The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Recent Trends in Clinical Research of Herbal Medicine for Tic Disorder in Children - Focused on Chinese Randomized Controlled Trials -

소아 틱장애의 한약치료에 대한 최신 임상연구 동향 - 중국 무작위 대조군 임상연구를 중심으로 -

  • Kim, Jae Hyun (Department of Korean Pediatrics, Graduate School, Kyung Hee University) ;
  • Park, Yong Seok (Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Jeong, Yoon Kyoung (Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Chang, Gyu Tae (Department of Korean Pediatrics, Graduate School, Kyung Hee University)
  • 김재현 (경희대학교 대학원 한방소아과) ;
  • 박용석 (강동경희대학교병원 한방소아과) ;
  • 정윤경 (강동경희대학교병원 한방소아과) ;
  • 장규태 (경희대학교 대학원 한방소아과)
  • Received : 2022.01.12
  • Accepted : 2022.02.21
  • Published : 2022.02.28
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Abstract

Objectives The purpose of this study was to analyze the trend of recent randomized controlled trials (RCTs) that used herbal medicine for the treatment of tic disorders in China and to evaluate the efficacy and safety of the treatment. Methods RCTs published from January 2017 to December 2021 were searched for using the China National Knowledge Infrastructure (CNKI). These were then analyzed using herbal medicine treatment methods and their results. Results A total of 35 randomized controlled trials were selected and analyzed. In most studies, evaluation indicators such as the Yale tic symptom scale and total effective rate were significantly improved in the herbal medicine treatment group compared to the control group. The most commonly used herb for tic disorder was Uncaria Rhynchophylla (釣鉤藤), followed by Glycyrrhizae Radix (甘草), Gastrodiae Rhizoma (天麻), Paeoniae Radix Alba (白芍藥), Batryticatus (白殭蠶), Poria (茯笭), and Bupleuri Radix (柴胡). In all studies that reported adverse events, herbal medicine was identified as a relatively safe treatment with fewer adverse reactions or no significant difference compared with the control group. Conclusions Based on the results of RCTs, herbal medicine has been shown to be safe and effective for the treatment of intellectual disability. However, additional well-designed large-scale clinical trials are needed to confirm these findings.

Keywords

References

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th Edition. Arlington, VA: American Psychiatric Association; 2013;81-6.
  2. Du JC, Chiu TF, Lee KM, Wu HL, Yang YC, Hsu SY, Sun CS, Hwang B, Leckman JF: Tourette syndrome in children: an updated review. Pediatr Neonatol 2010;51(5):255-64. https://doi.org/10.1016/S1875-9572(10)60050-2
  3. Scahill L, Specht M, Page C. The prevalence of tic disorders and clinical characteristics in children. J Obsessive Compuls Relat Disord. 2014;3(4):394-400. https://doi.org/10.1016/j.jocrd.2014.06.002
  4. Jankovic J, Kurlan R: Tourette syndrome: evolving concepts. Mov Disord 2011; 26(6):1149-56. https://doi.org/10.1002/mds.23618
  5. RD Freeman, DK Fast, L Burd, J Kerbashian, MM Robertson, P Sandor. An international perspective on Tourette syndrome: Selected findings from 3500 individuals in 22 countries. Dev Med Child Neurol. 2000;42(7):436-47. https://doi.org/10.1017/S0012162200000839
  6. Groth C, Debes NM, Rask CU, Lange T, Skov L. Course of Tourette syndrome and comorbidities in a large prospective clinical study. J Am Acad Child Adolesc Psychiatry. 2017;56(4):304-12. https://doi.org/10.1016/j.jaac.2017.01.010
  7. Conelea CA, Wodds DW, Zinne SH, Budman C, Murphy T, Scahill LD, Compton SN, Walkup J. Exploring the impact of chronic tic disorders on youth: results from the Tourette syndrome impact survey. Child Psychiatry Hum Dev. 2011;42(2):219-42. https://doi.org/10.1007/s10578-010-0211-4
  8. Kompoliti K, Fan W, Leurgans S. Complementary and alternative medicine use in Gilles de la Tourette syndrome. Mov Disord. 2009;24(13):2015-9. https://doi.org/10.1002/mds.22724
  9. Koo EJ, Kweon JH, Kim KB, Kim BNR, Kim JH, Min SY, Park EJ, Baek JH, Sung HK, Yu SA, Lee SH, Lee JH, Lee JY, Lee HL, Chang GT, Jung MJ, Jung AR, Jung HS, Cheon JH. Hanbangsoacheong-sonyeonuihak. 3rd ed. Seoul: Ui Sung Dang Publishing Co. 2020:517-23.
