• Journal of Ginseng Research
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• 제24권4호
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• pp.202-205
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• 2000

계지인삼탕중 고려인삼을 보기조양 효능이 더 강한 고려홍삼으로 바꾼 계지홍삼탕을 시료로 항산화작용과 지구력효과를 비교검토 하였다. 항산화작용중 AAPH에 의한 적혈구 용혈작용은 고려홍삼과 계지홍삼탕이 유효하게 억제되었으나,DPPH에 대한 유리산소 소거율은 BHT보다는 약하였지만 농도의존적으로 유의성 있게 감소되었고, in vivo에서 hAPn처리후 시간경과(1시간, 3시간, 6시간)에 따른 MDA제거율도두 실험군에서 대조군에 비해 시간과 농도에 비례하여 유의하게 감소하였지만 6시간후에는 두 실험군간에 통계적 편차는 없었다. 수영법에 의한 지구력 측정에서는 두 실험군이 대조군에 비해 유의한 증가를 보였지만 시료 투여후 2주에는 고려홍삼이 보다 유효했고, 4주째는 계지홍삼탕이 저농도(25mg/rg)에서만 유효했다. 이상의 결과로 보아 고려삼과계지홍삼탕은 항산화 및 지구력 증진 효과가 있는 것으로 사료되지만 지속적인 보완 연구가 필요하다고 사료된다.

• 한방안이비인후피부과학회지
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• 제32권4호
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• pp.101-115
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• 2019

Objectives : The purpose of this study is to analyze the use of herbal medicine as a treatment method in the case studies on warts in Korea, to identify trends in herbal medicines and herbal prescriptions according to the characteristics of individual patients and to systematically analyze concurrent therapies. Methods : Domestic databases (OASIS, RISS, NDSL, KTKP, KISS, KISTI, KISTI) were used to search for case studies related to the herbal medicine treatment of warts. There was no restriction on the time of publication. A total of 9 papers were selected. Results : A total of 13 prescriptions were presented 23 times in 18 cases. Among them, bojungikgi-tang gamibang(補中益氣湯加減方) was the most frequently prescribed. Gwakhyangjeonggi-san gamibang(藿香正氣散加減方) and Damsoeun-tang gagam were the next most frequently prescribed. 69 herbs were used in a total of 13 prescriptions. Herbs were commonly classified as heat-clearing medicine(淸熱藥), exterior-releasing medicine(解表藥), and tonifying and replenishing medicine(補益藥) in descending order. The herbs used more than 6 times included Coicis Semen(薏苡仁), Glycyrrhizae Radix et Rhizoma(甘草) (10 times), Bupleuri Radix(柴胡), and Scutellariae Radix(黃芩) (6 times). Concurrent therapies were performed except for 1 study, and they were acupuncture, moxibustion, pharmacopuncture, external agents, and cupping therapy. Conclusions : This is the first study to analyze the use of herbal medicine as a treatment method for warts in case studies performed in Korea. We hope that this study would give helpful information about the treatment of warts in clinical practices.

• 대한한의학방제학회지
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• 제27권3호
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• pp.189-197
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• 2019

Objectives : The purpose of this study was to confirm whether Codonopsis Radix(CR) could be used in the same way for expected indications or diseases of adaptation instead of Ginseng Radix(GR), which acts as a principal herb in Sagunja-tang. Methods : The Traditional Chinese Medicine Systems pharmacology(TCMSP), a database for the study of systems biology related to Chinese medicine, screened potential active compounds in each quartet. By searching for all the proteins that each compound provides, the target of Sagunja-tang with GR(GRST) and the target of Sagunja-tang with CR(CRST) were compared using the network analysis method, and the top ranked target of each serving was selected. Results : Through TCMSP, a Chinese medicine database, the potential effective ingredients of GRST or CRST screened, and the target proteins related to these substances were found to be the most affected by Glycyrrhizae Radix et Rhizome, an herbal medicine mixed in Sagunja-tang, and the target diseases were the same. And the same were found for the target protein, gene and target diseases of GRST and CRST. Conclusions : The prescription with similar composition is likely to have similar network pharmacology analysis results, and the analysis result may be controlled by the herbal medicines which are assumed to be the main function. Therefore, rich and reproducible basic studies is more important because network pharmacological studies can be dominated by data that has been done a lot of previous studies.

