tex tube graft (n=18), Hemashield graft (n=3), or, alternatively, a nonvalved aortic allograft (n=1) was cut and anastomosed end-to-end between inferior vena cava and undersurface of pulmonary artery using Gore-Tex or Prolene suture in a running fashion. In risk Fontan patients (n=12), a communication between the extracardiac conduit and the right atrium was constructed. In the most 13 recent patients, the procedures were done without cross-clamping of the aorta and with a beating heart. Operative mortality was 9.1% (n=2). Complications included persistent chest tube drainage for more than 7 days (n=5), chorea (n=2), and low cardiac output (n=1). There were no late deaths. Follow-up echocardiogram (mean: 6 months) demonstrated satisfactory hemodynamic results in the surviving 20 patients. Potential advantages of this technique consist of minimization of surgical manipulation of atrial tissue, reduction or elimination of myocardial ischemia, creationof a uniform and stable inferior vena cava-to-pulmonary artery conduit, and increased flexibility and safety in certain high-risk patients such as those with increased pulmonary vascular resistance, pulmonary hypertension, and impaired ventricular function. Further investigations during a longer follow-up are needed to confirm the intermediate and long-term results, especially the reduction of late atrial arrhythmias.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.40 no.3
• /
• pp.214-224
• /
• 2004

A large cage system for the purpose of fishes farming in the open sea was influenced by various forces from the ocean environment. The deformation of the cage by these forces affects the safety of the cage itself, as well as that of the cultivated creatures. In this research, theoretical model was established to analyzing dynamic movement influenced by current for cage. Also, to increase the accuracy of calculations, the reduction ratio of flow speed acquired using the flume tank experiment. Applying the reduction ratio of flow speed to the numerical calculation, the calculation values were compared with the measured values in the flume tank experiment using cage model. The results were as follows ; 1. When the flow speed of the flume tank is fixed, the decrease of the velocity of flow which is passed the upper panel side is proportion to the increase of porosity ratio of netting. 2. When the porosity ratio is fixed, the increase of the velocity of flow which is passed the upper panel side is proportion to the increase of velocity of flow. 3. When the porosity ratio and the flow speed of the flume tank are fixed, the decrease of the velocity of flow which is passed the upper panel side is proportion to the increase of attack angle. 4. As a result of comparison between the underwater shape by simulation which is applying the reduction ratio of flow speed from the experiment using plane netting and that by model experiment, it was found out that the result of the simulation was very close to that of model gear within ${\pm}$ 5 % error range.

• Food Science of Animal Resources
• /
• v.31 no.3
• /
• pp.460-468
• /
• 2011

We evaluated the effect of adding mechanically deboned chicken meat (MDCM) (0, 10, 20, 30 or 50%) on quality characteristics of chicken sausage. Adding MDCM decreased the protein content of chicken sausage, but ash content increased significantly. Adding MDCM had no effect on pH and water holding capacity of sausage. Adding MDCM increased cooking loss, but did not affect the shear force value of the sausage. Adding MDCM decreased the L- (lightness) and b- (yellowness) values but increased the a- (redness) value of sausage. Adding MDCM decreased the hardness and cohesiveness values, but did not affect the springiness value of chicken sausage. Adding MDCM decreased the juiciness and hardness but increased the flavor and chewiness scores of chicken sausage. Regardless of the MDCM addition level, all chicken sausage contained low residual nitrite ion (<4 ppm). During the 10 d of storage at $4^{\circ}C$, adding MDCM did not affect total microbial count or TBA values of chicken sausage, but the VBN value of the sausage increased slightly. However, all storage characteristic values in the sausage were within the safety range. Adding MDCM (0, 10 or 20%) to chicken sausage resulted in a finely structured protein matrix under scanning electron microscopy (SEM), which indicated a good meat emulsion, but adding MDCM at more than 20% resulted in a very coarse protein matrix structure.