  10. Lee SY, Yu SA. A clinical study of a child with tic-disorder with allergic rhinitis. J Pediatr Korean Med. 2016;30(1):40-4. https://doi.org/10.7778/JPKM.2016.30.1.040
  11. Kang KH, Park EJ. A case report of tic disorder children treated by Kuibiondamtanggami. J Pediatr Korean Med. 2014;28(4):118-24. https://doi.org/10.7778/JPKM.2014.28.4.0118
  12. Cho YS, Baek JH, A review of korean medicine treatment for tic disorder. J Pediatr Korean Med. 2017;31(4):9-18. https://doi.org/10.7778/JPKM.2017.31.4.009
  13. Lee KJ, Jeong MJ. Systematic review of acupuncture treatment for tic disorder. J Pediatr Korean Med. 2017;31(2):14-24. https://doi.org/10.7778/JPKM.2017.31.2.014
  14. Park JM. Review of latest traditional chinese medicine clinical studies on pediatric tic disorder with tuina treatment. J Korean Med. 2021;42(3):139-52 https://doi.org/10.13048/jkm.21030
  15. Kim YH, Son CG, Ku BC, Lee HW, Lim HS, Lee MS. Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials. Chinese Medicine. 2014;9(6):1-7. https://doi.org/10.1186/1749-8546-9-1
  16. Zhang FL. Clinical observation on 31 cases of tic disorders in children with spleen deficiency and liver exuberance syndrome treated by modified gouteng decoction as adjuvant therapy. J Pediatr TCM. 2021;17(5):63-5.
  17. Xu JC, Liu JY, Fang F, Xu Y, Peng YL. Comparison of pinggan jianpi bushen decoction and haloperidol in the treatment of children's tic disorders. Chin Rural Med. 2021;28(2):21-2.
  18. Du HB. Tianma gouteng decoction and chaihu longgu muli decoction treatment clinical observation of children's tic syndrome. Chin Naturop. 2021;29(8):73-5.
  19. Ding HM. Clinical observation on modified qianjin longdan decoction in the treatment of tourette syndrome in children. Chin Med Mod Distance Educ Chin. 2021;19(5):94-6.
  20. Shi XN. Clinical observation on treating infantile multiple tourette syndrome with the wendan decoction. Clin J Chin Med. 2020;12(35):124-6.
  21. Ai TM, Wu S. Effect analysis of self-made traditional chinese medicine decoction in the treatment of children with hyperactivity of liver and wind -induced tourette syndrome. Chin Contemp Med. 2021;28(25):178-80.
  22. Deng YQ. Clinical effect of tiapride hydrochloride tablets combined with changpu yujin decoction in the treatment of children with tourette syndrome. Chin J Clin Ration Drug Use. 2021;14(7):145-7.
  23. Liang YP. Clinical observation of modified yuzhen powder in treating tourette syndrome. J Pract Traidt Chin Med. 2020;36(4):444-5.
  24. Yang YT. Clinical observation of anshen jinggan decoction in the treatment of children with tic disorders of liver-kidney deficiency type. [Master]. [Chengdu]: Chengdu University of Chinese Medicine; 2020a. 68p
  25. Yang YB, Wang XY, KongLX, Zhang YM. Observation of the therapeutic effect of chaizhu tiaogan lipi decoction on children with tic disorders. Clin J Chin Med. 2020b;12(21):21-3.
