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Hemodynamic changes associated with a novel concentration of lidocaine HCl for impacted lower third molar surgery

  • Ping, Bushara;Kiattavorncharoen, Sirichai;Durward, Callum;Im, Puthavy;Saengsirinavin, Chavengkiat;Wongsirichat, Natthamet
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.15 no.3
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    • pp.121-128
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    • 2015
  • Background: The authors studied the hemodynamic effect influent by using the novel high concentration of lidocaine HCl for surgical removal impacted lower third molar. The objective of this study was to evaluate the hemodynamic change when using different concentrations of lidocaine in impacted lower third molar surgery. Methods: Split mouth single blind study comprising 31 healthy patients with a mean age of 23 years (range 19-33 years). Subjects had symmetrically impacted lower third molars as observed on panoramic radiograph. Each participant required 2 surgical interventions by the same surgeon with a 3-week washout period washout period. The participants were alternately assigned one of two types of local anesthetic (left or right) for the first surgery, then the other type of anesthetic for the second surgery. One solution was 4% lidocaine with 1:100,000 epinephrine and the other was 2% lidocaine with 1:100,000 epinephrine. A standard IANB with 1.8 ml volume was used. Any requirement for additional anesthetic and patient pain intra-operation was recorded. Post-operatively, patient was instructed to fill in the patient report form for any adverse effect and local anesthetic preference in terms of intra-operative pain. This form was collected at the seven day follow up appointment. Results: In the 4% lidocaine group, the heart rate increased during the first minute post-injection (P < 0.05). However, there was no significant change in arterial blood pressure during the operation. In the 2% lidocaine group, there was a significant increase in arterial blood pressure and heart rate in the first minute following injection for every procedure. When the hemodynamic changes in each group were compared, the 4% lidocaine group had significantly lower arterial blood pressure compared to the 2% lidocaine group following injection. Post-operatively, no adverse effects were observed by the operator and patient in either local anesthetic group. Patients reported less pain intra-operation in the 4% lidocaine group compared with the 2% lidocaine group (P < .05). Conclusions: Our results suggest that a 4% concentration of lidocaine HCl with 1:100,000 epinephrine has better clinical efficacy than 2% lidocaine HCl with 1:100,000 epinephrine when used for surgical extraction of lower third molars. Neither drug had any clinical adverse effects.

Occurrence and Mineral Characteristics of Au-Ag-Cu-Bi Bearing Quartz Veins in the Estancia de la Virgen area, Guatemala (과테말라 Estancia de la Virgen 지역 금-은-동-비스무스 광화대의 산상과 광물특성)

  • Shin, Eui-Cheol;Kim, Soo-Young;Hong, Sei-Sun;Kim, In-Joon
    • Economic and Environmental Geology
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    • v.31 no.6
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    • pp.463-472
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    • 1998
  • The survey was carried out in order to delineate the occurrence of ore deposits and the mineralized characteristics in the Estancia de la Virgen area through the 1:2,000 scaled geological mapping and topographic measuring surveys. Gold-silver mineralization is in the fault block developed between the San Agustin Fault and Cabanas Fault. It is associated with ore bearing quartz veins controlled by the fault structure. The contents of Au and Ag range from traces up to 72 g/t and 180 g/t respectively. According to traversing the outcrops, the quartz veins are traced by 0.5 Km trended to north and south. In those extended part, they continue for 1,000 m intermittently. Gold-silver mineralization could be divided into three stages. In the first stage, pyrite, galena, sphalerite, and chalcopyrite were formed with the primary silver and gold associated with galena and copper sulfides respectively. In the second stage, Cu-Bi-Au-Ag bearing sulfides such as chalcocite, covellite, and linarite are formed and usually deposited on the cataclastic fractures of galena and/or chalcopyrite. In the third stage, both the carbonation of galena and sphalerite and the sulphatization of galena, took place in the surface environment. And then primary silver was carried away off and was deposited on galena and/or copper sulfides during oxidation near the water table. Low partitionings of Fe in sphalerite assist that the minerals were formed at the relatively low temperature, which is coincided with previously reported homogenization temperature of fluid inclusions.