• Korean Journal of Clinical Pharmacy
• /
• v.27 no.2
• /
• pp.92-98
• /
• 2017

Background: Nebulized colistimethate is increasingly used, because there are problems such as renal dysfunction and low distribution within the lungs when colistimethate is administered intravenously. This study was designed to compare and analyze the changes in renal function by of nebulized colistimethate treatment for its safe administration. Methods: This study retrospectively reviewed the electronic medical records of adult patients above 19 years old, receiving only the nebulized colistimethate at least 4 days in Yonsei university health system from Nov 2014 to Aug 2015. Acute kidney injury (AKI) was determined by using the RIFLE criteria (Risk, Injury, Failure, Loss and End-stage renal disease) according to serum creatinine (SCr) levels before and after use of nebulized colistimethate. Results: 48 patients were included our study and their SCr increased significantly after nebulized colistimethate treatment ($SCr_0$ vs. $SCr_1$; $0.85{\pm}0.80$ vs. $1.00{\pm}0.82mg/dL$, n=48, p<0.001), but the changes were in normal range according to the standards at Yonsei university health $system^a$. Among 48 patients, 38 patients were in the non-AKI group (79.2%), and 10 patients developed AKI (20.8%). Within the AKI group, 2 patients were in the Injury group (20%) and the other 8 in the Risk group (80%). Conclusion: There was no significant difference in age, dosage and duration of treatment between AKI group and non-AKI group (p>0.05). The study has a significance in that it reviewed the safety of nebulized colistimethate only treatment to national patients, analyzing its nephrotoxicity. It has confirmed that nebulized colistimethate is a safer method than intravenous injection, and requires to establish a guideline for the use of nebulized colistimethate in further studies with broader patient groups. $^a$ : SCr Male 0.68-1.19 mg/dL, Female 0.49-0.91 mg/dL.

• Journal of Environmental Health Sciences
• /
• v.41 no.3
• /
• pp.203-215
• /
• 2015

Objectives: This study was designed to evaluate the filtration efficiencies and pressure drops of five commercial cloth masks (4 plate type, 1 cup type) in comparison to the performance of a class 1 disposable respirator (reference respirator). A further objective was to evaluate the effects of the number of layers and wash treatment independently on filtration efficiencies and pressure drops. Methods: Polydisperse NaCl aerosols were generated in an aerosol chamber and their concentrations were measured by an optical particle counter (OPC) in the size range of $0.3{\sim}10{\mu}m$ (five channels). Results: The filtration efficiencies of the five cloth masks and the reference respirator were D: 9.5%, C: 18.5%, E: 23.6%, A: 28.5%, B: 29.7% and R: 91.1%, respectively, and the pressure drops through them were C, D: 0.8 Pa, E: 1.7 Pa, B: 6.4 Pa, A: 42.7 Pa and R: 19.3 Pa, respectively. The filtration efficiencies of the cloth masks and reference respirator were below the class 1 respirator criterion (${\geq}94.0%$) of the Ministry of Employment and Labor (MOEL) and Ministry of Food and Drug Safety (MFDS). The pressure drops satisfied the class 1 respirator criterion (${\leq}70Pa$) of MOEL and MFDS. When the cloth masks were folded into two and four layers, the filtration efficiencies of cloth masks A, B, C, D (plate type) increased 1.7-4.6 times, and 2.3-6.8 times, respectively, compared to the efficiencies of the same products in a single layer. Pressure drops increased as the number of layers was increased. The filtration efficiency of cloth mask E with a liner was 1.3 times higher than that of the same mask without a liner, and the pressure drop was lower in the no-liner configuration. After a single washing, the filtration efficiencies of all the cloth mask products decreased 1.04-4.0 times compared to those of the same products intact. For the cloth masks C and E, their filtration efficiencies were significantly decreased after washing (p<0.05). The pressure drops of all cloth masks were 1.2-2.0 times lower after washing. Conclusions: The filtration efficiencies of the five cloth masks were below 30% and did not improve greatly by increasing the number of layers. After a single washing, their performances decreased. Considering the above and other issues identified with cloth masks, such as poor fit and stretched fibers through use, people should not expect protection against particulate matters from the cloth masks on the market.

• Journal of Korean Elementary Science Education
• /
• v.19 no.1
• /
• pp.157-170
• /
• 2000