  26. Yang CL, Zhang XJ, Zhao Q, Zhou J, Jia X, Li SS. Clinical observation on 60 cases of tourette syndrome in children with heat accumulation in spleen and stomach syndrome treated by jiawei xiehuang powder. J Pediatr Tradit Chin Med. 2020c;16(5):71-5.
  27. Guan ZJ, Xu JT, Li JY. Effect of modified sini powder on tic disorder in children. World J Integr Tradit West Med. 2020;15(2):310-3.
  28. Li HP, Li JX, Chen L, Wu LJ. Jingfeng decoction combined with tiapride in treating tic disorder in children with syndrome of spleen deficiency and liver hyperactivity. Acta Chin Med. 2020;35(26):184-6.
  29. Mu Z. Clinical study on tiantengzhichou granule in the treatment of tic disorder of spleen deficiency and liver hyperactivity. [Master]. [Hebei]: Hebei University of Chinese Medicine; 2020. 57p
  30. Tong Y. Clinical observation of sijun wendan decoction to treat children's tic disorder with spleen deficiency and phlegm accumulation. [Master]. [Heilongjiang]: Heilongjiang University of Chinese Medicine; 2020. 51p
  31. Liu YP, Zhang Y, Liu JF, Liu XL, Song ZR. Clinical observation and safety evaluation of chaihu guizhi decoction in the treatment of tourette syndrome. Chin Rural Health. 2019;11(1):42-3.
  32. Zhu WW. Sangye gouteng prescription for the treatment of qi stagnation and turbulence tic disorder efficacy observation. [Master]. [Guangzhou]: Guangzhou University of Chinese Medicine; 2019. 63p
  33. Cao MH. Clinical observation on modified Chaihu Shugan San in adjuvant treatment of 102 cases of tic disorder in children with stagnation of the liver-qi and deficiency of the spleen type. J Pediatr TCM. 2019;15(2):71-3.
  34. He WX, He L, Wang D, Zhang HQ, He YY, Gu YH, Zhang YR, Chen YN. Clinical observation on treating tic disorder in children with the tianma gouteng and ganmai dazao decoction. World Latest Med Inf. 2019;19(16):43-4.
  35. Chen YJ. Clinical observation of chaizao zhichou granulas in the treatment of multiple tic disorders with heart and liver burnt bloom. [Master]. [Huabei]: Huabei University of Technology; 2019. 57p
  36. Huang Q. Clinical observation on treatment of children's tic disorders (spleen deficiency and liver prosperity syndrome) with shuma zhichou granules. [Master]. [Hebei]: Hebei University of Chinese Medicine; 2019. 48p
  37. Xiong QJ, Ding LH, Liu S. Study of influence of jiuweixifeng granules combined with tiapride hydrochloride tablets on neurological function and quality of life of the children with tic disorder. Prim Med Forum. 2018a;22(11):1448-51.
  38. Xiong QJ, Ding LH, Liu S. Clinical observation of tianten capsule combined with tiapride hydrochloride tablets in treatment of pediatric tic disorder. North Pharm. 2018b;15(2):5-7.
  39. Yuan Y, Zhang Y, Jia CN, Qiu Q. Clinical observation on jia liujin's application of rougan qufeng decoction in treating tic disorders in children. Chin Naturop. 2018a;26(12):33-5.
  40. Yuan Y, Li F, Hao SF, Liu N, Zhang Y, Jia CN, Qiu Q. Clinical therapeutic effects of rougan qufeng decoction on children's tic disorder. World J Integr Tradit West Med. 2018b;13(3):310-4.
  41. Tan SW, Cui WT, Zhang XJ, Chen XR, Wang X, Feng XM. Clinical observation on treating tic disorder in children with the Longxie gouteng decoction. Clin J Chin Med. 2018;10(4):86-8.