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Determination of Adequate Method for Protein Extraction from Rice Bran and the Substitution of Dried Skim Milk with Protein Concentrate from Rice Bran in Early Weaned Pigs

  • Phipek, W.;Nagasinha, C.;Vallisuth, S.;Nongyao, C.
    • Asian-Australasian Journal of Animal Sciences
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    • v.24 no.9
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    • pp.1268-1273
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    • 2011
  • The present study was conducted to determine a feasible method of protein concentrate extraction from rice bran (RBPC) and its effect as a substitution for skim milk in early weaning pig diets. An investigation to extract protein concentrate from full fat rice bran was undertaken to determine the best ratio of water and rice bran, the amount of NaOH and a HCl solvent to use in a simple paddle-type mixer with modified spinning to produce RBPC. The results stated that the best ratio for water mixing in the RBPC extraction process was 1:5 with 20 g NaOH and 30 min in a paddle-type mixer at 300 rpm. A mix of 250 ml 0.2 N HCl was optimum for neutralization and protein precipitation. After the fluid was spun out with a washing machine, the sediment was left for 12-14 hours to complete the filtration. One kilogram of rice bran could produce an average of 324.5 gram RBPC and it contained 3.40% ash, 496.48 kcal of GE/100 gram, 1.94% crude fiber, 28.20% ether extract, 7.64% moisture and 16.66% crude protein, respectively. A total of 45 crossbred piglets, weaned at 3 weeks of age were allotted into control diet (A) and dietary treatments formulated with a four different rates of RBPC substitution for skim milk at a percentage of 25 (B), 50 (C), 77 (D) and 100 (E) respectively, in a randomized complete block (RCB) design. All piglets had free access to feed and water until 8 week of age when the experiment ended. Feed intake, average daily gain, growth rate and feed efficiency were not affected by dietary treatments. Blood test parameters after completion of the growth trial indicated normal health. Even though the mean of cell hemoglobin concentration was significantly different between treatments (p<0.05) it was still within the normal range. The cost difference for BW gain of 100% RBPC substituted for skim milk in the weaning diet was approximately 35% lower than that of the control and the relative cost of production was 96.67, 92.85, 70.75 and 64.48% lower for the replacement of 25, 50, 75 and 100% of skim milk respectively. These results implied that this technology is feasible for use by small scale farmers to improve their self-reliance.

Effect of Highly Water Absorbing Polymer(K-sorb) on Soil Water Retention (토양의 수분보유(水分保有)에 미치는 초흡수성 고분자중합체(高分子重合體)(K-sorb)의 효과)

  • Yoo, Sun-Ho;Kwun, Sun-Kuk;Ro, Hee-Myeong
    • Korean Journal of Soil Science and Fertilizer
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    • v.23 no.3
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    • pp.173-179
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    • 1990
  • The effect of a highly water absorbing polyacrylate polymer, commonly called K-sorb, at rates of 0.0, 0.05, 0.2, and 0.5% by weight on the water retention properties of three soils, and the longevities of these treatment effects were evaluated. Water retentions were measured for all the treatments by use of a pressure-plate extractor in the laboratory. Available water and three-phase distributions at moisture tensions of 0.01, 0.3, and 15b were calculated from water retentivity data. A randomized block experiment of Chinese cabbages was conducted to examine the effects and the longevities of the treatments(0.0, 0.05, 0.1, and 0.2%) on water retention of Jungdong sandy loam soil in the field. Water retentions for a loamy sand, sandy loam, and loam soil, treated with 0.2 and 0.5% K-sorb, were increased. K-sorb treatments were more effective in sandy soil than in loamy soils. Water contents for the 0.5% treatment were markedly greater than those for the 0.2% treatment at earth moisture tension. K-sorb only at a rate of 0.5% remained effective in water retention of each soil through repeated drying and wetting for 12 months. Duncan's multiple range showed 0.2% treatment was effective(at the level of 0.05) after 2 months but not after 10 months under field condition.

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Production Yield Enhancement of Mycosporine-like amino acid(MAA)s in Transformed Microalgae Culture by Radiofrequency (형질전환 미세조류의 고주파 처리 배양을 통한 MAA 생산량 증가)

  • Seo, Hyo Hyun;Song, Mi Young;Kulkarni, Atul;Suh, Sung-Suk;Lee, Taek-Kyun;Moh, Sang Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.6
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    • pp.3799-3804
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    • 2014
  • In sea water, microalgae are exposed to a range of critical environmental conditions. Microalgae are protected from UV-A radiation due to the presence of mycosporine like amino acids(MAAs). Owing to the UV-A absorption properties of MAAs, they are used widely as a UV protecting ingredient in cosmetics. Therefore, there is a need to increase the production yield of MAAs. This study investigated the production yield of MAAs in transformed microalgae by radiofrequency(RF) exposure. Initially, the Glut-1 gene was transformed to Chlamydomonas hedleyi microalgae as a glucose transporter. The biomass was enhanced after Glut-1 gene transformation. In addition, the MAAs production yield was increased during large scale production in bioreactors due to the RF treatment. Therefore, purified extracts of MAAs can be used as a sun block material in the cosmetic industrial field.