The purpose of this study is to survey the instructional state of the unit 'Small Living Things' in the Elementary School Science. for this study, 100 teachers were surveyed on teaching-learning practices. More specifically, questions were asked on the degree of accomplishing instruction objectives, frequency of field . study, experimental preparation, alternative instructional methods, amount of preparation, availability of reference books for teachers and availability of information materials on the Kwangju region. Our results show that teachers find the objectives related to the collection of living things for class experiments and the task of growing and observing them the most difficult to accomplish. It was reported that 38% of teachers have actually conducted field trips. The obstacles listed in going out on field study range from lack of knowledge of appropriate places, lack of time, to safety concerns. The most difficult problem in teaching this unit was preparing proper instructional materials, regardless of teacher's gender, career, and interest. Most respondents let children provide the experimental subjects. Teachers with collection experience tend to provide for the experimental materials themselves. Our Analysis also reveals that more than 70% of the respondents do not have adequate knowledge of the species dealt with in the unit. Gender, career, and interest area of the teachers did not make any difference (p< .05). In the case that proper experimental subjects have not been prepared, VTR, textbooks, and charts were reported as the most frequently used alternative instruction aids. The level of content and amount of knowledge contained in this unit were found to be appropriate. Information on instruction materials and experiment-observation were obtained through the teaching manual or periodicals (58%), information materials on the region(20%), and fellow teachers (12%). Reference books for teachers and materials on the region are perceived to be inadequate in order of importance in the areas of preparation method, level-wise learning guide, experimental observation, and information on species covered in text. Overall, it was judged that the highest concern was with obtaining experimental materials, and teacher's reference books and materials on the region need to be reinforced to allow teachers to more fully utilize them. Development and distribution of proper instruction-learning materials to the children's level is also required.

• Journal of Radiation Protection and Research
• /
• v.45 no.2
• /
• pp.76-80
• /
• 2020

Background: To improve the measurement accuracy of liquid-scintillation counting for activity standardization, it is necessary to significantly reduce the background caused by thermal noise or after-pulses. We have therefore improved a movable 3 photomultiplier (3PM)-γ coincidence-counting method using the logical sum of three double coincidences for β events. Materials and Methods: We designed a new data-acquisition system in which β events are obtained by counting the logical sum of three double coincidences. The change in β-detection efficiency can be derived by moving three photomultiplier tubes sequentially from the liquid-scintillation vial. The validity of the method was investigated by activity measurement of ¹³⁴Cs calibrated at the Korea Research Institute of Standards and Science (KRISS) with 4π(PC)β-γ(NaI(Tl)) coincidence counting using a proportional counter (PC) for the β detector. Results and Discussion: Measurements were taken over 14 counting intervals for each liquidscintillation sample by displacing three photomultiplier tubes up to 45 mm from the sample. The dead time in each β- and γ-counting channel was adjusted to be a non-extending type of 20 ㎲. The background ranged about 1.2-3.3 s^-1, such that the contributions of thermal noise or after-pulses were negligible. As the β-detection unit was moved away from the sample, the β-detection efficiencies varied between 0.54 and 0.81. The result obtained by the method at the reference date was 396.3 ± 1.7 kBq/g. This is consistent with the KRISS-certified value of 396.0 ± 2.0 kBq/g within the uncertainty range. Conclusion: The movable 3PM-γ method developed in the present work not only succeeded in reducing background counts to negligible levels but enabled β-detection efficiency to be varied by a geometrical method to apply the efficiency extrapolation method. Compared with our earlier work shown in the study of Hwang et al. [2], the measurement accuracy has much improved. Consequently, the method developed in this study is an improved method suitable for activity standardization of β-γ emitters.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.20
• /
• pp.8661-8666
• /
• 2014

Background: Docetaxel and cisplatin in combination with fluorouracil (DCF) regimen is accepted to be one of the standard regimens in the treatment of advanced gastric cancer. However, substantial toxicity has limited its use in daily clinical practice. Therefore, modification of DCF regimens, including introduction of capecitabine has been investigated to improve the safety profiles. In the present study, the efficacy and toxicity of a regimen with a modified dose of docetaxel and cisplatin in combination with oral capecitabine (DCX) was evaluated in untreated patients with HER2-negative advanced gastric cancer. Materials and Methods: Fifty-four patients with HER2-negative locally advanced or metastatic gastric cancer were included in this cohort. Patients received docetaxel $60mg/m^2$ plus cisplatin $60mg/m^2$ (day 1) combined with capecitabine $1650mg/m^2$ (days 1-14) every 3 weeks. Treatment response, survival, and toxicity were retrospectively analyzed. Results: The median age was 54 years (range: 24-76). The majority of patients (70%) had metastatic disease, while 11 patients (21%) had recurrent disease and underwent curative gastrectomy, and 5 patients (9%) had locally advanced disease (LAD). The median number of DCX cycles was 4. There were 28 partial responses and 11 complete responses, with an overall response rate of 72%. Curative surgery could be performed in four patients among five with LAD. At the median follow-up of 10 months, the median progression-free survival (PFS) and overall survival (OS) of the entire cohort of patients were 7.4 and 12.1 months, respectively. Dose modification was done in 12 patients due to toxicity in 8 and noncompliance in 4 patients. The most common hematological toxicity was neutropenia, which occurred at grade 3-4 intensity in 10 of 54 patients (27.7%). Febrile neutropenia was diagnosed only in two cases. Conclusions: DCX regimen offers prominent anti-tumor activity and considered to be effective first-line treatment with manageable toxicity for patients with HER2-negative advanced gastric cancer.