• 대한한방소아과학회지
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• 제36권1호
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• pp.38-56
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• 2022

Objectives The purpose of this study was to analyze the trend of recent randomized controlled trials (RCTs) that used herbal medicine for the treatment of tic disorders in China and to evaluate the efficacy and safety of the treatment. Methods RCTs published from January 2017 to December 2021 were searched for using the China National Knowledge Infrastructure (CNKI). These were then analyzed using herbal medicine treatment methods and their results. Results A total of 35 randomized controlled trials were selected and analyzed. In most studies, evaluation indicators such as the Yale tic symptom scale and total effective rate were significantly improved in the herbal medicine treatment group compared to the control group. The most commonly used herb for tic disorder was Uncaria Rhynchophylla (釣鉤藤), followed by Glycyrrhizae Radix (甘草), Gastrodiae Rhizoma (天麻), Paeoniae Radix Alba (白芍藥), Batryticatus (白殭蠶), Poria (茯笭), and Bupleuri Radix (柴胡). In all studies that reported adverse events, herbal medicine was identified as a relatively safe treatment with fewer adverse reactions or no significant difference compared with the control group. Conclusions Based on the results of RCTs, herbal medicine has been shown to be safe and effective for the treatment of intellectual disability. However, additional well-designed large-scale clinical trials are needed to confirm these findings.

• 한방안이비인후피부과학회지
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• 제32권3호
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• pp.151-163
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• 2019

Objectives : The purpose of this study is to investigate the use of herbal medicine for the treatment of atopic dermatitis in cases and to find the general tendency of herbal medicine treatment and to establish the primary treatment direction of Atopic dermatitis. Methods : In the domestic databases, Oriental medicine Advanced Searching Integrated System(OASIS), Korean Traditional Knowledge Portal(KTKP), National Discovery for Science Leader(NDSL), Research Information Sharing Service(RISS), we selected among the papers published in the last 20 years using search terms related to "Atopic dermatitis & Cases". Reports based on Sasang constitutional medicine and Six meridian pattern identification were excluded and a total of 21 papers were finally selected. Results : 113 herbal medicines were retrieved from 21 papers. The most commonly used herbs are Scutellariae Radix(黃芩), Rehmanniae Radix(地黃), and Glycyrrhizae Radix et Rhizoma(甘草). Atractylodis Rhizoma(蒼朮), Akebiae Caulis(木通), Smilacis Rhizoma(土茯?), Paeoniae Radix(芍藥) used mostly when Oozing exists, Trichosanthis Radix (瓜蔞), Asparagi Radix(天門冬), Persicae Semen(桃仁), Carthami Flos(紅花) used mostly when Dryness, Lichenification, and Pigmentation exist. The average score of SCORAD index was improved after Herbal medicine treatment. Conclusion : Through this study, we could find out the tendency of herbal medicine to treat Atopic dermatitis along with Symptoms.

• 대한한방소아과학회지
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• 제17권1호
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• pp.29-51
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• 2003

This study was progressed for oriental medical care of neonates by fetal toxicosis removal therapy, and the results as follows: 1. The purpose of fetal toxicosis removal therapy : It removes dirty blood in neonatal mouth and prevents diseases. 2. Kinds of fetal toxicosis removal therapy : Radix Glycyrrhizae(甘草), Rhizoma Coptidis(黃連), Cinnabaris-Mel(朱蜜), Calculus Bovis(牛黃), Sojae Semen Praepartum, Juice of Semen Allii Tuberosi(非汁) and mercury(汞粉). 3. A period of fetal toxicosis removal therapy : At birth, 3rd day or so, one week or so, after umbilical omission. 4. Methods of fetal toxicosis removal therapy: Purgative therapy(下法) and Emetic therapy(吐法).