A STUDY ON THE SAFETY ANALYSIS OF ROCK FILL DAM (1) (필댐의 안정성 해석 연구 (1))

  • HoWoongShon;DaeKeunLee
    • Journal of the Korean Geophysical Society
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    • v.6 no.3
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    • pp.165-177
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    • 2003
  • The purpose of this paper is to analyze the behavior and to study the safety evaluation of the Unmun Dam located in Cheongdo-Gun of GyeongBuk Province, Korea. For this purpose, soil analyses including boring data, geophysical surveys were conducted. In this paper, especially many geophysical methods were adopted to configure out the subsurface situation of dam. Applied geophysical methods were: 1) electric resistivity survey, 2) high frequency magnetotelluric (HFMT) survey, 3) ground penetrating radar (GPR) survey, 4) seismic refraction survey, 5) seismic cross-hole tomography survey, and 6) high frequency impedance (ZHF) survey. Each of geophysical surveys were analyzed and joint analyses between geophysical surveys were also performed to deduce the more reliable subsurface information of Dam by using the features and characteristics of each geophysical survey. Since many defects, such as gravel and weathered rock blocks in the dam core, and lots of amounts of leakage, by boring analyses were found, reinforcement by compaction grouting system (CGS) has been conducted in some range of dam. Some geophysical data and data of geotechnical gauges were also used to confirm the effects of reinforcement. Electric resistivity, EM, GPR, ZHF, seismic refraction and seismic tomography surveys show that left side of dam is weak, which means the possibility of existence of gravel, rock block, water and cavities in the core of dam. This result coincides with the boring data. Especially, electric survey after reinforcement shows that even the right side of the dam has been deformed by the strong pressure during the reinforcement itself. As a conclusion, some problems in the dam found. Especially, the dam near spillway shows the high possibility of leakage. It should be pointed out that only the left side of he dam has not a leakage problem. As a whole, the dam has problems of weakness, because of unsatisfactory construction. It is strongly recommended that highly intensive monitoring is required.

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A Wideband ${\Delta}{\Sigma}$ Frequency Synthesizer for T-DMB/DAB/FM Applications in $0.13{\mu}m$ CMOS (T-DMB/DAB/FM 수신기를 위한 광대역 델타시그마 분수분주형 주파수합성기)

  • Shin, Jae-Wook;Shin, Hyun-Chol
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.47 no.12
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    • pp.75-82
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    • 2010
  • This paper presents a wideband ${\Delta}{\Sigma}$ fractional-N frequency synthesizer for a multi-band single chip CMOS RFIC transceivers. A wideband VCO utilizes a 6-bit switched capacitor array bank for 2340~3940 MHz frequency range. VCO frequency calibration circuit is designed for optimal capacitor bank code selection before phase locking process. It finishes the calibration process in $2{\mu}s$ over the whole frequency band. The LO generation block has selectable multiple division ratios of ${\div}2$, ${\div}16$, and ${\div}32$ to generate LO I/Q signals for T-DMB/DAB/FM Radio systems in L-Band (1173~1973 MHz), VHF-III (147~246 MHz), VFH-II (74~123 MHz), respectively. The measured integrated phase noise is quite low as it is lower than 0.8 degree RMS over the whole frequency band. Total locking time of the ${\Delta}{\Sigma}$ frequency synthesizer including VCO frequency calibration time is less than $50{\mu}s$. The wideband ${\Delta}{\Sigma}$ fractional-N frequency synthesizer is fabricated in $0.13{\mu}m$ CMOS technology, and it consumes 15.8 mA from 1.2 V DC supply.

