• 대한한방소아과학회지
• /
• 제35권1호
• /
• pp.18-29
• /
• 2021

Objectives The purpose of this study is to provide evidence of treatment of growth disorder Methods We have reviewed clinical studies of growth disorder in children and adolescent through 6 databases until February, 2020. The searching keywords were "short stature OR dwarfism OR growth disorder" AND "acupuncture OR electric acupuncture OR electroacupuncture OR moxibustion OR herb medicine OR cupping OR Korean medicine OR oriental medicine OR chuna OR pharmacopuncture OR qigong OR traditional medicine OR traditional Korean medicine OR Korean medicine". There was no limit to time and language. Results As a result of the initial search, a total of 270 papers from six domestic databases were found. Among these papers, 156 papers were selected after excluding duplicated papers, and 109 of them were further excluded after checking the title and the abstract. Additionally, 28 papers were excluded by reviewing the full text. The author, year, number of patients, treatment, evaluation tools, and results of a total of 19 papers were included in this study and were summarized. 90.5% of the studies have shown that herbal remedies have improved childhood growth. Conclusions Random control studies and large-scale observational studies are needed in future to show high-quality evidence for the treatment of Korean medicine in pediatric growth.

• 대한치과교정학회지
• /
• 제52권3호
• /
• pp.182-200
• /
• 2022

Objective: This study aims to examine the effectiveness of miniscrew assisted rapid palatal expansion (MARPE) treatment in late adolescents and adult patients using cone-beam computed tomography (CBCT). Methods: Literature search was conducted in five electronic databases (PubMed, Embase, Scopus, Web of Science, and Cochrane Library) based on the PICOS keyword design focusing on MARPE. Out of the 18 CBCT screened outcomes, only nine parameters were sufficient for the quantitative meta-analysis. The parameters were classified into three main groups: 1) skeletal changes, 2) alveolar change, and 3) dental changes. Heterogeneity test, estimation of pooled means, publication bias, sensitivity analysis and risk of bias assessment were also performed. Results: Upon database searching, only 14 full-text articles were qualified from the 364 obtained results. Heterogeneity test indicated the use of the random-effects model. The pooled mean estimate were as follows: 1) Skeletal expansion: zygomatic width, 2.39 mm; nasal width, 2.68 mm; jugular width, 3.12 mm; and midpalatal suture at the posterior nasal spine and anterior nasal spine, 3.34 mm and 4.56 mm, respectively; 2) Alveolar molar width expansion, 4.80 mm; and 3) Dental expansion: inter-canine width, 3.96 mm; inter-premolar width, 4.99 mm and inter-molar width, 5.99 mm. The percentage of expansion demonstrated a skeletal expansion (PNS) of 55.76%, alveolar molar width expansion of 24.37% and dental expansion of 19.87%. Conclusions: In the coronal view, the skeletal and dental expansion created by MARPE was of the pyramidal pattern. MARPE could successfully expand the constricted maxilla in late adolescents and adult patients.

• Archives of Plastic Surgery
• /
• 제48권4호
• /
• pp.361-365
• /
• 2021

Background Pain in the postoperative body contouring patient has traditionally been managed with narcotic medication. In an effort to minimize side effects and prevent addiction, plastic surgeons are searching for novel ways to provide adequate analgesia, one of which is nerve blocks. This study was conducted with a meta-analysis that evaluates the efficacy of these blocks for patients who undergo breast surgery. Methods A search of the PubMed/MEDLINE database for articles including the terms "post-operative analgesia" OR "postoperative pain management" AND "in plastic surgery" OR "in cosmetic surgery" OR "in elective surgery" in February 2019 generated five studies on elective breast augmentation and reduction mammoplasty that reported pain scores and quantities of opioids consumed. Independent samples t-tests, one-way analysis of variance, and a random effects model were implemented for evaluation. Results A total of 317 patients were identified as having undergone body contouring of the breast, about half of which received a nerve block. Pain scores on a 1-10 scale and opioid dose-equivalents were calculated. Those who were blocked had an average score of 2.40 compared to 3.64 for those who did not (P<0.001), and required an average of 5.20 less narcotic doses (P<0.001). Pain relief following subpectoral augmentation was best achieved with type-II blocks as opposed to type-I and type-II with serratus plane (P<0.001). Conclusions The opioid epidemic has extended to all surgical specialties. Implementation of a nerve block seems to be an efficacious and cost-effective mechanism to not only help with post-operative pain, but also lower the need for narcotics, especially in subpectoral augmentation.