• The Journal of Churna Manual Medicine for Spine and Nerves
• /
• v.10 no.1
• /
• pp.117-127
• /
• 2015

Objectives : Most of pains are important symptoms caused by cancer transpered to spine. Harpagophyti Radix Pharmacopuncture is highly effective in reducing fever, pain, inflammation but was never used to reduce pain from cancer transpered to spine. So I intended to use Harpagophyti Radix Pharmacopuncture to control pain. The purpose of this study is to evaluate the clinical application of Harpagophyti Radix Pharmacopuncture for Bone Metastasis of Breast Cancer and Spinal Stenosis. Methods : We examined patient with Bone Metastasis of Breast Cancer and Spinal Stenosis who admitted Jaseng Korean Medicine Hospital. The patient was treated by Korean Medicine treatment and Harpagophyti Radix Pharmacopuncture. This case was assessed by Numerical Rating Scale(NRS), Oswestry Low Back Pain Disability Index(ODI), Short-Form 36 Health Survey(SF-36), ROM(Range of Movement) and Special Test. Results : In this study, the patient's pain was controlled and NRS, ODI were decreased. I could identify the improvement in life quality from the positive change of SF-36 and also found out that treatment was successful from the improvement of ROM, Special test. Conclusions : Harpagophyti Radix Pharmacopuncture with Korean Medicine treatment for Bone Metastasis of Breast Cancer and Spinal Stenosis was proved to be useful to the pain relief and function recovery, but further research should take place for clear understanding of the exact amount of dosage and safety. Moreover it must be accompanied by long term follow up research.

• Proceedings of the KSMRM Conference
• /
• 2003.10a
• /
• pp.103-105
• /
• 2003

After fifteen years of development, Magnetic Resonance (MR) technology for human imaging and spectroscopy is reaching a refined state with FDA approved 3T clinical products from Siemens, GE, and Philips. Broker has cleared CE approval with a 4T system. Varian supports a 4T system platform as well. Shielded magnets are standard at 3T from GE, Oxford, Magnex, and IGC. A shielded 4T whole body magnet is available from Oxford. Stronger switched gradients and dynamic shim coils, desired at any field, areespecially useful at higher static magnetic fields B0. In addition to the higher currents required for higher resolution slice or volume selection afforded by higher SNR, whole body gradient coils will be driven at increasing slew rates to meet the needs of new cardiac applications and other requirements. For example 3T and 4T systems are now being equipped with 2kV, 500A gradient coils and amplifiers capable of generating 4G/cm in 200msec, over a 67+/-cm bore diameter. High field EPI applications require oscillation rates at 1 kHz and higher. To achieve a benchmark 0.2 ppm shim over a 30cm sphere in a high field magnet, at least four stages of shimming need to be considered. 1) A good high field magnet will be built to a homogeneity spec. falling in the range of 100 to 150 ppm over this 30cm spherical "sweet spot" 2) Most modern high field magnets will also have superconducting shim coils capable of finding 1.5 ppm by their adjustment during system installation. 3) Passive ferro-magnetic shimming combined with 4) active, high order room temperature shim coils (as many as five orders are now being recommended) will accomplish 0.2 ppm over the 30cm sphere, and 0.1 ppm over a human brain in even the highest field magnets for human studies. Safety concerns for strong, fast gradients at any B0 field include acoustic noise and peripheral nerve stimulation. One or more of the mechanical decoupling methods may lead to quieter gradients. Patient positioning relative to asymmetric or short gradient coils may limit peripheral nerve stimulation at higher slew rates. Gradient designs combining a short coil for local speed and strength with a longer coil for coverage are being developed for 3T systems. Local gradients give another approach to maximizing performance over a limited region while keeping within the physiologically imposed dB0/dt performance limits.