Surgical Repair and Long Term Results in Sinus of Valsalva Aneurysm: Twelve Year Experience (발살바동 동맥류의 외과적 치료 및 장기 결과)

  • 방정희;조광현;우종수
    • Journal of Chest Surgery
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    • v.37 no.7
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    • pp.578-584
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    • 2004
  • Sinus of Valsalva aneurysm is a rare cardiac anomaly and a long-term survival after surgical treatment has not been well established. This study was designed to evaluate the long-term surgical results after the repair of sinus Valsalva aneurysm. Material and Method: From April 1991 to November 2003, 35 patients (23 male, 12 female, mean age 35.2 years, range 11∼64) underwent operation for sinus of Valsalva aneurysm. Twenty six patients (74.3%) were in the New York Heart Association (NYHA) class III∼IV before surgery. In preoperative echocardiogram, mean EF was 63.32 $\pm$ 11.43% and nine patients (25.7%) were in AR grade III∼IV. Direct closure, patch closure of ruptured sinus Valsalva were performed in fourteen patients (46.7%), sixteen patients (53.3%) respectively. Aortic valve replacement, valvuloplasty were performed in five patients (14.3%), three patients (8.6%) respectively. Three patients (8.6%) underwent the Bentall procedure. Concomitant procedures were performed in 15 patients (42.9%), which were closure of VSD and ASD. Mean CPB time and ACC time were 116.79 $\pm$ 38.79 and 81.2 $\pm$ 28.97 minutes. Result: There was no operative mortality. One patient (2.9%) developed complete heart block that required a permanent pacemaker implantation. Three patients (8.6%) required reoperation due to a recurred rupture of the sinus Valsalva aneurysm and developed aortic insufficiency. Mean follow-up time was 58.55 $\pm$ 38.38 months. There was one late death. Actuarial 5 year freedom rate from reoperation was 87.1 $\pm$ 7%. Conclusion: Surgical treatment for sinus of Valsalva aneurysm is safe and has satisfactory long-term results.

Model Identification for Control System Design of a Commercial 12-inch Rapid Thermal Processor (상업용 12인치 급속가열장치의 제어계 설계를 위한 모델인식)

  • Yun, Woohyun;Ji, Sang Hyun;Na, Byung-Cheol;Won, Wangyun;Lee, Kwang Soon
    • Korean Chemical Engineering Research
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    • v.46 no.3
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    • pp.486-491
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    • 2008
  • This paper describes a model identification method that has been applied to a commercial 12-inch RTP (rapid thermal processing) equipment with an ultimate aim to develop a high-performance advanced controller. Seven thermocouples are attached on the wafer surface and twelve tungsten-halogen lamp groups are used to heat up the wafer. To obtain a MIMO balanced state space model, multiple SIMO (single-input multiple-output) identification with highorder ARX models have been conducted and the resulting models have been combined, transformed and reduced to a MIMO balanced state space model through a balanced truncation technique. The identification experiments were designed to minimize the wafer warpage and an output linearization block has been proposed for compensation of the nonlinearity from the radiation-dominant heat transfer. As a result from the identification at around 600, 700, and $800^{\circ}C$, respectively, it was found that $y=T(K)^2$ and the state dimension of 80-100 are most desirable. With this choice the root-mean-square value of the one-step-ahead temperature prediction error was found to be in the range of 0.125-0.135 K.

A DLL-Based Multi-Clock Generator Having Fast-Relocking and Duty-Cycle Correction Scheme for Low Power and High Speed VLSIs (저전력 고속 VLSI를 위한 Fast-Relocking과 Duty-Cycle Correction 구조를 가지는 DLL 기반의 다중 클락 발생기)

  • Hwang Tae-Jin;Yeon Gyu-Sung;Jun Chi-Hoon;Wee Jae-Kyung
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.42 no.2 s.332
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    • pp.23-30
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    • 2005
  • This paper describes a DLL(delay locked loop)-based multi-clock generator having the lower active stand-by power as well as a fast relocking after re-activating the DLL. for low power and high speed VLSI chip. It enables a frequency multiplication using frequency multiplier scheme and produces output clocks with 50:50 duty-ratio regardless of the duty-ratio of system clock. Also, digital control scheme using DAC enables a fast relocking operation after exiting a standby-mode of the clock system which was obtained by storing analog locking information as digital codes in a register block. Also, for a clock multiplication, it has a feed-forward duty correction scheme using multiphase and phase mixing corrects a duty-error of system clock without requiring additional time. In this paper, the proposed DLL-based multi-clock generator can provides a synchronous clock to an external clock for I/O data communications and multiple clocks of slow and high speed operations for various IPs. The proposed DLL-based multi-clock generator was designed by the area of $1796{\mu}m\times654{\mu}m$ using $0.35-{\mu}m$ CMOS process and has $75MHz\~550MHz$ lock-range and maximum multiplication frequency of 800 MHz below 20psec static skew at 2.3v supply voltage.