• Clinical Nutrition Research
• /
• 제12권1호
• /
• pp.54-64
• /
• 2023

A systematic review and meta-analysis were designed to summarize studies conducted on the effects of raspberry and blackcurrant consumption on blood pressure (BP). Eligible studies were detected by searching numerous five online databases including PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar, until December 17, 2022. We pooled the mean difference and its 95% confidence interval (CI) by applying a random-effects model. Overall, the impact of raspberry and blackcurrant on BP was reported in ten randomized controlled trials (RCTs) (420 subjects). Pooled analysis of six clinical trials revealed that raspberry consumption has no significant reduction in systolic blood pressure (SBP) (weighted mean differences [WMDs], -1.42; 95% CI, -3.27 to 0.87; p = 0.224) and diastolic blood pressure (DBP) (WMD, -0.53; 95% CI, -1.77 to 0.71; p = 0.401), in comparison with placebo. Moreover, pooled analysis of four clinical trials indicated that blackcurrant consumption did not reduce SBP (WMD, -1.46; 95% CI, -6.62 to 3.7; p = 0.579), and DBP (WMD, -2.09; 95% CI, -4.38 to 0.20; p = 0.07). Raspberry and blackcurrant consumption elicited no significant reductions in BP. More accurate RCTs are required to clarify the impact of raspberry and blackcurrant intake on BP.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권5호
• /
• pp.1881-1895
• /
• 2015

Background: The vascular endothelial growth factor family has been implicated in tumorigenesis and metastasis. The prognostic value of each vascular endothelial growth factor family member, particular VEGF/VEGFR co-expression, in patients with non-small lung cancer remains controversial. Materials and Methods: Relevant literature was identified by searching PubMed, EMBASE and Web of Science. Studies evaluating expression of VEGFs and/or VEGFRs by immunohistochemistry or ELISA in lung cancer tissue were eligible for inclusion. Hazard ratios (HRs) and 95% confidence intervals (CIs) from individual study were pooled by using a fixed- or random-effect model, heterogeneity and publication bias analyses were also performed. Results: 74 studies covering 7,631 patients were included in the meta-analysis. Regarding pro-angiogenesis factors, the expression of VEGFA (HR=1.633, 95%CI: 1.490-1.791) and VEGFR1 (HR=1.924, 95%CI: 1.220-3.034) was associated separately with poor survival. Especially, VEGFA over-expression was an independent prognostic factor in adenocarcinoma (ADC) (HR=1.775, 95%CI: 1.384-2.275) and SCC (HR=2.919, 95%CI: 2.060-4.137). Co-expression of VEGFA/VEGFR2 (HR=2.011, 95%CI: 1.405-2.876) was also significantly associated with worse survival. For lymphangiogenesis factors, the expression of VEGFC (HR=1.611, 95%CI: 1.407-1.844) predicted a poor prognosis. Co-expression of VEGFC/VEGFR3 (HR=2.436, 95%CI: 1.468-4.043) emerged as a preferable prognostic marker. Conclusions: The expression of VEGFA (particularly in SCC and early stage NSCLC), VEGFC, VEGFR1 indicates separately an unfavorable prognosis in patients with NSCLC. Co-expression VEGFA/VEGFR2 is comparable with VEGFC/VEGFR3, both featuring sufficient discrimination value as preferable as prognostic biologic markers.