  42. Wang Q, Fan JP, Ni Xq, Chen JP. Clinical study on modified huanglian wendan decoction for treatment of tic disorder children with syndrome of wind stirring due to phlegm-heat. Chin j Inf TCM. 2018;25(1):10-4.
  43. Shen HL. The clinical effect evaluation of the treatment of children's twitch disroder (phlegm-fire-disturbing type) with the addition of lingjiao gou teng decoction. [Master]. [Zhejiang]: Zhejiang University of Traditional Chinese Medicine; 2018. 44p
  44. Shi WL, Du XB, Li W, Xing L, Chang LL. Dingfeng zhijing powder for treatment of 64 cases of children with tourette syndrome of yin deficiency and hyperactivity of liver. Tradit Chin Med Res. 2018;31(12):14-7.
  45. Di MQ. Clinical observation of modified changpu yujin decoction in treating tourette syndrome. CJGMCM. 2018;33(21):3170-2.
  46. Wang Y, Guo ZY, Wang YS. Clinical observation on treatment of 34 cases of infantile tic disorders by self-made qingxin zhidong decoction. Forum Chin Tradit Med. 2017;32(1):35-7.
  47. Du CY, Hu SY, Zhao BJ, Cai QH, Wei XW, Ding Y, Wang XF, Xiang XX. Clinical observation of jiuwei xifeng granules in treatment of tic disorder in children with kidney-yin deficiency and liver-wind stirring. Mod Med Clin. 2017;32(4):718-22.
  48. You DP. Contrast research on jiuweixifengkeli and haloperidol treat tic disorder. J Dis Monitor Control 2017;11(11):885-6.
  49. Liang YY. A clinical analysis of treating transient tic disorder of the xinpi liangxu type in children with the guipi decoction. Chin J Chin Med. 2017;9(13):124-5.
  50. Li N. Observation on therapeutic effect of chaihujia longgumuli decoction in treating children's tourette syndrome. Cap Food Med. 2017;24(16):93-4.
  51. Gunduz A, Okun MS. A review and update on Tourette syndrome: where is the field headed? Curr Neurol Neurosci Rep. 2016;16(4):37. https://doi.org/10.1007/s11910-016-0633-x
  52. Singer HS. Tourette's syndrome: from behaviour to biology. Lancet Neurol 2005;4(3):149-59. https://doi.org/10.1016/S1474-4422(05)70018-1
  53. Roessner V, Plessen KJ, Rothenberger A, Ludolph AG, Rizzo R, Skov L, Strand G, Stern JS, Termine C, Hoekstra PJ, the ESSTS Guidelines Group. European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. Eur Child Adolesc Psychiatry. 2011;20(4):173-96.
  54. Piacentini J, Woods DW, Scahill L, Wilhelm S, Peterson AL, Chang S, Ginsburg GS, Deckersbach T, Dziura J, Levi-Pearl S, Walkup JT. Behavior therapy for children with Tourette disorder. JAMA. 2010;303(19):1929. https://doi.org/10.1001/jama.2010.607
  55. Ong MT, Mordekar SR, Seal A. Fifteen minute consultation: tics and Tourette syndrome. Arch Dis Child Educ Pract Ed. 2016;101(2):87-94. https://doi.org/10.1136/archdischild-2015-309138
  56. National Oriental Medicine College Collaborative Textbook Compilation Committee. Herbalogy. 3rd ed. Seoul: Young Lim Publishing Co. 2011:392-3, 541-3.
  57. Zhou J, Zhou S. Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J Ethnopharmacol. 2010;132(1):15-27. https://doi.org/10.1016/j.jep.2010.08.041
  58. Zhang Q, Zhao JJ, Xu J, Feng F, Qu W. Medicinal uses, phytochemistry and pharmacology of the genus uncaria. J Ethnopharmacol. 2015;173:48-80 https://doi.org/10.1016/j.jep.2015.06.011
  59. Jung HC, Sung WY, Lee SH, Son JH, Han SH. A clinical report of a patient with tourett's disorder. J Orient Neuropsychiatry. 2003;14(2):213-8.