• 생약학회지
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• 제31권3호
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• pp.364-372
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• 2000

The Youngkaechulgamtang(Y) is composed of four herbal drugs, including Hoelen(H), Cinnamomi Ramulus(C), Atractylodis Rhizoma Alba(A) and Glycyrrhizae Radix(G). In oriental medicine literatures, Youngkaechulgamtang is described to be effective in headache, inflammation, uremia, gastritis, diarrhea, hypertension. To estimate the clinical effectiveness of Youngkaechulgamtang, several pharmacological experiments were carried out. The results are summarized as follows: On $HgCl_2-induced$ renal failure rat, Youngkaechulgamtang showed the significant increase of $Na^+,\;K^+,\;Cl^-$ contents in urine and the significant decrease of creatinine and BUN concentrations in serum. Youngkaechulgamtang was more effective than mixture of 4 ingredients in the urine volume and excretion of electrolytes. In the diuretic effect, Hoelen and Atractylodis Rhizoma Alba were more effective than other drugs.

• 대한한방내과학회지
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• 제15권2호
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• pp.70-108
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• 1994

The kinds and remedies of intoxication were investigated throughout total 22 books of oriental medicine. The results are as follows 1. The kinds of intoxication were 91, most of which were plant intoxications and animal intoxications. 2. The kinds of detoxication medicines was 203, the most popularly prescribed of which were Radix Glycyrrhizae Semen Glycine. 3. The prescribed medicines were most nonpoisonous ones, but some of them were poisonous. 4. The medicines with Han seong(寒性) were most popularly prescribed. The ones with On seong(溫性), Pung seong(平性), Youl seong(熱性), Yang seong(凉性) follows 5. The most popularly prescribed medicine was sweet taste(甘味). The nest ones were pungent taste(辛味), bitter taste(苦味), sour taste(酸味), salty taste(鹹味). 6. The most popularly prescribed medicine was Chung Youl(淸熱) medicines.

• 약학회지
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• 제32권6호
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• pp.377-385
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• 1988

The biologically active component of licoris(Glycyrrhizae Radix L.) is considered to be glycyrrhetinic acid, an aglycone of glycyrrhizin, on the basis of chemical and pharmacological studies. The present study was undertaken to investigate the effect of glycyrrhetinic acid on the hepatic morphine-6-dehydrogenase activity, which catalize morphine to morphinone. Morphine-6-dehydrogenase was further purified by centrifugation, $(NH_4)_2SO_4$ fractionation, sephadex G-100, hydroxyapatite column. Hepatic morphine-6-dehydrogenase activity was significantly decreased by the treatment of glycyrrhetinic acid. When effect of glycyrrhetinic acid on the hepatic morphine-6-dehydrogenase was investigated in vitro, it was powerfully inhibited the enzyme activity with dose-dependent manner. From the above results, glycyrrhetinic acid inhibits hepatic morphine-6-dehydrogenase activity and decreases the morphine induced harmful side effects.

• 혜화의학회지
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• 제14권1호
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• pp.101-112
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• 2005

As a result of studing on the "Joa-gui Em", we could reach conclusions as follows. 1. "Joa-gui Em" shows in vivo effect of that it supplement Kidney-Um essence and nomalize a physiological function of Kidney-Qi. 2. "Joa-gui Em" supplement Kidney-Um essence, it does not use in The Rise of Insubstantial Fire(음허화왕) body condition. 3. "Joa-gui Em" use in many ways women disease, in case of menstruation and meonpause disorder. 4. "Joa-gui Em" and "Joa-gui Hwan" are modification prescription of "Uk-mi-ji-hwang-hwan. 5. "Joa-gui Em" is a pure prescription in supplement Kidney-Um essence, Roast Glycyrrhizae Radix of prescription has effect of supplement Sam-cho Qi. 6. "Joa-gui Hwan" is similarly "Joa-gui Em." Colla Cornus Cervi and a Colla Cornus Glemmys of prescription have effect of supplement DUMAI and RENMAI CHONGMAI.