• 한국산림과학회지
• /
• 제102권4호
• /
• pp.608-616
• /
• 2013

이 연구에서는 교토의정서 제3조 4항의 산림경영활동에 따른 이산화탄소 흡수량 산정을 위한 산림경영율 추정방법으로 임의선택법, 계층추출법, 최대시업면적법, 중복시업면적법을 제시하였고, 그 중 측정 보고 검증가능한 (MRV) 방식에 있어서 현재 가장 합리적인 방법이라 판단되는 최대시업면적법을 적용하여 사례분석을 실시하였다. 산림경영율은 전체산림면적 대비 산림경영면적으로 정의될 수 있으며, 산림경영면적은 산림경영활동의 정의에 따라 전체 산림을 시업지와 제한지로 구분하였다. 시업지의 산림경영면적은 '국유림경영정보시스템'과 '사유림 경영정보 DB구축 사업'의 시업이력을 근거로, 제한지의 경우는 '산지구분도'상의 공익용 임지를 기준으로 산출되었다. 사례연구 대상지인 충청북도의 산림경영면적은 시업지 115,566 ha, 제한지 131,008 ha로 전체 산림면적 495,806 ha의 49.7%(산림경영율)로 나타났다. 이 연구는 교토의정서체계하에서의 우리나라 산림경영율을 추정할 수 있을 뿐만 아니라 산림경영율을 높일 수 있는 산림경영계획과 실행방안을 찾는데 기여할 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권1호
• /
• pp.189-193
• /
• 2013

Many epidemiological studies in Asian populations have investigated associations between the Arg399Gln gene polymorphism of X-ray repair cross complementing gene 1 (XRCC1) and risk of cervical carcinoma, but no conclusions have been available because of controversial results. Therefore a meta-analysis was conducted for clarification. Relevant studies were identified by searching the Pubmed, Embase, the Web of Science, Cochrane Collaboration's database, Chinese National Knowledge Infrastructure (CNKI), Wanfang database and China Biological Medicinse (CBM) until September, 2012. A total of eight studies were included in the present meta-analysis, which described 1,759 cervical carcinoma cases and 2,497 controls. Odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) as effect size were calculated by fixed-effect or random-effect models. The overall results indicated that the XRCC1-399G/A polymorphism was marginally associated with cervical carcinoma in Asians: OR (95%CI): 1.16 (1.07, 1.26) in the G/A vs G/G inheritance model, 1.24 (0.87, 1.76)in A/A vs G/G inheritance model, 1.13 (1.01, 1.27) in the dominant inheritance model and 1.18 (0.94, 1.47) in the recessive inheritance model. Subgroup analyses on sample size showed no significant correlation in the small-sample size group but the large-sample size group was consistent with the outcomes of overall meta-analysis. In the subgroup analysis by regions, we only found significant association under the G/A vs G/G inheritance model in the Chinese population. For the non-Chinese populations, no correlation was detected in any genetic inheritance model. In the Asian populations, XRCC1-399G/A gene polymorphism was implied to be associated with cervical carcinoma.

• 정보과학회 컴퓨팅의 실제 논문지
• /
• 제21권2호
• /
• pp.126-131
• /
• 2015

플래시 기반 저장장치가 서버와 데이터 센터에 활발하게 도입됨에 따라 신뢰성이 더욱 중요해지고 있다. 신뢰성을 향상시키는 방법들 중에 한 가지는 정적 마모도 평준화로, 이것은 삭제 횟수를 평준화시켜 결국 저장장치 수명을 향상시킬 수 있다. 하지만 저장장치의 용량이 증가함에 따라 정적 마모도 평준화를 위한 부하도 커지고 있다. 특히 전체 블록에서 최대 또는 최소의 삭제 횟수를 갖는 블록의 검색 비용이 용량의 증가에 따라 커지고 있다. 본 논문에서는 이러한 부하를 줄이기 위해 무작위 선택을 정적 마모도 평준화에 도입한다. 구체적으로 전수 조사 대신, n개의 블록을 무작위로 뽑고 이 중에서 최대 또는 최소 삭제 횟수를 갖는 블록들을 선택한다. 실험 결과 n이 2일 때에도 마모 평준화 효과가 있으며, n이 4 이상이며 전수 조사에 기반한 최적 평준화에 근접하는 결과를 보이는 것을 알 수 있었다. 성능 향상의 효과를 측정하기 위해 실제 보드에 구현을 하였으며, 블록 선택 시간이 3배 이상 향상된 것을 관찰할 수 있었다. 결국 제안 기법은 기존 정적 마모 평균화의 효과를 적은 부하로 얻을 수 있는 것이다.

• 대한교통학회지
• /
• 제34권2호
• /
• pp.158-167
• /
• 2016

본 연구는 실시간 자료를 기반으로 k-NN을 활용한 단기 교통상황 예측 시 각 단계별 세부절차 및 변수결정, 입력자료 구축 등의 각 단계별 잠재적 예측오차에 대한 원인분석 및 시사점 도출을 목적으로 한다. 다양한 단기 예측모형에 대한 선행연구 검토를 통하여 k-NN 모형의 유용성을 검토하였고 이에 대한 적용가능성을 분석하였다. 본 연구의 k-NN 모형은 이력자료 평활화 및 패턴DB 구축의 입력자료 부분, 실시간 자료와 과거 이력자료와의 유사성 측정 및 k 근접이웃 결정 등의 k-NN 알고리즘 부분, 그리고 예측 시간간격에 따른 출력결과 부분 등으로 구성되며 올림픽대로 김포방향 한강대교 남단~여의상류IC 구간을 대상으로 분석을 실시하였다. 교통자료의 불규칙 잡음으로 인하여 정확한 패턴매칭을 위해서 이력자료의 평활화를 실시하였으며, 이력자료 패턴 DB는 일반 및 이벤트 상황으로 구분하여 활용하였다. 최적의 시계열 자료 및 k 근접이웃 결정을 위해서 시행착오 방법을 적용하였으며, 단기 교통상황 예측 시 예측 시간간격이 증가할수록 예측오차가 증가하는 패턴, 그리고 교통상태가 급변하는 시점에서도 예측오차가 증가함을 알 수 있었다. 본 연구의 k-NN 모형에 대한 각 단계별 예측오차에 대한 원인을 분석하여 개선방향을 제시함으로써 향후 신뢰성 있는 단기 교통상황예측 정보제공 및 시스템에 활용이 가능할 것으로 판단된다.

• 미생물학회지
• /
• 제31권4호
• /
• pp.267-273
• /
• 1993

Escherichia coli 의 superoxide 라디칼 유도발현성 유전자의 탐색을 위하여 먼저 superoxide 라디칼에 의하여 발현이 유도되는 프로모터를 탐색하였다. 이를 위햐여, 프로모터 탐색벡터인 pJAC4 를 이용하여 E. coli MG1655 균주로부터 프로모터 library 를 구성하였다. Ampicillin 농도구 배정판법을 이용하여 프로모터 세기가 다른 클론들을 구별하여 프로모터 세기가 약한 것부터 중간정도까지 383개의 클론을 선별하였다. 이들 프로모터 클론들의 superoxide 라디칼 유도발현성을 paraquat 를 첨가한 ampicilin 농도구배평판에서 조사하였다. 이중 3개의 클론이 paraquat 에 의하여 유도됨을 확인하였고, 유도배율은 1.4-4배 정도이었다. 이들 프로모터의 염기서열을 결정한 결과 기종의 database 에 등록되어 있는 E. coli 염기서열들과는 다른 새로운 유전자임을 알았다. 이들 프로모터에 대하여 primer 연장법과 SS1 뉴클리아제 분석을 총하여 전사개시 자리를 결정하였고, paraquat 처리시 mRNA 의 양이 증가함을 관찰하였다. 특히 클론5의 경우는 두개의 전사개시 위치를 가지고 있으며, paraquat 처리시 상위 부분의 전사개시자리가 성택적으로 사용됨을 알 수 있었다. 프로모터 서열을 검색한 결과, RNA 중합효소($E\sigma^{70}$)에 의햐여 인지되는 -10과 -35부위를 가진 클론은 클론 5 뿐이었고, 나머지는 보존된 염기서열을 찾을 수 없었다. 이는 이들 프로모터들이 독특한 부류에 속하는 종류들로서, 새로운 전사조절인자를 요구할 가능성을 시사한다.